JP2003519676A5 - - Google Patents
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- Publication number
- JP2003519676A5 JP2003519676A5 JP2001551838A JP2001551838A JP2003519676A5 JP 2003519676 A5 JP2003519676 A5 JP 2003519676A5 JP 2001551838 A JP2001551838 A JP 2001551838A JP 2001551838 A JP2001551838 A JP 2001551838A JP 2003519676 A5 JP2003519676 A5 JP 2003519676A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- alkyl
- substituted
- unsubstituted
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 description 38
- 125000004404 heteroalkyl group Chemical group 0.000 description 33
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 32
- 150000001875 compounds Chemical class 0.000 description 27
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 24
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 description 20
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 20
- 125000001424 substituent group Chemical group 0.000 description 20
- 125000001072 heteroaryl group Chemical group 0.000 description 16
- 229910052736 halogen Inorganic materials 0.000 description 15
- 150000002367 halogens Chemical class 0.000 description 15
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 description 12
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 12
- 229910052739 hydrogen Inorganic materials 0.000 description 12
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 10
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 description 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 8
- 125000003118 aryl group Chemical group 0.000 description 8
- 125000004196 benzothienyl group Chemical group S1C(=CC2=C1C=CC=C2)* 0.000 description 8
- 125000004438 haloalkoxy group Chemical group 0.000 description 8
- 125000005842 heteroatom Chemical group 0.000 description 8
- 239000001257 hydrogen Substances 0.000 description 8
- 125000001041 indolyl group Chemical group 0.000 description 8
- 229910052757 nitrogen Inorganic materials 0.000 description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 description 8
- 125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 description 4
- 125000003785 benzimidazolyl group Chemical group N1=C(NC2=C1C=CC=C2)* 0.000 description 4
- 125000000499 benzofuranyl group Chemical group O1C(=CC2=C1C=CC=C2)* 0.000 description 4
- 125000001164 benzothiazolyl group Chemical group S1C(=NC2=C1C=CC=C2)* 0.000 description 4
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 description 4
- 125000002541 furyl group Chemical group 0.000 description 4
- 125000005647 linker group Chemical group 0.000 description 4
- 125000001624 naphthyl group Chemical group 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- -1 nitro, phenyl Chemical group 0.000 description 4
- 125000003226 pyrazolyl group Chemical group 0.000 description 4
- 125000000168 pyrrolyl group Chemical group 0.000 description 4
- 150000003839 salts Chemical class 0.000 description 4
- 125000001544 thienyl group Chemical group 0.000 description 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 description 3
- 125000004442 acylamino group Chemical group 0.000 description 2
- 125000003342 alkenyl group Chemical group 0.000 description 2
- 125000003545 alkoxy group Chemical group 0.000 description 2
- 125000003282 alkyl amino group Chemical group 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 125000000843 phenylene group Chemical group C1(=C(C=CC=C1)*)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17589200P | 2000-01-13 | 2000-01-13 | |
| US60/175,892 | 2000-01-13 | ||
| PCT/US2001/001219 WO2001051456A2 (en) | 2000-01-13 | 2001-01-12 | Antibacterial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2003519676A JP2003519676A (ja) | 2003-06-24 |
| JP2003519676A5 true JP2003519676A5 (enExample) | 2008-02-07 |
Family
ID=22642090
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001551838A Pending JP2003519676A (ja) | 2000-01-13 | 2001-01-12 | 抗菌剤 |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US6780858B2 (enExample) |
| EP (1) | EP1246795B1 (enExample) |
| JP (1) | JP2003519676A (enExample) |
| AT (1) | ATE376996T1 (enExample) |
| AU (1) | AU2001239725A1 (enExample) |
| CA (1) | CA2397575A1 (enExample) |
| DE (1) | DE60131138T2 (enExample) |
| ES (1) | ES2293980T3 (enExample) |
| WO (1) | WO2001051456A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6780858B2 (en) | 2000-01-13 | 2004-08-24 | Tularik Inc. | Antibacterial agents |
| DK1372674T3 (da) | 2001-03-08 | 2011-09-12 | Univ Pennsylvania | Facialt amphiphile polymerer som anti-infektive midler |
| MXPA04000224A (es) | 2001-07-10 | 2005-07-25 | 4Sc Ag | Novedosos compuestos como agentes antiinflamatorios, inmunomoduladores y antiproliferativos. |
| WO2003039529A1 (en) * | 2001-11-07 | 2003-05-15 | 4Sc A.G. | Selective antibacterial agents |
| US7338969B2 (en) | 2002-03-08 | 2008-03-04 | Quonova, Llc | Modulation of pathogenicity |
| US7335779B2 (en) | 2002-03-08 | 2008-02-26 | Quonova, Llc | Modulation of pathogenicity |
| CA2488202C (en) | 2002-06-12 | 2011-03-08 | Chemocentryx, Inc. | 1-aryl-4-substituted piperazine derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders |
| US7842693B2 (en) * | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
| US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
| US7589199B2 (en) * | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
| GB0215676D0 (en) | 2002-07-05 | 2002-08-14 | Novartis Ag | Organic compounds |
| US7476683B2 (en) * | 2002-08-27 | 2009-01-13 | Merck Patent Gmbh | Glycinamide derivatives as raf-kinase inhibitors |
| EP1562905A2 (en) * | 2002-10-24 | 2005-08-17 | MERCK PATENT GmbH | Methylene urea derivatives as raf-kinase inhibitors |
| US7078419B2 (en) | 2003-03-10 | 2006-07-18 | Boehringer Ingelheim Pharmaceuticals, Inc. | Cytokine inhibitors |
| JP2006521355A (ja) * | 2003-03-17 | 2006-09-21 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア・センター・フオー・テクノロジー・トランスフアー | 表面的に両親媒性のポリマー及びオリゴマーならびにそれらの使用 |
| WO2004089901A2 (en) * | 2003-03-31 | 2004-10-21 | Janssen Pharmaceutica N.V. | Phospholipase c inhibitors for use in treating inflammatory disorders |
| CA2536954C (en) * | 2003-08-29 | 2012-11-27 | Exelixis, Inc. | C-kit modulators and methods of use |
| US7932272B2 (en) | 2003-09-30 | 2011-04-26 | Eisai R&D Management Co., Ltd. | Antifungal agent containing heterocyclic compound |
| WO2005046683A1 (en) | 2003-10-07 | 2005-05-26 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| AU2005208771B2 (en) | 2004-01-23 | 2011-11-24 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polyaryl and polyarylalkynyl polymers and oligomers and uses thereof |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| JP4845873B2 (ja) * | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | 二環式および架橋した窒素複素環 |
| US7435831B2 (en) * | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
| US7250413B2 (en) | 2004-04-26 | 2007-07-31 | Cumbre Pharmaceuticals Inc. | C-25 carbamate rifamycin derivatives with activity against drug-resistant microbes |
| JP5089392B2 (ja) * | 2004-10-13 | 2012-12-05 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | キナーゼ阻害剤としての複素環式置換ビスアリール尿素誘導体 |
| ATE398616T1 (de) * | 2005-02-04 | 2008-07-15 | Ctg Pharma S R L | Neue 4-aminochinolinderivate als antimalariamittel |
| US7576099B2 (en) | 2005-02-28 | 2009-08-18 | Renovis, Inc. | Amide derivatives as ion-channel ligands and pharmaceutical compositions and methods of using the same |
| WO2006106711A1 (ja) | 2005-03-30 | 2006-10-12 | Eisai R & D Management Co., Ltd. | ピリジン誘導体を含有する抗真菌剤 |
| RS52711B (sr) | 2005-05-10 | 2013-08-30 | Incyte Corporation | Modulatori indolamin 2,3-dioksigenaze i postupci upotrebe istih |
| TWI385169B (zh) | 2005-10-31 | 2013-02-11 | Eisai R&D Man Co Ltd | 經雜環取代之吡啶衍生物及含有彼之抗真菌劑 |
| KR20080080176A (ko) * | 2005-12-13 | 2008-09-02 | 아르피다 아게 | 디페닐 유레아 유도체 |
| EP1971583B1 (en) | 2005-12-20 | 2015-03-25 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| NZ570014A (en) | 2006-02-03 | 2011-04-29 | Bionomics Ltd | Substituted benzofurans, benzothiophenes, benzoselenophenes and indoles and their use as tubulin polymerisation inhibitors |
| WO2007095050A2 (en) * | 2006-02-09 | 2007-08-23 | Incyte Corporation | N-hydroxyguanidines as modulators of indoleamine 2,3-dioxygenase |
| AU2007221207A1 (en) | 2006-02-28 | 2007-09-07 | Merck Sharp & Dohme Corp. | Inhibitors of histone deacetylase |
| WO2008036642A2 (en) | 2006-09-19 | 2008-03-27 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CL2007002650A1 (es) * | 2006-09-19 | 2008-02-08 | Incyte Corp | Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras. |
| US20080146624A1 (en) * | 2006-09-19 | 2008-06-19 | Incyte Corporation | Amidines as modulators of indoleamine 2,3-dioxygenase |
| WO2008058178A1 (en) * | 2006-11-08 | 2008-05-15 | Incyte Corporation | N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase |
| CA2680275C (en) | 2007-03-09 | 2016-08-23 | Renovis, Inc. | Bicycloheteroaryl compounds as p2x7 modulators and uses thereof |
| GB0718735D0 (en) * | 2007-09-25 | 2007-11-07 | Prolysis Ltd | Antibacterial agents |
| US8513287B2 (en) | 2007-12-27 | 2013-08-20 | Eisai R&D Management Co., Ltd. | Heterocyclic ring and phosphonoxymethyl group substituted pyridine derivatives and antifungal agent containing same |
| GB2461167B (en) * | 2008-06-24 | 2012-12-26 | Scynexis Inc | Novel amidoxime derivatives |
| PL2315756T3 (pl) | 2008-07-08 | 2015-02-27 | Incyte Holdings Corp | 1,2,5-oksadiazole jako inhibitory 2,3-dioksygenazy indoloaminy |
| WO2010077734A2 (en) * | 2008-12-09 | 2010-07-08 | Cytokine Pharmasciences, Inc. | Novel antiviral compounds, compositions, and methods of use |
| EP2385831A4 (en) * | 2009-01-09 | 2014-03-26 | Uab Research Foundation | SMALL MOLECULAR HEMMER OF NADS, NAMNAT AND NMNAT |
| US9162980B2 (en) | 2009-01-09 | 2015-10-20 | Board Of Regents Of The University Of Texas System | Anti-depression compounds |
| US9962368B2 (en) | 2009-01-09 | 2018-05-08 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102405043B (zh) * | 2009-01-09 | 2017-08-22 | 得克萨斯州大学系统董事会 | 前神经原性化合物 |
| US8362277B2 (en) | 2009-01-09 | 2013-01-29 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102803225A (zh) | 2009-04-30 | 2012-11-28 | 诺瓦提斯公司 | 咪唑衍生物和它们作为细胞周期蛋白依赖性激酶调节剂的应用 |
| WO2012006419A2 (en) | 2010-07-07 | 2012-01-12 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CA2860808A1 (en) * | 2012-01-10 | 2013-07-18 | Henry Yu | Benzamide derivatives as modulators of the follicle stimulating hormone |
| WO2014031986A1 (en) | 2012-08-24 | 2014-02-27 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| ES2728260T3 (es) * | 2012-11-21 | 2019-10-23 | Nippon Soda Co | Material de impresión producido utilizando un compuesto no fenólico |
| TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效ｒｏｃｋ１及ｒｏｃｋ２抑制劑之苯基吡唑衍生物 |
| EP2961746B1 (en) | 2013-02-28 | 2018-01-03 | Bristol-Myers Squibb Company | Phenylpyrazole derivatives as potent rock1 and rock2 inhibitors |
| KR102617531B1 (ko) | 2013-11-08 | 2023-12-27 | 인사이트 홀딩스 코포레이션 | 인돌아민 2,3-디옥시게나제 억제제의 합성 방법 |
| WO2015070234A2 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective compounds and use thereof |
| WO2015070237A1 (en) | 2013-11-11 | 2015-05-14 | Board Of Regents Of The University Of Texas System | Neuroprotective chemicals and methods for identifying and using same |
| CN104725276B (zh) * | 2013-12-18 | 2017-05-10 | 浙江省化工研究院有限公司 | 一种含七氟异丙基的羰基肟醚类化合物、其制备方法及应用 |
| CN116761603A (zh) * | 2021-02-06 | 2023-09-15 | 正大天晴药业集团股份有限公司 | 含有苯并杂环的作为egfr激酶抑制剂的大环化合物、其药物组合物和用途 |
| JP7728367B2 (ja) | 2021-06-14 | 2025-08-22 | スコーピオン・セラピューティクス・インコーポレイテッド | がんを処置するために使用され得る尿素誘導体 |
| CN114773250A (zh) * | 2021-08-02 | 2022-07-22 | 湖南大学 | 具有抗耐药性的抗菌脒类低聚物及其制作方法和用途 |
| EP4660184A1 (en) * | 2023-01-30 | 2025-12-10 | Eurofarma Laboratórios S.A. | Nav1.7- and/or nav1.8-inhibiting hydroxamates, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits |
| AR131715A1 (es) * | 2023-01-30 | 2025-04-23 | Eurofarma Laboratorios S A | AMIDAS BLOQUEADORAS DE Nav 1.7 Y/O Nav 1.8, SUS PROCESOS DE OBTENCIÓN, COMPOSICIONES, USOS, MÉTODOS DE TRATAMIENTO DE LOS MISMOS Y KITS |
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|---|---|---|---|---|
| US3347874A (en) * | 1963-01-09 | 1967-10-17 | Union Carbide Corp | 5-nitrofuryl-2-amidoximes |
| JPS49124204A (enExample) * | 1973-04-02 | 1974-11-28 | ||
| DE2623228C3 (de) * | 1976-05-24 | 1981-09-10 | Ludwig Merckle Kg Chem. Pharm. Fabrik, 7902 Blaubeuren | N-Acyl-substituierte Benzamide, Verfahren zu ihrer Herstellung und Arzneimittel, enthaltend solche Benzamide |
| DE2801509A1 (de) * | 1978-01-12 | 1979-07-19 | Schering Ag | 1,2,4-oxadiazolderivate, verfahren zur herstellung dieser verbindungen sowie diese enthaltende selektive herbizide mittel |
| JPS6434954A (en) * | 1987-02-18 | 1989-02-06 | Hokko Chem Ind Co | Benzenecarboximidamide derivative and agricultural and horticultural fungicide |
| JPS63316703A (ja) * | 1987-06-19 | 1988-12-26 | Hokko Chem Ind Co Ltd | 薬害軽減作用を有する農園芸用殺菌・除草剤 |
| JPS6413071A (en) * | 1987-07-07 | 1989-01-17 | Fuji Photo Film Co Ltd | Production of 3-alkoxy-5-amino-1h-pyrazoles |
| JPH01215994A (ja) * | 1988-02-24 | 1989-08-29 | Hokko Chem Ind Co Ltd | 電解反応によるベンゼンカルボキシイミダミド誘導体の製造方法 |
| JPH07122744B2 (ja) * | 1988-12-15 | 1995-12-25 | 富士写真フイルム株式会社 | マゼンタ色素形成カプラーおよびカラー画像形成方法 |
| JPH02201358A (ja) * | 1989-01-30 | 1990-08-09 | Konica Corp | 新規なシアンカプラーを含有するハロゲン化銀カラー写真感光材料 |
| JPH03148267A (ja) * | 1989-11-01 | 1991-06-25 | Hokko Chem Ind Co Ltd | １，２，４―オキサジアジン―５―オン誘導体および農園芸用殺菌剤 |
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| JP4401025B2 (ja) * | 1998-07-01 | 2010-01-20 | ザ・トラスティーズ・オブ・ザ・ユニバーシティ・オブ・ペンシルバニア | 分子間相互作用の腔誘導アロステリック修飾および同一の効果を持つ化合物の同定方法 |
| SK3842001A3 (en) * | 1998-09-18 | 2002-04-04 | Basf Ag | Pyrrolopyrimidines as protein kinase inhibitors (revised) |
| CN1337941A (zh) * | 1998-12-22 | 2002-02-27 | 三菱化学株式会社 | 酰胺衍生物 |
| US6780858B2 (en) * | 2000-01-13 | 2004-08-24 | Tularik Inc. | Antibacterial agents |
-
2001
- 2001-01-12 US US09/759,633 patent/US6780858B2/en not_active Expired - Fee Related
- 2001-01-12 DE DE60131138T patent/DE60131138T2/de not_active Expired - Fee Related
- 2001-01-12 ES ES01914329T patent/ES2293980T3/es not_active Expired - Lifetime
- 2001-01-12 WO PCT/US2001/001219 patent/WO2001051456A2/en not_active Ceased
- 2001-01-12 CA CA002397575A patent/CA2397575A1/en not_active Abandoned
- 2001-01-12 AT AT01914329T patent/ATE376996T1/de not_active IP Right Cessation
- 2001-01-12 JP JP2001551838A patent/JP2003519676A/ja active Pending
- 2001-01-12 AU AU2001239725A patent/AU2001239725A1/en not_active Abandoned
- 2001-01-12 EP EP01914329A patent/EP1246795B1/en not_active Expired - Lifetime
-
2004
- 2004-06-25 US US10/877,408 patent/US7053234B2/en not_active Expired - Fee Related
-
2006
- 2006-02-01 US US11/344,111 patent/US7148259B1/en not_active Expired - Fee Related