|
JPH0487425A
(ja)
*
|
1990-07-31 |
1992-03-19 |
Fujitsu Ltd |
回線切り替え装置
|
|
US6414002B1
(en)
*
|
1999-09-22 |
2002-07-02 |
Bristol-Myers Squibb Company |
Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
|
|
US6395767B2
(en)
*
|
2000-03-10 |
2002-05-28 |
Bristol-Myers Squibb Company |
Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
|
|
US7622503B2
(en)
|
2000-08-24 |
2009-11-24 |
University Of Tennessee Research Foundation |
Selective androgen receptor modulators and methods of use thereof
|
|
US6573287B2
(en)
*
|
2001-04-12 |
2003-06-03 |
Bristo-Myers Squibb Company |
2,1-oxazoline and 1,2-pyrazoline-based inhibitors of dipeptidyl peptidase IV and method
|
|
DE60221983T2
(de)
*
|
2001-06-27 |
2008-05-15 |
Smithkline Beecham Corp. |
Fluorpyrrolidine als dipeptidyl-peptidase inhibitoren
|
|
CN1990469A
(zh)
|
2001-06-27 |
2007-07-04 |
史密丝克莱恩比彻姆公司 |
作为二肽酶抑制剂的氟代吡咯烷
|
|
ES2296962T3
(es)
*
|
2001-06-27 |
2008-05-01 |
Smithkline Beecham Corporation |
Pirrolidinas como inhibidores de dipeptidil peptidasa.
|
|
US6984645B2
(en)
*
|
2001-11-16 |
2006-01-10 |
Bristol-Myers Squibb Company |
Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein
|
|
US8853266B2
(en)
|
2001-12-06 |
2014-10-07 |
University Of Tennessee Research Foundation |
Selective androgen receptor modulators for treating diabetes
|
|
US7772433B2
(en)
|
2002-02-28 |
2010-08-10 |
University Of Tennessee Research Foundation |
SARMS and method of use thereof
|
|
GB0205166D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0205162D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0205175D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0205165D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0205176D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
GB0205170D0
(en)
|
2002-03-06 |
2002-04-17 |
Astrazeneca Ab |
Chemical compounds
|
|
WO2003097038A1
(en)
*
|
2002-05-14 |
2003-11-27 |
Ralph Ryback |
Method for treating dermatoses and tissue damage
|
|
US7405234B2
(en)
*
|
2002-05-17 |
2008-07-29 |
Bristol-Myers Squibb Company |
Bicyclic modulators of androgen receptor function
|
|
US7378385B2
(en)
*
|
2002-08-08 |
2008-05-27 |
University Of Cincinnati |
Role for GLP-1 to mediate responses to disparate stressors
|
|
US7407955B2
(en)
|
2002-08-21 |
2008-08-05 |
Boehringer Ingelheim Pharma Gmbh & Co., Kg |
8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
|
|
US7262207B2
(en)
*
|
2002-09-19 |
2007-08-28 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
US7238724B2
(en)
*
|
2002-09-19 |
2007-07-03 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
US20040121964A1
(en)
*
|
2002-09-19 |
2004-06-24 |
Madar David J. |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
AU2003302084A1
(en)
*
|
2002-11-15 |
2004-06-15 |
Bristol-Myers Squibb Company |
Open chain prolyl urea-related modulators of androgen receptor function
|
|
US8309603B2
(en)
|
2004-06-07 |
2012-11-13 |
University Of Tennessee Research Foundation |
SARMs and method of use thereof
|
|
US7420079B2
(en)
*
|
2002-12-09 |
2008-09-02 |
Bristol-Myers Squibb Company |
Methods and compounds for producing dipeptidyl peptidase IV inhibitors and intermediates thereof
|
|
EP1583534A4
(en)
*
|
2002-12-20 |
2007-08-29 |
Merck & Co Inc |
3-AMINO-4-PHENYLBUTANIC ACID DERIVATIVES AS DIPEPTIDYL-PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
|
|
US20040242568A1
(en)
*
|
2003-03-25 |
2004-12-02 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
|
ATE462432T1
(de)
|
2003-05-05 |
2010-04-15 |
Probiodrug Ag |
Glutaminylcyclase-hemmer
|
|
EP1961416B1
(en)
|
2003-05-05 |
2013-01-23 |
Probiodrug AG |
Use of inhibitors of glutaminyl cyclase for treating psoriasis, rheumatoid arthritis or atherosclerosis.
|
|
NZ543146A
(en)
|
2003-05-05 |
2008-09-26 |
Probiodrug Ag |
Use of effectors of glutaminyl cyclase (QC) activity in combination with inhibitors of DP IV or DP IV-like enzymes for the treatment of conditions that can be treated by modulation of QC-and/or DPIV-activity
|
|
WO2004103993A1
(en)
|
2003-05-14 |
2004-12-02 |
Syrrx, Inc. |
Dipeptidyl peptidase inhibitors
|
|
US7459474B2
(en)
|
2003-06-11 |
2008-12-02 |
Bristol-Myers Squibb Company |
Modulators of the glucocorticoid receptor and method
|
|
US6995183B2
(en)
|
2003-08-01 |
2006-02-07 |
Bristol Myers Squibb Company |
Adamantylglycine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7678909B1
(en)
|
2003-08-13 |
2010-03-16 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7169926B1
(en)
|
2003-08-13 |
2007-01-30 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
EP1506967B1
(en)
*
|
2003-08-13 |
2007-11-21 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7205409B2
(en)
*
|
2003-09-04 |
2007-04-17 |
Abbott Laboratories |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
EP1699777B1
(en)
*
|
2003-09-08 |
2012-12-12 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
JP2007513058A
(ja)
*
|
2003-09-08 |
2007-05-24 |
武田薬品工業株式会社 |
ジペプチジルぺプチダーゼ阻害剤
|
|
US7371759B2
(en)
*
|
2003-09-25 |
2008-05-13 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
|
KR20120007079A
(ko)
|
2003-10-15 |
2012-01-19 |
프로비오드룩 아게 |
글루타미닐 및 글루타메이트 사이클라제 이펙터의 용도
|
|
JP2007509898A
(ja)
|
2003-11-03 |
2007-04-19 |
プロビオドルグ エージー |
神経障害治療に有用な組合せ
|
|
US7576121B2
(en)
*
|
2003-11-12 |
2009-08-18 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
|
US7317109B2
(en)
*
|
2003-11-12 |
2008-01-08 |
Phenomix Corporation |
Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
|
US7767828B2
(en)
*
|
2003-11-12 |
2010-08-03 |
Phenomix Corporation |
Methyl and ethyl substituted pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
|
US7674913B2
(en)
*
|
2003-11-12 |
2010-03-09 |
Phenomix Corporation |
Heterocyclic boronic acid compounds
|
|
CA2545641A1
(en)
|
2003-11-17 |
2005-06-02 |
Novartis Ag |
Use of organic compounds
|
|
US20070149451A1
(en)
*
|
2003-11-17 |
2007-06-28 |
Holmes David G |
Combination of a dpp IV inhibitor and an antiobesity or appetite regulating agent
|
|
US7420059B2
(en)
*
|
2003-11-20 |
2008-09-02 |
Bristol-Myers Squibb Company |
HMG-CoA reductase inhibitors and method
|
|
DK3366283T3
(da)
|
2004-01-20 |
2021-11-22 |
Novartis Ag |
Direkte sammenpresningsformulering og fremgangsmåde
|
|
US7470810B2
(en)
*
|
2004-01-21 |
2008-12-30 |
Bristol-Myers Squibb Company |
Alkyl and aryl-thiotrifluoroacetates and process
|
|
WO2005073186A1
(ja)
*
|
2004-01-29 |
2005-08-11 |
Ono Pharmaceutical Co., Ltd. |
ピロリジン誘導体
|
|
ES2375625T3
(es)
*
|
2004-02-05 |
2012-03-02 |
Kyorin Pharmaceutical Co., Ltd. |
Derivados de biciclo éster.
|
|
KR101099206B1
(ko)
|
2004-02-05 |
2011-12-27 |
프로비오드룩 아게 |
신규한 글루타미닐 시클라제 저해제
|
|
CA2554378A1
(en)
*
|
2004-02-18 |
2005-08-25 |
Kyorin Pharmaceutical Co., Ltd. |
Bicycloamide derivative
|
|
US7501426B2
(en)
|
2004-02-18 |
2009-03-10 |
Boehringer Ingelheim International Gmbh |
8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
|
|
US20070238753A1
(en)
*
|
2004-02-27 |
2007-10-11 |
Madar David J |
Pharmaceutical Compositions as Inhibitors of Dipeptidyl Peptidase-IV (DPP-IV)
|
|
WO2005082847A1
(ja)
*
|
2004-02-27 |
2005-09-09 |
Kyorin Pharmaceutical Co., Ltd. |
ビシクロ誘導体
|
|
US7732446B1
(en)
|
2004-03-11 |
2010-06-08 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
MXPA06010571A
(es)
*
|
2004-03-15 |
2007-02-16 |
Takeda Pharmaceutical |
Inhibidores de dipeptidil peptidasa.
|
|
TW200534879A
(en)
*
|
2004-03-25 |
2005-11-01 |
Bristol Myers Squibb Co |
Coated tablet formulation and method
|
|
TW200538122A
(en)
*
|
2004-03-31 |
2005-12-01 |
Bristol Myers Squibb Co |
Process for preparing a dipeptidyl peptidase Ⅳ inhibitor and intermediates employed therein
|
|
US7741082B2
(en)
*
|
2004-04-14 |
2010-06-22 |
Bristol-Myers Squibb Company |
Process for preparing dipeptidyl peptidase IV inhibitors and intermediates therefor
|
|
TW200536827A
(en)
*
|
2004-05-04 |
2005-11-16 |
Bristol Myers Squibb Co |
Enzymatic ammonolysis process for the preparation of intermediates for DPP IV inhibitors
|
|
US7829720B2
(en)
|
2004-05-04 |
2010-11-09 |
Bristol-Myers Squibb Company |
Process for preparing atazanavir bisulfate and novel forms
|
|
US20050256314A1
(en)
*
|
2004-05-04 |
2005-11-17 |
Soojin Kim |
Process employing controlled crystallization in forming crystals of a pharmaceutical
|
|
US7214702B2
(en)
*
|
2004-05-25 |
2007-05-08 |
Bristol-Myers Squibb Company |
Process for producing a dipeptidyl peptidase IV inhibitor
|
|
TWI354569B
(en)
*
|
2004-05-28 |
2011-12-21 |
Bristol Myers Squibb Co |
Coated tablet formulation and method
|
|
US7687638B2
(en)
*
|
2004-06-04 |
2010-03-30 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
US9889110B2
(en)
|
2004-06-07 |
2018-02-13 |
University Of Tennessee Research Foundation |
Selective androgen receptor modulator for treating hormone-related conditions
|
|
US9884038B2
(en)
|
2004-06-07 |
2018-02-06 |
University Of Tennessee Research Foundation |
Selective androgen receptor modulator and methods of use thereof
|
|
US7572805B2
(en)
|
2004-07-14 |
2009-08-11 |
Bristol-Myers Squibb Company |
Pyrrolo(oxo)isoquinolines as 5HT ligands
|
|
WO2006019965A2
(en)
|
2004-07-16 |
2006-02-23 |
Takeda San Diego, Inc. |
Dipeptidyl peptidase inhibitors
|
|
AU2005267093B2
(en)
*
|
2004-07-23 |
2009-10-01 |
Nuada Llc |
Peptidase inhibitors
|
|
TW200608967A
(en)
|
2004-07-29 |
2006-03-16 |
Sankyo Co |
Pharmaceutical compositions containing with diabetic agent
|
|
US20060035954A1
(en)
*
|
2004-08-11 |
2006-02-16 |
Sharma Padam N |
Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
|
|
AR051446A1
(es)
*
|
2004-09-23 |
2007-01-17 |
Bristol Myers Squibb Co |
Glucosidos de c-arilo como inhibidores selectivos de transportadores de glucosa (sglt2)
|
|
DE102004054054A1
(de)
|
2004-11-05 |
2006-05-11 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
|
|
EP1828192B1
(en)
|
2004-12-21 |
2014-12-03 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US7635699B2
(en)
*
|
2004-12-29 |
2009-12-22 |
Bristol-Myers Squibb Company |
Azolopyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US7589088B2
(en)
*
|
2004-12-29 |
2009-09-15 |
Bristol-Myers Squibb Company |
Pyrimidine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
JP2008024592A
(ja)
*
|
2005-01-28 |
2008-02-07 |
Taisho Pharmaceut Co Ltd |
シアノピロリジン誘導体含有固形製剤用組成物、それを含有する固形製剤及びその製造方法
|
|
WO2006086464A2
(en)
*
|
2005-02-10 |
2006-08-17 |
Bristol-Myers Squibb Company |
Dihydroquinazolinones as 5ht modulators
|
|
JP2008115080A
(ja)
*
|
2005-04-22 |
2008-05-22 |
Taisho Pharmaceutical Co Ltd |
併用医薬
|
|
US7521557B2
(en)
|
2005-05-20 |
2009-04-21 |
Bristol-Myers Squibb Company |
Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
|
|
US20060264433A1
(en)
*
|
2005-05-23 |
2006-11-23 |
Backes Bradley J |
Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
|
|
US7825139B2
(en)
*
|
2005-05-25 |
2010-11-02 |
Forest Laboratories Holdings Limited (BM) |
Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
|
|
MY152185A
(en)
|
2005-06-10 |
2014-08-29 |
Novartis Ag |
Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
|
|
AU2006275694A1
(en)
*
|
2005-07-28 |
2007-02-08 |
Bristol-Myers Squibb Company |
Substituted tetrahydro-1H-pyrido(4,3,b)indoles as serotonin receptor agonists and antagonists
|
|
DE102005035891A1
(de)
|
2005-07-30 |
2007-02-08 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
|
|
TW200738245A
(en)
*
|
2005-08-22 |
2007-10-16 |
Sankyo Co |
Pharmaceutical composition containing FBPase inhibitor
|
|
US7795436B2
(en)
*
|
2005-08-24 |
2010-09-14 |
Bristol-Myers Squibb Company |
Substituted tricyclic heterocycles as serotonin receptor agonists and antagonists
|
|
WO2007027582A2
(en)
|
2005-08-31 |
2007-03-08 |
University Of Tennessee Research Foundation |
Treating renal disease, burns, wounds and spinal cord injury with selective androgen receptor modulators
|
|
WO2007033265A1
(en)
*
|
2005-09-14 |
2007-03-22 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors for treating diabetis
|
|
CA2622608C
(en)
*
|
2005-09-14 |
2014-08-19 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors for treating diabetes
|
|
ME02005B
(me)
|
2005-09-14 |
2012-08-31 |
Takeda Pharmaceuticals Co |
Inhibitori dipeptidil peptidaze za lečenje dijabetesa
|
|
TW200745080A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
|
|
CN101360723A
(zh)
*
|
2005-09-16 |
2009-02-04 |
武田药品工业株式会社 |
制备嘧啶二酮衍生物的方法
|
|
TW200745079A
(en)
*
|
2005-09-16 |
2007-12-16 |
Takeda Pharmaceuticals Co |
Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
|
|
TW200738266A
(en)
*
|
2005-09-29 |
2007-10-16 |
Sankyo Co |
Pharmaceutical agent containing insulin resistance improving agent
|
|
US7488725B2
(en)
|
2005-10-31 |
2009-02-10 |
Bristol-Myers Squibb Co. |
Pyrrolidinyl beta-amino amide-based inhibitors of dipeptidyl peptidase IV and methods
|
|
WO2007054577A1
(en)
*
|
2005-11-14 |
2007-05-18 |
Probiodrug Ag |
Cyclopropyl-fused pyrrolidine derivatives as dipeptidyl peptidase iv inhibitors
|
|
GB0526291D0
(en)
|
2005-12-23 |
2006-02-01 |
Prosidion Ltd |
Therapeutic method
|
|
CN101395131B
(zh)
*
|
2006-03-08 |
2012-11-14 |
杏林制药株式会社 |
氨基乙酰基吡咯烷甲腈衍生物的制备方法及其制备中间体
|
|
RU2465264C2
(ru)
*
|
2006-03-16 |
2012-10-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
Дейтерированные ингибиторы протеазы гепатита с
|
|
US20100029941A1
(en)
*
|
2006-03-28 |
2010-02-04 |
Takeda Pharmaceutical Company Limited |
Preparation of (r)-3-aminopiperidine dihydrochloride
|
|
WO2007112347A1
(en)
|
2006-03-28 |
2007-10-04 |
Takeda Pharmaceutical Company Limited |
Dipeptidyl peptidase inhibitors
|
|
US20070238770A1
(en)
*
|
2006-04-05 |
2007-10-11 |
Bristol-Myers Squibb Company |
Process for preparing novel crystalline forms of peliglitazar, novel stable forms produced therein and formulations
|
|
PE20071221A1
(es)
|
2006-04-11 |
2007-12-14 |
Arena Pharm Inc |
Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
|
|
BRPI0710597A2
(pt)
*
|
2006-04-11 |
2012-06-19 |
Arena Pharm Inc |
método de uso do receptor gpr119 para identificar compostos úteis para aumento da massa óssea em um indivìduo
|
|
MX2008013130A
(es)
|
2006-04-12 |
2008-11-19 |
Probiodrug Ag |
Inhibidores de enzima.
|
|
CN101421238B
(zh)
*
|
2006-04-17 |
2013-01-09 |
住友化学株式会社 |
多环式脯氨酸衍生物或其酸加成盐的制造方法
|
|
PE20110235A1
(es)
|
2006-05-04 |
2011-04-14 |
Boehringer Ingelheim Int |
Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
|
|
MX2008014024A
(es)
|
2006-05-04 |
2008-11-14 |
Boehringer Ingelheim Int |
Formas poliformas.
|
|
EP1852108A1
(en)
|
2006-05-04 |
2007-11-07 |
Boehringer Ingelheim Pharma GmbH & Co.KG |
DPP IV inhibitor formulations
|
|
US7919598B2
(en)
|
2006-06-28 |
2011-04-05 |
Bristol-Myers Squibb Company |
Crystal structures of SGLT2 inhibitors and processes for preparing same
|
|
EA024161B1
(ru)
|
2006-07-12 |
2016-08-31 |
Юниверсити Оф Теннесси Рисерч Фаундейшн |
Фармацевтические композиции, содержащие замещенные ациланилиды
|
|
US9730908B2
(en)
|
2006-08-24 |
2017-08-15 |
University Of Tennessee Research Foundation |
SARMs and method of use thereof
|
|
US9844528B2
(en)
|
2006-08-24 |
2017-12-19 |
University Of Tennessee Research Foundation |
SARMs and method of use thereof
|
|
CA2662084A1
(en)
|
2006-09-07 |
2008-03-13 |
Nycomed Gmbh |
Combination treatment for diabetes mellitus
|
|
MY145447A
(en)
*
|
2006-09-13 |
2012-02-15 |
Takeda Pharmaceutical |
Use of 2-6(3-amino-piperidin-1-yl)-3-methyl-2, 4-dioxo-3, 4-dihydrp-2h-pyrimidin-1-ylmethyl-4-fluoro-benzonitrile
|
|
PE20121528A1
(es)
*
|
2006-09-13 |
2012-12-12 |
Smithkline Beecham Corp |
Metodos para administrar agentes hipoglucemiantes de larga duracion
|
|
US8324383B2
(en)
|
2006-09-13 |
2012-12-04 |
Takeda Pharmaceutical Company Limited |
Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
|
|
CN101594878A
(zh)
|
2006-09-18 |
2009-12-02 |
雷普特药品公司 |
通过给予受体相关蛋白(rap)-缀合物对肝病症的治疗
|
|
JP5379692B2
(ja)
|
2006-11-09 |
2013-12-25 |
プロビオドルグ エージー |
潰瘍、癌及び他の疾患の治療のためのグルタミニルシクラーゼの阻害薬としての3−ヒドロキシ−1,5−ジヒドロ−ピロール−2−オン誘導体
|
|
US8217025B2
(en)
*
|
2006-11-17 |
2012-07-10 |
Harbor Therapeutics, Inc. |
Drug screening and treatment methods
|
|
TW200838536A
(en)
*
|
2006-11-29 |
2008-10-01 |
Takeda Pharmaceutical |
Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
|
|
EP2091948B1
(en)
|
2006-11-30 |
2012-04-18 |
Probiodrug AG |
Novel inhibitors of glutaminyl cyclase
|
|
EP2106212B1
(en)
|
2007-01-22 |
2014-04-02 |
GTX, Inc. |
Nuclear receptor binding agents
|
|
US9623021B2
(en)
|
2007-01-22 |
2017-04-18 |
Gtx, Inc. |
Nuclear receptor binding agents
|
|
US9604931B2
(en)
|
2007-01-22 |
2017-03-28 |
Gtx, Inc. |
Nuclear receptor binding agents
|
|
CN101230058A
(zh)
*
|
2007-01-23 |
2008-07-30 |
上海恒瑞医药有限公司 |
双环氮杂烷类衍生物、其制备方法及其在医药上的用途
|
|
RS51592B
(sr)
|
2007-02-01 |
2011-08-31 |
Takeda Pharmaceutical Company Limited |
Čvrsti preparat koji sadrži alogliptin i pioglitazon
|
|
WO2008098256A1
(en)
*
|
2007-02-09 |
2008-08-14 |
Bristol-Myers Squibb Company |
Methods for identifying patients with an increased likelihood of responding to dpp-iv inhibitors
|
|
US8093236B2
(en)
|
2007-03-13 |
2012-01-10 |
Takeda Pharmaceuticals Company Limited |
Weekly administration of dipeptidyl peptidase inhibitors
|
|
US20080064701A1
(en)
*
|
2007-04-24 |
2008-03-13 |
Ramesh Sesha |
Anti-diabetic combinations
|
|
TW200904405A
(en)
|
2007-03-22 |
2009-02-01 |
Bristol Myers Squibb Co |
Pharmaceutical formulations containing an SGLT2 inhibitor
|
|
ATE550319T1
(de)
*
|
2007-03-22 |
2012-04-15 |
Kyorin Seiyaku Kk |
Verfahren zur herstellung eines aminoacetylpyrrolidincarbonitrilderivats
|
|
CN103330939A
(zh)
|
2007-04-03 |
2013-10-02 |
田边三菱制药株式会社 |
二肽基肽酶iv抑制化合物和甜味剂的并用
|
|
US9656991B2
(en)
|
2007-04-18 |
2017-05-23 |
Probiodrug Ag |
Inhibitors of glutaminyl cyclase
|
|
PE20090696A1
(es)
*
|
2007-04-20 |
2009-06-20 |
Bristol Myers Squibb Co |
Formas cristalinas de saxagliptina y procesos para preparar las mismas
|
|
WO2008144346A2
(en)
*
|
2007-05-18 |
2008-11-27 |
Bristol-Myers Squibb Company |
Crystal structures of sglt2 inhibitors and processes for their preparation
|
|
AU2008259342B2
(en)
|
2007-06-04 |
2014-07-10 |
Ben-Gurion University Of The Negev Research And Development Authority |
Tri-aryl compounds and compositions comprising the same
|
|
CN101318925A
(zh)
*
|
2007-06-04 |
2008-12-10 |
上海恒瑞医药有限公司 |
吡咯烷并四元环类衍生物、其制备方法及其在医药上的用途
|
|
AU2008268627A1
(en)
*
|
2007-06-22 |
2008-12-31 |
Bristol-Myers Squibb Company |
Tableted compositions containing atazanavir
|
|
DE602008005896D1
(de)
*
|
2007-06-22 |
2011-05-12 |
Bristol Myers Squibb Co |
Tablettierte atazanavirhaltige zusammensetzungen
|
|
SI2170292T1
(sl)
*
|
2007-06-22 |
2014-05-30 |
Bristol-Myers Squibb Holdings Ireland |
Tabletirani sestavki, ki vsebujejo atazanavir
|
|
US20100178340A1
(en)
*
|
2007-06-22 |
2010-07-15 |
Bristol-Myers Squibb Company |
Tableted compositions containing atazanavir
|
|
CL2008002427A1
(es)
|
2007-08-16 |
2009-09-11 |
Boehringer Ingelheim Int |
Composicion farmaceutica que comprende 1-cloro-4-(b-d-glucopiranos-1-il)-2-[4-((s)-tetrahidrofurano-3-iloxi)bencil]-benceno combinado con 1-[(4-metilquinazolin-2-il)metil]-3-metil-7-(2-butin-1-il)-8-(3-(r)-aminopiperidin-1-il)xantina; y su uso para tratar diabetes mellitus tipo 2.
|
|
EP3542801A1
(en)
*
|
2007-08-17 |
2019-09-25 |
Boehringer Ingelheim International GmbH |
Purin derivatives for use in the treatment of fap-related diseases
|
|
US7968603B2
(en)
|
2007-09-11 |
2011-06-28 |
University Of Tennessee Research Foundation |
Solid forms of selective androgen receptor modulators
|
|
US20090076118A1
(en)
*
|
2007-09-13 |
2009-03-19 |
Protia, Llc |
Deuterium-enriched saxagliptin
|
|
GB2465132B
(en)
*
|
2007-09-21 |
2012-06-06 |
Lupin Ltd |
Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
|
|
CL2008003653A1
(es)
|
2008-01-17 |
2010-03-05 |
Mitsubishi Tanabe Pharma Corp |
Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
|
|
US8551524B2
(en)
*
|
2008-03-14 |
2013-10-08 |
Iycus, Llc |
Anti-diabetic combinations
|
|
PE20140960A1
(es)
*
|
2008-04-03 |
2014-08-15 |
Boehringer Ingelheim Int |
Formulaciones que comprenden un inhibidor de dpp4
|
|
EP2108960A1
(en)
|
2008-04-07 |
2009-10-14 |
Arena Pharmaceuticals, Inc. |
Methods of using A G protein-coupled receptor to identify peptide YY (PYY) secretagogues and compounds useful in the treatment of conditons modulated by PYY
|
|
US20110152340A1
(en)
*
|
2008-05-16 |
2011-06-23 |
Bristol-Myers Squibb Company |
Methods for Identifying Subjects With an Increased Likelihood of Responding to DPP-IV Inhibitors
|
|
PE20100156A1
(es)
*
|
2008-06-03 |
2010-02-23 |
Boehringer Ingelheim Int |
Tratamiento de nafld
|
|
WO2009155481A1
(en)
|
2008-06-20 |
2009-12-23 |
Gtx, Inc. |
Metabolites of selective androgen receptor modulators and methods of use thereof
|
|
UY32030A
(es)
|
2008-08-06 |
2010-03-26 |
Boehringer Ingelheim Int |
"tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
|
|
KR20200118243A
(ko)
|
2008-08-06 |
2020-10-14 |
베링거 인겔하임 인터내셔날 게엠베하 |
메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
|
|
WO2010016584A1
(ja)
*
|
2008-08-07 |
2010-02-11 |
杏林製薬株式会社 |
ビシクロ[2.2.2]オクチルアミン誘導体の製造方法
|
|
EP2327406A4
(en)
*
|
2008-08-14 |
2014-04-09 |
Kyorin Seiyaku Kk |
STABILIZED PHARMACEUTICAL COMPOSITION
|
|
CN103816158A
(zh)
*
|
2008-08-15 |
2014-05-28 |
勃林格殷格翰国际有限公司 |
用于治疗fab-相关疾病的嘌呤衍生物
|
|
CN102149407A
(zh)
|
2008-09-10 |
2011-08-10 |
贝林格尔.英格海姆国际有限公司 |
治疗糖尿病和相关病症的组合疗法
|
|
US20200155558A1
(en)
|
2018-11-20 |
2020-05-21 |
Boehringer Ingelheim International Gmbh |
Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
|
|
EP3228320B1
(de)
|
2008-10-17 |
2019-12-18 |
Sanofi-Aventis Deutschland GmbH |
Kombination von einem insulin und einem glp-1-agonisten
|
|
WO2010054326A2
(en)
|
2008-11-07 |
2010-05-14 |
The General Hospital Corporation |
C-terminal fragments of glucagon-like peptide-1 (glp-1)
|
|
WO2010059639A2
(en)
*
|
2008-11-19 |
2010-05-27 |
Auspex Pharmaceuticals, Inc. |
Hydroxyadamantyl inhibitors of dipeptidylpeptidase iv
|
|
US20100144140A1
(en)
*
|
2008-12-10 |
2010-06-10 |
Novellus Systems, Inc. |
Methods for depositing tungsten films having low resistivity for gapfill applications
|
|
DE102008062136B4
(de)
|
2008-12-16 |
2012-05-03 |
Kamamed Ug |
Pharmazeutische Zusammensetzung auf Basis von Peptid aus Kamelmilch
|
|
CN107011345A
(zh)
|
2008-12-23 |
2017-08-04 |
勃林格殷格翰国际有限公司 |
有机化合物的盐形式
|
|
TW201036975A
(en)
|
2009-01-07 |
2010-10-16 |
Boehringer Ingelheim Int |
Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy
|
|
US8706650B2
(en)
*
|
2009-01-14 |
2014-04-22 |
Integral Analytics, Inc. |
Optimization of microgrid energy use and distribution
|
|
TWI466672B
(zh)
|
2009-01-29 |
2015-01-01 |
Boehringer Ingelheim Int |
小兒科病人糖尿病之治療
|
|
AU2010212823B2
(en)
|
2009-02-13 |
2016-01-28 |
Boehringer Ingelheim International Gmbh |
Antidiabetic medications comprising a DPP-4 inhibitor (linagliptin) optionally in combination with other antidiabetics
|
|
HUE050287T2
(hu)
|
2009-02-13 |
2020-11-30 |
Boehringer Ingelheim Int |
SGLT2-inhibitort, DPP-IV-inhibitort és adott esetben egy további antidiabetikus hatóanyagot tartalmazó gyógyászati készítmény és alkalmazásai
|
|
CA2756786A1
(en)
|
2009-03-27 |
2010-09-30 |
Bristol-Myers Squibb Company |
Methods for preventing major adverse cardiovascular events with dpp-iv inhibitors
|
|
WO2010110436A1
(ja)
|
2009-03-27 |
2010-09-30 |
杏林製薬株式会社 |
塩基性添加剤を含有するマトリックス型徐放性製剤
|
|
SG175054A1
(en)
*
|
2009-04-08 |
2011-11-28 |
Bristol Myers Squibb Co |
A genetically stable plasmid expressing pdh and fdh enzymes
|
|
US20120088808A1
(en)
*
|
2009-04-09 |
2012-04-12 |
Sandoz Ag |
Crystal forms of saxagliptin
|
|
GB2483614B
(en)
|
2009-06-18 |
2014-12-03 |
Lupin Ltd |
2-Amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors
|
|
EP3202394A1
(de)
|
2009-07-06 |
2017-08-09 |
Sanofi-Aventis Deutschland GmbH |
Wässrige insulinzubereitungen enthaltend methionin
|
|
AR077642A1
(es)
|
2009-07-09 |
2011-09-14 |
Arena Pharm Inc |
Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
|
|
BR112012008346B1
(pt)
|
2009-09-11 |
2021-12-21 |
Vivoryon Therapeutics N.V. |
Derivados heterocíclicos, seu processo de preparação, e composição farmacêutica
|
|
EP2308847B1
(en)
|
2009-10-09 |
2014-04-02 |
EMC microcollections GmbH |
Substituted pyridines as inhibitors of dipeptidyl peptidase IV and their application for the treatment of diabetes and related diseases
|
|
PT2554183T
(pt)
|
2009-11-13 |
2018-07-09 |
Sanofi Aventis Deutschland |
Composição farmacêutica que compreende um agonista de glp-1, uma insulina e metionina
|
|
PE20121316A1
(es)
|
2009-11-13 |
2012-10-05 |
Sanofi Aventis Deutschland |
Composicion farmaceutica que comprende un agonista de glp-1 y metionina
|
|
CN102740839B
(zh)
|
2009-11-13 |
2015-05-06 |
阿斯利康(瑞典)有限公司 |
立即释放片剂
|
|
CN105193761B
(zh)
|
2009-11-13 |
2019-12-06 |
阿斯利康(瑞典)有限公司 |
双层片剂
|
|
EP2504002B1
(en)
|
2009-11-27 |
2019-10-09 |
Boehringer Ingelheim International GmbH |
Treatment of genotyped diabetic patients with dpp-iv inhibitors such as linagliptin
|
|
TWI562775B
(en)
|
2010-03-02 |
2016-12-21 |
Lexicon Pharmaceuticals Inc |
Methods of using inhibitors of sodium-glucose cotransporters 1 and 2
|
|
WO2011107530A2
(en)
|
2010-03-03 |
2011-09-09 |
Probiodrug Ag |
Novel inhibitors
|
|
DK2545047T3
(da)
|
2010-03-10 |
2014-07-28 |
Probiodrug Ag |
Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
|
|
WO2011113947A1
(en)
|
2010-03-18 |
2011-09-22 |
Boehringer Ingelheim International Gmbh |
Combination of a gpr119 agonist and the dpp-iv inhibitor linagliptin for use in the treatment of diabetes and related conditions
|
|
EP2368874A1
(en)
|
2010-03-26 |
2011-09-28 |
Sandoz AG |
Racemisation of (R)-N-Boc-3-hydroxyadamant-1-yl glycine
|
|
WO2011125011A1
(en)
*
|
2010-04-05 |
2011-10-13 |
Cadila Pharmaceuticals Limited |
Novel hypoglycemic compounds
|
|
WO2011127051A1
(en)
|
2010-04-06 |
2011-10-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
EP2560953B1
(en)
|
2010-04-21 |
2016-01-06 |
Probiodrug AG |
Inhibitors of glutaminyl cyclase
|
|
KR101927068B1
(ko)
|
2010-05-05 |
2018-12-10 |
베링거 인겔하임 인터내셔날 게엠베하 |
체중 감소 치료에 후속하는 dpp-4 억제제에 의한 순차적 병용 요법
|
|
CN103140475A
(zh)
*
|
2010-05-05 |
2013-06-05 |
亚细亚化学工业有限公司 |
沙格列汀中间体,沙格列汀多晶型物,及其制备方法
|
|
KR20200028498A
(ko)
|
2010-06-24 |
2020-03-16 |
베링거 인겔하임 인터내셔날 게엠베하 |
당뇨병 요법
|
|
EP2601175A1
(en)
|
2010-08-06 |
2013-06-12 |
Sandoz AG |
A novel crystalline compound comprising saxagliptin and phosphoric acid
|
|
EP2601176A1
(en)
|
2010-08-06 |
2013-06-12 |
Sandoz AG |
Novel salts of saxagrliptin with organic di-acids
|
|
US20140148384A1
(en)
|
2010-08-30 |
2014-05-29 |
Sanofi-Aventis Deutschland Gmbh |
Use of ave0010 for the manufacture of a medicament for the treatment of diabetes mellitus type 2
|
|
EP2611770A1
(en)
|
2010-09-03 |
2013-07-10 |
Sandoz AG |
Process for the reductive amination of -keto carboxylic acids
|
|
MX2013002146A
(es)
|
2010-09-03 |
2013-04-03 |
Astrazeneca Uk Ltd |
Formulaciones farmaceuticas que utilizan antioxidantes solubles en agua.
|
|
US9616097B2
(en)
|
2010-09-15 |
2017-04-11 |
Synergy Pharmaceuticals, Inc. |
Formulations of guanylate cyclase C agonists and methods of use
|
|
SG188548A1
(en)
|
2010-09-22 |
2013-04-30 |
Arena Pharm Inc |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20120077778A1
(en)
|
2010-09-29 |
2012-03-29 |
Andrea Bourdelais |
Ladder-Frame Polyether Conjugates
|
|
EP2608788A1
(en)
|
2010-10-04 |
2013-07-03 |
Assia Chemical Industries Ltd. |
Polymorphs of saxagliptin hydrochloride and processes for preparing them
|
|
WO2012061466A2
(en)
|
2010-11-02 |
2012-05-10 |
The General Hospital Corporation |
Methods for treating steatotic disease
|
|
AR083878A1
(es)
|
2010-11-15 |
2013-03-27 |
Boehringer Ingelheim Int |
Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
|
|
TWI631963B
(zh)
|
2011-01-05 |
2018-08-11 |
雷西肯製藥股份有限公司 |
包含鈉-葡萄糖共同輸送體1與2之抑制劑的組合物與應用方法
|
|
CN103354757A
(zh)
|
2011-01-31 |
2013-10-16 |
卡迪拉保健有限公司 |
脂肪代谢障碍的治疗
|
|
RU2607480C2
(ru)
|
2011-02-01 |
2017-01-10 |
Бристол-Майерс Сквибб Компани |
Фармацевтические композиции, содержащие аминосоединение
|
|
WO2012123563A1
(en)
|
2011-03-16 |
2012-09-20 |
Probiodrug Ag |
Benz imidazole derivatives as inhibitors of glutaminyl cyclase
|
|
WO2012135570A1
(en)
|
2011-04-01 |
2012-10-04 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
US20140066369A1
(en)
|
2011-04-19 |
2014-03-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US20140038889A1
(en)
|
2011-04-22 |
2014-02-06 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US20140051714A1
(en)
|
2011-04-22 |
2014-02-20 |
Arena Pharmaceuticals, Inc. |
Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
|
|
US9821032B2
(en)
|
2011-05-13 |
2017-11-21 |
Sanofi-Aventis Deutschland Gmbh |
Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin
|
|
WO2012170702A1
(en)
|
2011-06-08 |
2012-12-13 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
EP2729157B1
(en)
|
2011-07-06 |
2019-01-16 |
The General Hospital Corporation |
A pentapeptide derived from the c-terminus of glucagon-like peptide 1 (glp-1) for use in treatment
|
|
HUE061596T2
(hu)
|
2011-07-15 |
2023-07-28 |
Boehringer Ingelheim Int |
Szubsztituált dimer kinazolin származék, annak elõállítása és alkalmazása az I. és II. típusú cukorbetegség kezelésére szolgáló gyógyszerkészítményekben
|
|
CN108079281A
(zh)
|
2011-08-29 |
2018-05-29 |
赛诺菲-安万特德国有限公司 |
用于2型糖尿病患者中的血糖控制的药物组合
|
|
TWI559929B
(en)
|
2011-09-01 |
2016-12-01 |
Sanofi Aventis Deutschland |
Pharmaceutical composition for use in the treatment of a neurodegenerative disease
|
|
EA201490556A1
(ru)
|
2011-09-07 |
2014-08-29 |
Сановел Илач Санайи Ве Тиджарет Аноним Ширкети |
Составы ингибитора дпп-4
|
|
PL2578208T3
(pl)
|
2011-10-06 |
2014-10-31 |
Sanovel Ilac Sanayi Ve Ticaret As |
Stałe formulacje dawkowane inhibitora DPP-IV
|
|
WO2013055910A1
(en)
|
2011-10-12 |
2013-04-18 |
Arena Pharmaceuticals, Inc. |
Modulators of the gpr119 receptor and the treatment of disorders related thereto
|
|
WO2013081100A1
(ja)
*
|
2011-11-30 |
2013-06-06 |
積水メディカル株式会社 |
アダマンチルヒダントイン化合物
|
|
US9115082B2
(en)
|
2012-01-18 |
2015-08-25 |
Catherine Yang |
Dipeptidyl-peptidase-IV inhibitors for treatment of type 2 diabetes complex with hypertension
|
|
US9555001B2
(en)
|
2012-03-07 |
2017-01-31 |
Boehringer Ingelheim International Gmbh |
Pharmaceutical composition and uses thereof
|
|
WO2013160354A1
(en)
|
2012-04-25 |
2013-10-31 |
Enantia, S.L. |
Crystalline forms of saxagliptin
|
|
ES2929025T3
(es)
|
2012-05-14 |
2022-11-24 |
Boehringer Ingelheim Int |
Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
|
|
US20130303462A1
(en)
|
2012-05-14 |
2013-11-14 |
Boehringer Ingelheim International Gmbh |
Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
|
|
US8664443B2
(en)
|
2012-05-23 |
2014-03-04 |
Divi's Laboratories Ltd. |
Process for the preparation of (1S, 3S, 5S)-2-[2(S)-2-amino-2-(3-hydroxy-1-adamantan-1-yl) acetyl]-2-azabicyclo [3.1.0] hexane-3-carbonitrile
|
|
WO2013174767A1
(en)
|
2012-05-24 |
2013-11-28 |
Boehringer Ingelheim International Gmbh |
A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
|
|
WO2013175297A1
(en)
|
2012-05-24 |
2013-11-28 |
Apotex Pharmachem India Pvt. Ltd |
Salts of saxagliptin with organic acids
|
|
AU2013285078A1
(en)
|
2012-07-02 |
2015-01-29 |
Sun Pharmaceutical Industries Limited |
Saxagliptin salts
|
|
CN103539724B
(zh)
*
|
2012-07-12 |
2017-09-26 |
博瑞生物医药(苏州)股份有限公司 |
沙格列汀单一立体异构体的新晶型和纯化方法
|
|
US9969683B2
(en)
|
2012-07-13 |
2018-05-15 |
Gtx, Inc. |
Method of treating estrogen receptor (ER)-positive breast cancers with selective androgen receptor modulator (SARMS)
|
|
US9744149B2
(en)
|
2012-07-13 |
2017-08-29 |
Gtx, Inc. |
Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
|
|
MX375256B
(es)
|
2012-07-13 |
2025-03-06 |
Gtx Inc |
Metodo para tratar canceres de mama positivos a receptor de androgeno (ar) con modulador de receptor de androgeno selectivo (sarms).
|
|
US10314807B2
(en)
|
2012-07-13 |
2019-06-11 |
Gtx, Inc. |
Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
|
|
US9622992B2
(en)
|
2012-07-13 |
2017-04-18 |
Gtx, Inc. |
Method of treating androgen receptor (AR)-positive breast cancers with selective androgen receptor modulator (SARMs)
|
|
US10987334B2
(en)
|
2012-07-13 |
2021-04-27 |
University Of Tennessee Research Foundation |
Method of treating ER mutant expressing breast cancers with selective androgen receptor modulators (SARMs)
|
|
US10258596B2
(en)
|
2012-07-13 |
2019-04-16 |
Gtx, Inc. |
Method of treating HER2-positive breast cancers with selective androgen receptor modulators (SARMS)
|
|
WO2014030051A1
(en)
|
2012-08-23 |
2014-02-27 |
Aurobindo Pharma Limited |
Stable pharmaceutical compositions comprising saxagliptin
|
|
WO2014057495A1
(en)
|
2012-10-11 |
2014-04-17 |
Lee Pharma Limited |
A process for industrial preparation of [(s)-n-tert butoxycarbonyl-3-hydroxy]adamantylglycine
|
|
TWI500613B
(zh)
|
2012-10-17 |
2015-09-21 |
Cadila Healthcare Ltd |
新穎之雜環化合物
|
|
WO2014074668A1
(en)
|
2012-11-08 |
2014-05-15 |
Arena Pharmaceuticals, Inc. |
Modulators of gpr119 and the treatment of disorders related thereto
|
|
UA117574C2
(uk)
|
2012-11-20 |
2018-08-27 |
Лексікон Фармасьютікалз, Інк. |
Інгібітори котранспортера натрій-глюкози 1
|
|
WO2014096983A1
(en)
|
2012-12-21 |
2014-06-26 |
Wockhardt Limited |
Stable pharmaceutical compositions of saxagliptin or salts thereof
|
|
US20150250734A1
(en)
|
2012-12-21 |
2015-09-10 |
Wockhardt Limited |
Stable pharmaceutical compositions of saxagliptin or salts thereof
|
|
WO2014108830A1
(en)
|
2013-01-10 |
2014-07-17 |
Wockhardt Limited |
A process for preparing pharmaceutically acceptable salt of saxagliptin
|
|
ITMI20130132A1
(it)
|
2013-01-30 |
2014-07-31 |
Laboratorio Chimico Int Spa |
Procedimento per la preparazione di intermedi di sintesi di saxagliptina e nuovi composti
|
|
TWI641381B
(zh)
|
2013-02-04 |
2018-11-21 |
法商賽諾菲公司 |
胰島素類似物及/或胰島素衍生物之穩定化醫藥調配物
|
|
US8652527B1
(en)
|
2013-03-13 |
2014-02-18 |
Upsher-Smith Laboratories, Inc |
Extended-release topiramate capsules
|
|
US9101545B2
(en)
|
2013-03-15 |
2015-08-11 |
Upsher-Smith Laboratories, Inc. |
Extended-release topiramate capsules
|
|
CN104059068B
(zh)
*
|
2013-03-20 |
2017-02-08 |
中国科学院上海药物研究所 |
β‑氨基羰基类化合物、其制备方法、药物组合物及其用途
|
|
CN104098481B
(zh)
*
|
2013-04-10 |
2016-05-11 |
浙江九洲药物科技有限公司 |
一种沙格列汀中间体的制备方法
|
|
EP2988736A1
(en)
|
2013-04-22 |
2016-03-02 |
Cadila Healthcare Limited |
A novel composition for nonalcoholic fatty liver disease (nafld)
|
|
WO2014193528A1
(en)
*
|
2013-04-29 |
2014-12-04 |
Anovel Pharmaceuticals, Llc |
Amorphous dosage forms and methods
|
|
US20160107989A1
(en)
|
2013-05-30 |
2016-04-21 |
Cadila Healthcare Limited |
A process for preparation of pyrroles having hypolipidemic hypocholesteremic activities
|
|
CN105764916B
(zh)
|
2013-06-05 |
2021-05-18 |
博士医疗爱尔兰有限公司 |
鸟苷酸环化酶c的超纯激动剂、制备和使用所述激动剂的方法
|
|
TW201636015A
(zh)
|
2013-07-05 |
2016-10-16 |
卡地拉保健有限公司 |
協同性組成物
|
|
IN2013MU02470A
(enExample)
|
2013-07-25 |
2015-06-26 |
Cadila Healthcare Ltd |
|
|
EP2832723B1
(en)
|
2013-07-29 |
2017-02-15 |
Zentiva, a.s. |
Stabilised amorphous forms of Saxagliptin
|
|
IN2013MU02813A
(enExample)
*
|
2013-08-28 |
2015-07-03 |
Amneal Pharmaceuticals Llc |
|
|
IN2013MU02905A
(enExample)
|
2013-09-06 |
2015-07-03 |
Cadila Healthcare Ltd |
|
|
ITMI20131677A1
(it)
*
|
2013-10-10 |
2015-04-11 |
Olon Spa |
Procedimento per la preparazione di saxagliptina
|
|
WO2015068156A1
(en)
|
2013-11-05 |
2015-05-14 |
Ben-Gurion University Of The Negev Research And Development Authority |
Compounds for the treatment of diabetes and disease complications arising from same
|
|
WO2015067223A1
(en)
|
2013-11-06 |
2015-05-14 |
Zentiva, K., S. |
L-tartrate salt of (1s,3s,5s)-2-[(2s)-2-amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl) acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile and process for preparation thereof
|
|
WO2015071889A1
(en)
|
2013-11-18 |
2015-05-21 |
Ranbaxy Laboratories Limited |
Oral compositions of saxagliptin
|
|
WO2015071887A1
(en)
|
2013-11-18 |
2015-05-21 |
Ranbaxy Laboratories Limited |
Oral pharmaceutical compositions of saxagliptin
|
|
WO2015087262A1
(en)
|
2013-12-11 |
2015-06-18 |
Ranbaxy Laboratories Limited |
Process for the preparation of saxagliptin and its intermediates
|
|
CN105899191B
(zh)
|
2014-01-09 |
2020-06-16 |
赛诺菲 |
胰岛素类似物和/或胰岛素衍生物的稳定化不含甘油的药物制剂
|
|
RU2016132340A
(ru)
|
2014-01-09 |
2018-02-14 |
Санофи |
Стабилизированные фармацевтические составы на основе инсулина аспарта
|
|
KR20160104724A
(ko)
|
2014-01-09 |
2016-09-05 |
사노피 |
인슐린 유사체 및/또는 인슐린 유도체의 안정화된 약제학적 제형
|
|
EP3110449B1
(en)
|
2014-02-28 |
2023-06-28 |
Boehringer Ingelheim International GmbH |
Medical use of a dpp-4 inhibitor
|
|
CZ2014177A3
(cs)
*
|
2014-03-24 |
2015-10-07 |
Zentiva, K.S. |
Způsob výroby saxagliptinu
|
|
ES2864079T3
(es)
|
2014-05-30 |
2021-10-13 |
Pfizer |
Derivados de carbonitrilo como moduladores selectivos del receptor de andrógenos
|
|
WO2016016770A1
(en)
|
2014-07-26 |
2016-02-04 |
Wockhardt Limited |
A novel modified release pharmaceutical composition of sitagliptin or pharmaceutically acceptable salt thereof
|
|
GB201415598D0
(en)
|
2014-09-03 |
2014-10-15 |
Univ Birmingham |
Elavated Itercranial Pressure Treatment
|
|
TWI758239B
(zh)
|
2014-12-12 |
2022-03-21 |
德商賽諾菲阿凡提斯德意志有限公司 |
甘精胰島素/利司那肽固定比率配製劑
|
|
CN104557667A
(zh)
*
|
2014-12-12 |
2015-04-29 |
山东省药学科学院 |
2-氰基吡咯烷类化合物、制备方法及其应用
|
|
MX386778B
(es)
|
2015-03-09 |
2025-03-19 |
Intekrin Therapeutics Inc |
Métodos para el tratamiento de enfermedad de hígado graso no alcohólico y/o lipodistrofia.
|
|
TWI748945B
(zh)
|
2015-03-13 |
2021-12-11 |
德商賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患治療
|
|
TW201705975A
(zh)
|
2015-03-18 |
2017-02-16 |
賽諾菲阿凡提斯德意志有限公司 |
第2型糖尿病病患之治療
|
|
CN105037245B
(zh)
*
|
2015-08-03 |
2017-04-12 |
沧州那瑞化学科技有限公司 |
一种沙格列汀中间体的制备方法
|
|
US10385017B2
(en)
|
2015-10-14 |
2019-08-20 |
Cadila Healthcare Limited |
Pyrrole compound, compositions and process for preparation thereof
|
|
KR101715682B1
(ko)
|
2015-10-29 |
2017-03-13 |
경동제약 주식회사 |
삭사글립틴의 제조를 위한 신규 중간체, 이의 제조방법 및 이를 이용한 삭사글립틴의 제조방법
|
|
BR112018072401A2
(pt)
|
2016-06-10 |
2019-02-19 |
Boehringer Ingelheim International Gmbh |
combinações de linagliptina e metformina
|
|
US11583516B2
(en)
*
|
2016-09-07 |
2023-02-21 |
Trustees Of Tufts College |
Dash inhibitors, and uses related thereto
|
|
WO2018104916A1
(en)
|
2016-12-09 |
2018-06-14 |
Cadila Healthcare Limited |
Treatment for primary biliary cholangitis
|
|
WO2018162722A1
(en)
|
2017-03-09 |
2018-09-13 |
Deutsches Institut Für Ernährungsforschung Potsdam-Rehbrücke |
Dpp-4 inhibitors for use in treating bone fractures
|
|
WO2018187350A1
(en)
|
2017-04-03 |
2018-10-11 |
Coherus Biosciences Inc. |
PPARγ AGONIST FOR TREATMENT OF PROGRESSIVE SUPRANUCLEAR PALSY
|
|
PL3461819T3
(pl)
|
2017-09-29 |
2020-11-30 |
Probiodrug Ag |
Inhibitory cyklazy glutaminylowej
|
|
CN109970620B
(zh)
*
|
2017-12-27 |
2022-07-12 |
江苏威凯尔医药科技有限公司 |
一种制备沙格列汀中间体的方法
|
|
EP3807894A1
(en)
|
2018-06-14 |
2021-04-21 |
AstraZeneca UK Limited |
Methods for lowering blood sugar with a dipeptidyl peptidase-4 inhibitor pharmaceutical composition
|
|
WO2020016335A1
(en)
|
2018-07-19 |
2020-01-23 |
Astrazeneca Ab |
Methods of treating hfpef employing dapagliflozin and compositions comprising the same
|
|
KR20210065974A
(ko)
|
2018-09-26 |
2021-06-04 |
렉시컨 파마슈티컬스 인코퍼레이티드 |
N-(1-((2-(디메틸아미노)에틸)아미노)-2-메틸-1-옥소프로판-2-일)-4-(4-(2-메틸-5-((2s,3r,4r,5s,6r)-3,4,5-트리히드록시-6-(메틸티오)테트라히드로-2h-피란-2-일)벤질)페닐)부탄아미드의 결정질 형태 및 그의 합성 방법
|
|
RU2712097C1
(ru)
*
|
2018-09-28 |
2020-01-24 |
Общество с ограниченной ответственностью "Необиотек" |
Ингибитор дипептидилпептидазы-4 для лечения сахарного диабета 2-го типа, соединения (варианты)
|
|
RU2727898C1
(ru)
*
|
2020-02-25 |
2020-07-24 |
Общество с ограниченной ответственностью «Необиотек» |
Фармацевтическая композиция на основе действующего вещества, ингибитора дипептидилпептидазы-4, для предупреждения развития и лечения сахарного диабета 2 типа
|
|
TW202220672A
(zh)
|
2020-07-27 |
2022-06-01 |
瑞典商阿斯特捷利康公司 |
用達格列淨治療慢性腎臟病之方法
|
|
SI4188389T1
(sl)
|
2020-07-27 |
2025-11-28 |
Astrazeneca Ab |
Dapagliflozin za uporabo pri postopkih zdravljenja kronične ledvične bolezni
|
|
WO2023275715A1
(en)
|
2021-06-30 |
2023-01-05 |
Pfizer Inc. |
Metabolites of selective androgen receptor modulators
|
|
CN113666846B
(zh)
*
|
2021-08-31 |
2023-06-27 |
济南立德医药技术有限公司 |
沙格列汀中间体的合成方法
|
|
US20250108065A1
(en)
|
2022-01-26 |
2025-04-03 |
Astrazeneca Ab |
Methods of treating prediabetes or reducing the risk of developing type 2 diabetes with dapagliflozin
|
|
WO2025090919A1
(en)
*
|
2023-10-25 |
2025-05-01 |
Piton Therapeutics, Inc. |
Compositions and methods for treating inflammatory bowel disease
|