|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
BR0112297A
(pt)
*
|
2000-06-27 |
2003-05-06 |
S A L V A T Lab Sa |
Compostos carbamatos derivados de arilalquilaminas
|
|
EP1345937B1
(en)
|
2000-12-22 |
2005-09-28 |
Almirall Prodesfarma AG |
Quinuclidine carbamate derivatives and their use as m3 antagonists
|
|
EE05404B1
(et)
|
2000-12-28 |
2011-04-15 |
Almirall Prodesfarma Ag |
Kinuklidiini derivaat, selle saamine ja kasutamine ravimi valmistamiseks, mis on ette nhtud respiratoorsete, kuseelundite v?i mao-soolte haiguste ravimiseks, ning seda sisaldav ravimkompositsioon
|
|
CA2470567A1
(en)
|
2001-12-14 |
2003-06-26 |
Targacept, Inc. |
Methods and compositions for treatment of central nervous system disorders
|
|
PL211250B1
(pl)
*
|
2001-12-20 |
2012-04-30 |
Chiesi Farma Spa |
Pochodne karbaminianu 1-alkilo-1-azoniabicyklo [2.2.2] oktanu, jej zastosowania, kompozycja farmaceutyczna zawierająca ten związek oraz związek pośredni
|
|
ES2203327B1
(es)
|
2002-06-21 |
2005-06-16 |
Almirall Prodesfarma, S.A. |
Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
ES2204295B1
(es)
|
2002-07-02 |
2005-08-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de quinuclidina-amida.
|
|
US7399779B2
(en)
|
2002-07-08 |
2008-07-15 |
Ranbaxy Laboratories Limited |
3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonists
|
|
TWI295669B
(en)
|
2002-10-30 |
2008-04-11 |
Theravance Inc |
Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
|
|
PE20040950A1
(es)
|
2003-02-14 |
2005-01-01 |
Theravance Inc |
DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
|
|
US7517905B2
(en)
|
2003-04-09 |
2009-04-14 |
Ranbaxy Laboratories Limited |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
|
|
US20070021487A1
(en)
|
2003-04-11 |
2007-01-25 |
Mohammad Salman |
Azabicyclo derivatives as muscarinic receptor antagonists
|
|
AR044519A1
(es)
|
2003-05-02 |
2005-09-14 |
Novartis Ag |
Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
|
|
ATE435862T1
(de)
|
2003-05-28 |
2009-07-15 |
Theravance Inc |
Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
|
|
JP2007524641A
(ja)
|
2003-07-11 |
2007-08-30 |
セラヴァンス, インコーポレーテッド |
置換4−アミノ−1−ベンジルピペリジン化合物
|
|
DE602004021959D1
(de)
|
2003-11-21 |
2009-08-20 |
Theravance Inc |
Verbindungen mit agonistischer wirkung am beta2-adrenergen rezeptor und am muscarinischen rezeptor
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
US7456199B2
(en)
|
2004-03-11 |
2008-11-25 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528412A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス, インコーポレーテッド |
ムスカリンレセプターアンタゴニストとして有用なビフェニル化合物
|
|
TW200538095A
(en)
|
2004-03-11 |
2005-12-01 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7501442B2
(en)
|
2004-03-11 |
2009-03-10 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TWI341836B
(en)
|
2004-03-11 |
2011-05-11 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
WO2005087736A1
(en)
|
2004-03-11 |
2005-09-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7524962B2
(en)
|
2004-03-11 |
2009-04-28 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528410A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス, インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
ES2246170B1
(es)
*
|
2004-07-29 |
2007-04-01 |
Almirall Prodesfarma, S.A. |
Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
|
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
EP1856112A1
(en)
|
2005-03-10 |
2007-11-21 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7659403B2
(en)
|
2005-03-10 |
2010-02-09 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7642355B2
(en)
|
2005-03-10 |
2010-01-05 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7479562B2
(en)
|
2005-03-10 |
2009-01-20 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200714587A
(en)
|
2005-03-10 |
2007-04-16 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
US7728144B2
(en)
|
2005-06-13 |
2010-06-01 |
Theravance, Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
DE602006017235D1
(de)
|
2005-08-22 |
2010-11-11 |
Targacept Inc |
Heteroarylsubstituierte diazatricycloalkane, verfahren zu deren herstellung und deren anwendung
|
|
JP5006330B2
(ja)
|
2005-10-21 |
2012-08-22 |
ノバルティス アーゲー |
Il13に対するヒト抗体および治療的使用
|
|
EP1968980A1
(en)
*
|
2005-12-30 |
2008-09-17 |
Ranbaxy Laboratories, Ltd. |
Muscarinic receptor antagonists
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
GB0602778D0
(en)
|
2006-02-10 |
2006-03-22 |
Glaxo Group Ltd |
Novel compound
|
|
WO2007121920A2
(en)
|
2006-04-21 |
2007-11-01 |
Novartis Ag |
Purine derivatives for use as adenosin a2a receptor agonists
|
|
ES2298049B1
(es)
|
2006-07-21 |
2009-10-20 |
Laboratorios Almirall S.A. |
Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
|
|
EP1882691A1
(en)
*
|
2006-07-26 |
2008-01-30 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine derivatives as M3 antagonists
|
|
KR20090073121A
(ko)
|
2006-09-29 |
2009-07-02 |
노파르티스 아게 |
Pi3k 지질 키나제 억제제로서의 피라졸로피리미딘
|
|
TW200825084A
(en)
*
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
DK2104535T3
(da)
|
2007-01-10 |
2011-04-04 |
Irm Llc |
Forbindelser og sammensætninger som kanalaktiverende proteaseinhibitorer
|
|
CA2678193A1
(en)
|
2007-02-09 |
2008-08-14 |
Astellas Pharma Inc. |
Aza-bridged-ring compound
|
|
US20090010923A1
(en)
*
|
2007-04-24 |
2009-01-08 |
University Of Maryland, Baltimore |
Treatment of cancer with anti-muscarinic receptor agents
|
|
CN101687851B
(zh)
|
2007-05-07 |
2013-02-27 |
诺瓦提斯公司 |
有机化合物
|
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
|
CN104193741B
(zh)
|
2007-10-01 |
2016-08-24 |
阿尔法梅根有限责任公司 |
作为α7-烟碱乙酰胆碱受体配体的奎宁环-4-基甲基1H-吲哚-3-甲酸酯衍生物
|
|
EP2065385A1
(en)
*
|
2007-11-28 |
2009-06-03 |
Laboratorios SALVAT, S.A. |
Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
|
|
EA017919B1
(ru)
|
2007-12-10 |
2013-04-30 |
Новартис Аг |
Производные пиразин-2-карбоксамида для лечения заболеваний, которые поддаются лечению путем блокирования эпителиальных натриевых каналов
|
|
CN101910153B
(zh)
|
2008-01-11 |
2014-01-22 |
诺华股份有限公司 |
作为激酶抑制剂的嘧啶类
|
|
EP2080507A1
(en)
*
|
2008-01-15 |
2009-07-22 |
CHIESI FARMACEUTICI S.p.A. |
Pharmaceutical formulations comprising an anticholinergic drug
|
|
RU2481123C2
(ru)
|
2008-02-13 |
2013-05-10 |
Таргасепт, Инк. |
Комбинация агонистов альфа 7 никотиновых рецепторов и антипсихотических средств
|
|
US20100055045A1
(en)
*
|
2008-02-26 |
2010-03-04 |
William Gerhart |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
WO2009134524A2
(en)
*
|
2008-02-26 |
2009-11-05 |
Elevation Pharmaceuticals, Inc. |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
EP2100598A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2100599A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
EA201001848A1
(ru)
|
2008-06-10 |
2011-08-30 |
Новартис Аг |
Производные пиразина в качестве блокаторов эпителиальных натриевых каналов
|
|
EP2154136A1
(en)
|
2008-08-08 |
2010-02-17 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine carbonate derivatives and medicinal compositions thereof
|
|
US20100112606A1
(en)
*
|
2008-10-17 |
2010-05-06 |
Michael Armstrong |
Measurement and analysis of leukotrienes
|
|
EP2206712A1
(en)
|
2008-12-23 |
2010-07-14 |
CHIESI FARMACEUTICI S.p.A. |
"Alkaloid aminoester derivatives and medicinal composition thereof"
|
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
|
JP2012516345A
(ja)
|
2009-01-29 |
2012-07-19 |
ノバルティス アーゲー |
星細胞腫治療用置換ベンゾイミダゾール
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
EA201200260A1
(ru)
|
2009-08-12 |
2012-09-28 |
Новартис Аг |
Гетероциклические гидразоны и их применение для лечения рака и воспаления
|
|
UA111579C2
(uk)
|
2009-08-17 |
2016-05-25 |
Інтеллікіне Ллк |
ГЕТЕРОЦИКЛІЧНІ ПОХІДНІ 2-АМІНОБЕНЗО[d]ОКСАЗОЛУ, ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ НА ЇХ ОСНОВІ ТА ЇХ ЗАСТОСУВАННЯ ДЛЯ ЛІКУВАННЯ ЗАХВОРЮВАННЯ, ПОВ'АНОГО З РІ3-КІНАЗОЮ
|
|
KR20120089463A
(ko)
|
2009-08-20 |
2012-08-10 |
노파르티스 아게 |
헤테로시클릭 옥심 화합물
|
|
JP2013508414A
(ja)
|
2009-10-22 |
2013-03-07 |
バーテックス ファーマシューティカルズ インコーポレイテッド |
嚢胞性線維症および他の慢性疾患の治療のための組成物
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
KR20130087406A
(ko)
|
2010-06-22 |
2013-08-06 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
RU2580835C2
(ru)
*
|
2010-06-22 |
2016-04-10 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Алкалоидные производные на основе сложных аминоэфиров и композиции лекарственных средств, содержащие их
|
|
CN102947298B
(zh)
*
|
2010-06-22 |
2016-03-02 |
奇斯药制品公司 |
生物碱氨基酯衍生物及其药物组合物
|
|
EA201291306A1
(ru)
|
2010-06-22 |
2013-05-30 |
КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. |
Состав сухого порошка, содержащий антимускариновое средство
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
|
BR112013012160A2
(pt)
|
2010-11-26 |
2019-09-24 |
Chiesi Farm Spa |
compostos, composição farmacêutica, uso de um composto e dispositivo
|
|
KR101928505B1
(ko)
*
|
2011-01-28 |
2018-12-12 |
에스케이바이오팜 주식회사 |
피리돈 유도체 및 이를 포함하는 약학적 조성물
|
|
US20130324526A1
(en)
|
2011-02-10 |
2013-12-05 |
Novartis Ag |
[1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
US20120220557A1
(en)
|
2011-02-17 |
2012-08-30 |
Chiesi Farmaceutici S.P.A. |
Liquid propellant-free formulation comprising an antimuscarinic drug
|
|
EP2678016B1
(en)
|
2011-02-23 |
2016-08-10 |
Intellikine, LLC |
Heterocyclic compounds and uses thereof
|
|
SG192795A1
(en)
|
2011-02-25 |
2013-09-30 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
UA118248C2
(uk)
*
|
2011-03-18 |
2018-12-26 |
Джензім Корпорейшн |
Інгібітори глюкозилцерамідсинтази
|
|
EP2510928A1
(en)
|
2011-04-15 |
2012-10-17 |
Almirall, S.A. |
Aclidinium for use in improving the quality of sleep in respiratory patients
|
|
CN103502213B
(zh)
*
|
2011-04-29 |
2016-09-28 |
奇斯药制品公司 |
生物碱酯及其氨基甲酸酯衍生物和医学组合物
|
|
UY34305A
(es)
|
2011-09-01 |
2013-04-30 |
Novartis Ag |
Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
|
|
AU2012310168B2
(en)
|
2011-09-15 |
2015-07-16 |
Novartis Ag |
6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase
|
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
US9056867B2
(en)
|
2011-09-16 |
2015-06-16 |
Novartis Ag |
N-substituted heterocyclyl carboxamides
|
|
CN103946221B
(zh)
|
2011-09-16 |
2016-08-03 |
诺华股份有限公司 |
用于治疗囊性纤维化的杂环化合物
|
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
|
US9174994B2
(en)
|
2011-11-23 |
2015-11-03 |
Intellikine, Llc |
Enhanced treatment regimens using mTor inhibitors
|
|
BR112014013179A2
(pt)
|
2011-12-30 |
2017-06-13 |
Chiesi Farm Spa |
compostos, combinação de um composto, composição farmacêutica e usos de um composto
|
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
|
KR102115047B1
(ko)
|
2012-04-03 |
2020-05-26 |
노파르티스 아게 |
티로신 키나제 억제제들을 갖는 조합 제품 및 그의 용도
|
|
MA37975B2
(fr)
|
2012-09-11 |
2021-03-31 |
Genzyme Corp |
Inhibiteurs de synthase de glucosylcéramide
|
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
|
CN105246482A
(zh)
|
2013-03-15 |
2016-01-13 |
因特利凯有限责任公司 |
激酶抑制剂的组合及其用途
|
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Mdm2抑制劑與BRAF抑制劑之組合及其用途
|
|
BR112016024533A8
(pt)
|
2014-04-24 |
2021-03-30 |
Novartis Ag |
derivados de amino pirazina como inibidores de fosfatidilinositol 3-cinase ou sal, seu uso, e composição e combinação farmacêuticas
|
|
WO2015162461A1
(en)
|
2014-04-24 |
2015-10-29 |
Novartis Ag |
Pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
KR20160145780A
(ko)
|
2014-04-24 |
2016-12-20 |
노파르티스 아게 |
포스파티딜이노시톨 3-키나제 억제제로서의 아미노 피리딘 유도체
|
|
US9434724B2
(en)
|
2014-07-11 |
2016-09-06 |
Alpharmagen, Llc |
Quinuclidines for modulating alpha 7 activity
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
WO2016016822A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
|
BR112021024668A2
(pt)
|
2019-06-10 |
2022-05-31 |
Novartis Ag |
Derivado de piridina e pirazina para o tratamento de fc, dpoc e bronquiectasia
|
|
KR20220052934A
(ko)
|
2019-08-28 |
2022-04-28 |
노파르티스 아게 |
치환 1,3-페닐 헤테로아릴 유도체 및 질환 치료에서의 이의 용도
|
|
TW202140550A
(zh)
|
2020-01-29 |
2021-11-01 |
瑞士商諾華公司 |
使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法
|
|
US12083115B2
(en)
|
2020-02-03 |
2024-09-10 |
Genzyme Corporation |
Methods for treating neurological symptoms associated with lysosomal storage diseases
|
|
BR112023000798A2
(pt)
|
2020-07-24 |
2023-02-07 |
Genzyme Corp |
Composições farmacêuticas compreendendo venglustat
|