JPS6466197A - 3'-substituted-triazole-2',3'-dideoxy-5-substituted pyrimidine nucleoside derivative - Google Patents
3'-substituted-triazole-2',3'-dideoxy-5-substituted pyrimidine nucleoside derivativeInfo
- Publication number
- JPS6466197A JPS6466197A JP22477987A JP22477987A JPS6466197A JP S6466197 A JPS6466197 A JP S6466197A JP 22477987 A JP22477987 A JP 22477987A JP 22477987 A JP22477987 A JP 22477987A JP S6466197 A JPS6466197 A JP S6466197A
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- dideoxy
- pyrimidine nucleoside
- triazole
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
NEW MATERIAL:A compound of formula I (W is H, Br, I, methyl, trifluoromethyl; R<1>, R<2> are H, lower alkyl, lower alkoxycarbonyl). EXAMPLE:3'-(1-Triazolyl)-2',3'-dideoxyuridine. USE:Antitumor agent, or antiviral. PREPARATION:The reaction between 3'-azide-2',3'-dideoxy-5-substituted pyrimidine nucleoside of formula II and an acetylene derivative of the formula: R<1>-CidenticalC-R<2> is carried out usually at 50-150 deg.C, when needed, in a sealed tube, in some cases in a solvent.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22477987A JP2587647B2 (en) | 1987-09-07 | 1987-09-07 | 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP22477987A JP2587647B2 (en) | 1987-09-07 | 1987-09-07 | 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6466197A true JPS6466197A (en) | 1989-03-13 |
JP2587647B2 JP2587647B2 (en) | 1997-03-05 |
Family
ID=16819079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP22477987A Expired - Lifetime JP2587647B2 (en) | 1987-09-07 | 1987-09-07 | 3'-substituted triazole-2 ', 3'-dideoxy-5-substituted pyrimidine nucleoside derivatives |
Country Status (1)
Country | Link |
---|---|
JP (1) | JP2587647B2 (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6914052B2 (en) | 2001-03-15 | 2005-07-05 | The Trustees Of Boston College | Selective anti-viral nucleoside chain terminators |
JP2016500101A (en) * | 2014-02-12 | 2016-01-07 | アダム ミツキエビツ ユニバーシティ | Cytotoxic 2 ', 5'-dideoxy-5-fluorouridine derivatives, process for their production and use thereof |
JP2016500100A (en) * | 2014-02-12 | 2016-01-07 | アダム ミツキエビツ ユニバーシティ | 2 ', 3'-dideoxy-5-fluorouridine derivatives, their production process and their use |
-
1987
- 1987-09-07 JP JP22477987A patent/JP2587647B2/en not_active Expired - Lifetime
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6914052B2 (en) | 2001-03-15 | 2005-07-05 | The Trustees Of Boston College | Selective anti-viral nucleoside chain terminators |
JP2016500101A (en) * | 2014-02-12 | 2016-01-07 | アダム ミツキエビツ ユニバーシティ | Cytotoxic 2 ', 5'-dideoxy-5-fluorouridine derivatives, process for their production and use thereof |
JP2016500100A (en) * | 2014-02-12 | 2016-01-07 | アダム ミツキエビツ ユニバーシティ | 2 ', 3'-dideoxy-5-fluorouridine derivatives, their production process and their use |
Also Published As
Publication number | Publication date |
---|---|
JP2587647B2 (en) | 1997-03-05 |
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