AR080185A1 - Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv). - Google Patents

Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv).

Info

Publication number
AR080185A1
AR080185A1 ARP110100459A ARP110100459A AR080185A1 AR 080185 A1 AR080185 A1 AR 080185A1 AR P110100459 A ARP110100459 A AR P110100459A AR P110100459 A ARP110100459 A AR P110100459A AR 080185 A1 AR080185 A1 AR 080185A1
Authority
AR
Argentina
Prior art keywords
alkyl
optionally substituted
cycloalkyl
hydroxyl
halogen
Prior art date
Application number
ARP110100459A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of AR080185A1 publication Critical patent/AR080185A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/84—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic System
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring
    • C07F9/65517—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a five-membered ring condensed with carbocyclic rings or carbocyclic ring systems

Abstract

Reivindicacion 1: Un compuesto de la formula (1) en donde: R1 es uno o más sustituyentes independientemente seleccionados a partir del grupo que consiste en halogeno, alquilo C1-6, alcoxilo, -CN, -CF3, O-arilo C6-10 opcionalmente sustituido por halogeno, y -O-heteroarilo opcionalmente sustituido por halogeno; R2 es hidrogeno, hidroxilo, alquilo C1-6, o cicloalquilo C3-6, en donde alquilo C1-6, o cicloalquilo C3-6 puede estar opcionalmente sustituido con hidroxilo; R3 es alquilo C1-6, cicloalquilo C3-6 o alcoxilo C1-6; R4 es -S(O)2R5, P(O)(OR5)R5 o P(O)(OH)R5; R5 es alquilo C1-6, o cicloalquilo C3-6; X es alquileno C1-6 opcionalmente sustituido con alquilo C1-6, hidroxilo, amino, o cicloalquilo C3-6; R6 es: (a) heteroarilo sustituido con B(OR7)(OR8), y opcionalmente sustituido con uno o más sustituyentes seleccionados a partir del grupo que consiste en halogeno, alcoxilo C1-6, -CF3, alquilo C1-6, hidroxilo, SO2R5, SO2NH2, -CN, -OCF3, y cicloalquilo C3-6; o R7 y R8, junto con los átomos de oxígeno con los que están unidos, forman un anillo carbocíclico o heterocíclico de 5 a 8 miembros, el cual puede ser monocíclico o bicíclico, y opcionalmente sustituido con uno o más oxo o alquilo C1-6; o (b) arilo C6-10 sustituido con B(OR7)(OR8), y opcionalmente sustituido con uno o más sustituyentes seleccionados a partir del grupo que consiste en halogeno, alcoxilo C1-6, -CF3, alquilo C1-6, hidroxilo, SO2R5, SO2NH2, -CN, -OCF3, y cicloalquilo C3-6; o R7 y R8, junto con los átomos de oxígeno con los que están unidos, forman un anillo carbocíclico o heterocíclico de 5 a 8 miembros, el cual puede ser monocíclico o bicíclico, y opcionalmente sustituido con uno o más oxo o alquilo C1-6; R7 y R8 son hidrogeno o alquilo C1-6; o una sal farmacéuticamente aceptable del mismo.
ARP110100459A 2010-02-19 2011-02-15 Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv). AR080185A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US30599910P 2010-02-19 2010-02-19

Publications (1)

Publication Number Publication Date
AR080185A1 true AR080185A1 (es) 2012-03-21

Family

ID=44483255

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP110100459A AR080185A1 (es) 2010-02-19 2011-02-15 Derivados de acido boronico y benzofurano, composiciones farmaceuticas que los contienen,y uso de los mismos en el tratamiento y/o prevencion de infecciones virales, en particular por el virus de hepatitis c(hcv).

Country Status (3)

Country Link
AR (1) AR080185A1 (es)
TW (1) TW201138786A (es)
WO (1) WO2011103063A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324212B2 (en) 2010-02-25 2012-12-04 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
US8354410B2 (en) 2010-03-11 2013-01-15 Bristol-Meyers Squibb Company Compounds for the treatment of hepatitis C
US8445497B2 (en) 2010-06-30 2013-05-21 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
EP2632261B1 (en) 2010-10-26 2016-07-13 Presidio Pharmaceuticals, Inc. Inhibitors of hepatitis c virus
PE20141391A1 (es) * 2011-08-17 2014-10-29 Glaxosmithkline Llc Combinacion que comprende un compuesto con actividad antiviral y un agente terapeutico
CA2844086A1 (en) 2011-08-19 2013-02-28 Glaxo Group Limited Benzofuran compounds for the treatment of hepatitis c virus infections
WO2013033899A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Substituted benzofuran compounds and methods of use thereof for the treatment of viral diseases
WO2013033901A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases
WO2013033900A1 (en) 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Tetracyclic heterocycle compounds and methods of use thereof for the treatment of viral diseases
US9303020B2 (en) 2012-02-08 2016-04-05 Bristol-Myers Squibb Company Compounds for the treatment of hepatitis C
WO2014205592A1 (en) * 2013-06-24 2014-12-31 Merck Sharp & Dohme Corp. Heterocyclic compounds and methods of use thereof for treatment of hepatitis c
CN115010621B (zh) * 2022-07-21 2023-11-03 山东百启生物医药有限公司 一种4-溴-3-甲基苯甲腈的合成方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1196436A2 (en) * 1999-07-07 2002-04-17 Bristol-Myers Squibb Pharma Company Peptide boronic acid inhibitors of hepatitis c virus protease
EP1625154B1 (en) * 2003-05-09 2014-01-08 Boehringer Ingelheim International GmbH Hepatitis c virus ns5b polymerase inhibitor binding pocket
WO2009137500A1 (en) * 2008-05-05 2009-11-12 Wyeth 6-substituted benzofuran compounds to treat infection with hepatitis c virus

Also Published As

Publication number Publication date
WO2011103063A1 (en) 2011-08-25
TW201138786A (en) 2011-11-16

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