JPS6426593A - Nucleoside derivative - Google Patents

Nucleoside derivative

Info

Publication number
JPS6426593A
JPS6426593A JP62180137A JP18013787A JPS6426593A JP S6426593 A JPS6426593 A JP S6426593A JP 62180137 A JP62180137 A JP 62180137A JP 18013787 A JP18013787 A JP 18013787A JP S6426593 A JPS6426593 A JP S6426593A
Authority
JP
Japan
Prior art keywords
deoxy
ethyl ester
triazol
beta
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP62180137A
Other languages
Japanese (ja)
Inventor
Toshiaki Nakayama
Yoshitomi Morisawa
Arata Yasuda
Keiichi Uchida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AGC Inc
Original Assignee
Asahi Glass Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Asahi Glass Co Ltd filed Critical Asahi Glass Co Ltd
Priority to JP62180137A priority Critical patent/JPS6426593A/en
Publication of JPS6426593A publication Critical patent/JPS6426593A/en
Pending legal-status Critical Current

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Saccharide Compounds (AREA)

Abstract

NEW MATERIAL:A compound shown by formula I [A is group shown by formula II or III (X and Y are amide, cyano, carboxy or alkoxycarbonyl); R<1> and R<2> are H or OH-protecting group]. EXAMPLE:1-(2,5-Di-O-benzyl-3-deoxy-3-fluoro-beta-D-ribofuranosyl)--1H- 1,2,4-triazol-3- ethyl ester. USE:An antitumor agent and an antiviral agent having anti-AIDS action. PREPARATION:3'-Deoxy-3'-fluororibofuranose protected as the 2-position and the 5-position is introduced to a 1-hydrazo derivative and this compound is condensed with ethanedicarboxylic acid ethyl ester thioamide. Then the con densed substance is subjected to ring closure with orthoformic triethyl ester to give 1-beta-D-(3-deoxy-3-fluororibofuranosyl)-1H-1,2,4-triazol-5-ethyl ester.
JP62180137A 1987-07-21 1987-07-21 Nucleoside derivative Pending JPS6426593A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62180137A JPS6426593A (en) 1987-07-21 1987-07-21 Nucleoside derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62180137A JPS6426593A (en) 1987-07-21 1987-07-21 Nucleoside derivative

Publications (1)

Publication Number Publication Date
JPS6426593A true JPS6426593A (en) 1989-01-27

Family

ID=16078056

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62180137A Pending JPS6426593A (en) 1987-07-21 1987-07-21 Nucleoside derivative

Country Status (1)

Country Link
JP (1) JPS6426593A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
WO2001068663A1 (en) * 2000-03-15 2001-09-20 Ribapharm Corp. Nucleoside compounds and uses thereof
WO2002016382A1 (en) * 2000-08-22 2002-02-28 Ribapharm Inc. Improved specificity in treatment of diseases
US6455508B1 (en) 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
JP2008044527A (en) * 2006-08-16 2008-02-28 Bridgestone Cycle Co Tension adjusting device and belt driving type bicycle
JP2010502748A (en) * 2006-09-11 2010-01-28 サザン リサーチ インスティテュート Azole nucleosides and use as RNA / DNA viral polymerase inhibitors
JP2011522784A (en) * 2008-04-30 2011-08-04 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル（イーエヌエスエーエールエム） Novel triazole derivatives, their preparation and their therapeutic application

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5157114A (en) * 1988-08-19 1992-10-20 Burroughs Wellcome Co. 2',3'-dideoxy-3'-fluoro-5-ethyngluridine
US6455508B1 (en) 2000-02-15 2002-09-24 Kanda S. Ramasamy Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
US6495677B1 (en) 2000-02-15 2002-12-17 Kanda S. Ramasamy Nucleoside compounds
WO2001068663A1 (en) * 2000-03-15 2001-09-20 Ribapharm Corp. Nucleoside compounds and uses thereof
WO2001068034A3 (en) * 2000-03-15 2002-03-21 Icn Pharmaceuticals 1, 2, 4-triazoloribonucleoside prodrugs and their administration to treat viral disease conditions
WO2002016382A1 (en) * 2000-08-22 2002-02-28 Ribapharm Inc. Improved specificity in treatment of diseases
JP2008044527A (en) * 2006-08-16 2008-02-28 Bridgestone Cycle Co Tension adjusting device and belt driving type bicycle
JP2010502748A (en) * 2006-09-11 2010-01-28 サザン リサーチ インスティテュート Azole nucleosides and use as RNA / DNA viral polymerase inhibitors
JP2011522784A (en) * 2008-04-30 2011-08-04 アンスティテュ ナシオナル ドゥ ラ サントゥ エ ドゥ ラ ルシェルシェ メディカル（イーエヌエスエーエールエム） Novel triazole derivatives, their preparation and their therapeutic application

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