JP2004510813A5 - - Google Patents
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- Publication number
- JP2004510813A5 JP2004510813A5 JP2002533848A JP2002533848A JP2004510813A5 JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5 JP 2002533848 A JP2002533848 A JP 2002533848A JP 2002533848 A JP2002533848 A JP 2002533848A JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- oct
- ene
- benzothienyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 description 2
- -1 2-benzothienyl Chemical group 0.000 description 1
- PPHKDTUWXDGPOO-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-8-ethyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1=CC=C2SC(C3=CC4CCC(C3)N4CC)=CC2=C1 PPHKDTUWXDGPOO-UHFFFAOYSA-N 0.000 description 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001535 | 2000-10-13 | ||
| US24214600P | 2000-10-23 | 2000-10-23 | |
| PCT/DK2001/000661 WO2002030405A2 (en) | 2000-10-13 | 2001-10-10 | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Division JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510813A JP2004510813A (ja) | 2004-04-08 |
| JP2004510813A5 true JP2004510813A5 (enExample) | 2006-09-28 |
| JP4312456B2 JP4312456B2 (ja) | 2009-08-12 |
Family
ID=26068892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002533848A Expired - Fee Related JP4312456B2 (ja) | 2000-10-13 | 2001-10-10 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7307087B2 (enExample) |
| EP (2) | EP1757600A2 (enExample) |
| JP (2) | JP4312456B2 (enExample) |
| CN (1) | CN100398103C (enExample) |
| AT (1) | ATE334979T1 (enExample) |
| AU (2) | AU9543601A (enExample) |
| CA (1) | CA2425638C (enExample) |
| DE (1) | DE60122015T2 (enExample) |
| DK (1) | DK1358177T3 (enExample) |
| ES (1) | ES2269467T3 (enExample) |
| MX (1) | MXPA03003264A (enExample) |
| NZ (1) | NZ524202A (enExample) |
| PT (1) | PT1358177E (enExample) |
| WO (1) | WO2002030405A2 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE245153T1 (de) * | 1999-04-26 | 2003-08-15 | Neurosearch As | Heteroaryl-diazacycloalkane, ihre herstellung und verwendung |
| CN100522976C (zh) | 2002-05-07 | 2009-08-05 | 神经研究公司 | 氮杂环乙炔基衍生物 |
| EP1511479A1 (en) * | 2002-05-15 | 2005-03-09 | Abbott Laboratories | Treatment of neuropathic pain |
| CN102657651A (zh) * | 2002-12-06 | 2012-09-12 | 范因斯坦医学研究院 | 用α 7受体结合胆碱能激动剂抑制炎症 |
| DE602004024033D1 (de) * | 2003-02-12 | 2009-12-24 | Neurosearch As | 8-azabicycloä3.2.1üoctanderivate und ihre verwendung als monoamine-neurotransmitter-reuptake inhibitoren |
| US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| TW201207390A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Method for screening agent for antidepressant activity |
| US8071603B2 (en) | 2004-09-20 | 2011-12-06 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| BRPI0515482A (pt) | 2004-09-20 | 2008-07-22 | Xenon Pharmaceuticals Inc | derivados heterocìclicos e seus usos como agentes terapêuticos |
| MX2007003327A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos, y su uso como mediadores de estearoil-coa desaturasa. |
| TW200626138A (en) | 2004-09-20 | 2006-08-01 | Xenon Pharmaceuticals Inc | Heterocyclic derivatives and their use as therapeutic agents |
| CA2580855A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| WO2006034341A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| AR051026A1 (es) | 2004-09-20 | 2006-12-13 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| WO2006050389A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds, compositions and methods |
| CA2591621A1 (en) * | 2004-12-17 | 2006-06-22 | Neurosearch A/S | Enantiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors |
| US8541457B2 (en) | 2005-06-03 | 2013-09-24 | Xenon Pharmaceuticals Inc. | Aminothiazole derivatives as human stearoyl-CoA desaturase inhibitors |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| EP2367818B1 (en) * | 2008-11-18 | 2018-07-25 | Initiator Pharma A/S | 8-azabicyclo[3.2.1]oct-2-ene derivatives and their use as mono-amine neurotransmitter re-uptake inhibitors |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501567D0 (sv) | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| JP3462505B2 (ja) * | 1995-10-13 | 2003-11-05 | ノイロサーチ アクティーゼルスカブ | ８−アザビシクロ［３．２．１］オクト−２−エン誘導体、それらの製造及び使用 |
| EE04057B1 (et) * | 1997-05-30 | 2003-06-16 | Neurosearch A/S | 8-asabitsüklo[3,2,1]okt-2-eeni ja -oktaani derivaadid, nende valmistamismeetod, kasutamine ja farmatseutiline kompositsioon |
| WO1998054182A1 (en) * | 1997-05-30 | 1998-12-03 | Neurosearch A/S | 9-AZABICYCLO(3.3.1)NON-2-ENE AND NONANE DERIVATIVES AS CHOLINERGIC LIGANDS AT NICOTINIC ACh RECEPTORS |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| JP4570773B2 (ja) * | 1997-10-27 | 2010-10-27 | ニューロサーチ、アクティーゼルスカブ | ニコチン性アセチルコリンレセプターに於けるコリン作動性リガンドとしてのヘテロアリールジアザシクロアルカン |
| AU2609999A (en) * | 1998-01-28 | 1999-08-16 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form |
| AU4819099A (en) | 1998-06-19 | 2000-01-05 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| SE9803156D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803157D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803155D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803732D0 (sv) | 1998-11-02 | 1998-11-02 | Maria Carlsson | Nicotine treatment for obsessive compulsive disorder |
| NZ510287A (en) * | 1998-11-27 | 2003-05-30 | Neurosearch As | 8-azabicyclo[3.2.1]oct-2-ene and -octane derivatives useful as cholinergic ligands at the nicotinic acetyl choline receptor |
| AU2278700A (en) * | 1999-01-28 | 2000-08-18 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| ATE245153T1 (de) * | 1999-04-26 | 2003-08-15 | Neurosearch As | Heteroaryl-diazacycloalkane, ihre herstellung und verwendung |
-
2001
- 2001-10-10 US US10/380,653 patent/US7307087B2/en not_active Expired - Fee Related
- 2001-10-10 JP JP2002533848A patent/JP4312456B2/ja not_active Expired - Fee Related
- 2001-10-10 CN CNB018168035A patent/CN100398103C/zh not_active Expired - Fee Related
- 2001-10-10 PT PT01976043T patent/PT1358177E/pt unknown
- 2001-10-10 WO PCT/DK2001/000661 patent/WO2002030405A2/en not_active Ceased
- 2001-10-10 DE DE60122015T patent/DE60122015T2/de not_active Expired - Lifetime
- 2001-10-10 CA CA2425638A patent/CA2425638C/en not_active Expired - Fee Related
- 2001-10-10 NZ NZ524202A patent/NZ524202A/en unknown
- 2001-10-10 DK DK01976043T patent/DK1358177T3/da active
- 2001-10-10 AU AU9543601A patent/AU9543601A/xx active Pending
- 2001-10-10 EP EP06116505A patent/EP1757600A2/en not_active Withdrawn
- 2001-10-10 ES ES01976043T patent/ES2269467T3/es not_active Expired - Lifetime
- 2001-10-10 AT AT01976043T patent/ATE334979T1/de active
- 2001-10-10 EP EP01976043A patent/EP1358177B1/en not_active Expired - Lifetime
- 2001-10-10 AU AU2001295436A patent/AU2001295436B2/en not_active Ceased
- 2001-10-10 MX MXPA03003264A patent/MXPA03003264A/es active IP Right Grant
-
2007
- 2007-07-24 US US11/782,385 patent/US20070265241A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008009961A patent/JP2008156364A/ja active Pending
-
2010
- 2010-05-21 US US12/784,890 patent/US20100267739A1/en not_active Abandoned
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