JP2012512891A5 - - Google Patents
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- JP2012512891A5 JP2012512891A5 JP2011542439A JP2011542439A JP2012512891A5 JP 2012512891 A5 JP2012512891 A5 JP 2012512891A5 JP 2011542439 A JP2011542439 A JP 2011542439A JP 2011542439 A JP2011542439 A JP 2011542439A JP 2012512891 A5 JP2012512891 A5 JP 2012512891A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- compound
- pharmaceutically acceptable
- acceptable salt
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 42
- 150000003839 salts Chemical class 0.000 claims 34
- 125000000217 alkyl group Chemical group 0.000 claims 22
- 229910052736 halogen Inorganic materials 0.000 claims 14
- 150000002367 halogens Chemical class 0.000 claims 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 14
- 125000004093 cyano group Chemical group *C#N 0.000 claims 12
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 11
- 125000004474 heteroalkylene group Chemical group 0.000 claims 10
- 229910052760 oxygen Inorganic materials 0.000 claims 10
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 9
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 9
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 9
- 229910052717 sulfur Inorganic materials 0.000 claims 9
- 125000004429 atom Chemical group 0.000 claims 8
- 229910052799 carbon Inorganic materials 0.000 claims 8
- 125000005842 heteroatom Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 8
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims 7
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 6
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 125000001424 substituent group Chemical group 0.000 claims 6
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 4
- 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 4
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 3
- 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims 3
- 125000004450 alkenylene group Chemical group 0.000 claims 3
- 125000002947 alkylene group Chemical group 0.000 claims 3
- 208000032027 Essential Thrombocythemia Diseases 0.000 claims 2
- 208000017733 acquired polycythemia vera Diseases 0.000 claims 2
- 125000004419 alkynylene group Chemical group 0.000 claims 2
- 238000013176 antiplatelet therapy Methods 0.000 claims 2
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 208000037244 polycythemia vera Diseases 0.000 claims 2
- 208000037803 restenosis Diseases 0.000 claims 2
- 238000001356 surgical procedure Methods 0.000 claims 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 125000005529 alkyleneoxy group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 229910052801 chlorine Inorganic materials 0.000 claims 1
- 239000000460 chlorine Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 229910052731 fluorine Inorganic materials 0.000 claims 1
- 239000011737 fluorine Substances 0.000 claims 1
- 125000004404 heteroalkyl group Chemical group 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- DXYYSGDWQCSKKO-UHFFFAOYSA-N Cc1nc(cccc2)c2[s]1 Chemical compound Cc1nc(cccc2)c2[s]1 DXYYSGDWQCSKKO-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13949208P | 2008-12-19 | 2008-12-19 | |
| US61/139,492 | 2008-12-19 | ||
| PCT/US2009/068496 WO2010080503A1 (en) | 2008-12-19 | 2009-12-17 | Heterocyclic compounds and methods of use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012512891A JP2012512891A (ja) | 2012-06-07 |
| JP2012512891A5 true JP2012512891A5 (enExample) | 2013-02-14 |
| JP5770102B2 JP5770102B2 (ja) | 2015-08-26 |
Family
ID=42316723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011542439A Active JP5770102B2 (ja) | 2008-12-19 | 2009-12-17 | 複素環化合物と使用方法 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US8232273B2 (enExample) |
| EP (1) | EP2373163B1 (enExample) |
| JP (1) | JP5770102B2 (enExample) |
| KR (1) | KR101685718B1 (enExample) |
| CN (1) | CN102316733B (enExample) |
| AU (1) | AU2009335843A1 (enExample) |
| BR (1) | BRPI0918360A8 (enExample) |
| CA (1) | CA2747170C (enExample) |
| CL (1) | CL2011001485A1 (enExample) |
| CO (1) | CO6390075A2 (enExample) |
| CR (1) | CR20110388A (enExample) |
| DO (1) | DOP2011000199A (enExample) |
| EC (1) | ECSP11011213A (enExample) |
| ES (1) | ES2544452T3 (enExample) |
| IL (1) | IL213596A0 (enExample) |
| MX (1) | MX2011006509A (enExample) |
| NZ (1) | NZ593537A (enExample) |
| PE (1) | PE20120334A1 (enExample) |
| RU (1) | RU2525116C2 (enExample) |
| SG (1) | SG172259A1 (enExample) |
| WO (1) | WO2010080503A1 (enExample) |
| ZA (1) | ZA201104467B (enExample) |
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| CN103987711B (zh) * | 2011-10-14 | 2016-08-24 | 艾伯维公司 | 作为用于治疗癌症和免疫性和自身免疫性疾病的凋亡诱导剂的8-氨基甲酰基-2-(2,3-二取代吡啶-6-基)-1,2,3,4-四氢异喹啉衍生物 |
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