BRPI0517947A - composto de piridazina, composições e métodos - Google Patents
composto de piridazina, composições e métodosInfo
- Publication number
- BRPI0517947A BRPI0517947A BRPI0517947-5A BRPI0517947A BRPI0517947A BR PI0517947 A BRPI0517947 A BR PI0517947A BR PI0517947 A BRPI0517947 A BR PI0517947A BR PI0517947 A BRPI0517947 A BR PI0517947A
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- pyridazine compound
- making
- pyridazine compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/20—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/02—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings
- C07D237/06—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D237/10—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D237/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
- C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
- C07D237/30—Phthalazines
- C07D237/34—Phthalazines with nitrogen atoms directly attached to carbon atoms of the nitrogen-containing ring, e.g. hydrazine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Abstract
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US62434604P | 2004-11-02 | 2004-11-02 | |
US72309005P | 2005-10-03 | 2005-10-03 | |
US72312405P | 2005-10-03 | 2005-10-03 | |
PCT/US2005/039541 WO2006050389A2 (en) | 2004-11-02 | 2005-11-02 | Pyridazine compounds, compositions and methods |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0517947A true BRPI0517947A (pt) | 2008-10-21 |
Family
ID=36319787
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0517947-5A BRPI0517947A (pt) | 2004-11-02 | 2005-11-02 | composto de piridazina, composições e métodos |
Country Status (11)
Country | Link |
---|---|
US (4) | US8367672B2 (pt) |
EP (2) | EP2592075B1 (pt) |
JP (1) | JP5337375B2 (pt) |
CN (1) | CN101087766B (pt) |
AU (1) | AU2005302225B2 (pt) |
BR (1) | BRPI0517947A (pt) |
CA (1) | CA2589106C (pt) |
ES (2) | ES2441718T3 (pt) |
IL (1) | IL182765A (pt) |
MX (1) | MX2007005247A (pt) |
WO (1) | WO2006050389A2 (pt) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20100210590A1 (en) * | 1995-09-27 | 2010-08-19 | Northwestern University | Compositions and treatments for seizure-related disorders |
EP2264014A1 (en) * | 2001-08-31 | 2010-12-22 | Université Louis Pasteur | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors |
WO2006050359A2 (en) * | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
EP2592075B1 (en) | 2004-11-02 | 2015-04-29 | Northwestern University | Pyridazine compounds for the treatment of inflammatory diseases |
EP2233470B1 (en) | 2005-07-04 | 2011-12-07 | High Point Pharmaceuticals, LLC | Histamine H3 receptor antagonists |
US8158627B2 (en) | 2006-04-28 | 2012-04-17 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
WO2007130383A2 (en) * | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
US20100168120A1 (en) * | 2006-04-28 | 2010-07-01 | Neuromedix Inc. | Salts of pyridazine compounds |
WO2007127475A2 (en) * | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
MX2008013843A (es) | 2006-04-28 | 2008-11-10 | Univ Northwestern | Formulaciones que contienen compuestos de piridazina para tratar enfermedades neuroinflamatorias. |
ES2375872T3 (es) | 2006-05-29 | 2012-03-07 | High Point Pharmaceuticals, Llc | 3-(1,3-benzodioxol-5-il)-6-(4-ciclopropilpiperacin-1-il)-piridacina, sus sales y solvatos, y su uso como antagonista del receptor h3 de la histamina. |
WO2008094208A2 (en) | 2006-08-02 | 2008-08-07 | Northwestern University | Protein kinase targeted therapeutics |
JP5603770B2 (ja) * | 2007-05-31 | 2014-10-08 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2受容体拮抗薬およびその使用 |
EP2014656A3 (en) | 2007-06-11 | 2011-08-24 | High Point Pharmaceuticals, LLC | New heteocyclic h3 antagonists |
PE20120061A1 (es) | 2008-12-19 | 2012-02-19 | Boehringer Ingelheim Int | Derivados de pirimidina como antagonistas del receptor ccr2 |
US20100227793A1 (en) * | 2009-03-04 | 2010-09-09 | Scott Thomas Brady | Compositions and Methods for Treating Amyotrophic Lateral Sclerosis |
EA024397B1 (ru) | 2009-12-17 | 2016-09-30 | Сентрекшн Терапьютикс Корпорейшн | Новые антагонисты рецептора ccr2 и их применение |
AR081626A1 (es) | 2010-04-23 | 2012-10-10 | Cytokinetics Inc | Compuestos amino-piridazinicos, composiciones farmaceuticas que los contienen y uso de los mismos para tratar trastornos musculares cardiacos y esqueleticos |
US9133123B2 (en) | 2010-04-23 | 2015-09-15 | Cytokinetics, Inc. | Certain amino-pyridines and amino-triazines, compositions thereof, and methods for their use |
AR081331A1 (es) | 2010-04-23 | 2012-08-08 | Cytokinetics Inc | Amino- pirimidinas composiciones de las mismas y metodos para el uso de los mismos |
JP2013526507A (ja) | 2010-05-12 | 2013-06-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規ccr2受容体アンタゴニスト、その製造方法及び薬物としてのその使用 |
WO2011141477A1 (en) | 2010-05-12 | 2011-11-17 | Boehringer Ingelheim International Gmbh | New ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments |
JP5647339B2 (ja) | 2010-05-17 | 2014-12-24 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ccr2アンタゴニスト及びこれらの使用 |
WO2011147772A1 (en) | 2010-05-25 | 2011-12-01 | Boehringer Ingelheim International Gmbh | Ccr2 receptor antagonists |
US8962656B2 (en) | 2010-06-01 | 2015-02-24 | Boehringer Ingelheim International Gmbh | CCR2 antagonists |
WO2011156901A2 (en) * | 2010-06-17 | 2011-12-22 | Waratah Pharmaceuticals Inc. | Compounds, compositions and methods for treatment of multiple sclerosis |
WO2012012891A1 (en) * | 2010-07-29 | 2012-02-02 | Waratah Pharmaceuticals Inc. | Compounds, compositions and methods for treatment of arthritis |
JP5786258B2 (ja) | 2011-07-15 | 2015-09-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 新規かつ選択的なccr2拮抗薬 |
EP2968322B1 (en) | 2013-03-15 | 2018-12-26 | The Trustees of Columbia University in the City of New York | Map kinase modulators and uses thereof |
JP6917910B2 (ja) | 2015-07-02 | 2021-08-11 | セントレクシオン セラピューティクス コーポレイション | (4−((3r,4r)−3−メトキシテトラヒドロ−ピラン−4−イルアミノ)ピペリジン−1−イル)(5−メチル−6−(((2r,6s)−6−(p−トリル)テトラヒドロ−2h−ピラン−2−イル)メチルアミノ)ピリミジン−4イル)メタノンクエン酸塩 |
CN109071524A (zh) * | 2016-01-15 | 2018-12-21 | 布里格姆及妇女医院股份有限公司 | 作为eaat2活化剂的哒嗪衍生物 |
CA3195960A1 (en) * | 2020-10-23 | 2022-04-28 | Madrigal Pharmaceuticals, Inc. | Process for the preparation of 6-(4-nitro-phenoxy)-2h-pyridazin-3-one and 6-(4-amino-phenoxy)-2h-pyridazin-3-one derivatives as intermediates of thyroid hormone analogues |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL92451C (pt) * | 1955-08-19 | |||
US3464988A (en) * | 1968-01-11 | 1969-09-02 | Bristol Myers Co | 3-hydrazinobenzo(h)cinnolines and 3 - hydrazinobenzocyclohepta-(5,6-c)pyridazines |
GB1345880A (en) | 1971-06-18 | 1974-02-06 | Cepbepe | Pyridazine derivatives |
FR2510998B1 (fr) * | 1981-08-07 | 1986-01-10 | Sanofi Sa | Nouveaux derives amines de la pyridazine, leur procede de preparation et les medicaments, a action desinhibitrice, qui en comportent |
FR2511366A1 (fr) * | 1981-08-11 | 1983-02-18 | Sanofi Sa | Nouveaux derives de la pyridazine, leur procede de preparation et les medicaments, actifs sur le systeme nerveux central, qui en contiennent |
DE3217325A1 (de) | 1982-05-08 | 1983-11-10 | Hoechst Ag, 6230 Frankfurt | 3-amino-6-aryl-1,2,4-triazolo(4,3-b)-pyridazine, ihre herstellung und ihre verwendung |
FR2540113A1 (fr) * | 1983-01-27 | 1984-08-03 | Sanofi Sa | Acides derives de la pyridazine actifs sur le systeme nerveux central |
JPS59212480A (ja) * | 1983-05-17 | 1984-12-01 | Nippon Soda Co Ltd | ピリダジン誘導体及び除草剤 |
AU578496B2 (en) * | 1984-11-01 | 1988-10-27 | Smith Kline & French Laboratories Limited | Tricyclic heterocyclic compounds |
DE3517617A1 (de) * | 1985-05-15 | 1986-11-20 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Neue pyridaziniumverbindungen, verfahren zu deren herstellung und diese enthaltende fungizide und algizide mittel |
ES8802151A1 (es) * | 1985-07-31 | 1988-04-01 | Janssen Pharmaceutica Nv | Un procedimiento para la preparacion de nuevos piridazinaminas. |
JPH0650381B2 (ja) | 1985-08-05 | 1994-06-29 | 富士写真フイルム株式会社 | ハロゲン化銀カラ−感光材料の処理方法 |
US4654343A (en) * | 1985-10-31 | 1987-03-31 | American Cyanamid Company | N-substituted-N[3-(1,2,4-triazolo[4,3-b]pyridazin-6-yl)phenyl]alkanamides, carbamates and ureas |
FR2601011B1 (fr) * | 1986-07-03 | 1988-10-28 | Sanofi Sa | Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant |
JP2531678B2 (ja) | 1987-05-27 | 1996-09-04 | 吉富製薬株式会社 | トリアゾロピリダジン誘導体 |
EP0351435B1 (en) * | 1987-11-02 | 1993-08-04 | Yoshitomi Pharmaceutical Industries, Ltd. | Fused pyridazine compounds and their medicinal uses |
US5461053A (en) * | 1989-02-07 | 1995-10-24 | Sanofi | Pyridazine derivatives |
PT93060B (pt) | 1989-02-07 | 1995-12-29 | Sanofi Sa | Processo para a obtencao de derivados de piridazina e de composicoes farmaceuticas que os contem |
CA2044564A1 (en) | 1990-06-28 | 1991-12-29 | Quirico Branca | Amino acid derivatives |
ES2114654T3 (es) | 1993-06-08 | 1998-06-01 | Vertex Pharma | Piridazinas como inhibidores de la enzima de conversion de la interleuquina-1beta. |
US5484940A (en) * | 1994-11-28 | 1996-01-16 | Grant; Francine S. | Substituted 3-indolyl-5-pyrazolone compounds |
FR2740686B1 (fr) * | 1995-11-03 | 1998-01-16 | Sanofi Sa | Formulation pharmaceutique lyophilisee stable |
GB9707693D0 (en) | 1997-04-16 | 1997-06-04 | Smithkline Beecham Plc | Novel method of treatment |
TWI241295B (en) | 1998-03-02 | 2005-10-11 | Kowa Co | Pyridazine derivative and medicine containing the same as effect component |
US6602872B1 (en) * | 1999-12-13 | 2003-08-05 | Merck & Co., Inc. | Substituted pyridazines having cytokine inhibitory activity |
EP1317449B1 (en) | 2000-09-15 | 2006-05-31 | Vertex Pharmaceuticals Incorporated | Pyrazole compounds useful as protein kinase inhibitors |
EP1757600A2 (en) | 2000-10-13 | 2007-02-28 | NeuroSearch A/S | Treatment of affective disorders by the combined action of a nicotinic receptor agonist and a monoaminergic substance |
WO2003014110A1 (fr) * | 2001-08-08 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Derive de benzazepine, son procede de preparation et d'utilisation |
EP2264014A1 (en) | 2001-08-31 | 2010-12-22 | Université Louis Pasteur | Substituted pyridazines as anti-inflammatory agents and protein kinase inhibitors |
GB0129260D0 (en) | 2001-12-06 | 2002-01-23 | Eisai London Res Lab Ltd | Pharmaceutical compositions and their uses |
JP4607458B2 (ja) * | 2002-02-05 | 2011-01-05 | ハイ・ポイント・ファーマスーティカルズ、エルエルシー | 新規なアリールおよびへテロアリールピペラジン |
GB0218876D0 (en) * | 2002-08-13 | 2002-09-25 | Merck Sharp & Dohme | Therapeutic agents |
FR2847253B1 (fr) | 2002-11-19 | 2007-05-18 | Aventis Pharma Sa | Nouveaux derives de pyridazinones a titre de medicaments et compositions pharmaceutiques les renfermant |
AU2004259263B2 (en) | 2003-07-29 | 2010-12-16 | High Point Pharmaceuticals, Llc | Pyridazinyl- piperazines and their use as histamine H3 receptor ligands |
US7378418B2 (en) | 2003-12-19 | 2008-05-27 | Bristol-Myers Squibb Company | Azabicyclic heterocycles as cannabinoid receptor modulators |
TW200530246A (en) | 2003-12-19 | 2005-09-16 | Bristol Myers Squibb Co | Azabicyclic heterocycles as cannabinoid receptor modulators |
JP4230380B2 (ja) | 2004-02-24 | 2009-02-25 | 三菱電機株式会社 | レンズクリーニングディスク |
MY145822A (en) | 2004-08-13 | 2012-04-30 | Neurogen Corp | Substituted biaryl piperazinyl-pyridine analogues |
WO2006050359A2 (en) | 2004-11-02 | 2006-05-11 | Northwestern University | Pyridazine compounds and methods |
EP2592075B1 (en) | 2004-11-02 | 2015-04-29 | Northwestern University | Pyridazine compounds for the treatment of inflammatory diseases |
US20090029958A1 (en) | 2006-03-08 | 2009-01-29 | Lilian Alcaraz | Phenethanolamine derivatives as beta2 adrenoreceptor agonists |
US20100168120A1 (en) | 2006-04-28 | 2010-07-01 | Neuromedix Inc. | Salts of pyridazine compounds |
WO2007130383A2 (en) | 2006-04-28 | 2007-11-15 | Northwestern University | Compositions and treatments using pyridazine compounds and secretases |
MX2008013843A (es) * | 2006-04-28 | 2008-11-10 | Univ Northwestern | Formulaciones que contienen compuestos de piridazina para tratar enfermedades neuroinflamatorias. |
US8158627B2 (en) | 2006-04-28 | 2012-04-17 | Northwestern University | Compositions and treatments using pyridazine compounds and cholinesterase inhibitors |
WO2007127475A2 (en) | 2006-04-28 | 2007-11-08 | Northwestern University | Pyridazines for demyelinating diseases and neuropathic pain |
US7732445B2 (en) * | 2006-07-21 | 2010-06-08 | Northwestern University | Myosin light chain kinase inhibitor compounds, compostions and related methods of use |
AU2008223066A1 (en) | 2007-03-02 | 2008-09-12 | Northwestern University | Compositions comprising derivatives of 3 -phenylpyridazine for treating seizure-related disorders |
US20100130442A1 (en) * | 2007-05-07 | 2010-05-27 | Raj Wadgaonkar | Lung Injury Treatment |
-
2005
- 2005-11-02 EP EP20130154085 patent/EP2592075B1/en not_active Not-in-force
- 2005-11-02 AU AU2005302225A patent/AU2005302225B2/en not_active Ceased
- 2005-11-02 BR BRPI0517947-5A patent/BRPI0517947A/pt not_active IP Right Cessation
- 2005-11-02 CA CA2589106A patent/CA2589106C/en active Active
- 2005-11-02 WO PCT/US2005/039541 patent/WO2006050389A2/en active Application Filing
- 2005-11-02 ES ES05817588.6T patent/ES2441718T3/es active Active
- 2005-11-02 EP EP05817588.6A patent/EP1812408B1/en not_active Not-in-force
- 2005-11-02 CN CN2005800377026A patent/CN101087766B/zh not_active Expired - Fee Related
- 2005-11-02 US US11/666,803 patent/US8367672B2/en active Active
- 2005-11-02 ES ES13154085.8T patent/ES2543813T3/es active Active
- 2005-11-02 MX MX2007005247A patent/MX2007005247A/es active IP Right Grant
- 2005-11-02 JP JP2007539305A patent/JP5337375B2/ja active Active
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2007
- 2007-04-23 IL IL182765A patent/IL182765A/en active IP Right Grant
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2012
- 2012-06-08 US US13/491,986 patent/US8933076B2/en active Active
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2014
- 2014-12-03 US US14/559,421 patent/US9527819B2/en active Active
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2016
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Also Published As
Publication number | Publication date |
---|---|
CA2589106A1 (en) | 2006-05-11 |
EP1812408A2 (en) | 2007-08-01 |
US9527819B2 (en) | 2016-12-27 |
IL182765A (en) | 2013-05-30 |
US20150175555A1 (en) | 2015-06-25 |
EP1812408A4 (en) | 2012-05-02 |
WO2006050389A2 (en) | 2006-05-11 |
MX2007005247A (es) | 2008-03-13 |
CA2589106C (en) | 2015-07-21 |
JP5337375B2 (ja) | 2013-11-06 |
EP1812408B1 (en) | 2013-10-09 |
US20120245125A1 (en) | 2012-09-27 |
ES2543813T3 (es) | 2015-08-24 |
JP2008518958A (ja) | 2008-06-05 |
IL182765A0 (en) | 2007-07-24 |
CN101087766B (zh) | 2011-09-07 |
AU2005302225B2 (en) | 2012-05-24 |
WO2006050389A3 (en) | 2006-07-06 |
US8933076B2 (en) | 2015-01-13 |
US9663493B2 (en) | 2017-05-30 |
AU2005302225A1 (en) | 2006-05-11 |
US20160326139A1 (en) | 2016-11-10 |
CN101087766A (zh) | 2007-12-12 |
ES2441718T3 (es) | 2014-02-06 |
US20080318899A1 (en) | 2008-12-25 |
US8367672B2 (en) | 2013-02-05 |
EP2592075A1 (en) | 2013-05-15 |
EP2592075B1 (en) | 2015-04-29 |
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