CO6231002A2 - Compuestos utiles como ligandos para tomar imagenes de inervacion cardiaca - Google Patents
Compuestos utiles como ligandos para tomar imagenes de inervacion cardiacaInfo
- Publication number
- CO6231002A2 CO6231002A2 CO09076173A CO09076173A CO6231002A2 CO 6231002 A2 CO6231002 A2 CO 6231002A2 CO 09076173 A CO09076173 A CO 09076173A CO 09076173 A CO09076173 A CO 09076173A CO 6231002 A2 CO6231002 A2 CO 6231002A2
- Authority
- CO
- Colombia
- Prior art keywords
- group
- aryl
- alkyl
- compound
- heteroaryl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 230000000747 cardiac effect Effects 0.000 title 1
- 125000003118 aryl group Chemical group 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- -1 OR3 Inorganic materials 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000002877 alkyl aryl group Chemical group 0.000 abstract 2
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000520 N-substituted aminocarbonyl group Chemical group [*]NC(=O)* 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- VUWZPRWSIVNGKG-UHFFFAOYSA-N fluoromethane Chemical compound F[CH2] VUWZPRWSIVNGKG-UHFFFAOYSA-N 0.000 abstract 1
- 125000000524 functional group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004001 thioalkyl group Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0453—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/56—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups
- C07C215/58—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
- C07C215/60—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by hydroxy groups with hydroxy groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain the chain having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/64—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms
- C07C217/66—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain
- C07C217/70—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains further substituted by singly-bound oxygen atoms with singly-bound oxygen atoms and six-membered aromatic rings bound to the same carbon atom of the carbon chain linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/06—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/08—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nuclear Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87721106P | 2006-12-26 | 2006-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CO6231002A2 true CO6231002A2 (es) | 2010-12-20 |
Family
ID=39307501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CO09076173A CO6231002A2 (es) | 2006-12-26 | 2009-07-22 | Compuestos utiles como ligandos para tomar imagenes de inervacion cardiaca |
Country Status (20)
| Country | Link |
|---|---|
| US (5) | US8491868B2 (enExample) |
| EP (5) | EP2474526A3 (enExample) |
| JP (3) | JP5656408B2 (enExample) |
| KR (4) | KR101810348B1 (enExample) |
| CN (3) | CN105622463B (enExample) |
| AU (1) | AU2007339954B2 (enExample) |
| BR (1) | BRPI0722082A8 (enExample) |
| CA (2) | CA2673853C (enExample) |
| CO (1) | CO6231002A2 (enExample) |
| DK (3) | DK2114873T3 (enExample) |
| ES (3) | ES2405655T3 (enExample) |
| IL (3) | IL199563A (enExample) |
| MX (2) | MX367292B (enExample) |
| PL (1) | PL2114873T3 (enExample) |
| PT (1) | PT2114873E (enExample) |
| RU (1) | RU2506256C2 (enExample) |
| SG (1) | SG177918A1 (enExample) |
| TW (2) | TWI549692B (enExample) |
| WO (1) | WO2008083056A2 (enExample) |
| ZA (1) | ZA200904828B (enExample) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| ES2405655T3 (es) | 2006-12-26 | 2013-05-31 | Lantheus Medical Imaging, Inc. | N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca |
| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| PL2902030T3 (pl) | 2010-05-14 | 2017-07-31 | Dana-Farber Cancer Institute, Inc. | Związki tienotriazolodiazepinowe do leczenia nowotworu |
| MX354217B (es) | 2010-05-14 | 2018-02-19 | Dana Farber Cancer Inst Inc | Composiciones y metodos para el tratamiento de leucemia. |
| EP2571875A4 (en) | 2010-05-14 | 2013-10-30 | Dana Farber Cancer Inst Inc | CONTRACEPTIVE COMPOSITIONS FOR MEN AND METHODS OF USE THEREOF |
| AR086113A1 (es) | 2011-04-30 | 2013-11-20 | Abbott Lab | Isoxazolinas como agentes terapeuticos |
| CN108484449A (zh) * | 2011-09-09 | 2018-09-04 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
| PT2836241T (pt) | 2012-04-10 | 2019-05-30 | Lantheus Medical Imaging Inc | Métodos de síntese de radiofármacos |
| AU2013203000B9 (en) | 2012-08-10 | 2017-02-02 | Lantheus Medical Imaging, Inc. | Compositions, methods, and systems for the synthesis and use of imaging agents |
| WO2014052454A1 (en) | 2012-09-25 | 2014-04-03 | The Regents Of The University Of Michigan | Imaging agents |
| US10939822B2 (en) * | 2013-01-24 | 2021-03-09 | Tylerton International Holdings Inc. | Body structure imaging |
| EP2948188B1 (en) | 2013-01-24 | 2021-09-08 | Tylerton International Holdings Inc. | Neuronal imaging and treatment |
| JP2016513526A (ja) * | 2013-03-11 | 2016-05-16 | タイラートン インターナショナル ホールディングス インコーポレイテッドＴｙｌｅｒｔｏｎ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｈｏｌｄｉｎｇｓ Ｉｎｃ． | 自律神経系モデリング及びその使用 |
| US9975896B2 (en) | 2013-07-25 | 2018-05-22 | Dana-Farber Cancer Institute, Inc. | Inhibitors of transcription factors and uses thereof |
| WO2015033317A2 (en) * | 2013-09-08 | 2015-03-12 | Shlomo Ben-Haim | Detection of reduced-control cardiac zones |
| RU2016122654A (ru) | 2013-11-08 | 2017-12-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Комбинированная терапия злокачественной опухоли с использованием ингибиторов бромодоменового и экстратерминального (вет) белка |
| CN106102583B (zh) | 2014-01-10 | 2024-08-09 | 泰勒顿国际控股公司 | 瘢痕和纤维心脏区的检测 |
| EP3099677A4 (en) | 2014-01-31 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | Diaminopyrimidine benzenesulfone derivatives and uses thereof |
| US10793571B2 (en) | 2014-01-31 | 2020-10-06 | Dana-Farber Cancer Institute, Inc. | Uses of diazepane derivatives |
| JP2017506666A (ja) | 2014-02-28 | 2017-03-09 | テンシャ セラピューティクス，インコーポレイテッド | 高インスリン血症に関連した症状の処置 |
| EP3174466B1 (en) | 2014-07-30 | 2020-06-17 | Navix International Limited | Probe localization |
| CN106715437A (zh) | 2014-08-08 | 2017-05-24 | 达纳-法伯癌症研究所股份有限公司 | 二氮杂环庚烷衍生物及其用途 |
| CN106793775B (zh) | 2014-08-08 | 2020-06-02 | 达纳-法伯癌症研究所股份有限公司 | 二氢碟啶酮衍生物及其用途 |
| WO2016201370A1 (en) | 2015-06-12 | 2016-12-15 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| RU2018112953A (ru) | 2015-09-11 | 2019-10-14 | Дана-Фарбер Кэнсер Инститьют, Инк. | Ацетамидтиенотриазолодиазепины и пути их применения |
| EP3347021A4 (en) | 2015-09-11 | 2019-07-24 | Dana-Farber Cancer Institute, Inc. | CYANOTHIENOTRIAZOLDIAZEPINE AND USES THEREOF |
| MX2018006499A (es) | 2015-11-25 | 2018-08-01 | Dana Farber Cancer Inst Inc | Inhibidores de bromodominio bivalentes y usos de los mismos. |
| CN107892651A (zh) * | 2017-11-29 | 2018-04-10 | 陕西慧康生物科技有限责任公司 | 一种合成dl‑盐酸麻黄碱的方法 |
| US20210379210A1 (en) * | 2018-10-15 | 2021-12-09 | Bristol-Myers Squibb Company | Radioligands for imaging the lpa1 receptor |
| EP3682906A1 (en) | 2019-01-17 | 2020-07-22 | Julius-Maximilians-Universität Würzburg | Compound targeting norepinephrine transporter |
| CN109748825B (zh) * | 2019-02-01 | 2022-02-18 | 原子高科股份有限公司 | 一种18f标记的胍甲基取代苯类似物及其应用 |
| KR102690858B1 (ko) | 2020-07-14 | 2024-08-02 | 한국과학기술원 | 이산화탄소와 개미산만으로 성장 가능한 재조합 미생물 및 상기 재조합 미생물을 이용하여 유용물질을 제조하는 방법 |
| WO2025244832A1 (en) * | 2024-05-21 | 2025-11-27 | Kong's Pharmaceutical Co. | Novel aminoguanidine derivatives, and compositions and methods thereof |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6012A (en) * | 1849-01-09 | Lithographing co | ||
| FR1010218A (fr) | 1949-02-10 | 1952-06-09 | American Cyanamid Co | Perfectionnements aux sels de guanidine |
| GB1215255A (en) | 1968-03-13 | 1970-12-09 | Pfizer & Co C | Halophenylalkylguanidine compounds |
| US4094881A (en) | 1976-03-10 | 1978-06-13 | Smithkline Corporation | Process for preparing triazolethiols |
| US4275074A (en) | 1979-03-09 | 1981-06-23 | Graham J. Dobbie | Catecholamine treatment of ocular hypertension |
| US4270537A (en) | 1979-11-19 | 1981-06-02 | Romaine Richard A | Automatic hypodermic syringe |
| US4258188A (en) * | 1980-02-04 | 1981-03-24 | American Home Products Corporation | 2-(1-Piperazinyl)-cycloheptimidazole derivatives |
| US4622217A (en) | 1984-04-27 | 1986-11-11 | The Regents Of The University Of Michigan | I-4-amino-3-iodobenzylguanidine as imaging and therapeutic agent |
| US4596556A (en) | 1985-03-25 | 1986-06-24 | Bioject, Inc. | Hypodermic injection apparatus |
| CA1283827C (en) | 1986-12-18 | 1991-05-07 | Giorgio Cirelli | Appliance for injection of liquid formulations |
| GB8704027D0 (en) | 1987-02-20 | 1987-03-25 | Owen Mumford Ltd | Syringe needle combination |
| AU1503888A (en) * | 1987-04-24 | 1988-10-27 | King Faisal Specialist Hospital & Research Centre | Method of producing iodine124 and meta-iodobenzlyguanidine containing iodine124 |
| US4790824A (en) | 1987-06-19 | 1988-12-13 | Bioject, Inc. | Non-invasive hypodermic injection device |
| US4941880A (en) | 1987-06-19 | 1990-07-17 | Bioject, Inc. | Pre-filled ampule and non-invasive hypodermic injection device assembly |
| US4940460A (en) | 1987-06-19 | 1990-07-10 | Bioject, Inc. | Patient-fillable and non-invasive hypodermic injection device assembly |
| US5339163A (en) | 1988-03-16 | 1994-08-16 | Canon Kabushiki Kaisha | Automatic exposure control device using plural image plane detection areas |
| FR2638359A1 (fr) | 1988-11-03 | 1990-05-04 | Tino Dalto | Guide de seringue avec reglage de la profondeur de penetration de l'aiguille dans la peau |
| US5064413A (en) | 1989-11-09 | 1991-11-12 | Bioject, Inc. | Needleless hypodermic injection device |
| US5312335A (en) | 1989-11-09 | 1994-05-17 | Bioject Inc. | Needleless hypodermic injection device |
| US5190521A (en) | 1990-08-22 | 1993-03-02 | Tecnol Medical Products, Inc. | Apparatus and method for raising a skin wheal and anesthetizing skin |
| US5527288A (en) | 1990-12-13 | 1996-06-18 | Elan Medical Technologies Limited | Intradermal drug delivery device and method for intradermal delivery of drugs |
| GB9118204D0 (en) | 1991-08-23 | 1991-10-09 | Weston Terence E | Needle-less injector |
| SE9102652D0 (sv) | 1991-09-13 | 1991-09-13 | Kabi Pharmacia Ab | Injection needle arrangement |
| US5674863A (en) * | 1991-10-18 | 1997-10-07 | Genentech, Inc. | Nonpeptidyl integrin inhibitors having specificity for the GPIIb IIIa receptor |
| US5328483A (en) | 1992-02-27 | 1994-07-12 | Jacoby Richard M | Intradermal injection device with medication and needle guard |
| US5383851A (en) | 1992-07-24 | 1995-01-24 | Bioject Inc. | Needleless hypodermic injection device |
| US5569189A (en) | 1992-09-28 | 1996-10-29 | Equidyne Systems, Inc. | hypodermic jet injector |
| US5334144A (en) | 1992-10-30 | 1994-08-02 | Becton, Dickinson And Company | Single use disposable needleless injector |
| TW279864B (enExample) * | 1993-02-19 | 1996-07-01 | Janssen Pharmaceutica Nv | |
| US5879657A (en) | 1993-03-30 | 1999-03-09 | The Dupont Merck Pharmaceutical Company | Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders |
| EP0639573A1 (de) * | 1993-08-03 | 1995-02-22 | Hoechst Aktiengesellschaft | Benzokondensierte 5-Ringheterocyclen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, ihre Verwendung als Diagnostikum, sowie sie enthaltendes Medikament |
| WO1995024176A1 (en) | 1994-03-07 | 1995-09-14 | Bioject, Inc. | Ampule filling device |
| US5466220A (en) | 1994-03-08 | 1995-11-14 | Bioject, Inc. | Drug vial mixing and transfer device |
| US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
| US5730723A (en) | 1995-10-10 | 1998-03-24 | Visionary Medical Products Corporation, Inc. | Gas pressured needle-less injection device and method |
| JP3356289B2 (ja) | 1995-06-26 | 2002-12-16 | コンキャット リミティド | 第一遷移系列元素に対してキレート化親和性および選択性のある化合物とその医療および診断への使用 |
| US5893397A (en) | 1996-01-12 | 1999-04-13 | Bioject Inc. | Medication vial/syringe liquid-transfer apparatus |
| GB9607549D0 (en) | 1996-04-11 | 1996-06-12 | Weston Medical Ltd | Spring-powered dispensing device |
| TW499412B (en) | 1996-11-26 | 2002-08-21 | Dimensional Pharm Inc | Aminoguanidines and alkoxyguanidines as protease inhibitors |
| IL129344A0 (en) | 1996-11-27 | 2000-02-17 | Du Pont Pharm Co | Novel integrin receptor antagonists |
| US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
| CA2345710C (en) * | 1997-10-02 | 2008-12-30 | The University Of Western Ontario | Preparation of radiolabelled haloaromatics via polymer-bound intermediates |
| IT1298087B1 (it) | 1998-01-08 | 1999-12-20 | Fiderm S R L | Dispositivo per il controllo della profondita' di penetrazione di un ago, in particolare applicabile ad una siringa per iniezioni |
| WO1999052861A1 (de) | 1998-04-09 | 1999-10-21 | Institut für Diagnostikforschung GmbH an der Freien Universität Berlin | Neue benzylguanidinderivate für die therapie, in-vivo- und in-vitro-diagnostik |
| WO2000009115A1 (en) | 1998-08-14 | 2000-02-24 | Smithkline Beecham Corporation | Grp receptor ligands |
| EP1140204A2 (en) | 1998-12-18 | 2001-10-10 | Du Pont Pharmaceuticals Company | Vitronectin receptor antagonist pharmaceuticals |
| US6656448B1 (en) | 2000-02-15 | 2003-12-02 | Bristol-Myers Squibb Pharma Company | Matrix metalloproteinase inhibitors |
| GB0019357D0 (en) | 2000-08-07 | 2000-09-27 | Melacure Therapeutics Ab | Novel phenyl guanidines |
| DE10114561A1 (de) | 2001-03-24 | 2002-09-26 | Wella Ag | Verwendung von Mitteln enthaltend Kreatin, Kreatin und/oder deren Derivaten zur Verstärkung und Strukturverbesserung von keratinischen Fasern |
| US7344702B2 (en) | 2004-02-13 | 2008-03-18 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardial perfusion imaging |
| RS20050117A (sr) | 2002-08-17 | 2007-06-04 | Altana Pharma Ag., | Novi benzonaftiridini |
| WO2004037166A2 (en) | 2002-09-17 | 2004-05-06 | Isis Pharmaceuticals, Inc. | Therapeutic guanidines |
| JP2007527389A (ja) | 2003-06-30 | 2007-09-27 | メルク エンド カムパニー インコーポレーテッド | 放射性カンナビノイド−１受容体修飾因子 |
| AU2004294989B2 (en) | 2003-12-01 | 2009-03-19 | Ignasi Carrio | Novel differential imaging method |
| WO2005095345A2 (en) * | 2004-03-23 | 2005-10-13 | Achillion Pharmaceuticals, Inc. | Heteroaryl guanidines as inhibitors of viral replication |
| EP1749815B1 (en) | 2004-05-28 | 2017-06-21 | Hamamatsu Photonics K.K. | Radioactive tyrosine derivative, method for producing same, labeling agent for positron imaging and medical agent for assessing grade of malignancy of tumor respectively composed of radioactive tyrosine derivative, and method for detecting tumor |
| US20070292354A1 (en) | 2004-09-23 | 2007-12-20 | Guerbet | Contrast Agents Encapsulating Systems for Cest Imaging |
| US20060083681A1 (en) | 2004-10-18 | 2006-04-20 | Ajay Purohit | Compounds for myocardial perfusion imaging |
| US7534418B2 (en) | 2004-12-10 | 2009-05-19 | The Regents Of The University Of Michigan | Imaging agents |
| GB0512770D0 (en) | 2005-06-23 | 2005-07-27 | Hammersmith Imanet Ltd | Imaging compounds |
| CA2672617A1 (en) | 2006-12-13 | 2008-06-19 | F. Hoffmann-La Roche Ag | Novel 2-imidazoles as ligands for trace amine associated receptors (taar) |
| GB0625523D0 (en) | 2006-12-21 | 2007-01-31 | Ge Healthcare Ltd | In vivo imaging agents |
| ES2405655T3 (es) | 2006-12-26 | 2013-05-31 | Lantheus Medical Imaging, Inc. | N-[3-bromo-4-(3-[18F]fluoropropoxi)-bencil]-guanidina para la formación de imágenes de la inervación cardíaca |
| WO2008082305A1 (en) | 2006-12-28 | 2008-07-10 | Raufoss Technology As | Control arm |
| WO2008115593A1 (en) | 2007-03-21 | 2008-09-25 | The University Of Montana | 1-[(2'-substituted)-piperazin-1'-yl]-isoquinolines as norepinephrine transporter inhibitor therapeutics and positron emission tomography imaging agents |
| CA2702500A1 (en) | 2007-10-18 | 2009-04-23 | Boehringer Ingelheim International Gmbh | Preparation of dihydrothieno [3, 2-d] pyrimidines and intermediates used therein |
| WO2010015340A1 (en) | 2008-08-06 | 2010-02-11 | Bayer Schering Pharma Aktiengesellschaft | Daa-pyridine as peripheral benzodiazepine receptor ligand for diagnostic imaging and pharmaceutical treatment |
| GB0906274D0 (en) | 2009-04-09 | 2009-05-20 | Ge Healthcare Ltd | Imaging the central nervous system |
| KR20160030589A (ko) | 2009-04-15 | 2016-03-18 | 랜티우스 메디컬 이메징, 인크. | 아스코르브산을 사용한 방사성 약제 조성물의 안정화 |
| CN101555232B (zh) | 2009-05-21 | 2011-01-05 | 北京师范大学 | 氟-18标记哒嗪酮类化合物及制备方法和应用 |
| WO2011005322A2 (en) | 2009-07-08 | 2011-01-13 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| DK3323810T3 (da) | 2010-02-08 | 2022-03-28 | Lantheus Medical Imaging Inc | Automatiseret reaktionssystem, kassette og indretning til syntese af billeddannelsesmidler |
| ES2763815T3 (es) | 2010-05-11 | 2020-06-01 | Lantheus Medical Imaging Inc | Composiciones, métodos y sistemas para la síntesis y uso de agentes de formación de imágenes |
| CN108484449A (zh) | 2011-09-09 | 2018-09-04 | 蓝瑟斯医学影像公司 | 用于合成和使用显像剂的组合物、方法和系统 |
| EP2671575A1 (en) | 2012-06-04 | 2013-12-11 | Universität Regensburg | Ras inhibitors |
| JP2017131851A (ja) | 2016-01-29 | 2017-08-03 | 日本特殊陶業株式会社 | マイクロ波加熱用触媒材料、マイクロ波加熱用触媒体、及び、その製造方法 |
-
2007
- 2007-12-21 ES ES07869717T patent/ES2405655T3/es active Active
- 2007-12-21 CN CN201510856954.7A patent/CN105622463B/zh not_active Expired - Fee Related
- 2007-12-21 TW TW096149600A patent/TWI549692B/zh not_active IP Right Cessation
- 2007-12-21 MX MX2014010520A patent/MX367292B/es unknown
- 2007-12-21 EP EP12152818A patent/EP2474526A3/en not_active Withdrawn
- 2007-12-21 KR KR1020167010430A patent/KR101810348B1/ko not_active Expired - Fee Related
- 2007-12-21 US US12/448,575 patent/US8491868B2/en active Active
- 2007-12-21 DK DK07869717.4T patent/DK2114873T3/da active
- 2007-12-21 AU AU2007339954A patent/AU2007339954B2/en active Active
- 2007-12-21 CN CN201910053427.0A patent/CN110003079A/zh active Pending
- 2007-12-21 CN CN200780051773.0A patent/CN101687780B/zh not_active Expired - Fee Related
- 2007-12-21 BR BRPI0722082A patent/BRPI0722082A8/pt not_active Application Discontinuation
- 2007-12-21 RU RU2009128591/04A patent/RU2506256C2/ru active
- 2007-12-21 KR KR1020177024416A patent/KR20170102580A/ko not_active Ceased
- 2007-12-21 KR KR1020147032350A patent/KR20140140134A/ko not_active Ceased
- 2007-12-21 TW TW105113601A patent/TWI618544B/zh not_active IP Right Cessation
- 2007-12-21 EP EP12152816A patent/EP2474524A3/en active Pending
- 2007-12-21 DK DK12152817.8T patent/DK2474525T3/da active
- 2007-12-21 CA CA2673853A patent/CA2673853C/en active Active
- 2007-12-21 ES ES12152815T patent/ES2804801T3/es active Active
- 2007-12-21 EP EP12152815.2A patent/EP2474523B1/en active Active
- 2007-12-21 EP EP07869717A patent/EP2114873B1/en active Active
- 2007-12-21 WO PCT/US2007/088500 patent/WO2008083056A2/en not_active Ceased
- 2007-12-21 EP EP12152817.8A patent/EP2474525B1/en active Active
- 2007-12-21 DK DK12152815.2T patent/DK2474523T3/da active
- 2007-12-21 PL PL07869717T patent/PL2114873T3/pl unknown
- 2007-12-21 ES ES12152817T patent/ES2805286T3/es active Active
- 2007-12-21 KR KR1020097015613A patent/KR101718160B1/ko not_active Expired - Fee Related
- 2007-12-21 MX MX2009007018A patent/MX2009007018A/es active IP Right Grant
- 2007-12-21 SG SG2011095601A patent/SG177918A1/en unknown
- 2007-12-21 CA CA2984226A patent/CA2984226C/en active Active
- 2007-12-21 PT PT78697174T patent/PT2114873E/pt unknown
- 2007-12-21 JP JP2009544215A patent/JP5656408B2/ja active Active
-
2009
- 2009-06-25 IL IL199563A patent/IL199563A/en active IP Right Grant
- 2009-07-09 ZA ZA2009/04828A patent/ZA200904828B/en unknown
- 2009-07-22 CO CO09076173A patent/CO6231002A2/es active IP Right Grant
-
2013
- 2013-01-24 IL IL224396A patent/IL224396B/en active IP Right Grant
- 2013-06-12 US US13/916,205 patent/US10010631B2/en active Active
-
2014
- 2014-07-25 JP JP2014152244A patent/JP6021860B2/ja active Active
-
2016
- 2016-04-21 JP JP2016085372A patent/JP2016183164A/ja active Pending
-
2017
- 2017-08-07 IL IL253885A patent/IL253885A0/en unknown
-
2018
- 2018-05-22 US US15/986,680 patent/US11241509B2/en active Active
-
2022
- 2022-01-28 US US17/587,454 patent/US12324845B2/en active Active
-
2025
- 2025-01-17 US US19/027,961 patent/US20250161500A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CO6231002A2 (es) | Compuestos utiles como ligandos para tomar imagenes de inervacion cardiaca | |
| AR056327A1 (es) | Compuestos de nucleosidos para el tratamiento de infecciones virales | |
| CO6300861A2 (es) | Compuestos inhibidores de dipeptidil peptidasa iv metodos de preparacion de los mismos y composiciones farmaceuticas que los contienen como agentes activos | |
| EA200970510A1 (ru) | Гетеромоноциклическое соединение и его применение | |
| ES2422204T3 (es) | Novedosos derivados de imidazolidin-2-ona como moduladores selectivos de receptor de andrógenos (SARMS) | |
| AR044519A1 (es) | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina | |
| PE20130155A1 (es) | Derivados de ariletinilo | |
| AR083743A1 (es) | Composiciones plaguicidas y procesos relacionados con dichas composiciones | |
| MX368721B (es) | Moduladores de ror gamma (rory). | |
| AR068538A1 (es) | Compuesto heterociclico de 5 miembros con actividad supresora de la secrecion de acido | |
| CU20180011A7 (es) | Composiciones farmacéuticas que comprenden compuestos derivados de diaminopirido (3,2-d) como moduladores de receptor de tipo toll | |
| MX2015017715A (es) | Composiciones con efecto inhibidor de ureasa mejorado que comprende triamida de acido (tio)fosforico y compuestos adicionales. | |
| EA200970478A1 (ru) | Аналоги тиофена для лечения или предупреждения флавивирусных инфекций | |
| AR079226A1 (es) | Espiroindolinona- pirrolidinas, procesos de preparacion y uso de los mismos para el tratamiento y profilaxis del cancer | |
| ECSP12011756A (es) | Nuevos maitansinoides y el uso de dichos maitansinoides | |
| AR082029A1 (es) | Derivados de heterociclos nitrogenados, composiciones y metodos para modular la via de señalizacion de wnt | |
| AR066691A1 (es) | Compuestos espiro heterociclicos derivados de imidazol. composiciones farmaceuticas. | |
| AR065795A1 (es) | Derivados de aza-piridopirimidinona,metodo de preparacion,medicamentos que los contienen y usos como agentes antitromboticos, antihiperlipidemicos y antidiabeticos,entre otros. | |
| NZ605010A (en) | Novel calcium salts of compound as anti-inflammatory, immunomodulatory and anti-proliferatory agents | |
| ATE557004T1 (de) | 1h-benzoägüindol- verbindungen und sie enthaltende organische lumineszenzvorrichtung | |
| ES2626801T3 (es) | Compuestos de triazolopiridina como inhibidores de pde10a | |
| AR080185A1 (es) | Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv). | |
| CO2018010787A2 (es) | Compuesto de griseofulvina | |
| AR101255A1 (es) | Derivados de isoindolinona | |
| MX2013006811A (es) | Compuestos, composiciones y articulos fotocromaticos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Application granted |