|
ES2165768B1
(es)
|
1999-07-14 |
2003-04-01 |
Almirall Prodesfarma Sa |
Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
MXPA03000141A
(es)
|
2000-06-27 |
2003-05-27 |
S A L V A T Lab Sa |
Carbamatos derivados de arilalquilaminas.
|
|
SK8002003A3
(en)
|
2000-12-22 |
2004-05-04 |
Almirall Prodesfarma Ag |
Quinuclidine carbamate derivatives and their use as M3 antagonists
|
|
EP1353919B1
(en)
|
2000-12-28 |
2006-07-26 |
Almirall Prodesfarma AG |
Novel quinuclidine derivatives and medicinal compositions containing the same
|
|
US7067261B2
(en)
|
2001-12-14 |
2006-06-27 |
Targacept, Inc. |
Methods and compositions for treatment of central nervous system disorders
|
|
KR100944580B1
(ko)
*
|
2001-12-20 |
2010-02-25 |
치에시 파마슈티시 에스.피.아. |
1-알킬-1-아조니아비시클로[2.2.2]옥탄 카르바메이트유도체 및 이의 무스카린 수용체 길항제로서의 용도
|
|
ES2203327B1
(es)
*
|
2002-06-21 |
2005-06-16 |
Almirall Prodesfarma, S.A. |
Nuevos carbamatos de quinuclidina y composiciones farmaceuticas que los contienen.
|
|
ES2204295B1
(es)
|
2002-07-02 |
2005-08-01 |
Almirall Prodesfarma, S.A. |
Nuevos derivados de quinuclidina-amida.
|
|
BR0215801A
(pt)
*
|
2002-07-08 |
2005-05-10 |
Ranbaxy Lab Ltd |
Derivados de 3,6-dissubstituìdos azabiciclo [3.1.0] hexano úteis como antagonistas de receptores muscarìnicos
|
|
TWI295669B
(en)
|
2002-10-30 |
2008-04-11 |
Theravance Inc |
Substituted 4-amino-1-(pyridylmethyl) piperidine and related compounds
|
|
PE20040950A1
(es)
|
2003-02-14 |
2005-01-01 |
Theravance Inc |
DERIVADOS DE BIFENILO COMO AGONISTAS DE LOS RECEPTORES ADRENERGICOS ß2 Y COMO ANTAGONISTAS DE LOS RECEPTORES MUSCARINICOS
|
|
EP1618091A1
(en)
|
2003-04-09 |
2006-01-25 |
Ranbaxy Laboratories, Ltd. |
Substituted azabicyclo hexane derivatives as muscarinic receptor antagonists
|
|
WO2004089900A1
(en)
|
2003-04-11 |
2004-10-21 |
Ranbaxy Laboratories Limited |
Azabicyclo derivatives as muscarinic receptor antagonists
|
|
AR044519A1
(es)
|
2003-05-02 |
2005-09-14 |
Novartis Ag |
Derivados de piridin-tiazol amina y de pirimidin-tiazol amina
|
|
ATE435862T1
(de)
|
2003-05-28 |
2009-07-15 |
Theravance Inc |
Azabicycloalkanverbindungen als muscarinrezeptor antagonisten
|
|
EP1644356A1
(en)
|
2003-07-11 |
2006-04-12 |
Theravance, Inc. |
Substituted 4-amino-1-benzylpiperidine compounds
|
|
WO2005051946A2
(en)
|
2003-11-21 |
2005-06-09 |
Theravance, Inc. |
Compounds having beta2 adrenergic receptor agonist and muscarinic receptor antagonist activity
|
|
GB0401334D0
(en)
|
2004-01-21 |
2004-02-25 |
Novartis Ag |
Organic compounds
|
|
US7560469B2
(en)
|
2004-03-11 |
2009-07-14 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528416A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
JP2007528408A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
TW200538095A
(en)
|
2004-03-11 |
2005-12-01 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528412A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとして有用なビフェニル化合物
|
|
EP1723113A1
(en)
|
2004-03-11 |
2006-11-22 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2007528415A
(ja)
|
2004-03-11 |
2007-10-11 |
セラヴァンス， インコーポレーテッド |
ムスカリンレセプターアンタゴニストとしての有用なビフェニル化合物
|
|
TWI341836B
(en)
|
2004-03-11 |
2011-05-11 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
GB0411056D0
(en)
|
2004-05-18 |
2004-06-23 |
Novartis Ag |
Organic compounds
|
|
ES2246170B1
(es)
*
|
2004-07-29 |
2007-04-01 |
Almirall Prodesfarma, S.A. |
Nuevo procedimiento para preparar derivados de carbamato de quinuclidinio.
|
|
GT200500281A
(es)
|
2004-10-22 |
2006-04-24 |
Novartis Ag |
Compuestos organicos.
|
|
GB0424284D0
(en)
|
2004-11-02 |
2004-12-01 |
Novartis Ag |
Organic compounds
|
|
GB0426164D0
(en)
|
2004-11-29 |
2004-12-29 |
Novartis Ag |
Organic compounds
|
|
EP1856112A1
(en)
|
2005-03-10 |
2007-11-21 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
TW200714587A
(en)
|
2005-03-10 |
2007-04-16 |
Theravance Inc |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
US7659403B2
(en)
|
2005-03-10 |
2010-02-09 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
EP1856049A1
(en)
|
2005-03-10 |
2007-11-21 |
Theravance, Inc. |
Biphenyl compounds useful as muscarinic receptor antagonists
|
|
JP2008538104A
(ja)
|
2005-03-10 |
2008-10-09 |
セラヴァンス， インコーポレーテッド |
ムスカリン受容体アンタゴニストとして有用なビフェニル化合物
|
|
GB0507577D0
(en)
|
2005-04-14 |
2005-05-18 |
Novartis Ag |
Organic compounds
|
|
GB0510390D0
(en)
|
2005-05-20 |
2005-06-29 |
Novartis Ag |
Organic compounds
|
|
JP2008546695A
(ja)
|
2005-06-13 |
2008-12-25 |
セラヴァンス， インコーポレーテッド |
ムスカリン受容体アンタゴニストとして有用なビフェニル化合物
|
|
NZ565628A
(en)
|
2005-08-22 |
2011-03-31 |
Targacept Inc |
Heteroaryl-substituted diazatricycloalkanes, methods for its preparation and use thereof
|
|
NZ567124A
(en)
|
2005-10-21 |
2011-08-26 |
Novartis Ag |
Human antibodies against Interleukin-13 and therapeutic uses to treat asthma
|
|
EP1968980A1
(en)
*
|
2005-12-30 |
2008-09-17 |
Ranbaxy Laboratories, Ltd. |
Muscarinic receptor antagonists
|
|
GB0601951D0
(en)
|
2006-01-31 |
2006-03-15 |
Novartis Ag |
Organic compounds
|
|
GB0602778D0
(en)
|
2006-02-10 |
2006-03-22 |
Glaxo Group Ltd |
Novel compound
|
|
JP5373599B2
(ja)
|
2006-04-21 |
2013-12-18 |
ノバルティス アーゲー |
アデノシンａ２ａ受容体アゴニストとして使用するためのプリン誘導体
|
|
ES2298049B1
(es)
|
2006-07-21 |
2009-10-20 |
Laboratorios Almirall S.A. |
Procedimiento para fabricar bromuro de 3(r)-(2-hidroxi-2,2-ditien-2-ilacetoxi)-1-(3-fenoxipropil)-1-azoniabiciclo (2.2.2) octano.
|
|
EP1882691A1
(en)
*
|
2006-07-26 |
2008-01-30 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine derivatives as M3 antagonists
|
|
AU2007302263A1
(en)
|
2006-09-29 |
2008-04-03 |
Novartis Ag |
Pyrazolopyrimidines as P13K lipid kinase inhibitors
|
|
TW200825084A
(en)
*
|
2006-11-14 |
2008-06-16 |
Astrazeneca Ab |
New compounds 521
|
|
JP2010515729A
(ja)
|
2007-01-10 |
2010-05-13 |
アイアールエム・リミテッド・ライアビリティ・カンパニー |
チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
|
|
EP2119716A4
(en)
|
2007-02-09 |
2011-06-01 |
Astellas Pharma Inc |
AZA BRIDGE CYCLE COMPOUND
|
|
US20090010923A1
(en)
*
|
2007-04-24 |
2009-01-08 |
University Of Maryland, Baltimore |
Treatment of cancer with anti-muscarinic receptor agents
|
|
EP2332933A1
(en)
|
2007-05-07 |
2011-06-15 |
Novartis AG |
Epithelial sodium channel (ENaC) inhibitors
|
|
SA08290475B1
(ar)
|
2007-08-02 |
2013-06-22 |
Targacept Inc |
(2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
|
|
KR101565469B1
(ko)
|
2007-10-01 |
2015-11-03 |
코멘티스, 인코포레이티드 |
알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1ｈ-인돌-3-카르복실레이트 유도체
|
|
EP2065385A1
(en)
*
|
2007-11-28 |
2009-06-03 |
Laboratorios SALVAT, S.A. |
Stable crystalline salt of (R)-3-fluorophenyl-3,4,5-trifluorobenzylcarbamic acid 1-azabiciyclo [2.2.2]oct-3-yl ester
|
|
EP2444120B1
(en)
|
2007-12-10 |
2017-09-27 |
Novartis AG |
Spirocyclic amiloride analogues as ENac blockers
|
|
MX2010007604A
(es)
|
2008-01-11 |
2010-08-02 |
Novartis Ag |
Pirimidinas como inhibidores de cinasa.
|
|
EP2080507A1
(en)
*
|
2008-01-15 |
2009-07-22 |
CHIESI FARMACEUTICI S.p.A. |
Pharmaceutical formulations comprising an anticholinergic drug
|
|
CN103143023A
(zh)
|
2008-02-13 |
2013-06-12 |
塔加西普特公司 |
α7烟碱激动剂和抗精神病药的组合
|
|
GB2468073B
(en)
|
2008-02-26 |
2012-09-05 |
Elevation Pharmaceuticals Inc |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
US20100055045A1
(en)
|
2008-02-26 |
2010-03-04 |
William Gerhart |
Method and system for the treatment of chronic obstructive pulmonary disease with nebulized anticholinergic administrations
|
|
EP2100598A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
EP2100599A1
(en)
|
2008-03-13 |
2009-09-16 |
Laboratorios Almirall, S.A. |
Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
|
|
US8268834B2
(en)
|
2008-03-19 |
2012-09-18 |
Novartis Ag |
Pyrazine derivatives that inhibit phosphatidylinositol 3-kinase enzyme
|
|
CA2727196A1
(en)
|
2008-06-10 |
2009-12-17 |
Novartis Ag |
Organic compounds
|
|
EP2154136A1
(en)
|
2008-08-08 |
2010-02-17 |
CHIESI FARMACEUTICI S.p.A. |
Quinuclidine carbonate derivatives and medicinal compositions thereof
|
|
WO2010045633A2
(en)
*
|
2008-10-17 |
2010-04-22 |
National Jewish Health |
Measurement and analysis of leukotrienes
|
|
EP2206712A1
(en)
|
2008-12-23 |
2010-07-14 |
CHIESI FARMACEUTICI S.p.A. |
"Alkaloid aminoester derivatives and medicinal composition thereof"
|
|
TW201031664A
(en)
|
2009-01-26 |
2010-09-01 |
Targacept Inc |
Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
|
|
TW201031406A
(en)
|
2009-01-29 |
2010-09-01 |
Novartis Ag |
Substituted benzimidazoles for the treatment of astrocytomas
|
|
US8389526B2
(en)
|
2009-08-07 |
2013-03-05 |
Novartis Ag |
3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives
|
|
MX2012001838A
(es)
|
2009-08-12 |
2012-02-29 |
Novartis Ag |
Compuestos de hidrazona heterociclico y sus usos para tratar cancer e inflamacion.
|
|
CN102573846B
(zh)
|
2009-08-17 |
2015-10-07 |
因特利凯公司 |
杂环化合物及其用途
|
|
KR20120089463A
(ko)
|
2009-08-20 |
2012-08-10 |
노파르티스 아게 |
헤테로시클릭 옥심 화합물
|
|
EP2813227A1
(en)
|
2009-10-22 |
2014-12-17 |
Vertex Pharmaceuticals Incorporated |
Compositions for treatment of cystic fibrosis and other chronic diseases
|
|
US8247436B2
(en)
|
2010-03-19 |
2012-08-21 |
Novartis Ag |
Pyridine and pyrazine derivative for the treatment of CF
|
|
CN102947300B
(zh)
|
2010-06-22 |
2016-09-21 |
奇斯药制品公司 |
生物碱氨基酯衍生物及其药物组合物
|
|
JP2013529606A
(ja)
|
2010-06-22 |
2013-07-22 |
シエシー ファルマセウティチィ ソシエタ ペル アチオニ |
抗ムスカリン薬含有乾燥粉末配合物
|
|
KR20130111968A
(ko)
*
|
2010-06-22 |
2013-10-11 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
KR20130087406A
(ko)
|
2010-06-22 |
2013-08-06 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 아미노에스테르 유도체 및 이의 의약 조성물
|
|
UY33597A
(es)
|
2010-09-09 |
2012-04-30 |
Irm Llc |
Compuestos y composiciones como inhibidores de la trk
|
|
WO2012034095A1
(en)
|
2010-09-09 |
2012-03-15 |
Irm Llc |
Compounds and compositions as trk inhibitors
|
|
US8372845B2
(en)
|
2010-09-17 |
2013-02-12 |
Novartis Ag |
Pyrazine derivatives as enac blockers
|
|
CA2820600A1
(en)
*
|
2010-11-26 |
2012-05-31 |
Chiesi Farmaceutici S.P.A. |
Glycine derivatives and their use as muscarinic receptor antagonists
|
|
KR101928505B1
(ko)
*
|
2011-01-28 |
2018-12-12 |
에스케이바이오팜 주식회사 |
피리돈 유도체 및 이를 포함하는 약학적 조성물
|
|
US20130324526A1
(en)
|
2011-02-10 |
2013-12-05 |
Novartis Ag |
[1,2,4] triazolo [4,3-b] pyridazine compounds as inhibitors of the c-met tyrosine kinase
|
|
US20120220557A1
(en)
|
2011-02-17 |
2012-08-30 |
Chiesi Farmaceutici S.P.A. |
Liquid propellant-free formulation comprising an antimuscarinic drug
|
|
WO2012116237A2
(en)
|
2011-02-23 |
2012-08-30 |
Intellikine, Llc |
Heterocyclic compounds and uses thereof
|
|
MX2013009767A
(es)
|
2011-02-25 |
2013-10-01 |
Irm Llc |
Compuestos y composiciones como inhibidores de trk.
|
|
FI3673906T3
(fi)
*
|
2011-03-18 |
2025-08-14 |
Genzyme Corp |
Glukosyylikeramidisyntaasi-inhibiittoreita
|
|
EP2510928A1
(en)
|
2011-04-15 |
2012-10-17 |
Almirall, S.A. |
Aclidinium for use in improving the quality of sleep in respiratory patients
|
|
KR20140019409A
(ko)
*
|
2011-04-29 |
2014-02-14 |
키에시 파르마슈티시 엣스. 피. 에이. |
알칼로이드 에스텔 및 카바메이트 유도체와 그들의 의약조성물
|
|
UY34305A
(es)
|
2011-09-01 |
2013-04-30 |
Novartis Ag |
Derivados de heterociclos bicíclicos para el tratamiento de la hipertensión arterial pulmonar
|
|
UY34329A
(es)
|
2011-09-15 |
2013-04-30 |
Novartis Ag |
Compuestos de triazolopiridina
|
|
WO2013038373A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
ES2882807T3
(es)
|
2011-09-16 |
2021-12-02 |
Novartis Ag |
Heterociclil carboxamidas N-sustituidas
|
|
WO2013038381A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine/pyrazine amide derivatives
|
|
ES2558457T3
(es)
|
2011-09-16 |
2016-02-04 |
Novartis Ag |
Compuestos heterocíclicos para el tratamiento de fibrosis quística
|
|
WO2013038378A1
(en)
|
2011-09-16 |
2013-03-21 |
Novartis Ag |
Pyridine amide derivatives
|
|
US9174994B2
(en)
|
2011-11-23 |
2015-11-03 |
Intellikine, Llc |
Enhanced treatment regimens using mTor inhibitors
|
|
KR20140105746A
(ko)
|
2011-12-30 |
2014-09-02 |
키에시 파르마슈티시 엣스. 피. 에이. |
항무스카린제로서 1-아자헤테로시클릴아세트산의 퀴누클리딘 에스터, 이들의 제조 방법 및 이들의 의약 조성물
|
|
US8809340B2
(en)
|
2012-03-19 |
2014-08-19 |
Novartis Ag |
Crystalline form
|
|
US20150297604A1
(en)
|
2012-04-03 |
2015-10-22 |
Novartis Ag |
Combination Products with Tyrosine Kinase Inhibitors and their Use
|
|
MA37975B2
(fr)
|
2012-09-11 |
2021-03-31 |
Genzyme Corp |
Inhibiteurs de synthase de glucosylcéramide
|
|
US9073921B2
(en)
|
2013-03-01 |
2015-07-07 |
Novartis Ag |
Salt forms of bicyclic heterocyclic derivatives
|
|
EP2968340A4
(en)
|
2013-03-15 |
2016-08-10 |
Intellikine Llc |
COMBINING KINASE INHIBITORS AND USES THEREOF
|
|
TW201605450A
(zh)
|
2013-12-03 |
2016-02-16 |
諾華公司 |
Ｍｄｍ２抑制劑與ＢＲＡＦ抑制劑之組合及其用途
|
|
BR112016023967A2
(pt)
|
2014-04-24 |
2017-08-15 |
Novartis Ag |
derivados de pirazina como inibidores de fosfatidilinositol 3-cinase
|
|
CA2945212A1
(en)
|
2014-04-24 |
2015-10-29 |
Novartis Ag |
Amino pyrazine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
AU2014391605A1
(en)
|
2014-04-24 |
2016-10-27 |
Novartis Ag |
Amino pyridine derivatives as phosphatidylinositol 3-kinase inhibitors
|
|
US20170166561A1
(en)
|
2014-07-11 |
2017-06-15 |
Alpharmagen, Llc |
Quinuclidine compounds for modulating alpha7-nicotinic acetylcholine receptor activity
|
|
WO2016011658A1
(en)
|
2014-07-25 |
2016-01-28 |
Novartis Ag |
Combination therapy
|
|
CA2954862A1
(en)
|
2014-07-31 |
2016-02-04 |
Novartis Ag |
Combination therapy
|
|
US9724340B2
(en)
|
2015-07-31 |
2017-08-08 |
Attenua, Inc. |
Antitussive compositions and methods
|
|
JP7633169B2
(ja)
|
2019-02-04 |
2025-02-19 |
ジェンザイム・コーポレーション |
グルコシルセラミドシンターゼ（ｇｃｓ）阻害剤を使用した繊毛病の処置
|
|
BR112021024668A2
(pt)
|
2019-06-10 |
2022-05-31 |
Novartis Ag |
Derivado de piridina e pirazina para o tratamento de fc, dpoc e bronquiectasia
|
|
AR119819A1
(es)
|
2019-08-28 |
2022-01-12 |
Novartis Ag |
Derivados de 1,3-fenil heteroarilo sustituidos y su uso en el tratamiento de enfermedades
|
|
TW202140550A
(zh)
|
2020-01-29 |
2021-11-01 |
瑞士商諾華公司 |
使用抗ｔｓｌｐ抗體治療炎性或阻塞性氣道疾病之方法
|
|
US12083115B2
(en)
|
2020-02-03 |
2024-09-10 |
Genzyme Corporation |
Methods for treating neurological symptoms associated with lysosomal storage diseases
|
|
US11857512B2
(en)
|
2020-07-24 |
2024-01-02 |
Genzyme Corporation |
Pharmaceutical compositions comprising venglustat
|