JP2006511484A5 - - Google Patents
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- Publication number
- JP2006511484A5 JP2006511484A5 JP2004543510A JP2004543510A JP2006511484A5 JP 2006511484 A5 JP2006511484 A5 JP 2006511484A5 JP 2004543510 A JP2004543510 A JP 2004543510A JP 2004543510 A JP2004543510 A JP 2004543510A JP 2006511484 A5 JP2006511484 A5 JP 2006511484A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- group
- alkyl
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- -1 biphenylyl Chemical group 0.000 claims 66
- 125000000217 alkyl group Chemical group 0.000 claims 46
- 125000000753 cycloalkyl group Chemical group 0.000 claims 45
- 150000001875 compounds Chemical class 0.000 claims 33
- 125000003342 alkenyl group Chemical group 0.000 claims 31
- 125000000304 alkynyl group Chemical group 0.000 claims 31
- 125000004404 heteroalkyl group Chemical group 0.000 claims 31
- 239000000203 mixture Substances 0.000 claims 29
- 229910052739 hydrogen Inorganic materials 0.000 claims 28
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 28
- 125000003710 aryl alkyl group Chemical group 0.000 claims 22
- 229910052760 oxygen Inorganic materials 0.000 claims 20
- 239000001257 hydrogen Substances 0.000 claims 18
- 229910052717 sulfur Inorganic materials 0.000 claims 18
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 125000004103 aminoalkyl group Chemical group 0.000 claims 14
- 125000003118 aryl group Chemical group 0.000 claims 14
- 150000003857 carboxamides Chemical class 0.000 claims 14
- 125000001188 haloalkyl group Chemical group 0.000 claims 14
- 125000005843 halogen group Chemical group 0.000 claims 14
- 150000002431 hydrogen Chemical class 0.000 claims 14
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 14
- 229940124530 sulfonamide Drugs 0.000 claims 13
- 150000003456 sulfonamides Chemical class 0.000 claims 13
- 125000004104 aryloxy group Chemical group 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- 125000003107 substituted aryl group Chemical group 0.000 claims 8
- 241000124008 Mammalia Species 0.000 claims 7
- 239000005977 Ethylene Substances 0.000 claims 6
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 6
- 125000002541 furyl group Chemical group 0.000 claims 6
- 125000001624 naphthyl group Chemical group 0.000 claims 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
- 108010046094 fatty-acid amide hydrolase Proteins 0.000 claims 4
- 125000002252 acyl group Chemical group 0.000 claims 3
- 125000003435 aroyl group Chemical group 0.000 claims 3
- 125000002102 aryl alkyloxo group Chemical group 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 125000001162 cycloheptenyl group Chemical group C1(=CCCCCC1)* 0.000 claims 3
- 125000000582 cycloheptyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 3
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims 3
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 claims 3
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 3
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000000623 heterocyclic group Chemical group 0.000 claims 3
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- 230000002401 inhibitory effect Effects 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000002757 morpholinyl group Chemical group 0.000 claims 3
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003386 piperidinyl group Chemical group 0.000 claims 3
- 229920006395 saturated elastomer Polymers 0.000 claims 3
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 3
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 claims 2
- 102100029111 Fatty-acid amide hydrolase 1 Human genes 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000002837 carbocyclic group Chemical group 0.000 claims 2
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 2
- 125000005032 thiofuranyl group Chemical group S1C(=CC=C1)* 0.000 claims 2
- 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims 1
- 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims 1
- 229940122746 Fatty acid amide hydrolase inhibitor Drugs 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 239000003940 fatty acid amidase inhibitor Substances 0.000 claims 1
- 125000004005 formimidoyl group Chemical group [H]\N=C(/[H])* 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 125000004312 morpholin-2-yl group Chemical group [H]N1C([H])([H])C([H])([H])OC([H])(*)C1([H])[H] 0.000 claims 1
- 125000004572 morpholin-3-yl group Chemical group N1C(COCC1)* 0.000 claims 1
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 0 C*(CCNCC=*(C)C1)C1(C)C=C Chemical compound C*(CCNCC=*(C)C1)C1(C)C=C 0.000 description 3
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41700802P | 2002-10-07 | 2002-10-07 | |
| PCT/US2003/031844 WO2004033422A2 (en) | 2002-10-07 | 2003-10-07 | Modulation of anxiety through blockade of anandamide hydrolysis |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2006511484A JP2006511484A (ja) | 2006-04-06 |
| JP2006511484A5 true JP2006511484A5 (enExample) | 2006-11-24 |
| JP4515911B2 JP4515911B2 (ja) | 2010-08-04 |
Family
ID=32093946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004543510A Expired - Fee Related JP4515911B2 (ja) | 2002-10-07 | 2003-10-07 | アナンダミド加水分解の遮断による不安の調節 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7176201B2 (enExample) |
| EP (1) | EP1558591B1 (enExample) |
| JP (1) | JP4515911B2 (enExample) |
| KR (1) | KR20050088992A (enExample) |
| CN (1) | CN100408556C (enExample) |
| AU (1) | AU2003279877B2 (enExample) |
| CA (1) | CA2501506C (enExample) |
| EA (1) | EA010267B1 (enExample) |
| MX (1) | MXPA05003715A (enExample) |
| UA (1) | UA80841C2 (enExample) |
| WO (1) | WO2004033422A2 (enExample) |
Families Citing this family (61)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9923738D0 (en) * | 1999-10-07 | 1999-12-08 | Nestle Sa | Nutritional composition |
| US20050054730A1 (en) * | 2001-03-27 | 2005-03-10 | The Regents Of The University Of California | Compounds, compositions and treatment of oleoylethanolamide-like modulators of PPARalpha |
| ATE519485T1 (de) * | 2001-03-29 | 2011-08-15 | Michael Davis | Akute pharmakologische verstärkung einer psychotherapie mit d-cycloserine |
| AU2003296895A1 (en) * | 2002-08-20 | 2004-05-04 | The Regents Of The University Of California | Combination therapy for controlling appetites |
| EP1558591B1 (en) * | 2002-10-07 | 2014-05-07 | The Regents of The University of California | Modulation of anxiety through blockade of anandamide hydrolysis |
| WO2004089296A2 (en) | 2003-04-03 | 2004-10-21 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| JP2007509066A (ja) * | 2003-10-16 | 2007-04-12 | ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア | 体脂肪を減らし、食欲を抑制し、脂肪酸代謝を調節するための食物および他の組成物、化合物ならびに方法 |
| FR2865205B1 (fr) * | 2004-01-16 | 2006-02-24 | Sanofi Synthelabo | Derives de type aryloxyalkylcarbamates, leur preparation et leur application en therapeutique |
| FR2866886B1 (fr) * | 2004-02-26 | 2007-08-31 | Sanofi Synthelabo | Derives d'aryl-et d'heteroaryl-akylcarbamates, leur preparation et leur application en therapeutique |
| EP1765311A4 (en) | 2004-03-16 | 2009-04-29 | Univ California | REDUCTION OF NEPHROPATHY WITH INHIBITORS OF SOLUBLE EPOXY HYDROLASE AND EPOXYEICOSANOIDS |
| CA2571505A1 (en) * | 2004-06-23 | 2006-01-05 | F. Hoffmann-La Roche Ag | New mao-b inhibitors |
| US20060084659A1 (en) * | 2004-10-19 | 2006-04-20 | Michael Davis | Augmentation of psychotherapy with cannabinoid reuptake inhibitors |
| WO2006045119A2 (en) | 2004-10-20 | 2006-04-27 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
| KR100693528B1 (ko) * | 2004-10-29 | 2007-03-14 | 주식회사 팬택 | 전원 지연 인가 기능을 가지는 무선통신 단말기 |
| EP1817025A2 (en) * | 2004-11-23 | 2007-08-15 | PTC Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control |
| MX2007010076A (es) | 2005-02-17 | 2007-10-16 | Astellas Pharma Inc | Derivado de heterociclico-1-carboxilato que contiene nitrogeno no aromatico de piridilo. |
| US20090082435A1 (en) * | 2005-04-28 | 2009-03-26 | The Regents Of The University Of California | Methods, Compositions, And Compounds For Modulation Of Monoacylglycerol Lipase, Pain, And Stress-Related Disorders |
| US20090111778A1 (en) * | 2005-11-18 | 2009-04-30 | Richard Apodaca | 2-Keto-Oxazoles as Modulators of Fatty Acid Amide Hydrolase |
| MX2008008529A (es) * | 2005-12-29 | 2008-09-26 | Organon Nv | Inhibidores de amida hidrolasa de acido graso. |
| US20070155707A1 (en) * | 2005-12-29 | 2007-07-05 | Kadmus Pharmaceuticals, Inc. | Ionizable inhibitors of fatty acid amide hydrolase |
| WO2007106706A1 (en) * | 2006-03-10 | 2007-09-20 | Boehringer Ingelheim International Gmbh | Cyclic urea compounds as soluble epoxide hydrolase inhibitors effective for the treatment of cardiovascular disorders |
| US20100292266A1 (en) * | 2006-05-26 | 2010-11-18 | Richard Apodaca | Oxazolyl Piperidine Modulators of Fatty Acid Amide Hydrolase |
| WO2008021625A2 (en) * | 2006-08-18 | 2008-02-21 | N.V. Organon | Combination faah inhibitor and analgesic, anti-inflammatory or anti-pyretic agent |
| US7888394B2 (en) * | 2006-08-21 | 2011-02-15 | N.V. Organon | Synthesis, polymorphs, and pharmaceutical formulation of FAAH inhibitors |
| JPWO2008023720A1 (ja) | 2006-08-23 | 2010-01-14 | アステラス製薬株式会社 | ウレア化合物又はその塩 |
| US20080089845A1 (en) * | 2006-09-07 | 2008-04-17 | N.V. Organon | Methods for determining effective doses of fatty acid amide hydrolase inhibitors in vivo |
| US20090099240A1 (en) * | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
| EP2096915A1 (en) * | 2006-11-20 | 2009-09-09 | N.V. Organon | Metabolically-stabilized inhibitors of fatty acid amide hydrolase |
| WO2008100977A2 (en) * | 2007-02-14 | 2008-08-21 | N.V. Organon | Carbamates therapeutic release agents as amidase inhibitors |
| DE102007022007A1 (de) * | 2007-05-08 | 2008-11-13 | Schebo Biotech Ag | Neuartike Pharmazeutika, Verfahren zu ihrer Herstellung und ihre Verwendung in der Prophylaxe und Therapie von ZNS-Erkrankungen und Diabetes |
| AU2008257154B2 (en) | 2007-05-25 | 2014-03-06 | The Scripps Research Institute | Tetracyclic inhibitors of fatty acid amide hydrolase |
| WO2008150492A1 (en) * | 2007-05-31 | 2008-12-11 | The Scripps Research Institute | Tricyclic inhibitors of fatty acid amide hydrolase |
| US8207226B1 (en) | 2008-06-03 | 2012-06-26 | Alcon Research, Ltd. | Use of FAAH antagonists for treating dry eye and ocular pain |
| TWI434842B (zh) | 2008-07-14 | 2014-04-21 | Astellas Pharma Inc | Azole compounds |
| JPWO2010053120A1 (ja) | 2008-11-06 | 2012-04-05 | アステラス製薬株式会社 | カルバメート化合物又はその塩 |
| FR2938537B1 (fr) | 2008-11-14 | 2012-10-26 | Sanofi Aventis | Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique. |
| AU2009330821B2 (en) * | 2008-12-24 | 2015-06-11 | Bial - Portela & Ca, S.A. | Pharmaceutical compounds |
| FR2941696B1 (fr) * | 2009-02-05 | 2011-04-15 | Sanofi Aventis | Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique |
| ES2626246T3 (es) | 2009-09-09 | 2017-07-24 | Sumitomo Dainippon Pharma Co., Ltd. | Derivado de 8-oxodihidropurina |
| US20130150346A1 (en) | 2010-01-08 | 2013-06-13 | Quest Ventures Ltd. | Use of FAAH Inhibitors for Treating Parkinson's Disease and Restless Legs Syndrome |
| JP5833570B2 (ja) * | 2010-01-20 | 2015-12-16 | サノフイ | アルキル−複素環カルバメート誘導体、この調製およびこの治療的適用 |
| FR2955580A1 (fr) * | 2010-01-28 | 2011-07-29 | Sanofi Aventis | Derives de carbamate d'alkyl-heterocycles, leur preparation et leur application en therapeutique |
| WO2011123719A2 (en) | 2010-03-31 | 2011-10-06 | Ironwood Pharmaceuticals, Inc. | Use of faah inhibitors for treating abdominal, visceral and pelvic pain |
| EP2389922A1 (en) | 2010-05-25 | 2011-11-30 | Symrise AG | Cyclohexyl carbamate compounds as anti-ageing actives |
| WO2010122178A2 (en) | 2010-05-25 | 2010-10-28 | Symrise Gmbh & Co. Kg | Cyclohexyl carbamate compounds as skin and/or hair lightening actives |
| JP5838497B2 (ja) * | 2010-05-25 | 2016-01-06 | シムライズ アーゲー | 抗セルライト有効成分としてのシクロヘキシルカルバメート化合物 |
| EP2598477B1 (en) * | 2010-07-28 | 2016-03-02 | The Regents of The University of California | Peripherally restricted faah inhibitors |
| EP2433527B1 (en) * | 2010-09-28 | 2013-04-03 | Gruppo Cimbali S.p.A. | Improved automatic milk frothing wand |
| JP6092870B2 (ja) * | 2011-08-19 | 2017-03-08 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | メタ置換ビフェニル末梢に限局されたｆａａｈ阻害剤 |
| WO2014023325A1 (en) * | 2012-08-06 | 2014-02-13 | Fondazione Istituto Italiano Di Tecnologia | Multitarget faah and cox inhibitors and therapeutical uses thereof |
| ITMI20131180A1 (it) | 2013-07-15 | 2015-01-16 | Fond Istituto Italiano Di Tecnologia | O-alchil triazolil carbammati come inibitori di idrolasi delle ammidi degli acidi grassi (faah) |
| EP3022179B1 (en) * | 2013-07-18 | 2017-11-15 | Fondazione Istituto Italiano Di Tecnologia | Phenyl carbamates and their use as inhibitors of the fatty acid amide hydrolase (faah) enzyme and modulators of the d3 dopamine receptor (d3dr) |
| AR100387A1 (es) * | 2014-02-18 | 2016-10-05 | Basf Se | Copolímeros que comprenden etileno, ésteres de vinilo y ésteres de ácido (met)acrílico, sus formulaciones y usos como depresor del punto de fluidez, inhibidor de cera y potenciador de flujo para petróleos crudos |
| ES2908240T3 (es) | 2014-04-07 | 2022-04-28 | Univ California | Inhibidores de la enzima amida hidrolasa de ácidos grasos (FAAH) con biodisponibilidad oral mejorada y su uso como medicamentos |
| AU2016271432A1 (en) * | 2015-06-05 | 2017-12-07 | Dana-Farber Cancer Institute, Inc. | Compounds and methods for treating cancer |
| TW201733620A (zh) | 2015-12-11 | 2017-10-01 | 國立大學法人靜岡大學 | 油凝膠化劑 |
| US10220061B1 (en) | 2017-09-26 | 2019-03-05 | Cynthia Denapoli | Method of reducing stress and anxiety in equines |
| ES3053087T3 (en) | 2018-03-05 | 2026-01-19 | Wylder Nation Found | A fatty acid amide hydrolase (faahi) inhibitor for use in inhibiting the cellular accumulation of a sphingolipid in a subject that has lysosomal storage disease or disorder |
| US10414721B1 (en) | 2018-06-04 | 2019-09-17 | University Of Bern | Inhibitor of endocannabinoid cellular reuptake |
| US20240180905A1 (en) * | 2020-07-21 | 2024-06-06 | Neuritek Ltd. | Uses of fatty acid amide hydrolase inhibitors in treatment of trauma related psychiatric disorders |
| WO2025015420A1 (en) * | 2023-07-17 | 2025-01-23 | Apogee Pharmaceuticals, Inc. | Novel fatty acid amide hydrolase modulators, compositions comprising the same and uses thereof |
Family Cites Families (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL190462A (enExample) * | 1953-09-02 | |||
| US3084096A (en) * | 1955-08-29 | 1963-04-02 | Union Carbide Corp | Indanyl n-methyl carbamate |
| US3275512A (en) * | 1962-11-27 | 1966-09-27 | Upjohn Co | Process for treating inflammation with biphenylcarbamates |
| US3632631A (en) * | 1967-09-08 | 1972-01-04 | Ethyl Corp | Sterically hindered bisphenyl carbamates |
| US3880908A (en) * | 1972-01-24 | 1975-04-29 | Standard Oil Co | Urethane derivatives of polymethyl biphenyl useful as fungicides |
| DE2943480A1 (de) | 1979-10-27 | 1981-05-07 | Bayer Ag, 5090 Leverkusen | Verfahren zur herstellung von n,o-disubstituierten urethanen, sowie ihre verwendung als ausgangsmaterial zur herstellung von isocyanaten |
| HU197831B (en) | 1984-12-20 | 1989-06-28 | Chinoin Gyogyszer Es Vegyeszet | Insecticide compositions containing alkenyl-oxy-phenyl-carbamat derivatives as active components and process for producing the active components |
| IL74497A (en) * | 1985-03-05 | 1990-02-09 | Proterra Ag | Pharmaceutical compositions containing phenyl carbamate derivatives and certain phenyl carbamate derivatives |
| JPS63303661A (ja) | 1987-01-22 | 1988-12-12 | Ishikawajima Harima Heavy Ind Co Ltd | 注湯装置 |
| US4987233A (en) * | 1988-06-15 | 1991-01-22 | Eli Lilly And Company | Process for preparing herbicidal ureas and insecticidal carbamates and carbamate derivatives |
| IL95994A0 (en) | 1989-11-15 | 1991-07-18 | American Home Prod | Carbamate esters and pharmaceutical compositions containing them |
| US5112859A (en) * | 1990-09-14 | 1992-05-12 | American Home Products Corporation | Biphenyl amide cholesterol ester hydrolase inhibitors |
| US5476944A (en) * | 1991-11-18 | 1995-12-19 | G. D. Searle & Co. | Derivatives of cyclic phenolic thioethers |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| DE69314148T2 (de) | 1992-12-17 | 1998-01-15 | Valeo Systemes Essuyage | Stromversorgungsverfahren und -vorrichtung für einen elektrischen Motor zum Antrieb eines Scheibenwischers eines Kraftfahrzeugs |
| US5576220A (en) | 1993-02-19 | 1996-11-19 | Arris Pharmaceutical Corporation | Thin film HPMP matrix systems and methods for constructing and displaying ligands |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| IT1271679B (it) * | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | Derivati del fenilcarbammato atti all'impiego come anticolinesterasici |
| DE4430600A1 (de) | 1994-08-22 | 1996-02-29 | Hoechst Schering Agrevo Gmbh | Biphenyl-Derivate |
| JPH0892167A (ja) | 1994-09-21 | 1996-04-09 | Idemitsu Kosan Co Ltd | 芳香族炭酸ジエステルの製造方法 |
| US5585492A (en) * | 1994-10-11 | 1996-12-17 | G. D. Searle & Co. | LTA4 Hydrolase inhibitors |
| US6271015B1 (en) * | 1995-06-12 | 2001-08-07 | The Scripps Research Institute | Fatty-acid amide hydrolase |
| CA2206192A1 (en) * | 1996-06-13 | 1997-12-13 | F. Hoffmann-La Roche Ag | Modulation of lc132 (opioid-like) receptor function |
| US5856537A (en) * | 1996-06-26 | 1999-01-05 | The Scripps Research Institute | Inhibitors of oleamide hydrolase |
| US6150415A (en) | 1996-08-13 | 2000-11-21 | The Regents Of The University Of California | Epoxide hydrolase complexes and methods therewith |
| US6531506B1 (en) * | 1996-08-13 | 2003-03-11 | Regents Of The University Of California | Inhibitors of epoxide hydrolases for the treatment of hypertension |
| CZ172799A3 (cs) | 1996-11-19 | 1999-10-13 | Icn Pharmaceuticals, Inc. | Vícemocné soli pyridostigminu a příbuzných sloučenin |
| US5925672A (en) | 1996-12-06 | 1999-07-20 | Neurosciences Research Foundation, Inc. | Methods of treating mental diseases, inflammation and pain |
| TW492882B (en) | 1997-11-28 | 2002-07-01 | Caleb Pharmaceuticals Inc | Cholinergic antagonist plaster composition |
| US7897598B2 (en) * | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
| US6251931B1 (en) * | 1998-11-24 | 2001-06-26 | The Scripps Research Institute | Inhibitors of gap junction communication |
| US6414002B1 (en) * | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
| US6359010B1 (en) * | 1999-11-23 | 2002-03-19 | Thomas D. Geracioti, Jr. | Methods of treating anxiety and mood disorders with oleamide |
| US6261595B1 (en) | 2000-02-29 | 2001-07-17 | Zars, Inc. | Transdermal drug patch with attached pocket for controlled heating device |
| BR0112655A (pt) | 2000-07-19 | 2003-06-24 | Hoffmann La Roche | Derivados de pirrolidino como inibidores de metaloproteases |
| FR2812876B1 (fr) * | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| HRP20030086A2 (en) | 2000-08-16 | 2005-02-28 | F. Hoffmann - La Roche Ag | Novel aminocyclohexane derivatives |
| DE60216830T2 (de) | 2001-02-06 | 2007-06-14 | Pfizer Products Inc., Groton | Pharmazeutische Zusammensetzungen zur Behandlung von Störungen des ZNS oder anderen Erkrankungen |
| MXPA03009850A (es) * | 2001-04-27 | 2004-02-12 | Bristol Myers Squibb Co | Inhibidores de bisarilimidazolil de hidrolasa de amida del acido graso. |
| BR0214967A (pt) | 2001-12-14 | 2005-05-10 | Novo Nordisk As | Composto, sal famaceuticamente aceitável, processo para a preparação de um composto, composição farmacêutica, uso de um composto e método de tratar um distúrbio de um paciente |
| US6908939B2 (en) * | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
| PL373970A1 (en) * | 2002-02-08 | 2005-09-19 | Bristol-Myers Squibb Company | (oxime)carbamoyl fatty acid amide hydrolase inhibitors |
| FR2843964B1 (fr) * | 2002-08-29 | 2004-10-01 | Sanofi Synthelabo | Derives de dioxane-2-alkylcarbamates, leur preparation et leur application en therapeutique |
| EP1558591B1 (en) | 2002-10-07 | 2014-05-07 | The Regents of The University of California | Modulation of anxiety through blockade of anandamide hydrolysis |
-
2003
- 2003-10-07 EP EP03773201.3A patent/EP1558591B1/en not_active Expired - Lifetime
- 2003-10-07 AU AU2003279877A patent/AU2003279877B2/en not_active Ceased
- 2003-10-07 UA UAA200504339A patent/UA80841C2/xx unknown
- 2003-10-07 KR KR1020057005995A patent/KR20050088992A/ko not_active Ceased
- 2003-10-07 EA EA200500615A patent/EA010267B1/ru not_active IP Right Cessation
- 2003-10-07 MX MXPA05003715A patent/MXPA05003715A/es unknown
- 2003-10-07 CA CA2501506A patent/CA2501506C/en not_active Expired - Fee Related
- 2003-10-07 JP JP2004543510A patent/JP4515911B2/ja not_active Expired - Fee Related
- 2003-10-07 US US10/681,858 patent/US7176201B2/en not_active Expired - Lifetime
- 2003-10-07 CN CNB2003801052130A patent/CN100408556C/zh not_active Expired - Fee Related
- 2003-10-07 WO PCT/US2003/031844 patent/WO2004033422A2/en not_active Ceased
-
2006
- 2006-07-28 US US11/496,051 patent/US8003693B2/en active Active
-
2011
- 2011-08-16 US US13/211,219 patent/US20120010283A1/en not_active Abandoned
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