JP2002536329A5 - - Google Patents
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- Publication number
- JP2002536329A5 JP2002536329A5 JP2000596934A JP2000596934A JP2002536329A5 JP 2002536329 A5 JP2002536329 A5 JP 2002536329A5 JP 2000596934 A JP2000596934 A JP 2000596934A JP 2000596934 A JP2000596934 A JP 2000596934A JP 2002536329 A5 JP2002536329 A5 JP 2002536329A5
- Authority
- JP
- Japan
- Prior art keywords
- methylene
- phenylenebis
- bis
- linker
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 description 16
- 239000000203 mixture Substances 0.000 description 16
- 125000003118 aryl group Chemical group 0.000 description 14
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 12
- 125000005647 linker group Chemical group 0.000 description 10
- 125000004122 cyclic group Chemical group 0.000 description 8
- 125000004433 nitrogen atom Chemical group N* 0.000 description 8
- 150000003839 salts Chemical class 0.000 description 7
- 150000001875 compounds Chemical class 0.000 description 6
- 229910052757 nitrogen Inorganic materials 0.000 description 6
- 210000000265 leukocyte Anatomy 0.000 description 5
- 229920000768 polyamine Polymers 0.000 description 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 4
- AMNPXXIGUOKIPP-UHFFFAOYSA-N [4-(carbamothioylamino)phenyl]thiourea Chemical compound NC(=S)NC1=CC=C(NC(N)=S)C=C1 AMNPXXIGUOKIPP-UHFFFAOYSA-N 0.000 description 4
- 239000002253 acid Substances 0.000 description 4
- YIQPUIGJQJDJOS-UHFFFAOYSA-N plerixafor Chemical compound C=1C=C(CN2CCNCCCNCCNCCC2)C=CC=1CN1CCCNCCNCCCNCC1 YIQPUIGJQJDJOS-UHFFFAOYSA-N 0.000 description 4
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 description 3
- 125000002947 alkylene group Chemical group 0.000 description 3
- -1 azo cyclotetradecane Chemical compound 0.000 description 3
- 125000004432 carbon atom Chemical group C* 0.000 description 3
- 125000001072 heteroaryl group Chemical group 0.000 description 3
- 125000005842 heteroatom Chemical group 0.000 description 3
- 125000000623 heterocyclic group Chemical group 0.000 description 3
- 125000000468 ketone group Chemical group 0.000 description 3
- 125000004430 oxygen atom Chemical group O* 0.000 description 3
- 229910052717 sulfur Inorganic materials 0.000 description 3
- 125000004434 sulfur atom Chemical group 0.000 description 3
- LXUJUJYVZSBOKU-UHFFFAOYSA-N 1,4,7-triazacyclotetradecane Chemical compound C1CCCNCCNCCNCCC1 LXUJUJYVZSBOKU-UHFFFAOYSA-N 0.000 description 2
- YUEOTDBNBGFZSZ-UHFFFAOYSA-N 1-[1-(1,4,8,11-tetrazacyclotetradec-1-yl)propan-2-yl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C1CCNCCNCCCNCCN1C(C)CN1CCCNCCNCCCNCC1 YUEOTDBNBGFZSZ-UHFFFAOYSA-N 0.000 description 2
- PXTXSIAYIFRMDE-UHFFFAOYSA-N 1-[[3-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCNCCNCCCC2)=CC=1CN1CCCCNCCNCCNCC1 PXTXSIAYIFRMDE-UHFFFAOYSA-N 0.000 description 2
- TWROELGOZKDRSL-UHFFFAOYSA-N 1-[[3-(1,4,8,11-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,8,11-tetrazacyclotetradecane Chemical compound C=1C=CC(CN2CCNCCCNCCNCCC2)=CC=1CN1CCCNCCNCCCNCC1 TWROELGOZKDRSL-UHFFFAOYSA-N 0.000 description 2
- BNXRQMCWXHZHTF-UHFFFAOYSA-N 1-[[4-(1,4,7,10-tetrazacyclotetradec-1-ylmethyl)phenyl]methyl]-1,4,7,10-tetrazacyclotetradecane Chemical compound C=1C=C(CN2CCNCCNCCNCCCC2)C=CC=1CN1CCCCNCCNCCNCC1 BNXRQMCWXHZHTF-UHFFFAOYSA-N 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical group Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229960002169 plerixafor Drugs 0.000 description 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 2
- 208000032467 Aplastic anaemia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 238000002512 chemotherapy Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 208000032839 leukemia Diseases 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000001959 radiotherapy Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 238000002054 transplantation Methods 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11825599P | 1999-02-02 | 1999-02-02 | |
| US60/118,255 | 1999-02-02 | ||
| PCT/CA2000/000104 WO2000045814A1 (en) | 1999-02-02 | 2000-02-02 | Methods and compositions to enhance white blood cell count |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011023235A Division JP2011088937A (ja) | 1999-02-02 | 2011-02-04 | 白血球数を高めるための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002536329A JP2002536329A (ja) | 2002-10-29 |
| JP2002536329A5 true JP2002536329A5 (enExample) | 2007-03-15 |
| JP4968868B2 JP4968868B2 (ja) | 2012-07-04 |
Family
ID=22377471
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000596934A Expired - Fee Related JP4968868B2 (ja) | 1999-02-02 | 2000-02-02 | 白血球数を高めるための方法および組成物 |
| JP2011023235A Withdrawn JP2011088937A (ja) | 1999-02-02 | 2011-02-04 | 白血球数を高めるための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011023235A Withdrawn JP2011088937A (ja) | 1999-02-02 | 2011-02-04 | 白血球数を高めるための方法および組成物 |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US6365583B1 (enExample) |
| EP (1) | EP1148875B1 (enExample) |
| JP (2) | JP4968868B2 (enExample) |
| KR (1) | KR100643553B1 (enExample) |
| CN (1) | CN1310642C (enExample) |
| AP (1) | AP1497A (enExample) |
| AT (1) | ATE268597T1 (enExample) |
| AU (2) | AU772979B2 (enExample) |
| BR (1) | BR0007924A (enExample) |
| CA (1) | CA2361587C (enExample) |
| CZ (1) | CZ20012698A3 (enExample) |
| DE (1) | DE60011391T2 (enExample) |
| DK (1) | DK1148875T3 (enExample) |
| ES (1) | ES2222174T3 (enExample) |
| HK (1) | HK1038319B (enExample) |
| HU (1) | HUP0200100A3 (enExample) |
| IL (1) | IL144400A (enExample) |
| MX (1) | MXPA01007801A (enExample) |
| NO (1) | NO20013770L (enExample) |
| NZ (1) | NZ513602A (enExample) |
| PT (1) | PT1148875E (enExample) |
| SI (1) | SI1148875T1 (enExample) |
| TR (1) | TR200102239T2 (enExample) |
| WO (1) | WO2000045814A1 (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| CN100335478C (zh) * | 1999-12-17 | 2007-09-05 | 阿诺麦德股份有限公司 | 结合趋化因子受体的杂环化合物 |
| US8435939B2 (en) | 2000-09-05 | 2013-05-07 | Biokine Therapeutics Ltd. | Polypeptide anti-HIV agent containing the same |
| DK1317451T3 (da) * | 2000-09-15 | 2006-12-18 | Anormed Inc | Kemokinreceptorbindende heterocykliske forbindelser |
| NZ524421A (en) * | 2000-09-15 | 2005-02-25 | Anormed Inc | Chemokine receptor binding heterocyclic compounds |
| EP1322626B1 (en) | 2000-09-29 | 2008-11-05 | Anormed Inc. | Process for preparation of n-1 protected n ring nitrogen containing cyclic polyamines and products thereof |
| US7169750B2 (en) * | 2001-07-31 | 2007-01-30 | Anormed, Inc. | Methods to mobilize progenitor/stem cells |
| EP2371361B1 (en) * | 2001-07-31 | 2019-08-07 | Genzyme Corporation | Methods to mobilize progenitor/stem cells |
| US6825351B2 (en) * | 2001-09-12 | 2004-11-30 | Anormed, Inc. | Synthesis of enantiomerically pure amino-substituted fused bicyclic rings |
| US7354932B2 (en) * | 2001-12-21 | 2008-04-08 | Anormed, Inc. | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| MXPA04006136A (es) * | 2001-12-21 | 2004-11-01 | Anormed Inc | Compuestos heterociclicos que se unen a receptor de quimiocina con eficacia incrementada. |
| EP1541585B1 (en) | 2002-08-27 | 2013-01-30 | Biokine Therapeutics Ltd. | Cxcr4 antagonist and use thereof |
| WO2004091518A2 (en) | 2003-04-11 | 2004-10-28 | Anormed Inc. | Cxcr4 chemokine receptor binding compounds |
| US7501518B2 (en) * | 2003-04-22 | 2009-03-10 | Genzyme Corporation | Methods of making 2,6-diaryl piperidine derivatives |
| EP2374804A1 (en) * | 2003-04-22 | 2011-10-12 | Genzyme Corporation | Chemokine receptor binding heterocyclic compounds with enhanced efficacy |
| EP1708703A4 (en) * | 2003-12-11 | 2008-04-09 | Anormed Inc | CHEMOKIN RECEPTOR BINDING COMPOUNDS |
| US7498346B2 (en) * | 2003-12-11 | 2009-03-03 | Genzyme Corporation | Chemokine receptor binding compounds |
| WO2006020891A2 (en) * | 2004-08-13 | 2006-02-23 | Anormed Inc. | Chemokine combinations to mobilize progenitor/stem cells |
| CA2612325A1 (en) * | 2005-06-15 | 2006-12-28 | Anormed Inc. | Chemokine receptor binding compounds |
| EP1924265A4 (en) * | 2005-08-16 | 2010-06-02 | Genzyme Corp | COMPOUNDS BINDING TO CHEMOKINE RECEPTORS |
| JP2009527552A (ja) * | 2006-02-24 | 2009-07-30 | ジェンザイム・コーポレーション | 血流の増加および組織再生の促進またはそのいずれかのための方法 |
| AR063470A1 (es) * | 2006-08-02 | 2009-01-28 | Genzyme Corp | Terapia combinada |
| AR062271A1 (es) * | 2006-08-07 | 2008-10-29 | Genzyme Corp | Uso de una cantidad efectiva de al menos un inhibidor de cxcr4, al menos un agonista de cxcr2 y g-csf para movilizar las celulas progenitoras y/o celulas madre |
| CA2673719C (en) * | 2006-12-21 | 2018-07-24 | Biokine Therapeutics Ltd. | T-140 peptide analogs having cxcr4 super-agonist activity for bone marrow recovery |
| EP2396023A2 (en) | 2009-02-11 | 2011-12-21 | Yeda Research and Development Co. Ltd. | Short beta-defensin-derived peptides |
| EP2442822B1 (en) | 2009-06-14 | 2014-03-05 | Biokine Therapeutics Ltd. | Peptide therapy for increasing platelet levels |
| CA2807552A1 (en) | 2010-08-06 | 2012-02-09 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| PL2709991T3 (pl) * | 2011-05-16 | 2021-04-06 | Genzyme Corporation | Zastosowanie antagonistów CXCR4 w leczeniu zespołu WHIM, mielokateksji, neutropenii i limfocytopenii |
| WO2013160895A1 (en) | 2012-04-24 | 2013-10-31 | Biokine Therapeutics Ltd. | Peptides and use thereof in the treatment of large cell lung cancer |
| CN116196426A (zh) | 2015-07-16 | 2023-06-02 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| EP3389634B1 (en) | 2015-12-14 | 2021-10-06 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| JP6958820B2 (ja) | 2015-12-14 | 2021-11-02 | エックス４ ファーマシューティカルズ， インコーポレイテッド | がんを処置する方法 |
| JP7055380B2 (ja) | 2015-12-22 | 2022-04-18 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 免疫不全疾患を処置するための方法 |
| AU2017222495B2 (en) | 2016-02-23 | 2019-08-08 | Biolinerx Ltd. | Methods of treating acute myeloid leukemia |
| WO2017177230A1 (en) | 2016-04-08 | 2017-10-12 | X4 Pharmaceuticals, Inc. | Methods for treating cancer |
| EP3808748A1 (en) | 2016-06-21 | 2021-04-21 | X4 Pharmaceuticals, Inc. | Substituted piperidines as cxcr4-inhibitors |
| CN109640988A (zh) | 2016-06-21 | 2019-04-16 | X4 制药有限公司 | Cxcr4抑制剂及其用途 |
| CA3027500A1 (en) | 2016-06-21 | 2017-12-28 | X4 Pharmaceuticals, Inc. | Cxcr4 inhibitors and uses thereof |
| US10548889B1 (en) | 2018-08-31 | 2020-02-04 | X4 Pharmaceuticals, Inc. | Compositions of CXCR4 inhibitors and methods of preparation and use |
| CN109187337A (zh) * | 2018-09-10 | 2019-01-11 | 南京工业职业技术学院 | 一种筛选强韧性FeAl晶界的方法 |
| JP2023517956A (ja) | 2020-03-10 | 2023-04-27 | エックス４ ファーマシューティカルズ， インコーポレイテッド | 好中球減少症を処置する方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4810643A (en) | 1985-08-23 | 1989-03-07 | Kirin- Amgen Inc. | Production of pluripotent granulocyte colony-stimulating factor |
| US5021409A (en) * | 1989-12-21 | 1991-06-04 | Johnson Matthey Plc | Antiviral cyclic polyamines |
| GB9126677D0 (en) | 1991-12-16 | 1992-02-12 | Johnson Matthey Plc | Improvements in chemical compounds |
| GB9400411D0 (en) | 1994-01-11 | 1994-03-09 | Johnson Matthey Plc | Improvements in chemical compounds |
| US5612478A (en) | 1995-03-30 | 1997-03-18 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US5606053A (en) | 1995-05-02 | 1997-02-25 | Johnson Matthey Plc | Process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane |
| US6506770B1 (en) | 1996-06-06 | 2003-01-14 | Anormed, Inc. | Antiviral compounds |
| GB9511357D0 (en) | 1995-06-06 | 1995-08-02 | Johnson Matthey Plc | Improved antiviral compounds |
| EP1133291B1 (en) * | 1998-11-17 | 2006-01-11 | Smithkline Beecham Corporation | Cyclic polyamines for treating thrombocytopenia |
-
2000
- 2000-02-01 US US09/495,298 patent/US6365583B1/en not_active Expired - Lifetime
- 2000-02-02 CN CNB008033285A patent/CN1310642C/zh not_active Expired - Fee Related
- 2000-02-02 AU AU25278/00A patent/AU772979B2/en not_active Ceased
- 2000-02-02 TR TR2001/02239T patent/TR200102239T2/xx unknown
- 2000-02-02 WO PCT/CA2000/000104 patent/WO2000045814A1/en not_active Ceased
- 2000-02-02 CZ CZ20012698A patent/CZ20012698A3/cs unknown
- 2000-02-02 EP EP00903441A patent/EP1148875B1/en not_active Expired - Lifetime
- 2000-02-02 HK HK02100103.2A patent/HK1038319B/en not_active IP Right Cessation
- 2000-02-02 PT PT00903441T patent/PT1148875E/pt unknown
- 2000-02-02 ES ES00903441T patent/ES2222174T3/es not_active Expired - Lifetime
- 2000-02-02 BR BR0007924-3A patent/BR0007924A/pt not_active Application Discontinuation
- 2000-02-02 KR KR1020017009649A patent/KR100643553B1/ko not_active Expired - Fee Related
- 2000-02-02 AT AT00903441T patent/ATE268597T1/de not_active IP Right Cessation
- 2000-02-02 IL IL144400A patent/IL144400A/en not_active IP Right Cessation
- 2000-02-02 DE DE60011391T patent/DE60011391T2/de not_active Expired - Lifetime
- 2000-02-02 SI SI200030444T patent/SI1148875T1/xx unknown
- 2000-02-02 DK DK00903441T patent/DK1148875T3/da active
- 2000-02-02 NZ NZ513602A patent/NZ513602A/en unknown
- 2000-02-02 AP APAP/P/2001/002221A patent/AP1497A/en active
- 2000-02-02 CA CA2361587A patent/CA2361587C/en not_active Expired - Fee Related
- 2000-02-02 MX MXPA01007801A patent/MXPA01007801A/es not_active IP Right Cessation
- 2000-02-02 HU HU0200100A patent/HUP0200100A3/hu unknown
- 2000-02-02 JP JP2000596934A patent/JP4968868B2/ja not_active Expired - Fee Related
-
2001
- 2001-08-01 NO NO20013770A patent/NO20013770L/no not_active Application Discontinuation
-
2002
- 2002-01-04 US US10/039,150 patent/US6670354B2/en not_active Expired - Lifetime
-
2004
- 2004-08-13 AU AU2004203847A patent/AU2004203847B2/en not_active Ceased
-
2011
- 2011-02-04 JP JP2011023235A patent/JP2011088937A/ja not_active Withdrawn
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