MXPA02007932A - Analogos de nucleosidos con base biciclica modificada con carboxamidina. - Google Patents

Analogos de nucleosidos con base biciclica modificada con carboxamidina.

Info

Publication number
MXPA02007932A
MXPA02007932A MXPA02007932A MXPA02007932A MXPA02007932A MX PA02007932 A MXPA02007932 A MX PA02007932A MX PA02007932 A MXPA02007932 A MX PA02007932A MX PA02007932 A MXPA02007932 A MX PA02007932A MX PA02007932 A MXPA02007932 A MX PA02007932A
Authority
MX
Mexico
Prior art keywords
nucleoside analogs
bicyclic base
modified bicyclic
carboxamidine
type
Prior art date
Application number
MXPA02007932A
Other languages
English (en)
Inventor
Zhi Hong
Original Assignee
Ribapharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ribapharm Inc filed Critical Ribapharm Inc
Publication of MXPA02007932A publication Critical patent/MXPA02007932A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/7056—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing five-membered rings with nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/21—Interferons [IFN]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/14—Pyrrolo-pyrimidine radicals

Abstract

Se describen nuevos compuestos analogos de nucleosidos. Los nuevos compuestos o esteres farmaceuticamente aceptables o sales de los mismos, se pueden utilizar en composiciones farmaceuticas y tales composiciones se pueden usar para tratar una infeccion, una infestacion, una neoplasia, o una enfermedad autoinmunitaria. Los nuevos compuestos tambien se pueden usar para modular aspectos del sistema inmunitario, incluyendo modulacion de la actividad Tipo 1 y Tipo 2.
MXPA02007932A 2000-02-15 2001-02-15 Analogos de nucleosidos con base biciclica modificada con carboxamidina. MXPA02007932A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US18267600P 2000-02-15 2000-02-15
US09/595,365 US6455508B1 (en) 2000-02-15 2000-10-05 Methods for treating diseases with tirazole and pyrrolo-pyrimidine ribofuranosyl nucleosides
PCT/US2001/005172 WO2001060381A1 (en) 2000-02-15 2001-02-15 Nucleoside analogs with carboxamidine-modified bicyclic base

Publications (1)

Publication Number Publication Date
MXPA02007932A true MXPA02007932A (es) 2004-10-15

Family

ID=26878297

Family Applications (2)

Application Number Title Priority Date Filing Date
MXPA02007931A MXPA02007931A (es) 2000-02-15 2001-02-15 Analogos de nucleosido con base monociclica modificada con carboxamidina.
MXPA02007932A MXPA02007932A (es) 2000-02-15 2001-02-15 Analogos de nucleosidos con base biciclica modificada con carboxamidina.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MXPA02007931A MXPA02007931A (es) 2000-02-15 2001-02-15 Analogos de nucleosido con base monociclica modificada con carboxamidina.

Country Status (29)

Country Link
US (1) US6455508B1 (es)
EP (3) EP1257281B8 (es)
JP (3) JP2004510691A (es)
KR (2) KR20030005190A (es)
CN (2) CN1420779A (es)
AT (1) ATE377422T1 (es)
AU (2) AU3845001A (es)
BR (2) BR0108401A (es)
CA (2) CA2395854A1 (es)
CY (1) CY1107103T1 (es)
CZ (2) CZ302327B6 (es)
DE (1) DE60131250T8 (es)
DK (1) DK1257281T3 (es)
ES (2) ES2528429T3 (es)
HK (1) HK1051149A1 (es)
HR (2) HRP20020583A2 (es)
HU (2) HU229480B1 (es)
IL (3) IL150555A0 (es)
MX (2) MXPA02007931A (es)
NO (2) NO20023852L (es)
NZ (2) NZ521390A (es)
PL (2) PL365239A1 (es)
PT (1) PT1257281E (es)
RS (1) RS20090086A (es)
RU (2) RU2259831C2 (es)
SI (2) SI21076A (es)
SK (2) SK287765B6 (es)
WO (2) WO2001060381A1 (es)
YU (1) YU61502A (es)

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Also Published As

Publication number Publication date
YU61502A (sh) 2006-03-03
PL357945A1 (en) 2004-08-09
BR0108401A (pt) 2004-01-06
AU3845001A (en) 2001-08-27
RU2002120922A (ru) 2004-01-27
EP1813278B1 (en) 2014-10-29
HUP0300027A3 (en) 2003-09-29
HRP20020657A2 (en) 2005-10-31
SI21076A (sl) 2003-06-30
DE60131250T2 (de) 2008-08-28
HK1051149A1 (en) 2003-07-25
SK287765B6 (sk) 2011-09-05
IL150990A0 (en) 2003-02-12
CA2399208C (en) 2010-04-13
ATE377422T1 (de) 2007-11-15
IL150555A0 (en) 2003-02-12
HUP0300027A2 (en) 2003-05-28
CZ20022799A3 (cs) 2003-09-17
US6455508B1 (en) 2002-09-24
AU783142B2 (en) 2005-09-29
PT1257281E (pt) 2007-12-11
HRP20020583A2 (en) 2005-10-31
CZ20022798A3 (cs) 2003-03-12
EP1813278A1 (en) 2007-08-01
EP1278528A4 (en) 2003-03-19
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JP2009102406A (ja) 2009-05-14
MXPA02007931A (es) 2004-10-15
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CN1438891A (zh) 2003-08-27
NO20023852L (no) 2002-10-09
NZ520877A (en) 2004-12-24
RS20090086A (en) 2010-06-30
CZ302327B6 (cs) 2011-03-16
EP1257281A1 (en) 2002-11-20
SI21077A (sl) 2003-06-30
EP1257281A4 (en) 2003-03-19
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HUP0300912A2 (hu) 2003-08-28
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CA2395854A1 (en) 2001-08-23
CN1420779A (zh) 2003-05-28
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SK11492002A3 (sk) 2003-02-04
RU2002120483A (ru) 2004-01-27
AU4798801A (en) 2001-08-27
BR0108402A (pt) 2003-03-11
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NO20023852D0 (no) 2002-08-14
KR20030032917A (ko) 2003-04-26
EP1257281B8 (en) 2008-01-23
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IL150990A (en) 2009-05-04
SK11572002A3 (sk) 2003-02-04
HU229480B1 (en) 2014-01-28
JP2004509061A (ja) 2004-03-25
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CN1268335C (zh) 2006-08-09
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