ES2422290T3 - Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados - Google Patents

Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados

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Publication number
ES2422290T3
ES2422290T3 ES06847905T ES06847905T ES2422290T3 ES 2422290 T3 ES2422290 T3 ES 2422290T3 ES 06847905 T ES06847905 T ES 06847905T ES 06847905 T ES06847905 T ES 06847905T ES 2422290 T3 ES2422290 T3 ES 2422290T3
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Spain
Prior art keywords
preparing
procedure
preparation
compound
formula
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Application number
ES06847905T
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English (en)
Inventor
Benjamin Alexander Mayes
Adel Moussa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Idenix Pharmaceuticals LLC
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Idenix Pharmaceuticals LLC
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Application filed by Idenix Pharmaceuticals LLC filed Critical Idenix Pharmaceuticals LLC
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Publication of ES2422290T3 publication Critical patent/ES2422290T3/es
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/048—Pyridine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/22—Pteridine radicals

Abstract

Un procedimiento para preparar un compuesto de Fórmula II **Fórmula** en la que R1 es alquilo de cadena lineal o de cadena ramificada, cicloalquilo, alquenilo, alquinilo, alenilo, CF3, ciano,arilo, aralquilo, o heterocíclico, que comprende a) proporcionar un compuesto de estructura (i) o (ii) **Fórmula** en donde OR es un grupo lábil y X es halógeno; b) poner en contacto el compuesto con un agente de fluoración bajo condiciones anhidras; y c) eliminar el grupo protector de hidroxilo del producto de la etapa b).
ES06847905T 2005-12-23 2006-12-22 Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados Active ES2422290T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75350705P 2005-12-23 2005-12-23
PCT/US2006/048769 WO2007075876A2 (en) 2005-12-23 2006-12-22 Process for preparing a synthetic intermediate for preparation of branched nucleosides

Publications (1)

Publication Number Publication Date
ES2422290T3 true ES2422290T3 (es) 2013-09-10

Family

ID=38218604

Family Applications (1)

Application Number Title Priority Date Filing Date
ES06847905T Active ES2422290T3 (es) 2005-12-23 2006-12-22 Procedimiento para preparar un producto intermedio sintético para la preparación de nucleósidos ramificados

Country Status (7)

Country Link
US (1) US7781576B2 (es)
EP (1) EP1976382B1 (es)
JP (1) JP5254033B2 (es)
CA (1) CA2634749C (es)
ES (1) ES2422290T3 (es)
HK (1) HK1123682A1 (es)
WO (1) WO2007075876A2 (es)

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EP1976382B1 (en) 2005-12-23 2013-04-24 IDENIX Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides
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EP2909222B1 (en) 2012-10-22 2021-05-26 Idenix Pharmaceuticals LLC 2',4'-bridged nucleosides for hcv infection
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US20140271547A1 (en) 2013-03-13 2014-09-18 Idenix Pharmaceuticals, Inc. Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv
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EP3004130B1 (en) 2013-06-05 2019-08-07 Idenix Pharmaceuticals LLC. 1',4'-thio nucleosides for the treatment of hcv
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CN105418547A (zh) * 2015-11-17 2016-03-23 海门慧聚药业有限公司 索非布韦关键中间体的制备
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US20070203334A1 (en) 2007-08-30
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