JP2004509061A5 - - Google Patents

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Publication number
JP2004509061A5
JP2004509061A5 JP2001559475A JP2001559475A JP2004509061A5 JP 2004509061 A5 JP2004509061 A5 JP 2004509061A5 JP 2001559475 A JP2001559475 A JP 2001559475A JP 2001559475 A JP2001559475 A JP 2001559475A JP 2004509061 A5 JP2004509061 A5 JP 2004509061A5
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JP
Japan
Prior art keywords
pharmaceutical composition
pharmaceutically acceptable
hepatitis
virus
use according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2001559475A
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English (en)
Japanese (ja)
Other versions
JP2004509061A (ja
JP4975930B2 (ja
Filing date
Publication date
Priority claimed from US09/595,365 external-priority patent/US6455508B1/en
Application filed filed Critical
Publication of JP2004509061A publication Critical patent/JP2004509061A/ja
Publication of JP2004509061A5 publication Critical patent/JP2004509061A5/ja
Application granted granted Critical
Publication of JP4975930B2 publication Critical patent/JP4975930B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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JP2001559475A 2000-02-15 2001-02-15 カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ Expired - Fee Related JP4975930B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US18267600P 2000-02-15 2000-02-15
US60/182,676 2000-02-15
US09/595,365 2000-06-16
US09/595,365 US6455508B1 (en) 2000-02-15 2000-10-05 Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
PCT/US2001/040148 WO2001060379A1 (en) 2000-02-15 2001-02-15 Nucleoside analogs with carboxamidine modified monocyclic base

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009018382A Division JP5253204B2 (ja) 2000-02-15 2009-01-29 カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ

Publications (3)

Publication Number Publication Date
JP2004509061A JP2004509061A (ja) 2004-03-25
JP2004509061A5 true JP2004509061A5 (enExample) 2006-01-05
JP4975930B2 JP4975930B2 (ja) 2012-07-11

Family

ID=26878297

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2001559477A Pending JP2004510691A (ja) 2000-02-15 2001-02-15 カルボキサミジンで修飾した二環式塩基を有するヌクレオシドアナログ
JP2001559475A Expired - Fee Related JP4975930B2 (ja) 2000-02-15 2001-02-15 カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ
JP2009018382A Expired - Fee Related JP5253204B2 (ja) 2000-02-15 2009-01-29 カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2001559477A Pending JP2004510691A (ja) 2000-02-15 2001-02-15 カルボキサミジンで修飾した二環式塩基を有するヌクレオシドアナログ

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2009018382A Expired - Fee Related JP5253204B2 (ja) 2000-02-15 2009-01-29 カルボキサミジンで修飾した単環式塩基を有するヌクレオシドアナログ

Country Status (28)

Country Link
US (1) US6455508B1 (enExample)
EP (3) EP1257281B8 (enExample)
JP (3) JP2004510691A (enExample)
KR (2) KR100811927B1 (enExample)
CN (2) CN1420779A (enExample)
AT (1) ATE377422T1 (enExample)
AU (2) AU3845001A (enExample)
BR (2) BR0108402A (enExample)
CA (2) CA2399208C (enExample)
CY (1) CY1107103T1 (enExample)
CZ (2) CZ302327B6 (enExample)
DE (1) DE60131250T8 (enExample)
DK (1) DK1257281T3 (enExample)
ES (2) ES2528429T3 (enExample)
HR (2) HRP20020657A2 (enExample)
HU (2) HU229480B1 (enExample)
IL (3) IL150555A0 (enExample)
MX (2) MXPA02007931A (enExample)
NO (2) NO20023852L (enExample)
NZ (2) NZ521390A (enExample)
PL (2) PL200140B1 (enExample)
PT (1) PT1257281E (enExample)
RS (1) RS20090086A (enExample)
RU (2) RU2002120483A (enExample)
SI (2) SI21077A (enExample)
SK (2) SK11572002A3 (enExample)
WO (2) WO2001060381A1 (enExample)
YU (1) YU61502A (enExample)

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US7056895B2 (en) * 2000-02-15 2006-06-06 Valeant Pharmaceuticals International Tirazole nucleoside analogs and methods for using same
US7638496B2 (en) * 2000-02-15 2009-12-29 Valeant Pharmaceuticals North America Nucleoside analogs with carboxamidine modified monocyclic base
PY0111577A (es) 2000-05-23 2017-01-02 Idenix Cayman Ltd Métodos y composiciones para el tratamiento del virus de la hepatitis c
AP2006003708A0 (en) * 2000-05-26 2006-08-31 Idenix Cayman Ltd Methods and compositions for treating flavivirusesand pestiviruses
SI1355916T1 (sl) 2001-01-22 2007-04-30 Merck & Co Inc Nukleozidni derivati kot inhibitorji RNA-odvisne RNA virusne polimeraze
WO2003037908A1 (en) * 2001-10-31 2003-05-08 Ribapharm Inc. Antiviral combination therapy and compositions
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN101172993A (zh) 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
CN1678326A (zh) 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
PL377287A1 (pl) 2002-12-12 2006-01-23 Idenix (Cayman) Limited Sposób wytwarzania 2'-rozgałęzionych nukleozydów
WO2004084796A2 (en) * 2003-03-28 2004-10-07 Pharmasset Ltd. Compounds for the treatment of flaviviridae infections
US20040197287A1 (en) * 2003-04-04 2004-10-07 The Procter & Gamble Company Personal care composition containing an antidandruff component and a nonionic surfactant
US20040202636A1 (en) * 2003-04-11 2004-10-14 Kaczvinsky Joseph Robert Personal care composition containing an antidandruff component and a nonionic surfactant
US20040197292A1 (en) * 2003-04-04 2004-10-07 The Procter & Gamble Company Personal care composition containing an antidandruff component and a nonionic surfactant
US6930093B2 (en) * 2003-07-10 2005-08-16 Valeant Research & Development Use of ribofuranose derivatives against inflammatory bowel diseases
US20050009848A1 (en) * 2003-07-10 2005-01-13 Icn Pharmaceuticals Switzerland Ltd. Use of antivirals against inflammatory bowel diseases
WO2005018330A1 (en) * 2003-08-18 2005-03-03 Pharmasset, Inc. Dosing regimen for flaviviridae therapy
US20050095218A1 (en) * 2003-10-29 2005-05-05 The Procter & Gamble Company Personal care composition containing a detersive surfactant, an antidandruff component, and ketoamide surfactants
US20050182252A1 (en) 2004-02-13 2005-08-18 Reddy K. R. Novel 2'-C-methyl nucleoside derivatives
US7534767B2 (en) 2004-06-15 2009-05-19 Merck & Co., Inc. C-purine nucleoside analogs as inhibitors of RNA-dependent RNA viral polymerase
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
WO2006119061A2 (en) 2005-05-02 2006-11-09 Merck & Co., Inc. Hcv ns3 protease inhibitors
TWI387603B (zh) 2005-07-20 2013-03-01 Merck Sharp & Dohme Ｈｃｖ ｎｓ３蛋白酶抑制劑
KR20080036598A (ko) 2005-08-01 2008-04-28 머크 앤드 캄파니 인코포레이티드 Ｈｃｖ ｎｓ３ 프로테아제 억제제로서의 마크로사이클릭펩티드
JP5254033B2 (ja) 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
WO2007123579A2 (en) * 2005-12-28 2007-11-01 Translational Therapeutics Translational dysfunction based therapeutics
US8497292B2 (en) 2005-12-28 2013-07-30 Translational Therapeutics, Inc. Translational dysfunction based therapeutics
GB0609492D0 (en) 2006-05-15 2006-06-21 Angeletti P Ist Richerche Bio Therapeutic agents
GB0612423D0 (en) 2006-06-23 2006-08-02 Angeletti P Ist Richerche Bio Therapeutic agents
WO2008005542A2 (en) * 2006-07-07 2008-01-10 Gilead Sciences, Inc., Antiviral phosphinate compounds
AU2007309488B2 (en) 2006-10-24 2012-10-11 Merck Sharp & Dohme Corp. HCV NS3 protease inhibitors
EP2079479B1 (en) 2006-10-24 2014-11-26 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
AU2007309546A1 (en) 2006-10-24 2008-05-02 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HCV NS3 protease inhibitors
CA2667031C (en) 2006-10-27 2013-01-22 Merck & Co., Inc. Hcv ns3 protease inhibitors
CN101568346B (zh) 2006-10-27 2015-11-25 默沙东公司 Hcv ns3蛋白酶抑制剂
CA2672250C (en) 2006-12-20 2013-04-30 Ian Stansfield Antiviral indoles
GB0625345D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
GB0625349D0 (en) 2006-12-20 2007-01-31 Angeletti P Ist Richerche Bio Therapeutic compounds
JP2010533699A (ja) 2007-07-17 2010-10-28 イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー Ｃ型肝炎感染症の治療のための大環状インドール誘導体
AU2008277377B2 (en) 2007-07-19 2013-08-01 Msd Italia S.R.L. Macrocyclic compounds as antiviral agents
EP2271345B1 (en) 2008-04-28 2015-05-20 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
ME02024B (me) 2008-07-22 2015-05-20 Merck Sharp & Dohme Makrociklična jedinjenja hinoksalina kao inhibitori hcv ns3 proteaze
WO2010082050A1 (en) 2009-01-16 2010-07-22 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Macrocyclic and 7-aminoalkyl-substituted benzoxazocines for treatment of hepatitis c infections
GB0900914D0 (en) 2009-01-20 2009-03-04 Angeletti P Ist Richerche Bio Antiviral agents
WO2011014487A1 (en) 2009-07-30 2011-02-03 Merck Sharp & Dohme Corp. Hepatitis c virus ns3 protease inhibitors
WO2013074386A2 (en) 2011-11-15 2013-05-23 Merck Sharp & Dohme Corp. Hcv ns3 protease inhibitors
US20140356325A1 (en) 2012-01-12 2014-12-04 Ligand Pharmaceuticals Incorporated Novel 2'-c-methyl nucleoside derivative compounds
CN102978264B (zh) * 2012-11-14 2014-12-10 广东肇庆星湖生物科技股份有限公司 一种他立韦林的制备方法
WO2014121418A1 (en) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
WO2014121417A1 (en) 2013-02-07 2014-08-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of hepatitis c
US10449210B2 (en) 2014-02-13 2019-10-22 Ligand Pharmaceuticals Inc. Prodrug compounds and their uses
CN106687118A (zh) 2014-07-02 2017-05-17 配体药物公司 前药化合物及其用途
WO2017024310A1 (en) 2015-08-06 2017-02-09 Chimerix, Inc. Pyrrolopyrimidine nucleosides and analogs thereof useful as antiviral agents
WO2019060692A1 (en) 2017-09-21 2019-03-28 Chimerix, Inc. MORPHIC FORMS OF 4-AMINO-7- (3,4-DIHYDROXY-5- (HYDROXYMETHYL) -ETRAHYDROFURAN-2-YL) -2-METHYL-7H-PYRROLO [2,3-D] PYRIMIDINE-5-CARBOXAMIDE AND THEIR USES
CN111788196A (zh) 2018-01-09 2020-10-16 配体药物公司 缩醛化合物及其治疗用途

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US3991078A (en) 1971-06-01 1976-11-09 Icn Pharmaceuticals, Inc. N-substituted 1,2,4-triazoles
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US3984396A (en) 1971-06-01 1976-10-05 Icn Pharmaceuticals, Inc. 1-(β,-D-ribofuranosyl)-1,2,4-triazole acid esters
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US4892865A (en) * 1987-12-01 1990-01-09 The Regents Of The University Of Michigan Pyrrolo[2,3-d]pyrimidine nucleosides as antiviral agents
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PT879056E (pt) * 1996-01-23 2002-10-31 Ribapharm Inc Modulacao da expressao das citocinas th1/th2 atraves de ribavirina em linfocitos t activados
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