JP2003503449A5 - - Google Patents
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- Publication number
- JP2003503449A5 JP2003503449A5 JP2001507466A JP2001507466A JP2003503449A5 JP 2003503449 A5 JP2003503449 A5 JP 2003503449A5 JP 2001507466 A JP2001507466 A JP 2001507466A JP 2001507466 A JP2001507466 A JP 2001507466A JP 2003503449 A5 JP2003503449 A5 JP 2003503449A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- pharmaceutically acceptable
- difluoropyrrolidinyl
- decahydroisoquinoline
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14248599P | 1999-07-06 | 1999-07-06 | |
| US60/142,485 | 1999-07-06 | ||
| US15116599P | 1999-08-27 | 1999-08-27 | |
| US60/151,165 | 1999-08-27 | ||
| PCT/US2000/016297 WO2001001972A2 (en) | 1999-07-06 | 2000-06-27 | SELECTIVE iGluR5 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF MIGRAINE |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503449A JP2003503449A (ja) | 2003-01-28 |
| JP2003503449A5 true JP2003503449A5 (enExample) | 2007-08-16 |
| JP4619595B2 JP4619595B2 (ja) | 2011-01-26 |
Family
ID=26840135
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001507466A Expired - Fee Related JP4619595B2 (ja) | 1999-07-06 | 2000-06-27 | 偏頭痛の処置のための選択的なｉＧｌｕＲ５受容体拮抗薬 |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US6566370B1 (enExample) |
| EP (1) | EP1200073B1 (enExample) |
| JP (1) | JP4619595B2 (enExample) |
| KR (1) | KR20020024300A (enExample) |
| CN (1) | CN1230174C (enExample) |
| AR (1) | AR029373A1 (enExample) |
| AU (1) | AU773304B2 (enExample) |
| BR (1) | BR0012175A (enExample) |
| CA (1) | CA2378613C (enExample) |
| CZ (1) | CZ20014488A3 (enExample) |
| DE (1) | DE60032905T2 (enExample) |
| DK (1) | DK1200073T3 (enExample) |
| DZ (1) | DZ3209A1 (enExample) |
| EA (1) | EA004290B1 (enExample) |
| ES (1) | ES2278619T3 (enExample) |
| HK (1) | HK1047036A1 (enExample) |
| HR (1) | HRP20020013A2 (enExample) |
| HU (1) | HUP0202253A3 (enExample) |
| IL (1) | IL146697A0 (enExample) |
| MX (1) | MXPA01012726A (enExample) |
| MY (1) | MY133503A (enExample) |
| NO (1) | NO20016246L (enExample) |
| NZ (1) | NZ515616A (enExample) |
| PE (1) | PE20010299A1 (enExample) |
| PT (1) | PT1200073E (enExample) |
| SK (1) | SK112002A3 (enExample) |
| TR (1) | TR200200066T2 (enExample) |
| WO (1) | WO2001001972A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1257545A1 (en) * | 1999-12-22 | 2002-11-20 | Eli Lilly And Company | SELECTIVE iGLUR 5? RECEPTOR ANTAGONISTS |
| AU2002227020A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Pyrrolidinylmethyl- and piperidinyl substituted decahydroisoquinolines as excitatory amino acid receptor antagonists |
| MXPA03005981A (es) * | 2001-01-05 | 2003-09-10 | Lilly Co Eli | Antagonistas de receptores de aminoacidos excitatorios. |
| AU2002241565A1 (en) * | 2001-01-05 | 2002-07-16 | Eli Lilly And Company | Excitatory amino acid receptor antagonist and 5-ht1f agonist combination: a method for the treatment of neurological disorders |
| US6924294B2 (en) | 2001-01-05 | 2005-08-02 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| DK1368032T3 (da) * | 2001-01-05 | 2008-09-29 | Lilly Co Eli | Exitatoriske aminosyrereceptorantagonister |
| US7205313B2 (en) | 2001-01-05 | 2007-04-17 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US6855725B2 (en) * | 2001-01-05 | 2005-02-15 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| GB0128996D0 (en) | 2001-12-04 | 2002-01-23 | Novartis Ag | Organic compounds |
| US20040082606A1 (en) * | 2001-12-20 | 2004-04-29 | Khau Vien Van | Excitatory amino acid receptor antagonists |
| BR0308911A (pt) | 2002-04-26 | 2005-01-04 | Lilly Co Eli | Composto, composição farmacêutica, métodos de tratamento de dor e de enxaqueca, e, uso de um composto |
| US7960436B2 (en) | 2006-06-05 | 2011-06-14 | Valeant Pharmaceuticals International | Substituted arylamino-1,2,3,4-tetrahydro naphthalenes and-2,3-dihydro-1H-indenes as potassium channel modulators |
| US8993593B2 (en) | 2006-08-23 | 2015-03-31 | Valeant Pharmaceuticals International | N-(4-(6-fluoro-3,4-dihydroisoquinolin-2(1H)-yl)-2,6-dimethylphenyl)-3,3-dimethylbutanamide as potassium channel modulators |
| MX2009002002A (es) | 2006-08-23 | 2009-07-22 | Valeant Pharmaceuticals Int | Derivados de 4-(n-azacicloalquil) anilidas como moduladores de canal de potasio. |
| US8722929B2 (en) | 2006-10-10 | 2014-05-13 | Valeant Pharmaceuticals International | N-[2-amino-4-(phenylmethoxy)phenyl] amides and related compounds as potassium channel modulators |
| US8030518B2 (en) | 2006-11-28 | 2011-10-04 | Valeant Pharmaceuticals International | 1,4 diamino bicyclic retigabine analogues as potassium channel modulators |
| US8367684B2 (en) | 2007-06-13 | 2013-02-05 | Valeant Pharmaceuticals International | Derivatives of 4-(N-azacycloalkyl) anilides as potassium channel modulators |
| US8563566B2 (en) | 2007-08-01 | 2013-10-22 | Valeant Pharmaceuticals International | Naphthyridine derivatives as potassium channel modulators |
| US7786146B2 (en) | 2007-08-13 | 2010-08-31 | Valeant Pharmaceuticals International | Derivatives of 5-amino-4,6-disubstituted indole and 5-amino-4,6-disubstituted indoline as potassium channel modulators |
| KR20200035035A (ko) | 2017-07-31 | 2020-04-01 | 노파르티스 아게 | 코카인 사용 감소 또는 코카인 사용 재발 예방에 있어서 마보글루란트의 용도 |
| JP7399096B2 (ja) | 2018-03-05 | 2023-12-15 | ヤンセン ファーマシューティカ エヌ．ベー． | 神経変性を検出するためのアッセイ |
| TWI886158B (zh) | 2019-10-10 | 2025-06-11 | 加拿大商再諾製藥公司 | 選擇性鉀通道調節劑之固態晶型 |
| MA56607A1 (fr) | 2019-11-08 | 2022-10-31 | Xenon Pharmaceuticals Inc | Méthodes de traitement de troubles dépressifs |
| JP2024508660A (ja) | 2021-02-09 | 2024-02-28 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 快感消失の治療に使用するための電位依存性カリウムチャネル開口薬 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5284957A (en) * | 1992-09-03 | 1994-02-08 | Eli Lilly And Company | Excitatory amino acid receptor antagonists |
| US5356902A (en) | 1992-11-06 | 1994-10-18 | Eli Lilly And Company | Decahydroisoquinoline compounds as excitatory amino acid receptor antagonists |
| US5446051A (en) | 1994-05-31 | 1995-08-29 | Eli Lilly And Company | Aryl-spaced decahydroisoquinoline-3-carboxylic acids as excitatory amino acid receptor antagonists |
| US5767117A (en) * | 1994-11-18 | 1998-06-16 | The General Hospital Corporation | Method for treating vascular headaches |
| KR20010006075A (ko) | 1997-04-07 | 2001-01-15 | 피터 지. 스트링거 | 약제 |
| US6486175B1 (en) * | 1999-07-06 | 2002-11-26 | Eli Lilly And Company | Diester prodrugs of a decahydroisoquinoline-3-carboxylic acid |
-
2000
- 2000-06-27 MX MXPA01012726A patent/MXPA01012726A/es active IP Right Grant
- 2000-06-27 TR TR2002/00066T patent/TR200200066T2/xx unknown
- 2000-06-27 KR KR1020027000138A patent/KR20020024300A/ko not_active Withdrawn
- 2000-06-27 DZ DZ003209A patent/DZ3209A1/xx active
- 2000-06-27 SK SK11-2002A patent/SK112002A3/sk not_active Application Discontinuation
- 2000-06-27 HU HU0202253A patent/HUP0202253A3/hu unknown
- 2000-06-27 CA CA002378613A patent/CA2378613C/en not_active Expired - Fee Related
- 2000-06-27 BR BR0012175-4A patent/BR0012175A/pt not_active Application Discontinuation
- 2000-06-27 WO PCT/US2000/016297 patent/WO2001001972A2/en not_active Ceased
- 2000-06-27 IL IL14669700A patent/IL146697A0/xx unknown
- 2000-06-27 PT PT00944671T patent/PT1200073E/pt unknown
- 2000-06-27 US US10/009,655 patent/US6566370B1/en not_active Expired - Fee Related
- 2000-06-27 EA EA200200132A patent/EA004290B1/ru not_active IP Right Cessation
- 2000-06-27 NZ NZ515616A patent/NZ515616A/en unknown
- 2000-06-27 HR HR20020013A patent/HRP20020013A2/hr not_active Application Discontinuation
- 2000-06-27 DE DE60032905T patent/DE60032905T2/de not_active Expired - Lifetime
- 2000-06-27 HK HK02107174.1A patent/HK1047036A1/zh unknown
- 2000-06-27 ES ES00944671T patent/ES2278619T3/es not_active Expired - Lifetime
- 2000-06-27 CN CNB008096880A patent/CN1230174C/zh not_active Expired - Fee Related
- 2000-06-27 EP EP00944671A patent/EP1200073B1/en not_active Expired - Lifetime
- 2000-06-27 DK DK00944671T patent/DK1200073T3/da active
- 2000-06-27 AU AU58732/00A patent/AU773304B2/en not_active Ceased
- 2000-06-27 CZ CZ20014488A patent/CZ20014488A3/cs unknown
- 2000-06-27 JP JP2001507466A patent/JP4619595B2/ja not_active Expired - Fee Related
- 2000-06-29 AR ARP000103296A patent/AR029373A1/es unknown
- 2000-07-04 PE PE2000000672A patent/PE20010299A1/es not_active Application Discontinuation
- 2000-07-04 MY MYPI20003046 patent/MY133503A/en unknown
-
2001
- 2001-12-19 NO NO20016246A patent/NO20016246L/no not_active Application Discontinuation
-
2003
- 2003-03-06 US US10/383,296 patent/US6759418B2/en not_active Expired - Fee Related
-
2004
- 2004-04-09 US US10/821,698 patent/US6855823B2/en not_active Expired - Fee Related
-
2005
- 2005-01-11 US US11/032,759 patent/US7157582B2/en not_active Expired - Fee Related