JP2004510813A5 - - Google Patents
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- Publication number
- JP2004510813A5 JP2004510813A5 JP2002533848A JP2002533848A JP2004510813A5 JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5 JP 2002533848 A JP2002533848 A JP 2002533848A JP 2002533848 A JP2002533848 A JP 2002533848A JP 2004510813 A5 JP2004510813 A5 JP 2004510813A5
- Authority
- JP
- Japan
- Prior art keywords
- azabicyclo
- oct
- ene
- benzothienyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- SURHOQQBDZIWSO-UHFFFAOYSA-N 8-azabicyclo[3.2.1]oct-3-ene Chemical class N1C2CCC1C=CC2 SURHOQQBDZIWSO-UHFFFAOYSA-N 0.000 description 2
- -1 2-benzothienyl Chemical group 0.000 description 1
- PPHKDTUWXDGPOO-UHFFFAOYSA-N 3-(1-benzothiophen-2-yl)-8-ethyl-8-azabicyclo[3.2.1]oct-3-ene Chemical compound C1=CC=C2SC(C3=CC4CCC(C3)N4CC)=CC2=C1 PPHKDTUWXDGPOO-UHFFFAOYSA-N 0.000 description 1
- 125000003342 alkenyl group Chemical group 0.000 description 1
- 125000005466 alkylenyl group Chemical group 0.000 description 1
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
Description
【請求項１】
一般式ＶＩ
【化１】
（式中、
Ｒは水素、アルキル又はアルケニルであり、
Ｒ1 はベンゾチエニルである。）
で表わされる８−アザビシクロ［３．２．１］オクト−２−エン誘導体
［この８−アザビシクロ［３．２．１］オクト−２−エン誘導体は
（±）−３−（２−ベンゾチエニル）−８−Ｈ−８−アザビシクロ［３．２．１］オクト−２−エン；
（±）−３−（２−ベンゾチエニル）−８−エチル−８−アザビシクロ［３．２．１］オクト−２−エン又は
（±）−８−アリル−３−（２−ベンゾチエニル）−８−アザビシクロ［３．２．１］オクト−２−エンである。］
又はその対掌体又はその対掌体の混合物、又はそのアイソトープ又はその薬学的に許容し得る塩。
一般式ＶＩ
【化１】
Ｒは水素、アルキル又はアルケニルであり、
Ｒ1 はベンゾチエニルである。）
で表わされる８−アザビシクロ［３．２．１］オクト−２−エン誘導体
［この８−アザビシクロ［３．２．１］オクト−２−エン誘導体は
（±）−３−（２−ベンゾチエニル）−８−Ｈ−８−アザビシクロ［３．２．１］オクト−２−エン；
（±）−３−（２−ベンゾチエニル）−８−エチル−８−アザビシクロ［３．２．１］オクト−２−エン又は
（±）−８−アリル−３−（２−ベンゾチエニル）−８−アザビシクロ［３．２．１］オクト−２−エンである。］
又はその対掌体又はその対掌体の混合物、又はそのアイソトープ又はその薬学的に許容し得る塩。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200001535 | 2000-10-13 | ||
| US24214600P | 2000-10-23 | 2000-10-23 | |
| PCT/DK2001/000661 WO2002030405A2 (en) | 2000-10-13 | 2001-10-10 | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Division JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004510813A JP2004510813A (ja) | 2004-04-08 |
| JP2004510813A5 true JP2004510813A5 (ja) | 2006-09-28 |
| JP4312456B2 JP4312456B2 (ja) | 2009-08-12 |
Family
ID=26068892
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002533848A Expired - Fee Related JP4312456B2 (ja) | 2000-10-13 | 2001-10-10 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008009961A Pending JP2008156364A (ja) | 2000-10-13 | 2008-01-21 | ニコチン性レセプターアゴニスト及びモノアミン作動性物質の組み合わせ作用による情動障害の治療法 |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US7307087B2 (ja) |
| EP (2) | EP1757600A2 (ja) |
| JP (2) | JP4312456B2 (ja) |
| CN (1) | CN100398103C (ja) |
| AT (1) | ATE334979T1 (ja) |
| AU (2) | AU9543601A (ja) |
| CA (1) | CA2425638C (ja) |
| DE (1) | DE60122015T2 (ja) |
| DK (1) | DK1358177T3 (ja) |
| ES (1) | ES2269467T3 (ja) |
| HK (1) | HK1078466A1 (ja) |
| MX (1) | MXPA03003264A (ja) |
| NZ (1) | NZ524202A (ja) |
| PT (1) | PT1358177E (ja) |
| WO (1) | WO2002030405A2 (ja) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2002543070A (ja) * | 1999-04-26 | 2002-12-17 | ニューロサーチ、アクティーゼルスカブ | ヘテロアリールジアザシクロアルカン類、その製造方法及びその使用方法 |
| JP2005524712A (ja) * | 2002-05-07 | 2005-08-18 | ニューロサーチ、アクティーゼルスカブ | 新規アザシクロエチニル誘導体 |
| WO2003097043A1 (en) * | 2002-05-15 | 2003-11-27 | Abbott Laboratories | Treatment of neuropathic pain |
| ES2293086T3 (es) * | 2002-12-06 | 2008-03-16 | The Feinstein Institute For Medical Research | Inhibicion de la inflamacion usando agonistas colinergicos de union al receptor alfa 7. |
| DK1594868T3 (da) * | 2003-02-12 | 2010-03-15 | Neurosearch As | 8-aza-bicyclo[3.2.1]octanderivater og anvendelse deraf som monoamin-neurotransmitter-genoptagelsesinhibitorer |
| US7550485B2 (en) | 2003-10-14 | 2009-06-23 | Wyeth | Substituted N-heterocycle derivatives and methods of their use |
| TW201206425A (en) * | 2004-05-18 | 2012-02-16 | Brni Neurosciences Inst | Treatment of depressive disorders |
| EP2316458A1 (en) | 2004-09-20 | 2011-05-04 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-coa-desaturase |
| MX2007003321A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| US7592343B2 (en) | 2004-09-20 | 2009-09-22 | Xenon Pharmaceuticals Inc. | Pyridazine-piperazine compounds and their use as stearoyl-CoA desaturase inhibitors |
| CN101084212A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶介导剂的用途 |
| CN101084207A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为硬脂酰CoA去饱和酶抑制剂的用途 |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| WO2006034440A2 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| BRPI0517947A (pt) * | 2004-11-02 | 2008-10-21 | Univ Northwestern | composto de piridazina, composições e métodos |
| EP1828173A1 (en) | 2004-12-17 | 2007-09-05 | Neurosearch A/S | Enentiomers of 3-heteroaryl-8h-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN101208089A (zh) | 2005-06-03 | 2008-06-25 | 泽农医药公司 | 氨基噻唑衍生物作为人硬酯酰-CoA去饱和酶抑制剂 |
| FR2889847B1 (fr) | 2005-08-18 | 2007-10-05 | Sanofi Aventis Sa | Derives de 5-pyridazinyl-1-azabicyclo[3.2.1]octave, leur preparation en therapeutique. |
| CN102216295A (zh) * | 2008-11-18 | 2011-10-12 | 神经研究公司 | 8-氮杂双环[3.2.1]辛-2-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9501567D0 (sv) | 1995-04-27 | 1995-04-27 | Astra Ab | A new combination |
| IL123583A (en) * | 1995-10-13 | 2003-07-31 | Neurosearch As | 3-substituted -8-azabicyclo [3,2,1] oct-2-ene derivatives, their preparation and pharmaceutical compositions containing them |
| JP4447663B2 (ja) * | 1997-05-30 | 2010-04-07 | ニューロサーチ、アクティーゼルスカブ | ニコチン性ａｃｈレセプターに於けるコリン作動性リガンドとしての８−アザビシクロ（３．２．１）オクト−２−エン及びオクタン誘導体 |
| AU736798B2 (en) * | 1997-05-30 | 2001-08-02 | Neurosearch A/S | 9-Azabicyclo(3.3.1)non-2-ene and nonane derivatives as cholinergic ligands at nicotinic ACh receptors |
| US5948807A (en) * | 1997-09-03 | 1999-09-07 | Regents Of The University Of Minnesota | Spiroindanamines and Spiroindanimides |
| HU226859B1 (en) | 1997-10-27 | 2009-12-28 | Neurosearch As | Phenyl- or heteroaryl-homopiperazines, their use and medicaments containing them |
| AU2609999A (en) * | 1998-01-28 | 1999-08-16 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and use of 8-azabicyclo(3.2.1)oct-2-ene derivatives in labelled and unlabelled form |
| AU4819099A (en) | 1998-06-19 | 2000-01-05 | Eli Lilly And Company | Inhibition of serotonin reuptake |
| SE9803157D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803155D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803156D0 (sv) * | 1998-09-16 | 1998-09-16 | Astra Ab | A new composition |
| SE9803732D0 (sv) | 1998-11-02 | 1998-11-02 | Maria Carlsson | Nicotine treatment for obsessive compulsive disorder |
| AU761055B2 (en) | 1998-11-27 | 2003-05-29 | Neurosearch A/S | 8-azabicyclo(3.2.1)oct-2-ene and -octane derivatives |
| WO2000044746A1 (en) * | 1999-01-28 | 2000-08-03 | Neurosearch A/S | Novel azabicyclo derivatives and their use |
| FR2788982B1 (fr) * | 1999-02-02 | 2002-08-02 | Synthelabo | Compositions pharmaceutiques contenant de la nicotine et leur application dans le sevrage tabagique |
| JP2002543070A (ja) | 1999-04-26 | 2002-12-17 | ニューロサーチ、アクティーゼルスカブ | ヘテロアリールジアザシクロアルカン類、その製造方法及びその使用方法 |
-
2001
- 2001-10-10 AT AT01976043T patent/ATE334979T1/de active
- 2001-10-10 US US10/380,653 patent/US7307087B2/en not_active Expired - Fee Related
- 2001-10-10 AU AU9543601A patent/AU9543601A/xx active Pending
- 2001-10-10 NZ NZ524202A patent/NZ524202A/en unknown
- 2001-10-10 MX MXPA03003264A patent/MXPA03003264A/es active IP Right Grant
- 2001-10-10 AU AU2001295436A patent/AU2001295436B2/en not_active Ceased
- 2001-10-10 PT PT01976043T patent/PT1358177E/pt unknown
- 2001-10-10 CN CNB018168035A patent/CN100398103C/zh not_active Expired - Fee Related
- 2001-10-10 ES ES01976043T patent/ES2269467T3/es not_active Expired - Lifetime
- 2001-10-10 WO PCT/DK2001/000661 patent/WO2002030405A2/en active IP Right Grant
- 2001-10-10 EP EP06116505A patent/EP1757600A2/en not_active Withdrawn
- 2001-10-10 JP JP2002533848A patent/JP4312456B2/ja not_active Expired - Fee Related
- 2001-10-10 CA CA2425638A patent/CA2425638C/en not_active Expired - Fee Related
- 2001-10-10 EP EP01976043A patent/EP1358177B1/en not_active Expired - Lifetime
- 2001-10-10 DK DK01976043T patent/DK1358177T3/da active
- 2001-10-10 DE DE60122015T patent/DE60122015T2/de not_active Expired - Lifetime
-
2005
- 2005-11-18 HK HK05110393.7A patent/HK1078466A1/xx not_active IP Right Cessation
-
2007
- 2007-07-24 US US11/782,385 patent/US20070265241A1/en not_active Abandoned
-
2008
- 2008-01-21 JP JP2008009961A patent/JP2008156364A/ja active Pending
-
2010
- 2010-05-21 US US12/784,890 patent/US20100267739A1/en not_active Abandoned
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