JP2001523712A5 - - Google Patents
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- Publication number
- JP2001523712A5 JP2001523712A5 JP2000521818A JP2000521818A JP2001523712A5 JP 2001523712 A5 JP2001523712 A5 JP 2001523712A5 JP 2000521818 A JP2000521818 A JP 2000521818A JP 2000521818 A JP2000521818 A JP 2000521818A JP 2001523712 A5 JP2001523712 A5 JP 2001523712A5
- Authority
- JP
- Japan
- Prior art keywords
- cycloalkyl
- pharmaceutically acceptable
- general formula
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 150000001875 compounds Chemical class 0.000 description 2
- 125000000753 cycloalkyl group Chemical group 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 125000004433 nitrogen atom Chemical group N* 0.000 description 1
- 239000002587 phosphodiesterase IV inhibitor Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
Description
【特許請求の範囲】
【請求項１】 一般式
【化２】
〔式中、Ｒ1およびＲ2は低級アルキルまたはシクロアルキルであり；
Ｒ3およびＲ4は独立してＣ1−Ｃ4アルキル、シクロアルキル、１個の二重結合を有するＣ2−Ｃ4アルキレン、１個の三重結合を有するＣ2−Ｃ4アルキリン、(ＣＨ2)nＣＯ(ＣＨ2)mＣＨ3、(ＣＨ2)pＣＮ、(ＣＨ2)pＣＯ2Ｍｅであるか、またはそれらが結合している窒素原子と一緒になって３−〜１０−員環を形成し；
ｎおよびｍは０〜３であり；
ｐは１〜３である〕の化合物またはその薬学的に許容しうる塩および薬学的に許容しうる担体を含有する医薬組成物。
【請求項２】 請求項１に記載の一般式で表される化合物からなるＰＤＥ−IV阻害剤。
【請求項１】 一般式
【化２】
Ｒ3およびＲ4は独立してＣ1−Ｃ4アルキル、シクロアルキル、１個の二重結合を有するＣ2−Ｃ4アルキレン、１個の三重結合を有するＣ2−Ｃ4アルキリン、(ＣＨ2)nＣＯ(ＣＨ2)mＣＨ3、(ＣＨ2)pＣＮ、(ＣＨ2)pＣＯ2Ｍｅであるか、またはそれらが結合している窒素原子と一緒になって３−〜１０−員環を形成し；
ｎおよびｍは０〜３であり；
ｐは１〜３である〕の化合物またはその薬学的に許容しうる塩および薬学的に許容しうる担体を含有する医薬組成物。
【請求項２】 請求項１に記載の一般式で表される化合物からなるＰＤＥ−IV阻害剤。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6694397P | 1997-11-25 | 1997-11-25 | |
| US60/066,943 | 1997-11-25 | ||
| PCT/US1998/023482 WO1999026616A1 (en) | 1997-11-25 | 1998-11-04 | Benzenesulfonamide inhibitors of pde-iv and their therapeutic use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2001523712A JP2001523712A (ja) | 2001-11-27 |
| JP2001523712A5 true JP2001523712A5 (ja) | 2006-01-05 |
Family
ID=22072726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000521818A Abandoned JP2001523712A (ja) | 1997-11-25 | 1998-11-04 | Ｐｄｅ−ｉｖのベンゼンスルホンアミド阻害剤およびそれらの治療的使用 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US6162830A (ja) |
| EP (1) | EP1045690B1 (ja) |
| JP (1) | JP2001523712A (ja) |
| KR (1) | KR20010024268A (ja) |
| AT (1) | ATE238048T1 (ja) |
| AU (1) | AU751453C (ja) |
| BR (1) | BR9812527A (ja) |
| CA (1) | CA2299399C (ja) |
| DE (1) | DE69813895T2 (ja) |
| DK (1) | DK1045690T3 (ja) |
| ES (1) | ES2195419T3 (ja) |
| NZ (1) | NZ502965A (ja) |
| PT (1) | PT1045690E (ja) |
| WO (1) | WO1999026616A1 (ja) |
| ZA (1) | ZA9810735B (ja) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6316503B1 (en) * | 1999-03-15 | 2001-11-13 | Tularik Inc. | LXR modulators |
| US6699890B2 (en) | 2000-12-22 | 2004-03-02 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| JP3940290B2 (ja) * | 2000-12-22 | 2007-07-04 | ザ・ヨルダニアン・フアーマシユーテイカル・エム・エフ・ジー・アンド・メデイカル・イクイツプメント・カンパニー・リミテツド | 新規化合物 |
| SE0004780D0 (sv) | 2000-12-22 | 2000-12-22 | Jordanian Pharmaceutical Mfg & | Novel compunds |
| US7205320B2 (en) * | 2001-01-22 | 2007-04-17 | Memory Pharmaceuticals Corp. | Phosphodiesterase 4 inhibitors |
| US7153871B2 (en) * | 2001-01-22 | 2006-12-26 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors, including aminoindazole and aminobenzofuran analogs |
| ATE411279T1 (de) | 2002-01-30 | 2008-10-15 | Amgen Inc | Arylsulfonamidobenzylverbindungen |
| WO2003063796A2 (en) * | 2002-01-30 | 2003-08-07 | Tularik Inc. | Heterocyclic arylsulfonamidobenzylic compounds |
| US7276529B2 (en) * | 2002-03-20 | 2007-10-02 | Celgene Corporation | Methods of the treatment or prevention of exercise-induced asthma using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US6962940B2 (en) | 2002-03-20 | 2005-11-08 | Celgene Corporation | (+)-2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione: methods of using and compositions thereof |
| US7208516B2 (en) * | 2002-03-20 | 2007-04-24 | Celgene Corporation | Methods of the treatment of psoriatic arthritis using (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione |
| US7893101B2 (en) | 2002-03-20 | 2011-02-22 | Celgene Corporation | Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof |
| US20050148034A1 (en) * | 2002-04-12 | 2005-07-07 | Hariri Robert J. | Methods for identification of modulators of angiogenesis, compounds discovered thereby, and methods of treatment using the compounds |
| ES2195785B1 (es) * | 2002-05-16 | 2005-03-16 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| BR0313000A (pt) * | 2002-07-19 | 2005-07-12 | Memory Pharm Corp | Compostos, composição farmacêutica e método para efetuar a inibição da enzima pde4, realçar a cognição e/ou tratar a psicose em um paciente |
| NZ537724A (en) | 2002-07-19 | 2006-10-27 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including N-substituted aniline and diphenylamine analogs |
| BR0315705A (pt) * | 2002-11-19 | 2005-09-06 | Memory Pharm Corp | Inibidores de fosfodiesterase-4 |
| ES2211344B1 (es) * | 2002-12-26 | 2005-10-01 | Almirall Prodesfarma, S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| WO2005016277A2 (en) * | 2003-08-12 | 2005-02-24 | Amgen Inc. | Arylsulfonamidobenzylic compounds |
| MY141255A (en) * | 2003-12-11 | 2010-03-31 | Memory Pharm Corp | Phosphodiesterase 4 inhibitors, including n-substituted diarylamine analogs |
| ES2251866B1 (es) * | 2004-06-18 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2251867B1 (es) * | 2004-06-21 | 2007-06-16 | Laboratorios Almirall S.A. | Nuevos derivados de piridazin-3(2h)-ona. |
| ES2320954B1 (es) * | 2007-03-02 | 2010-03-16 | Laboratorio Almirall S.A. | Nuevo procedimiento de preparacion de 3-metil-4-fenilisoxazolo (3,4-d)iridazin-7(6h)-ona. |
| MX2010010334A (es) * | 2008-03-24 | 2010-10-08 | Celgene Corp | Tratamiento de psoriasis o artritis psoriatica utilizando ciclopropil-n-{2-{(1s)-1-(3-etoxi-4-metoxifenil)-2-(metilsulfonil )etil]-3-oxoisoindolina-4-il}carboxamida. |
| US20100029689A1 (en) * | 2008-07-02 | 2010-02-04 | Memory Pharmaceuticals Corporation | Phosphodiesterase 4 inhibitors |
| FR2962649A1 (fr) | 2010-07-19 | 2012-01-20 | Conservatoire Nat Arts Et Metiers | Traitement d'une pathologie liee a un effet excessif du tnf par un compose de benzene sulfonamide |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| US10300042B2 (en) | 2014-06-23 | 2019-05-28 | Celgene Corporation | Apremilast for the treatment of a liver disease or a liver function abnormality |
| CN111925313B (zh) * | 2020-09-22 | 2021-06-25 | 纳兰迦(上海)生物医药科技有限公司 | 具有pde4抑制活性的化合物、制备方法、组合物及用途 |
| EP4197318A1 (en) * | 2021-12-17 | 2023-06-21 | Albert-Ludwigs-Universität Freiburg | Phosphodiesterases inhibitors to promote in vitro plant cell reprogramming towards plant embryogenesis or microcallus formation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5283352A (en) * | 1986-11-28 | 1994-02-01 | Orion-Yhtyma Oy | Pharmacologically active compounds, methods for the preparation thereof and compositions containing the same |
| PL307265A1 (en) * | 1992-07-28 | 1995-05-15 | Rhone Poulenc Rorer Ltd | Compounds containing a phenyl group bonded with aryl or heteroaryl group through their bonding aliphatic group or that containing heteroatom |
| US6245774B1 (en) * | 1994-06-21 | 2001-06-12 | Celltech Therapeutics Limited | Tri-substituted phenyl or pyridine derivatives |
| AU5772396A (en) * | 1995-05-19 | 1996-11-29 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| US5728712A (en) * | 1995-05-19 | 1998-03-17 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| WO1996036595A1 (en) * | 1995-05-19 | 1996-11-21 | Chiroscience Limited | 3,4-disubstituted-phenylsulphonamides and their therapeutic use |
| AU722662B2 (en) * | 1996-05-20 | 2000-08-10 | Darwin Discovery Limited | Quinoline sulfonamides as TNF inhibitors and as PDE-IV inhibitors |
-
1998
- 1998-11-04 JP JP2000521818A patent/JP2001523712A/ja not_active Abandoned
- 1998-11-04 AU AU13800/99A patent/AU751453C/en not_active Ceased
- 1998-11-04 US US09/485,252 patent/US6162830A/en not_active Expired - Fee Related
- 1998-11-04 BR BR9812527-3A patent/BR9812527A/pt not_active Application Discontinuation
- 1998-11-04 EP EP98957571A patent/EP1045690B1/en not_active Expired - Lifetime
- 1998-11-04 WO PCT/US1998/023482 patent/WO1999026616A1/en not_active Application Discontinuation
- 1998-11-04 AT AT98957571T patent/ATE238048T1/de not_active IP Right Cessation
- 1998-11-04 NZ NZ502965A patent/NZ502965A/en unknown
- 1998-11-04 DE DE69813895T patent/DE69813895T2/de not_active Expired - Fee Related
- 1998-11-04 CA CA002299399A patent/CA2299399C/en not_active Expired - Fee Related
- 1998-11-04 ES ES98957571T patent/ES2195419T3/es not_active Expired - Lifetime
- 1998-11-04 KR KR1020007003155A patent/KR20010024268A/ko not_active Application Discontinuation
- 1998-11-04 PT PT98957571T patent/PT1045690E/pt unknown
- 1998-11-04 DK DK98957571T patent/DK1045690T3/da active
- 1998-11-24 ZA ZA9810735A patent/ZA9810735B/xx unknown
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