JP2004510813A5 - - Google Patents
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- Publication number
- JP2004510813A5 JP2004510813A5 JP2002533848A JP2002533848A JP2004510813A5 JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5 JP 2002533848 A JP2002533848 A JP 2002533848A JP 2002533848 A JP2002533848 A JP 2002533848A JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- oct
- ene
- benzothienyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 description 2
- -1 2-benzothienyl Chemical group 0.000 description 1
- PPHKDTUWXDGPOO-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-8-ethyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1=CC=C2SC(C3=CC4CCC(C3)N4CC)=CC2=C1 PPHKDTUWXDGPOO-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001535 | 2000-10-13 | ||
| US24214600P | 2000-10-23 | 2000-10-23 | |
| PCT/DK2001/000661 WO2002030405A2 (en) | 2000-10-13 | 2001-10-10 | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Division JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510813A JP2004510813A (ja) | 2004-04-08 |
| JP2004510813A5 true JP2004510813A5 (enExample) | 2006-09-28 |
| JP4312456B2 JP4312456B2 (ja) | 2009-08-12 |
Family
ID=26068892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002533848A Expired - Fee Related JP4312456B2 (ja) | 2000-10-13 | 2001-10-10 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7307087B2 (enExample) |
| EP (2) | EP1358177B1 (enExample) |
| JP (2) | JP4312456B2 (enExample) |
| CN (1) | CN100398103C (enExample) |
| AT (1) | ATE334979T1 (enExample) |
| AU (2) | AU9543601A (enExample) |
| CA (1) | CA2425638C (enExample) |
| DE (1) | DE60122015T2 (enExample) |
| DK (1) | DK1358177T3 (enExample) |
| ES (1) | ES2269467T3 (enExample) |
| MX (1) | MXPA03003264A (enExample) |
| NZ (1) | NZ524202A (enExample) |
| PT (1) | PT1358177E (enExample) |
| WO (1) | WO2002030405A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064885A1 (en) * | 1999-04-26 | 2000-11-02 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
| MXPA04010965A (es) | 2002-05-07 | 2005-01-25 | Neurosearch As | Derivados de etinilo azaciclico novedoso. |
| CA2485466A1 (en) * | 2002-05-15 | 2003-11-27 | Abbott Laboratories | Treatment of neuropathic pain |
| CN1735414A (zh) * | 2002-12-06 | 2006-02-15 | 北岸长岛犹太人研究学院 | 用α7受体结合类胆碱激动剂抑制炎症 |
| MXPA05008314A (es) * | 2003-02-12 | 2005-10-05 | Neurosearch As | Derivados de 8-aza-biciclo[3.2.1]octano y su uso como inhibidores de reabsorcion del neurotransmisor de monoamina. |
| US7550485B2 (en) * | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| TW201207390A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| US7951805B2 (en) | 2004-09-20 | 2011-05-31 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| WO2006101521A2 (en) | 2004-09-20 | 2006-09-28 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| AU2005286846A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| MX2007005247A (es) | 2004-11-02 | 2008-03-13 | Univ Northwestern | Compuestos de piridazina, composiciones y metodos. |
| CA2591621A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors |
| JP2009513563A (ja) | 2005-06-03 | 2009-04-02 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | ヒトのステアロイル−ＣｏＡデサチュラーゼ阻害剤としてのアミノチアゾール誘導体 |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| JP2012509354A (ja) * | 2008-11-18 | 2012-04-19 | ノイロサーチ アクティーゼルスカブ | ８−アザビシクロ［３．２．１］オクタ−２−エン誘導体及びモノアミン神経伝達物質再取込阻害剤としてのそれらの使用 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501567D0 (sv) | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| DK0859777T3 (da) * | 1995-10-13 | 2007-09-03 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-en-derivater, deres fremstilling og anvendelse |
| JP2002502383A (ja) * | 1997-05-30 | 2002-01-22 | ニューロサーアチ・アクティーゼルスカブ | ニコチンＡＣｈレセプターに於けるコリン作動性リガンドとしての９−アザビシクロ（３．３．１）ノン−２−エン及びノナン誘導体 |
| KR100589872B1 (ko) * | 1997-05-30 | 2006-06-15 | 뉴로서치 에이/에스 | 8-아자비사이클로(3,2,1)옥트-2-엔 유도체 및 이의 제조방법 |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| PL203140B1 (pl) * | 1997-10-27 | 2009-08-31 | Neurosearch As | Pochodna homopiperazyny, kompozycja farmaceutyczna zawierająca te pochodne i zastosowanie tej pochodnej |
| JP2002501921A (ja) * | 1998-01-28 | 2002-01-22 | ニューロサーチ、アクティーゼルスカブ | 標識された形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体及び標識された及び標識されていない形での８−アザビシクロ［３．２．１］オクト−２−エン誘導体の使用方法 |
| AU4819099A (en) | 1998-06-19 | 2000-01-05 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| SE9803157D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803156D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803155D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803732D0 (sv) | 1998-11-02 | 1998-11-02 | Maria Carlsson | Nicotine treatment for obsessive compulsive disorder |
| ATE259804T1 (de) * | 1998-11-27 | 2004-03-15 | Neurosearch As | 8-azabicyclo(3.2.1)okt-2-en- und -oktanderivate |
| EP1149095B1 (en) * | 1999-01-28 | 2004-01-21 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| FR2788982B1 (fr) | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| WO2000064885A1 (en) * | 1999-04-26 | 2000-11-02 | Neurosearch A/S | Heteroaryl diazacycloalkanes, their preparation and use |
-
2001
- 2001-10-10 US US10/380,653 patent/US7307087B2/en not_active Expired - Fee Related
- 2001-10-10 JP JP2002533848A patent/JP4312456B2/ja not_active Expired - Fee Related
- 2001-10-10 AT AT01976043T patent/ATE334979T1/de active
- 2001-10-10 NZ NZ524202A patent/NZ524202A/en unknown
- 2001-10-10 DK DK01976043T patent/DK1358177T3/da active
- 2001-10-10 PT PT01976043T patent/PT1358177E/pt unknown
- 2001-10-10 MX MXPA03003264A patent/MXPA03003264A/es active IP Right Grant
- 2001-10-10 CN CNB018168035A patent/CN100398103C/zh not_active Expired - Fee Related
- 2001-10-10 CA CA2425638A patent/CA2425638C/en not_active Expired - Fee Related
- 2001-10-10 AU AU9543601A patent/AU9543601A/xx active Pending
- 2001-10-10 EP EP01976043A patent/EP1358177B1/en not_active Expired - Lifetime
- 2001-10-10 DE DE60122015T patent/DE60122015T2/de not_active Expired - Lifetime
- 2001-10-10 ES ES01976043T patent/ES2269467T3/es not_active Expired - Lifetime
- 2001-10-10 WO PCT/DK2001/000661 patent/WO2002030405A2/en not_active Ceased
- 2001-10-10 AU AU2001295436A patent/AU2001295436B2/en not_active Ceased
- 2001-10-10 EP EP06116505A patent/EP1757600A2/en not_active Withdrawn
-
2007
- 2007-07-24 US US11/782,385 patent/US20070265241A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008009961A patent/JP2008156364A/ja active Pending
-
2010
- 2010-05-21 US US12/784,890 patent/US20100267739A1/en not_active Abandoned
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