DE69231674T2 - Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv - Google Patents

Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv

Info

Publication number
DE69231674T2
DE69231674T2 DE69231674T DE69231674T DE69231674T2 DE 69231674 T2 DE69231674 T2 DE 69231674T2 DE 69231674 T DE69231674 T DE 69231674T DE 69231674 T DE69231674 T DE 69231674T DE 69231674 T2 DE69231674 T2 DE 69231674T2
Authority
DE
Germany
Prior art keywords
inhibitors
dipeptidyl aminopeptidase
aminopeptidase type
type
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69231674T
Other languages
English (en)
Other versions
DE69231674D1 (de
Inventor
W Bachovchin
G Plaut
R Flentke
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
New England Medical Center Hospitals Inc
Tufts University
Original Assignee
New England Medical Center Hospitals Inc
Tufts University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New England Medical Center Hospitals Inc, Tufts University filed Critical New England Medical Center Hospitals Inc
Publication of DE69231674D1 publication Critical patent/DE69231674D1/de
Application granted granted Critical
Publication of DE69231674T2 publication Critical patent/DE69231674T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
DE69231674T 1991-10-22 1992-10-21 Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv Expired - Fee Related DE69231674T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US78155291A 1991-10-22 1991-10-22
PCT/US1992/009026 WO1993008259A2 (en) 1991-10-22 1992-10-21 Inhibitors of dipeptidyl-aminopeptidase type iv

Publications (2)

Publication Number Publication Date
DE69231674D1 DE69231674D1 (de) 2001-03-08
DE69231674T2 true DE69231674T2 (de) 2001-08-09

Family

ID=25123110

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69233671T Expired - Fee Related DE69233671T2 (de) 1991-10-22 1992-10-21 Inhibitoren der Dipeptidyl-Aminopeptidase vom Typ IV
DE69231674T Expired - Fee Related DE69231674T2 (de) 1991-10-22 1992-10-21 Inhibitoren der dipeptidyl-aminopeptidase vom typ-iv

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69233671T Expired - Fee Related DE69233671T2 (de) 1991-10-22 1992-10-21 Inhibitoren der Dipeptidyl-Aminopeptidase vom Typ IV

Country Status (10)

Country Link
EP (2) EP1050540B1 (de)
JP (1) JPH07504158A (de)
AT (2) ATE349461T1 (de)
CA (1) CA2121369C (de)
DE (2) DE69233671T2 (de)
DK (1) DK0610317T3 (de)
ES (1) ES2153831T3 (de)
GR (1) GR3035730T3 (de)
HK (1) HK1015611A1 (de)
WO (1) WO1993008259A2 (de)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
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FR2733995B1 (fr) * 1995-05-09 1997-07-25 Inst Nat Sante Rech Med Inhibiteurs de l'inactivation de neuropeptides endogenes notamment la cholecystokinine, leurs procedes de preparation leur utilisation comme medicaments et procede de criblage de medicaments
DE122010000020I1 (de) 1996-04-25 2010-07-08 Prosidion Ltd Verfahren zur Senkung des Blutglukosespiegels in Säugern
US5965532A (en) 1996-06-28 1999-10-12 Trustees Of Tufts College Multivalent compounds for crosslinking receptors and uses thereof
US6011155A (en) * 1996-11-07 2000-01-04 Novartis Ag N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6040145A (en) 1997-05-07 2000-03-21 Tufts University Potentiation of the immune response
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DE19828113A1 (de) 1998-06-24 2000-01-05 Probiodrug Ges Fuer Arzneim Prodrugs von Inhibitoren der Dipeptidyl Peptidase IV
DE19828114A1 (de) * 1998-06-24 2000-01-27 Probiodrug Ges Fuer Arzneim Produgs instabiler Inhibitoren der Dipeptidyl Peptidase IV
DE19834591A1 (de) 1998-07-31 2000-02-03 Probiodrug Ges Fuer Arzneim Verfahren zur Steigerung des Blutglukosespiegels in Säugern
KR20010079669A (ko) * 1998-08-21 2001-08-22 바바라 피. 월너 기질 활성의 조절
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GB9906714D0 (en) * 1999-03-23 1999-05-19 Ferring Bv Compositions for improving fertility
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US6617340B1 (en) 1999-07-29 2003-09-09 Novartis Ag N-(substituted glycyl)-pyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
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US6844316B2 (en) 2001-09-06 2005-01-18 Probiodrug Ag Inhibitors of dipeptidyl peptidase I
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PT1689757E (pt) 2003-11-12 2014-12-09 Sino Med Internat Alliance Inc Compostos heterocíclicos de ácido borónico
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
CN102079743B (zh) 2004-03-15 2020-08-25 武田药品工业株式会社 二肽基肽酶抑制剂
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DK1942898T4 (da) 2005-09-14 2014-06-02 Takeda Pharmaceutical Dipeptidylpeptidase-inhibitorer til behandling af diabetes
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Also Published As

Publication number Publication date
DE69233671D1 (de) 2007-02-08
CA2121369A1 (en) 1993-04-29
ES2153831T3 (es) 2001-03-16
EP0610317A1 (de) 1994-08-17
DK0610317T3 (da) 2001-02-19
DE69233671T2 (de) 2007-10-18
EP1050540A3 (de) 2002-01-02
ATE349461T1 (de) 2007-01-15
EP1050540B1 (de) 2006-12-27
EP0610317A4 (de) 1996-12-04
EP0610317B1 (de) 2001-01-31
GR3035730T3 (en) 2001-07-31
ATE199016T1 (de) 2001-02-15
CA2121369C (en) 2003-04-29
WO1993008259A2 (en) 1993-04-29
EP1050540A2 (de) 2000-11-08
HK1015611A1 (en) 1999-10-15
DE69231674D1 (de) 2001-03-08
JPH07504158A (ja) 1995-05-11
WO1993008259A3 (en) 1994-08-18

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