JP2001523712A5 - - Google Patents
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- Publication number
- JP2001523712A5 JP2001523712A5 JP2000521818A JP2000521818A JP2001523712A5 JP 2001523712 A5 JP2001523712 A5 JP 2001523712A5 JP 2000521818 A JP2000521818 A JP 2000521818A JP 2000521818 A JP2000521818 A JP 2000521818A JP 2001523712 A5 JP2001523712 A5 JP 2001523712A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- pharmaceutically acceptable
- general formula
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6694397P | 1997-11-25 | 1997-11-25 | |
| US60/066,943 | 1997-11-25 | ||
| PCT/US1998/023482 WO1999026616A1 (en) | 1997-11-25 | 1998-11-04 | Benzenesulfonamide inhibitors of pde-iv and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001523712A JP2001523712A (ja) | 2001-11-27 |
| JP2001523712A5 true JP2001523712A5 (enExample) | 2006-01-05 |
Family
ID=22072726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521818A Abandoned JP2001523712A (ja) | 1997-11-25 | 1998-11-04 | Ｐｄｅ−ｉｖのベンゼンスルホンアミド阻害剤およびそれらの治療的使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6162830A (enExample) |
| EP (1) | EP1045690B1 (enExample) |
| JP (1) | JP2001523712A (enExample) |
| KR (1) | KR20010024268A (enExample) |
| AT (1) | ATE238048T1 (enExample) |
| AU (1) | AU751453C (enExample) |
| BR (1) | BR9812527A (enExample) |
| CA (1) | CA2299399C (enExample) |
| DE (1) | DE69813895T2 (enExample) |
| DK (1) | DK1045690T3 (enExample) |
| ES (1) | ES2195419T3 (enExample) |
| NZ (1) | NZ502965A (enExample) |
| PT (1) | PT1045690E (enExample) |
| WO (1) | WO1999026616A1 (enExample) |
| ZA (1) | ZA9810735B (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| US6699890B2 (en) | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| US7205320B2 (en) * | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7153871B2 (en) * | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| WO2003063796A2 (en) * | 2002-01-30 | 2003-08-07 | Tularik Inc. | Heterocyclic arylsulfonamidobenzylic compounds |
| JP4434744B2 (ja) * | 2002-01-30 | 2010-03-17 | アムジェン インコーポレイテッド | アリールスルホンアミドベンジル化合物 |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| CA2481387A1 (en) | 2002-04-12 | 2003-10-23 | Celgene Corporation | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| ES2195785B1 (es) * | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| BR0313000A (pt) * | 2002-07-19 | 2005-07-12 | Memory Pharm Corp | Compostos, composição farmacêutica e método para efetuar a inibição da enzima pde4, realçar a cognição e/ou tratar a psicose em um paciente |
| EP1539697A1 (en) | 2002-07-19 | 2005-06-15 | Memory Pharmaceutical Corporation | Phosphodiesterase 4 inhibitors, including n-substituted aniline and diphenylamine analogs |
| CN100513397C (zh) * | 2002-11-19 | 2009-07-15 | 记忆药物公司 | 磷酸二酯酶4抑制剂 |
| ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| MXPA06001566A (es) * | 2003-08-12 | 2006-05-15 | Amgen Inc | Compuestos arilsulfonamidobencilicos. |
| MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| ES2251866B1 (es) * | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2320954B1 (es) * | 2007-03-02 | 2010-03-16 | Laboratorio Almirall S.A. | Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona. |
| MX2010010334A (es) * | 2008-03-24 | 2010-10-08 | Celgene Corp | Tratamiento de psoriasis o artritis psoriatica utilizando ciclopropil-n-{2-{(1s)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfonil )etil]-3-oxoisoindolina-4-il}carboxamida. |
| WO2010003084A2 (en) * | 2008-07-02 | 2010-01-07 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| FR2962649B1 (fr) * | 2010-07-19 | 2025-10-24 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| JP6687550B2 (ja) | 2014-06-23 | 2020-04-22 | セルジーン コーポレイション | 肝疾患又は肝機能異常を治療するためのアプレミラスト |
| CN111925313B (zh) * | 2020-09-22 | 2021-06-25 | 纳兰迦(上海)生物医药科技有限公司 | 具有pde4抑制活性的化合物、制备方法、组合物及用途 |
| JP7769365B2 (ja) * | 2021-09-22 | 2025-11-13 | 日本メナード化粧品株式会社 | 皮膚幹細胞増殖促進剤及び皮膚再生促進剤 |
| EP4197318B1 (en) * | 2021-12-17 | 2025-11-19 | Albert-Ludwigs-Universität Freiburg | Phosphodiesterases inhibitors to promote in vitro plant cell reprogramming towards plant embryogenesis or microcallus formation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283352A (en) * | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
| EP0652868B1 (en) * | 1992-07-28 | 2004-11-10 | Aventis Pharma Limited | INHIBITORS OF c-AMP PHOSPHODIESTERASE |
| US6245774B1 (en) * | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| US5728712A (en) * | 1995-05-19 | 1998-03-17 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| AU5772296A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| WO1996036596A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| US5834485A (en) * | 1996-05-20 | 1998-11-10 | Chiroscience Limited | Quinoline sulfonamides and their therapeutic use |
-
1998
- 1998-11-04 KR KR1020007003155A patent/KR20010024268A/ko not_active Ceased
- 1998-11-04 NZ NZ502965A patent/NZ502965A/en unknown
- 1998-11-04 ES ES98957571T patent/ES2195419T3/es not_active Expired - Lifetime
- 1998-11-04 JP JP2000521818A patent/JP2001523712A/ja not_active Abandoned
- 1998-11-04 AU AU13800/99A patent/AU751453C/en not_active Ceased
- 1998-11-04 WO PCT/US1998/023482 patent/WO1999026616A1/en not_active Ceased
- 1998-11-04 US US09/485,252 patent/US6162830A/en not_active Expired - Fee Related
- 1998-11-04 BR BR9812527-3A patent/BR9812527A/pt not_active Application Discontinuation
- 1998-11-04 CA CA002299399A patent/CA2299399C/en not_active Expired - Fee Related
- 1998-11-04 DE DE69813895T patent/DE69813895T2/de not_active Expired - Fee Related
- 1998-11-04 DK DK98957571T patent/DK1045690T3/da active
- 1998-11-04 AT AT98957571T patent/ATE238048T1/de not_active IP Right Cessation
- 1998-11-04 EP EP98957571A patent/EP1045690B1/en not_active Expired - Lifetime
- 1998-11-04 PT PT98957571T patent/PT1045690E/pt unknown
- 1998-11-24 ZA ZA9810735A patent/ZA9810735B/xx unknown
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