JP2004504406A5 - - Google Patents

Info

Publication number

JP2004504406A5

JP2004504406A5 JP2002514154A JP2002514154A JP2004504406A5 JP 2004504406 A5 JP2004504406 A5 JP 2004504406A5 JP 2002514154 A JP2002514154 A JP 2002514154A JP 2002514154 A JP2002514154 A JP 2002514154A JP 2004504406 A5 JP2004504406 A5 JP 2004504406A5

Authority

JP

Japan

Prior art keywords

ser

peptide

mammal

leu

pro

Prior art date

2001-07-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
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• 108090000765 processed proteins & peptides Proteins 0.000 claims 18
• 241000124008 Mammalia Species 0.000 claims 11
• 238000000034 method Methods 0.000 claims 11
• WCORRBXVISTKQL-WHFBIAKZSA-N Gly-Ser-Ser Chemical compound NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O WCORRBXVISTKQL-WHFBIAKZSA-N 0.000 claims 7
• 125000002801 octanoyl group Chemical group C(CCCCCCC)(=O)* 0.000 claims 7
• 238000009472 formulation Methods 0.000 claims 6
• 239000000203 mixture Substances 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 101800001586 Ghrelin Proteins 0.000 claims 3
• 102400000442 Ghrelin-28 Human genes 0.000 claims 3
• 102000018997 Growth Hormone Human genes 0.000 claims 3
• 108010051696 Growth Hormone Proteins 0.000 claims 3
• GNKDKYIHGQKHHM-RJKLHVOGSA-N ghrelin Chemical compound C([C@H](NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CN)COC(=O)CCCCCCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1N=CNC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C1=CC=CC=C1 GNKDKYIHGQKHHM-RJKLHVOGSA-N 0.000 claims 3
• 239000000122 growth hormone Substances 0.000 claims 3
• 102000004196 processed proteins & peptides Human genes 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 2
• 238000007911 parenteral administration Methods 0.000 claims 2
• 238000013268 sustained release Methods 0.000 claims 2
• 239000012730 sustained-release form Substances 0.000 claims 2
• 206010000599 Acromegaly Diseases 0.000 claims 1
• 230000003042 antagnostic effect Effects 0.000 claims 1
• 239000005557 antagonist Substances 0.000 claims 1
• 239000008280 blood Substances 0.000 claims 1
• 210000004369 blood Anatomy 0.000 claims 1
• 230000037396 body weight Effects 0.000 claims 1
• 239000005556 hormone Substances 0.000 claims 1
• 229940088597 hormone Drugs 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1