JP2007516180A5 - - Google Patents
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- Publication number
- JP2007516180A5 JP2007516180A5 JP2006517562A JP2006517562A JP2007516180A5 JP 2007516180 A5 JP2007516180 A5 JP 2007516180A5 JP 2006517562 A JP2006517562 A JP 2006517562A JP 2006517562 A JP2006517562 A JP 2006517562A JP 2007516180 A5 JP2007516180 A5 JP 2007516180A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- heteroalicyclic
- substituted
- lower alkyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 125000000217 alkyl group Chemical group 0.000 claims 23
- -1 heteroalicyclic Chemical group 0.000 claims 17
- 125000001072 heteroaryl group Chemical group 0.000 claims 17
- 125000003342 alkenyl group Chemical group 0.000 claims 16
- 125000000304 alkynyl group Chemical group 0.000 claims 16
- 125000000753 cycloalkyl group Chemical group 0.000 claims 16
- 125000004093 cyano group Chemical group *C#N 0.000 claims 15
- 125000003118 aryl group Chemical group 0.000 claims 13
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 239000001257 hydrogen Substances 0.000 claims 13
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 12
- 125000000278 alkyl amino alkyl group Chemical group 0.000 claims 11
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 claims 11
- 229910052736 halogen Inorganic materials 0.000 claims 10
- 150000002367 halogens Chemical class 0.000 claims 10
- 125000004103 aminoalkyl group Chemical group 0.000 claims 8
- 125000004432 carbon atom Chemical group C* 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003282 alkyl amino group Chemical group 0.000 claims 4
- 125000004429 atom Chemical group 0.000 claims 4
- 125000004663 dialkyl amino group Chemical group 0.000 claims 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000006467 substitution reaction Methods 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 0 *C1=C(*)*C(N(*)*)=C(*)*1 Chemical compound *C1=C(*)*C(N(*)*)=C(*)*1 0.000 description 5
- ALHUOJVTRLCLQE-UHFFFAOYSA-N CCc1ccc(C[n](cn2)c3c2ncc(-c(cc2)ccc2F)n3)cc1 Chemical compound CCc1ccc(C[n](cn2)c3c2ncc(-c(cc2)ccc2F)n3)cc1 ALHUOJVTRLCLQE-UHFFFAOYSA-N 0.000 description 1
- UHRHUVFFZCTDLN-UHFFFAOYSA-N Cc1ccc(CN2[I]=Cc(nc3)c2nc3-c2ccc(CCCN3CCCCC3)cc2)cc1 Chemical compound Cc1ccc(CN2[I]=Cc(nc3)c2nc3-c2ccc(CCCN3CCCCC3)cc2)cc1 UHRHUVFFZCTDLN-UHFFFAOYSA-N 0.000 description 1
- UKAPITGKNGBDAP-UHFFFAOYSA-N Fc1ccc(CC2N=[I]c(nc3)c2nc3-c2cccc(OCCN3CCCCC3)c2)cc1 Chemical compound Fc1ccc(CC2N=[I]c(nc3)c2nc3-c2cccc(OCCN3CCCCC3)c2)cc1 UKAPITGKNGBDAP-UHFFFAOYSA-N 0.000 description 1
- JQIZPFARSHSJDU-UHFFFAOYSA-N Fc1ccc(C[n]2ncc(nc3)c2nc3-c2cc3ccccc3[nH]2)cc1 Chemical compound Fc1ccc(C[n]2ncc(nc3)c2nc3-c2cc3ccccc3[nH]2)cc1 JQIZPFARSHSJDU-UHFFFAOYSA-N 0.000 description 1
- HYBCIFYCVCYVEK-UHFFFAOYSA-N Oc1ccc(C[n](cc2)c3c2ncc(-c2ccc[s]2)n3)cc1 Chemical compound Oc1ccc(C[n](cc2)c3c2ncc(-c2ccc[s]2)n3)cc1 HYBCIFYCVCYVEK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48422003P | 2003-07-02 | 2003-07-02 | |
| PCT/US2004/020062 WO2005004607A1 (en) | 2003-07-02 | 2004-06-25 | Arylmethyl triazolo and imidazopyrazines as c-met inhibitors |
| US10/875,507 US7250417B2 (en) | 2003-07-02 | 2004-06-25 | Arylmethyl triazolo- and imidazopyrazines as c-Met inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007516180A JP2007516180A (ja) | 2007-06-21 |
| JP2007516180A5 true JP2007516180A5 (enExample) | 2007-08-09 |
Family
ID=34068189
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006517562A Withdrawn JP2007516180A (ja) | 2003-07-02 | 2004-06-25 | ｃ−Ｍｅｔ阻害薬としてのアリールメチルトリアゾロおよびイミダゾピラジン類 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US7250417B2 (enExample) |
| EP (1) | EP1643836A4 (enExample) |
| JP (1) | JP2007516180A (enExample) |
| BR (1) | BRPI0412003A (enExample) |
| CA (1) | CA2530589A1 (enExample) |
| MX (1) | MXPA06000091A (enExample) |
| WO (1) | WO2005004607A1 (enExample) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7550470B2 (en) | 2002-12-11 | 2009-06-23 | Merck & Co. Inc. | Substituted pyrazolo[1,5-A]pyrimidines as tyrosine kinase inhibitors |
| TWI377198B (en) | 2005-08-24 | 2012-11-21 | Eisai R&D Man Co Ltd | Novel pyridine derivatives and pyrimidine derivatives (3) |
| RS55630B1 (sr) * | 2005-12-21 | 2017-06-30 | Janssen Pharmaceutica Nv | Triazolopiridazini kao modulatori tirozin kinaze |
| NL2000613C2 (nl) * | 2006-05-11 | 2007-11-20 | Pfizer Prod Inc | Triazoolpyrazinederivaten. |
| PE20121506A1 (es) * | 2006-07-14 | 2012-11-26 | Amgen Inc | Compuestos triazolopiridinas como inhibidores de c-met |
| US7683060B2 (en) | 2006-08-07 | 2010-03-23 | Incyte Corporation | Triazolotriazines as kinase inhibitors |
| ATE535520T1 (de) | 2006-08-23 | 2011-12-15 | Eisai R&D Man Co Ltd | Salz eines phenoxypyridinderivats oder kristall davon und verfahren zu dessen herstellung |
| US7790885B2 (en) | 2006-08-31 | 2010-09-07 | Eisai R&D Management Co., Ltd. | Process for preparing phenoxypyridine derivatives |
| GEP20125658B (en) | 2006-11-22 | 2012-10-10 | Incyte Corp | Imidazotriazines and imidazo pyrimidines as kinase inhibitors |
| US20090042906A1 (en) * | 2007-04-26 | 2009-02-12 | Massachusetts Institute Of Technology | Methods for treating cancers associated with constitutive egfr signaling |
| DE102007026341A1 (de) | 2007-06-06 | 2008-12-11 | Merck Patent Gmbh | Benzoxazolonderivate |
| EP2170894A1 (en) | 2007-06-21 | 2010-04-07 | Janssen Pharmaceutica N.V. | Polymorphic and hydrate forms, salts and process for preparing 6-{difluoro[6-(1-methyl-1h-pyrazol-4-yl)[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}quinoline |
| DE102007032507A1 (de) | 2007-07-12 | 2009-04-02 | Merck Patent Gmbh | Pyridazinonderivate |
| JP2009132660A (ja) | 2007-11-30 | 2009-06-18 | Eisai R & D Management Co Ltd | 食道癌治療用組成物 |
| DE102007061963A1 (de) | 2007-12-21 | 2009-06-25 | Merck Patent Gmbh | Pyridazinonderivate |
| US8598184B2 (en) * | 2008-03-03 | 2013-12-03 | Tiger Pharmatech | Protein kinase inhibitors |
| WO2009111644A2 (en) * | 2008-03-05 | 2009-09-11 | The Regents Of The University Of Michigan | Compositions and methods for diagnosing and treating pancreatic cancer |
| DE102008019907A1 (de) | 2008-04-21 | 2009-10-22 | Merck Patent Gmbh | Pyridazinonderivate |
| SI2300455T1 (sl) | 2008-05-21 | 2017-12-29 | Incyte Holdings Corporation | Soli 2-fluoro-n-metil-4-(7-(kinolin-6-il-metil)-imidazo(1,2-b)1,2,4) triazin-2-il)benzamid in postopki v zvezi z njihovo pripravo |
| JP2011520986A (ja) | 2008-05-22 | 2011-07-21 | アムジエン・インコーポレーテツド | タンパク質キナーゼ阻害薬としての複素環類 |
| DE102008028905A1 (de) | 2008-06-18 | 2009-12-24 | Merck Patent Gmbh | 3-(3-Pyrimidin-2-yl-benzyl)-[1,2,4]triazolo[4,3-b]pyridazinderivate |
| DE102008037790A1 (de) * | 2008-08-14 | 2010-02-18 | Merck Patent Gmbh | Bicyclische Triazolderivate |
| EP2356116A1 (en) | 2008-11-20 | 2011-08-17 | OSI Pharmaceuticals, Inc. | Substituted pyrroloý2,3-b¨-pyridines and-pyrazines |
| CN102264743B (zh) * | 2008-11-25 | 2015-02-11 | 罗彻斯特大学 | Mlk抑制剂及其使用方法 |
| EA019320B1 (ru) | 2008-12-22 | 2014-02-28 | Мерк Патент Гмбх | Новые полиморфные формы дигидрофосфата 6-(1-метил-1h-пиразол-4-ил)-2-{3-[5-(2-морфолин-4-илэтокси)пиримидин-2-ил]бензил}-2h-пиридазин-3-она и способы их получения |
| DE102009003975A1 (de) | 2009-01-07 | 2010-07-08 | Merck Patent Gmbh | Benzothiazolonderivate |
| AU2010232729A1 (en) | 2009-03-31 | 2011-10-20 | Arqule, Inc. | Substituted indolo-pyridinone compounds |
| US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
| BR112012003262A8 (pt) | 2009-08-12 | 2016-05-17 | Novartis Ag | compostos de hidrazona heterocíclica e seus usos para tratar câncer e inflamação |
| IN2012DN01453A (enExample) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
| PT3511330T (pt) * | 2009-12-31 | 2020-12-24 | Hutchison Medipharma Ltd | Intermediário sintético útil na preparação de inibidores de triazolopiridina c-met |
| MX2012008898A (es) | 2010-02-03 | 2012-11-06 | Incyte Corp | Imidazo - [1, 2 - b] [1, 2, 4] triazinas como inhibidores de c - met. |
| US20130072495A1 (en) | 2010-05-14 | 2013-03-21 | OSI Pharmaceuticals, LLC | Fused bicyclic kinase inhibitors |
| AR081039A1 (es) | 2010-05-14 | 2012-05-30 | Osi Pharmaceuticals Llc | Inhibidores biciclicos fusionados de quinasa |
| JP5960688B2 (ja) | 2010-05-17 | 2016-08-02 | インコゼン セラピューティクス プライベート リミテッド | プロテインキナーゼ調節物質としての新規３，５−二置換−３ｈ−［１，２，３］トリアゾロ［４，５−ｂ］ピリジン化合物 |
| KR101594002B1 (ko) | 2010-10-06 | 2016-02-15 | 글락소스미스클라인 엘엘씨 | Ｐｉ３ 키나제 억제제로서의 벤즈이미다졸 유도체 |
| WO2012059932A1 (en) | 2010-11-01 | 2012-05-10 | Aurigene Discovery Technologies Limited | 2, 4 -diaminopyrimidine derivatives as protein kinase inhibitors |
| CN102532141A (zh) | 2010-12-08 | 2012-07-04 | 中国科学院上海药物研究所 | [1，2，4]三唑并[4，3-b][1，2，4]三嗪类化合物、其制备方法和用途 |
| JP2014513724A (ja) | 2011-05-16 | 2014-06-05 | オーエスアイ・ファーマシューティカルズ，エルエルシー | 融合二環キナーゼ阻害剤 |
| US20140348819A1 (en) | 2011-06-24 | 2014-11-27 | Dana-Farber Cancer Institute, Inc. | Methods of Treating Cancer |
| CN105968115B (zh) * | 2013-04-17 | 2018-11-09 | 上海医药集团股份有限公司 | 喹啉类化合物、其制备方法、中间体、药物组合物和应用 |
| CN104250257B (zh) * | 2013-06-25 | 2017-06-16 | 上海翰森生物医药科技有限公司 | 3,4‑二氢‑1H‑苯并[c][1,2]噁硼酸类化合物或其可药用盐及其制备方法和用途 |
| WO2017049711A1 (zh) | 2015-09-24 | 2017-03-30 | 上海海聚生物科技有限公司 | 喹啉类衍生物、其药物组合物、制备方法及应用 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK209976A (da) * | 1975-05-28 | 1976-11-29 | Merck & Co Inc | Fremgangsmade til fremstilling af 3h-1,2,2-triazol(4,5-b)pyridiner |
| US4804658A (en) * | 1986-09-15 | 1989-02-14 | G. D. Searle & Co. | Imidazopyridine derivatives and pharmaceutical compositions |
| EP0470543A1 (de) | 1990-08-10 | 1992-02-12 | Dr. Karl Thomae GmbH | Heterocyclische Imidazole, diese Verbindungen enthaltende Arzneimittel und Verfahren zur ihrer Herstellung |
| WO1992006086A1 (en) | 1990-10-01 | 1992-04-16 | Janssen Pharmaceutica N.V. | Novel 4-piperidinylcarbonyl derivatives |
| GB9200209D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5359073A (en) | 1992-11-24 | 1994-10-25 | G. D. Searle & Co. | Substituted-phenyl (N,N'-cycloalkyl/alkyl carboxamide)-1H/3H-imidazo[4,5-b]pyridine compounds as PAF antagonists |
| US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
| CA2262569A1 (en) | 1996-08-09 | 1998-02-19 | Norihito Ohi | Benzopiperidine derivatives |
| WO2001000578A1 (en) | 1999-06-25 | 2001-01-04 | Merck & Co., Inc. | 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof |
| MXPA02010763A (es) * | 2000-06-14 | 2003-03-10 | Warner Lambert Co | Heterociclicos biciclos-6,5 fusionados. |
| AU2002341715A1 (en) | 2001-09-17 | 2003-04-01 | Bristol-Myers Squibb Company | Cyclic hydroxamic acids as inhibitors of matrix metalloproteinases and/or tnf-alpha converting enzyme (tace) |
| WO2003032989A1 (en) | 2001-10-18 | 2003-04-24 | Boehringer Ingelheim Pharmaceuticals, Inc. | 1,4-disubstituted benzo-fused urea compounds as cytokine inhibitors |
| EP1547616A1 (en) | 2002-08-22 | 2005-06-29 | Kyowa Hakko Kogyo Co., Ltd. | Preventive and/or therapeutic drugs for itch |
| US20060239999A1 (en) | 2002-08-22 | 2006-10-26 | Mayumi Saki | Preventive and/or therapeutic drugs for asthma |
| CA2521907A1 (en) * | 2003-04-10 | 2004-10-21 | Pfizer Inc. | Bicyclic compounds as nr2b receptor antagonists |
-
2004
- 2004-06-25 JP JP2006517562A patent/JP2007516180A/ja not_active Withdrawn
- 2004-06-25 EP EP04776951A patent/EP1643836A4/en not_active Withdrawn
- 2004-06-25 WO PCT/US2004/020062 patent/WO2005004607A1/en not_active Ceased
- 2004-06-25 CA CA002530589A patent/CA2530589A1/en not_active Abandoned
- 2004-06-25 MX MXPA06000091A patent/MXPA06000091A/es unknown
- 2004-06-25 US US10/875,507 patent/US7250417B2/en not_active Expired - Fee Related
- 2004-06-25 BR BRPI0412003-5A patent/BRPI0412003A/pt not_active IP Right Cessation
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