JP2010514786A5 - - Google Patents

Download PDF

Info

Publication number
JP2010514786A5
JP2010514786A5 JP2009544215A JP2009544215A JP2010514786A5 JP 2010514786 A5 JP2010514786 A5 JP 2010514786A5 JP 2009544215 A JP2009544215 A JP 2009544215A JP 2009544215 A JP2009544215 A JP 2009544215A JP 2010514786 A5 JP2010514786 A5 JP 2010514786A5
Authority
JP
Japan
Prior art keywords
group
aryl
alkyl
heteroaryl
nhr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2009544215A
Other languages
English (en)
Japanese (ja)
Other versions
JP5656408B2 (ja
JP2010514786A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2007/088500 external-priority patent/WO2008083056A2/en
Publication of JP2010514786A publication Critical patent/JP2010514786A/ja
Publication of JP2010514786A5 publication Critical patent/JP2010514786A5/ja
Application granted granted Critical
Publication of JP5656408B2 publication Critical patent/JP5656408B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2009544215A 2006-12-26 2007-12-21 心臓の神経支配を画像化するためのリガンド Active JP5656408B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87721106P 2006-12-26 2006-12-26
US60/877,211 2006-12-26
PCT/US2007/088500 WO2008083056A2 (en) 2006-12-26 2007-12-21 Ligands for imaging cardiac innervation

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014152244A Division JP6021860B2 (ja) 2006-12-26 2014-07-25 心臓の神経支配を画像化するためのリガンド

Publications (3)

Publication Number Publication Date
JP2010514786A JP2010514786A (ja) 2010-05-06
JP2010514786A5 true JP2010514786A5 (enExample) 2011-02-24
JP5656408B2 JP5656408B2 (ja) 2015-01-21

Family

ID=39307501

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2009544215A Active JP5656408B2 (ja) 2006-12-26 2007-12-21 心臓の神経支配を画像化するためのリガンド
JP2014152244A Active JP6021860B2 (ja) 2006-12-26 2014-07-25 心臓の神経支配を画像化するためのリガンド
JP2016085372A Pending JP2016183164A (ja) 2006-12-26 2016-04-21 心臓の神経支配を画像化するためのリガンド

Family Applications After (2)

Application Number Title Priority Date Filing Date
JP2014152244A Active JP6021860B2 (ja) 2006-12-26 2014-07-25 心臓の神経支配を画像化するためのリガンド
JP2016085372A Pending JP2016183164A (ja) 2006-12-26 2016-04-21 心臓の神経支配を画像化するためのリガンド

Country Status (20)

Country Link
US (5) US8491868B2 (enExample)
EP (5) EP2474524A3 (enExample)
JP (3) JP5656408B2 (enExample)
KR (4) KR101718160B1 (enExample)
CN (3) CN110003079A (enExample)
AU (1) AU2007339954B2 (enExample)
BR (1) BRPI0722082A8 (enExample)
CA (2) CA2673853C (enExample)
CO (1) CO6231002A2 (enExample)
DK (3) DK2474523T3 (enExample)
ES (3) ES2804801T3 (enExample)
IL (3) IL199563A (enExample)
MX (2) MX367292B (enExample)
PL (1) PL2114873T3 (enExample)
PT (1) PT2114873E (enExample)
RU (1) RU2506256C2 (enExample)
SG (1) SG177918A1 (enExample)
TW (2) TWI618544B (enExample)
WO (1) WO2008083056A2 (enExample)
ZA (1) ZA200904828B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
JP5656408B2 (ja) * 2006-12-26 2015-01-21 ランセウス メディカル イメージング， インコーポレイテッド 心臓の神経支配を画像化するためのリガンド
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
RU2710736C2 (ru) 2010-05-11 2020-01-10 Лантеус Медикал Имэджинг, Инк. Композиции, способы и системы для синтеза и применение визуализирующих средств
US9301962B2 (en) 2010-05-14 2016-04-05 Baylor College Of Medicine Male contraceptive compositions and methods of use
CA2799403C (en) 2010-05-14 2020-01-21 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
BR112012029005A2 (pt) 2010-05-14 2016-07-26 Dana Farber Cancer Inst Inc composições e métodos de tratamento de neoplasia, doença inflamatória e outros distúrbios
AR086113A1 (es) 2011-04-30 2013-11-20 Abbott Lab Isoxazolinas como agentes terapeuticos
KR102527562B1 (ko) 2011-09-09 2023-05-03 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
BR112014024997B1 (pt) 2012-04-10 2021-03-09 Lantheus Medical Imaging, Inc. métodos de síntese radiofarmacêutica
AU2013203000B9 (en) 2012-08-10 2017-02-02 Lantheus Medical Imaging, Inc. Compositions, methods, and systems for the synthesis and use of imaging agents
US20150246142A1 (en) * 2012-09-25 2015-09-03 The Regents Of The University Of Michigan Imaging agents
EP2948045B1 (en) 2013-01-24 2022-04-13 Tylerton International Holdings Inc. Body structure imaging
US20150366523A1 (en) * 2013-01-24 2015-12-24 Shlomo Ben-Haim Neuronal imaging and treatment
CN105163657A (zh) * 2013-03-11 2015-12-16 泰勒顿国际控股公司 自主神经系统建模及其用途
BR112016001457A2 (pt) 2013-07-25 2017-08-29 Dana Farber Cancer Inst Inc Inibidores de fatores de transcrição e usos dos mesmos
US20160220835A1 (en) * 2013-09-08 2016-08-04 Tylerton International Inc. Apparatus and methods for diagnosis and treatment of patterns of nervous system activity affecting disease
CN105849110B (zh) 2013-11-08 2019-08-02 达纳-法伯癌症研究所有限公司 使用溴结构域和额外终端(bet)蛋白抑制剂的用于癌症的组合疗法
WO2015104672A2 (en) 2014-01-10 2015-07-16 Tylerton International Holdings Inc. Detection of scar and fibrous cardiac zones
JP2017504651A (ja) 2014-01-31 2017-02-09 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド ジアゼパン誘導体の使用
WO2015117053A1 (en) 2014-01-31 2015-08-06 Dana-Farber Cancer Institute, Inc. Diaminopyrimidine benzenesulfone derivatives and uses thereof
MX377534B (es) 2014-02-28 2025-03-10 Tensha Therapeutics Inc Compuestos para usarse en el tratamiento de hiperinsulinemia.
EP3174464A4 (en) 2014-07-30 2018-08-29 Navix International Limited Registering nuclear medicine data
BR112017002369A2 (pt) 2014-08-08 2017-12-05 Dana Farber Cancer Inst Inc derivados de diazepana e usos dos mesmos
EP3177147A4 (en) 2014-08-08 2018-01-24 Dana-Farber Cancer Institute, Inc. Dihydropteridinone derivatives and uses thereof
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. COMBINATION THERAPY OF TRANSCRIPTION INHIBITORS AND CHINESE INHIBITORS
CN108472300A (zh) 2015-09-11 2018-08-31 达纳-法伯癌症研究所股份有限公司 氰基噻吩并三唑并二氮杂环庚三烯及其用途
AU2016319785C1 (en) 2015-09-11 2021-04-01 Dana-Farber Cancer Institute, Inc. Acetamide thienotriazolodiazepines and uses thereof
KR20180081809A (ko) 2015-11-25 2018-07-17 다나-파버 캔서 인스티튜트 인크. 2가 브로모도메인 억제제 및 그의 용도
CN107892651A (zh) * 2017-11-29 2018-04-10 陕西慧康生物科技有限责任公司 一种合成dl‑盐酸麻黄碱的方法
US20210379210A1 (en) * 2018-10-15 2021-12-09 Bristol-Myers Squibb Company Radioligands for imaging the lpa1 receptor
EP3682906A1 (en) * 2019-01-17 2020-07-22 Julius-Maximilians-Universität Würzburg Compound targeting norepinephrine transporter
CN109748825B (zh) * 2019-02-01 2022-02-18 原子高科股份有限公司 一种18f标记的胍甲基取代苯类似物及其应用
KR102690858B1 (ko) 2020-07-14 2024-08-02 한국과학기술원 이산화탄소와 개미산만으로 성장 가능한 재조합 미생물 및 상기 재조합 미생물을 이용하여 유용물질을 제조하는 방법

Family Cites Families (76)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6012A (en) * 1849-01-09 Lithographing co
FR1010218A (fr) 1949-02-10 1952-06-09 American Cyanamid Co Perfectionnements aux sels de guanidine
GB1215255A (en) 1968-03-13 1970-12-09 Pfizer & Co C Halophenylalkylguanidine compounds
US4094881A (en) 1976-03-10 1978-06-13 Smithkline Corporation Process for preparing triazolethiols
US4275074A (en) 1979-03-09 1981-06-23 Graham J. Dobbie Catecholamine treatment of ocular hypertension
US4270537A (en) 1979-11-19 1981-06-02 Romaine Richard A Automatic hypodermic syringe
US4258188A (en) * 1980-02-04 1981-03-24 American Home Products Corporation 2-(1-Piperazinyl)-cycloheptimidazole derivatives
US4622217A (en) * 1984-04-27 1986-11-11 The Regents Of The University Of Michigan I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent
US4596556A (en) 1985-03-25 1986-06-24 Bioject, Inc. Hypodermic injection apparatus
US4886499A (en) 1986-12-18 1989-12-12 Hoffmann-La Roche Inc. Portable injection appliance
GB8704027D0 (en) 1987-02-20 1987-03-25 Owen Mumford Ltd Syringe needle combination
EP0288284A3 (en) * 1987-04-24 1990-07-25 King Faisal Specialist Hospital And Research Centre Method of producing iodine 124 and meta-iodobenzylguanidine containing iodine 124
US4941880A (en) 1987-06-19 1990-07-17 Bioject, Inc. Pre-filled ampule and non-invasive hypodermic injection device assembly
US4790824A (en) 1987-06-19 1988-12-13 Bioject, Inc. Non-invasive hypodermic injection device
US4940460A (en) 1987-06-19 1990-07-10 Bioject, Inc. Patient-fillable and non-invasive hypodermic injection device assembly
US5339163A (en) 1988-03-16 1994-08-16 Canon Kabushiki Kaisha Automatic exposure control device using plural image plane detection areas
FR2638359A1 (fr) 1988-11-03 1990-05-04 Tino Dalto Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau
US5064413A (en) 1989-11-09 1991-11-12 Bioject, Inc. Needleless hypodermic injection device
US5312335A (en) 1989-11-09 1994-05-17 Bioject Inc. Needleless hypodermic injection device
US5190521A (en) 1990-08-22 1993-03-02 Tecnol Medical Products, Inc. Apparatus and method for raising a skin wheal and anesthetizing skin
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
GB9118204D0 (en) 1991-08-23 1991-10-09 Weston Terence E Needle-less injector
SE9102652D0 (sv) 1991-09-13 1991-09-13 Kabi Pharmacia Ab Injection needle arrangement
US5674865A (en) * 1991-10-18 1997-10-07 Genentech, Inc. Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa
US5328483A (en) 1992-02-27 1994-07-12 Jacoby Richard M Intradermal injection device with medication and needle guard
US5383851A (en) 1992-07-24 1995-01-24 Bioject Inc. Needleless hypodermic injection device
US5569189A (en) 1992-09-28 1996-10-29 Equidyne Systems, Inc. hypodermic jet injector
US5334144A (en) 1992-10-30 1994-08-02 Becton, Dickinson And Company Single use disposable needleless injector
TW279864B (enExample) * 1993-02-19 1996-07-01 Janssen Pharmaceutica Nv
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
EP0639573A1 (de) * 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament
WO1995024176A1 (en) 1994-03-07 1995-09-14 Bioject, Inc. Ampule filling device
US5466220A (en) 1994-03-08 1995-11-14 Bioject, Inc. Drug vial mixing and transfer device
US5599302A (en) 1995-01-09 1997-02-04 Medi-Ject Corporation Medical injection system and method, gas spring thereof and launching device using gas spring
US5730723A (en) 1995-10-10 1998-03-24 Visionary Medical Products Corporation, Inc. Gas pressured needle-less injection device and method
DE69635460T2 (de) 1995-06-26 2006-08-10 Chelator Llc, Concord Methode zur Hemmung des Wachstums von Bakterien oder Pilzen mit einem Komplexbildner
US5893397A (en) 1996-01-12 1999-04-13 Bioject Inc. Medication vial/syringe liquid-transfer apparatus
GB9607549D0 (en) 1996-04-11 1996-06-12 Weston Medical Ltd Spring-powered dispensing device
TW499412B (en) 1996-11-26 2002-08-21 Dimensional Pharm Inc Aminoguanidines and alkoxyguanidines as protease inhibitors
US6130231A (en) 1996-11-27 2000-10-10 Dupont Pharmaceuticals Integrin receptor antagonists
US5993412A (en) 1997-05-19 1999-11-30 Bioject, Inc. Injection apparatus
WO1999018053A1 (en) * 1997-10-02 1999-04-15 The University Of Western Ontario Preparation of radiolabelled haloaromatics via polymer-bound intermediates
IT1298087B1 (it) 1998-01-08 1999-12-20 Fiderm S R L Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni
AU3406599A (en) 1998-04-09 1999-11-01 Institut Fur Diagnostikforschung Gmbh An Der Freien Universitat Berlin Novel benzyl guanidine derivatives for therapy and (in-vivo) and (in-vitro) diagnosis
AU5671699A (en) 1998-08-14 2000-03-06 Smithkline Beecham Corporation Grp receptor ligands
HK1047694A1 (zh) 1998-12-18 2003-03-07 杜邦药品公司 玻连蛋白受体拮抗剂药物
US6656448B1 (en) 2000-02-15 2003-12-02 Bristol-Myers Squibb Pharma Company Matrix metalloproteinase inhibitors
GB0019357D0 (en) 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
DE10114561A1 (de) 2001-03-24 2002-09-26 Wella Ag Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern
US7344702B2 (en) 2004-02-13 2008-03-18 Bristol-Myers Squibb Pharma Company Contrast agents for myocardial perfusion imaging
AU2003263216A1 (en) 2002-08-17 2004-03-11 Nycomed Gmbh Benzonaphthyridines with PDE 3/4 inhibiting activity
AU2003298582A1 (en) 2002-09-17 2004-05-13 Isis Pharmaceuticals, Inc. Therapeutic guanidines
EP1641493A4 (en) * 2003-06-30 2007-10-31 Merck & Co Inc RADIOACTIVELY MARKED CANNABINOID-1 RECEPTOR MODULATORS
CN101137326B (zh) * 2003-12-01 2010-10-20 医疗物理有限公司 肾上腺素能成像剂和肾上腺素能干扰剂的应用及相关试剂盒
WO2005095345A2 (en) * 2004-03-23 2005-10-13 Achillion Pharmaceuticals, Inc. Heteroaryl guanidines as inhibitors of viral replication
JP4842123B2 (ja) 2004-05-28 2011-12-21 浜松ホトニクス株式会社 放射性チロシン誘導体、その製造方法、放射性チロシン誘導体からなるポジトロンイメージング用標識剤及び腫瘍の悪性度評価薬剤並びに腫瘍の検出方法
JP2008513533A (ja) 2004-09-23 2008-05-01 ゲルベ Ｃｅｓｔイメージング用の造影剤封入システム
US20060083681A1 (en) 2004-10-18 2006-04-20 Ajay Purohit Compounds for myocardial perfusion imaging
US7534418B2 (en) * 2004-12-10 2009-05-19 The Regents Of The University Of Michigan Imaging agents
GB0512770D0 (en) 2005-06-23 2005-07-27 Hammersmith Imanet Ltd Imaging compounds
JP2010513238A (ja) 2006-12-13 2010-04-30 エフ．ホフマン−ラ ロシュ アーゲー 微量アミン関連受容体（ｔａａｒ）に対するリガンドとしての新規２−イミダゾール
GB0625523D0 (en) 2006-12-21 2007-01-31 Ge Healthcare Ltd In vivo imaging agents
JP5656408B2 (ja) 2006-12-26 2015-01-21 ランセウス メディカル イメージング， インコーポレイテッド 心臓の神経支配を画像化するためのリガンド
WO2008082305A1 (en) 2006-12-28 2008-07-10 Raufoss Technology As Control arm
WO2008115593A1 (en) 2007-03-21 2008-09-25 The University Of Montana 1-[(2'-substituted)-piperazin-1'-yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents
RU2528340C2 (ru) 2007-10-18 2014-09-10 Бёрингер Ингельхайм Интернациональ Гмбх ПОЛУЧЕНИЕ ДИГИДРОТИЕНО[3,2-d]ПИРИМИДИНОВ И ПРОМЕЖУТОЧНЫХ ПРОДУКТОВ, ПРИМЕНЯЮЩИХСЯ ДЛЯ ИХ СИНТЕЗА
WO2010015340A1 (en) 2008-08-06 2010-02-11 Bayer Schering Pharma Aktiengesellschaft Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment
GB0906274D0 (en) 2009-04-09 2009-05-20 Ge Healthcare Ltd Imaging the central nervous system
US9687571B2 (en) 2009-04-15 2017-06-27 Lantheus Medical Imaging, Inc. Stabilization of radiopharmaceutical compositions using ascorbic acid
CN101555232B (zh) 2009-05-21 2011-01-05 北京师范大学 氟-18标记哒嗪酮类化合物及制备方法和应用
WO2011005322A2 (en) 2009-07-08 2011-01-13 Lantheus Medical Imaging, Inc. N-alkoxyamide conjugates as imaging agents
CN102858752B (zh) 2010-02-08 2018-10-16 兰休斯医疗成像公司 用于合成显像剂和其中间体的方法和装置
RU2710736C2 (ru) 2010-05-11 2020-01-10 Лантеус Медикал Имэджинг, Инк. Композиции, способы и системы для синтеза и применение визуализирующих средств
KR102527562B1 (ko) 2011-09-09 2023-05-03 랜티우스 메디컬 이메징, 인크. 영상화제의 합성 및 사용을 위한 조성물, 방법 및 시스템
EP2671575A1 (en) 2012-06-04 2013-12-11 Universität Regensburg Ras inhibitors
JP2017131851A (ja) 2016-01-29 2017-08-03 日本特殊陶業株式会社 マイクロ波加熱用触媒材料、マイクロ波加熱用触媒体、及び、その製造方法

Similar Documents

Publication Publication Date Title
JP2010514786A5 (enExample)
RU2468029C2 (ru) Ингибиторы hcv ns3 протеазы
RU2325381C2 (ru) Замещенные гетероциклические производные и их применение
JP2005522480A5 (enExample)
JP2012505871A5 (enExample)
JP2004525117A5 (enExample)
JP2003519676A5 (enExample)
JP2012502048A5 (enExample)
JP2002543185A5 (enExample)
JP2005539088A5 (enExample)
JP2007504171A5 (enExample)
JP2009526034A5 (enExample)
RU2001104339A (ru) Производные тиобензимидазола
JP2009535307A5 (enExample)
JP2011137006A5 (enExample)
JP2013528180A5 (enExample)
JP2007501859A5 (enExample)
JP2010513441A5 (enExample)
JP2004530641A5 (enExample)
JP2010527913A5 (enExample)
JP2008533191A5 (enExample)
JP2009535358A5 (enExample)
JP2010510171A5 (enExample)
JP2008505157A5 (enExample)
JP2007534702A5 (enExample)