AR106729A1 - 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación - Google Patents

4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Info

Publication number
AR106729A1
AR106729A1 ARP160103515A ARP160103515A AR106729A1 AR 106729 A1 AR106729 A1 AR 106729A1 AR P160103515 A ARP160103515 A AR P160103515A AR P160103515 A ARP160103515 A AR P160103515A AR 106729 A1 AR106729 A1 AR 106729A1
Authority
AR
Argentina
Prior art keywords
oxoetil
difluorofenil
piridin
oxi
benzonitrile
Prior art date
Application number
ARP160103515A
Other languages
English (en)
Inventor
Whiteker Gregory
Ryan Sarah
Hao Yan
Yang Qiang
Original Assignee
Viamet Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viamet Pharmaceuticals Inc filed Critical Viamet Pharmaceuticals Inc
Publication of AR106729A1 publication Critical patent/AR106729A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/40—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom six-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pyridine Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Reivindicación 1: Un método para preparar un compuesto de fórmula (1) que comprende el paso de poner en contacto un compuesto de fórmula (2) con una mezcla formada combinando 1-bromo-2,4-difluorobenceno con un reactivo metálico u organometálico, y un ácido.
ARP160103515A 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación AR106729A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201562256399P 2015-11-17 2015-11-17

Publications (1)

Publication Number Publication Date
AR106729A1 true AR106729A1 (es) 2018-02-14

Family

ID=58717794

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP160103515A AR106729A1 (es) 2015-11-17 2016-11-17 4-((6-(2-(2,4-difluorofenil)-1,1-difluoro-2-oxoetil)piridin-3-il)oxi)benzonitrilo y proceso para su preparación

Country Status (12)

Country Link
US (1) US20180327359A1 (es)
EP (1) EP3376866A4 (es)
JP (1) JP6987070B2 (es)
KR (1) KR20180101343A (es)
CN (1) CN108882709A (es)
AR (1) AR106729A1 (es)
BR (1) BR112018009924A2 (es)
CA (1) CA3005744A1 (es)
IL (1) IL259400B (es)
TW (1) TWI636045B (es)
WO (1) WO2017087597A1 (es)
ZA (1) ZA201803748B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3119764B1 (en) 2014-03-19 2019-04-17 Viamet Pharmaceuticals (NC), Inc. Antifungal compound process
WO2015143192A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
US9914726B2 (en) 2014-03-19 2018-03-13 Vps-3, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1H-tetrazol-1-yl)propan-2-ols and processes for their preparation
MX369357B (es) 2014-03-19 2019-11-06 Mycovia Pharmaceuticals Inc Procedimiento de compuesto antifungico.
EP3119754A4 (en) 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
AU2015231234B2 (en) 2014-03-19 2019-04-04 Mycovia Pharmaceuticals, Inc. Antifungal compound process
JP2017514790A (ja) 2014-03-19 2017-06-08 ヴィアメット ファーマスーティカルズ，インコーポレイテッド 抗真菌化合物の調製方法
WO2015143166A1 (en) 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. Antifungal compound process
MX365494B (es) 2014-03-19 2019-06-05 Us Health Procedimiento de compuesto antifungico.
US10308632B2 (en) 2015-09-18 2019-06-04 Vps-3, Inc. Antifungal compounds and processes for making
TWI750188B (zh) 2016-06-20 2021-12-21 日商鹽野義製藥股份有限公司 用於製備經取代多環吡啶酮衍生物之方法及其結晶

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR0113633A (pt) * 2000-08-30 2005-06-07 Dow Agrosciences Llc Compostos úteis como inseticidas, compostos úteis como acaricidas e processos para utilização e obtenção dos mesmos
JP5036316B2 (ja) * 2004-11-02 2012-09-26 Ｍｓｄ株式会社 アリールオキシ置換ベンズイミダゾール誘導体
EP1905769B1 (en) * 2005-07-13 2017-03-29 Msd K.K. Heterocycle-substituted benzimidazole derivative
JP4990783B2 (ja) * 2005-09-30 2012-08-01 Ｍｓｄ株式会社 ２−ヘテロアリール置換インドール誘導体
KR101912850B1 (ko) 2011-06-19 2018-10-30 비아멧 파마슈티컬즈(엔씨), 인코포레이티드 금속효소 억제제 화합물
EA024789B1 (ru) 2011-06-19 2016-10-31 Ваймет Фармасьютикалс, Инк. Соединения, ингибирующие металлоферменты
EP2723730A4 (en) * 2011-06-23 2014-12-31 Viamet Pharmaceuticals Inc METALLOENZYMHEMMERVERBINDUNGEN
WO2014043376A1 (en) * 2012-09-12 2014-03-20 Dow Agrosciences Llc Metalloenzyme inhibitor compounds
JP6387401B2 (ja) * 2013-05-28 2018-09-05 ヴィアメット ファーマスーティカルズ（エヌシー），インコーポレイテッド 殺真菌組成物
WO2015143192A1 (en) * 2014-03-19 2015-09-24 Viamet Pharmaceuticals, Inc. 2-(2,4-difluorophenyl)-1,1-difluoro-1-(5-substituted-pyridin-2-yl)-3-(1h-tetrazol-1-yl)propan-2-ols and processes for their preparation
EP3119754A4 (en) * 2014-03-19 2017-12-13 Viamet Pharmaceuticals, Inc. Antifungal compound process
CR20170574A (es) * 2015-05-18 2018-07-19 Viamet Pharmaceuticals Inc Compuestos antifíngicos

Also Published As

Publication number Publication date
TW201726620A (zh) 2017-08-01
EP3376866A1 (en) 2018-09-26
CA3005744A1 (en) 2017-05-26
EP3376866A4 (en) 2019-04-10
JP2018535262A (ja) 2018-11-29
KR20180101343A (ko) 2018-09-12
ZA201803748B (en) 2019-03-27
BR112018009924A2 (pt) 2018-11-13
CN108882709A (zh) 2018-11-23
US20180327359A1 (en) 2018-11-15
TWI636045B (zh) 2018-09-21
IL259400A (en) 2018-07-31
JP6987070B2 (ja) 2021-12-22
IL259400B (en) 2021-06-30
WO2017087597A1 (en) 2017-05-26

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