TW200745082A - Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives - Google Patents

Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives

Info

Publication number
TW200745082A
TW200745082A TW095135518A TW95135518A TW200745082A TW 200745082 A TW200745082 A TW 200745082A TW 095135518 A TW095135518 A TW 095135518A TW 95135518 A TW95135518 A TW 95135518A TW 200745082 A TW200745082 A TW 200745082A
Authority
TW
Taiwan
Prior art keywords
methyl
pyrimidin
methanone
piperidin
ylmethyl
Prior art date
Application number
TW095135518A
Other languages
English (en)
Inventor
Bernard Vacher
Jean-Louis Maurel
Serge Brunel
Original Assignee
Pf Medicament
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pf Medicament filed Critical Pf Medicament
Publication of TW200745082A publication Critical patent/TW200745082A/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/26—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
TW095135518A 2005-09-27 2006-09-26 Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives TW200745082A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0509852A FR2891274B1 (fr) 2005-09-27 2005-09-27 Procede de preparation du (3-chloro-4-fluoro-phenyl)-(4- fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}- piperidin-1-yl)-methanone et nouveaux derives pyrimidiniques intermediaires.

Publications (1)

Publication Number Publication Date
TW200745082A true TW200745082A (en) 2007-12-16

Family

ID=36593226

Family Applications (1)

Application Number Title Priority Date Filing Date
TW095135518A TW200745082A (en) 2005-09-27 2006-09-26 Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives

Country Status (10)

Country Link
US (1) US20090118507A1 (zh)
EP (1) EP1928857B1 (zh)
JP (1) JP2009510017A (zh)
AR (1) AR056543A1 (zh)
AT (1) ATE471935T1 (zh)
CA (1) CA2624020A1 (zh)
DE (1) DE602006015070D1 (zh)
FR (1) FR2891274B1 (zh)
TW (1) TW200745082A (zh)
WO (1) WO2007039499A1 (zh)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104086539A (zh) * 2014-07-17 2014-10-08 天津炜捷制药有限公司 一种利伐沙班的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4121214A1 (de) * 1991-06-27 1993-01-14 Bayer Ag 7-azaisoindolinyl-chinolon- und -naphthyridoncarbonsaeure-derivate
FR2755967B1 (fr) * 1996-11-21 1999-01-29 Pf Medicament Derives de la pyridin-2-yl-methylamine, leur procede de preparation et leur application comme medicaments
FR2820743B1 (fr) * 2001-02-09 2005-02-25 Pf Medicament Procede et intermediaires de synthese pour la preparation de derives de pyridin-2-yl-methylamine
FR2827172B1 (fr) * 2001-07-13 2004-07-02 Pf Medicament Derives de pyridin-2-yl-methylamine pour le traitement de la dependance aux opioides
FR2840900B1 (fr) * 2002-06-18 2005-02-25 Pf Medicament Nouveaux derives d'aryl[4-halogeno-4- [(heteroaryl-methylamino)-methyl]-piperidin-1-yl]-methanone, leur procede de preparation et leur utilisation a titre de medicaments

Also Published As

Publication number Publication date
EP1928857A1 (en) 2008-06-11
EP1928857B1 (en) 2010-06-23
FR2891274A1 (fr) 2007-03-30
DE602006015070D1 (de) 2010-08-05
ATE471935T1 (de) 2010-07-15
AR056543A1 (es) 2007-10-10
US20090118507A1 (en) 2009-05-07
WO2007039499A1 (en) 2007-04-12
FR2891274B1 (fr) 2007-11-23
JP2009510017A (ja) 2009-03-12
CA2624020A1 (en) 2007-04-12

Similar Documents

Publication Publication Date Title
GEP20094785B (en) Pyrrolopyrazoles, potent kinase inhibitors
WO2005108358A3 (en) Pyrrolidine derivatives useful as bace inhibitors
HK1088597A1 (en) Method for the production of substituted 3-aryl-butyl amine compounds
TNSN07195A1 (en) Potentiators of glutamate receptors
WO2003093269A3 (de) Substituierte pyrazolo-pyrimidin-4-one
MY134136A (en) Novel compounds comprising jak3 kinase inhibitors
WO2005037198A3 (en) Preparation of 1,7-disubstituted azabenzimidazoles as kinase inhibitors
MXPA05012026A (es) Compuestos de azaindol como inhibidores de cinasa.
GB2431927A9 (en) 1,2-Disubstituted indoles & derivatives thereof astherapeutic 5-iipoxygenase-activating protein (fl ap) inhibitors
WO2006034093A3 (en) 3- (2-acylamino-1-hydroxyethyl)- morpholine derivatives and their use as bace inhibitors
MXPA05013553A (es) Pirrolodihidroisoquinolinas como inhibidores de pde10.
MY147790A (en) Stable emulsion composition
TW200745039A (en) Isotopically substituted pantoprazole
PL371127A1 (en) 6-aminomorphinane derivatives, method for the production and use thereof
TW200800986A (en) Tetrahydroquinolines, synthesis thereof, and intermediates thereto
MXPA05013751A (es) Procedimiento e intermediarios para la preparacion de 3-(amino)-3-ciclobutilmetil-2-hidroxi-propionamida o sus sales.
WO2007016029A3 (en) Diazepinoquinolines, synthesis thereof, and intermediates thereto
TW200613308A (en) Cyclobutanetetracarboxylate compound and preparation method thereof
PL374461A1 (pl) Sposób otrzymywania pochodnych 13,14-dihydro-PGF
TW200740729A (en) Methods for preparing glutamic acid derivatives
TW200716128A (en) Intermediates useful in preparing certain pyrrolotriazine compounds and process for making such intermediates
TW200510323A (en) Process for the preparation of nonpeptide substituted spirobenzoazepine derivatives
TW200745082A (en) Method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone and novel intermediate pyrimidine derivatives
WO2006097809A3 (en) Novel tyrosine derivatives
EP1613606A4 (en) PROCESS FOR PREPARING 2,3,5,6-SUBSTITUTED 3H-PYRIMIDIN-4-ONES