JP2009526865A5 - - Google Patents
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- JP2009526865A5 JP2009526865A5 JP2008555472A JP2008555472A JP2009526865A5 JP 2009526865 A5 JP2009526865 A5 JP 2009526865A5 JP 2008555472 A JP2008555472 A JP 2008555472A JP 2008555472 A JP2008555472 A JP 2008555472A JP 2009526865 A5 JP2009526865 A5 JP 2009526865A5
- Authority
- JP
- Japan
- Prior art keywords
- unsubstituted
- substituted
- moiety
- branched
- unbranched
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 26
- 229910052739 hydrogen Inorganic materials 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 15
- 125000002252 acyl group Chemical group 0.000 claims 11
- 125000003118 aryl group Chemical group 0.000 claims 11
- 125000001072 heteroaryl group Chemical group 0.000 claims 11
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 125000002015 acyclic group Chemical group 0.000 claims 10
- 125000001931 aliphatic group Chemical group 0.000 claims 10
- 125000004122 cyclic group Chemical group 0.000 claims 10
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 6
- 150000002367 halogens Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 102000003964 Histone deacetylase Human genes 0.000 claims 5
- 108090000353 Histone deacetylase Proteins 0.000 claims 5
- 125000003545 alkoxy group Chemical group 0.000 claims 5
- 125000004414 alkyl thio group Chemical group 0.000 claims 5
- 125000005110 aryl thio group Chemical group 0.000 claims 5
- 125000004104 aryloxy group Chemical group 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000005553 heteroaryloxy group Chemical group 0.000 claims 5
- 125000005368 heteroarylthio group Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000006239 protecting group Chemical group 0.000 claims 5
- 125000003282 alkyl amino group Chemical group 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 230000002062 proliferating effect Effects 0.000 claims 3
- 125000005122 aminoalkylamino group Chemical group 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- VDFVNEFVBPFDSB-UHFFFAOYSA-N 1,3-dioxane Chemical group C1COCOC1 VDFVNEFVBPFDSB-UHFFFAOYSA-N 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 102100022537 Histone deacetylase 6 Human genes 0.000 claims 1
- 101000899330 Homo sapiens Histone deacetylase 6 Proteins 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- WWGBHDIHIVGYLZ-UHFFFAOYSA-N N-[4-[3-[[[7-(hydroxyamino)-7-oxoheptyl]amino]-oxomethyl]-5-isoxazolyl]phenyl]carbamic acid tert-butyl ester Chemical group C1=CC(NC(=O)OC(C)(C)C)=CC=C1C1=CC(C(=O)NCCCCCCC(=O)NO)=NO1 WWGBHDIHIVGYLZ-UHFFFAOYSA-N 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 208000009905 Neurofibromatoses Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 1
- 125000001118 alkylidene group Chemical group 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 1
- 208000024963 hair loss Diseases 0.000 claims 1
- 230000003676 hair loss Effects 0.000 claims 1
- 208000031066 hyperpigmentation of the skin Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- -1 monosubstituted phenyl Chemical group 0.000 claims 1
- 201000005962 mycosis fungoides Diseases 0.000 claims 1
- 201000004931 neurofibromatosis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000000849 skin cancer Diseases 0.000 claims 1
- 230000008470 skin growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US77317206P | 2006-02-14 | 2006-02-14 | |
| US60/773,172 | 2006-02-14 | ||
| PCT/US2007/062152 WO2007095584A2 (en) | 2006-02-14 | 2007-02-14 | Histone Deacetylase Inhibitors |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013008195A Division JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009526865A JP2009526865A (ja) | 2009-07-23 |
| JP2009526865A5 true JP2009526865A5 (enExample) | 2011-09-15 |
| JP5409015B2 JP5409015B2 (ja) | 2014-02-05 |
Family
ID=38372243
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008555472A Active JP5409015B2 (ja) | 2006-02-14 | 2007-02-14 | ヒストンデアセチラーゼ阻害剤 |
| JP2013008195A Pending JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013008195A Pending JP2013100327A (ja) | 2006-02-14 | 2013-01-21 | ヒストンデアセチラーゼ阻害剤 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8383855B2 (enExample) |
| EP (1) | EP2010168B1 (enExample) |
| JP (2) | JP5409015B2 (enExample) |
| CN (2) | CN101528679A (enExample) |
| AU (1) | AU2007214458C1 (enExample) |
| BR (1) | BRPI0707826B1 (enExample) |
| CA (1) | CA2642288C (enExample) |
| DK (1) | DK2010168T3 (enExample) |
| ES (1) | ES2481413T3 (enExample) |
| IL (1) | IL193458A (enExample) |
| MX (1) | MX2008010462A (enExample) |
| PL (1) | PL2010168T3 (enExample) |
| WO (1) | WO2007095584A2 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6777217B1 (en) | 1996-03-26 | 2004-08-17 | President And Fellows Of Harvard College | Histone deacetylases, and uses related thereto |
| US20030129724A1 (en) * | 2000-03-03 | 2003-07-10 | Grozinger Christina M. | Class II human histone deacetylases, and uses related thereto |
| US7244853B2 (en) | 2001-05-09 | 2007-07-17 | President And Fellows Of Harvard College | Dioxanes and uses thereof |
| CN101495116A (zh) | 2005-03-22 | 2009-07-29 | 哈佛大学校长及研究员协会 | 蛋白降解病症的治疗 |
| EP2010168B1 (en) | 2006-02-14 | 2014-04-16 | The President and Fellows of Harvard College | Histone deacetylase inhibitors |
| JP5441416B2 (ja) * | 2006-02-14 | 2014-03-12 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二官能性ヒストンデアセチラーゼインヒビター |
| CN101484156B (zh) * | 2006-05-03 | 2015-11-25 | 哈佛大学校长及研究员协会 | 组蛋白脱乙酰基酶和微管蛋白脱乙酰基酶抑制剂 |
| RU2515611C2 (ru) * | 2008-07-23 | 2014-05-20 | Президент Энд Феллоуз Оф Гарвард Колледж | Ингибиторы деацетилазы и их применение |
| CN102421428B (zh) * | 2009-05-12 | 2014-01-29 | 株式会社爱茉莉太平洋 | 用于防止脱发或促进毛发生长的组合物 |
| US8716344B2 (en) | 2009-08-11 | 2014-05-06 | President And Fellows Of Harvard College | Class- and isoform-specific HDAC inhibitors and uses thereof |
| US9255066B2 (en) | 2010-10-13 | 2016-02-09 | Tetralogic Shape Uk Ltd | Pharmaceutical formulation for histone deacetylase inhibitors |
| CN104447608B (zh) * | 2014-11-10 | 2017-01-11 | 华东师范大学 | 含有噻唑啉酮结构的异羟肟酸类小分子有机化合物及其衍生物、用途及其制备方法 |
| CN104744431A (zh) * | 2015-03-06 | 2015-07-01 | 芜湖杨燕制药有限公司 | 一种组蛋白去乙酰化酶抑制剂及其制备方法和用途 |
| WO2018191171A1 (en) * | 2017-04-10 | 2018-10-18 | City Of Hope | P38 gamma inhibitors and method of use thereof |
| CN108299313B (zh) * | 2018-01-16 | 2020-10-02 | 长沙霍滋生物科技有限公司 | 一种化合物及其在药学上的应用 |
| CN111943892B (zh) * | 2019-05-17 | 2022-04-05 | 上海中泽医药科技有限公司 | 组蛋白去乙酰化酶亚型抑制剂硫乙酰芳胺类化合物及用途 |
| CN114748463A (zh) * | 2022-05-25 | 2022-07-15 | 中南大学湘雅医院 | Remetinostat在制备治疗银屑病的药物中的应用 |
| CN115364226A (zh) * | 2022-09-23 | 2022-11-22 | 华中科技大学同济医学院附属同济医院 | 组蛋白去乙酰化酶hdac3在制备防治支架及内膜剥脱术后血管再狭窄的药物中的应用 |
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| EP2010168B1 (en) * | 2006-02-14 | 2014-04-16 | The President and Fellows of Harvard College | Histone deacetylase inhibitors |
| JP5441416B2 (ja) | 2006-02-14 | 2014-03-12 | プレジデント アンド フェロウズ オブ ハーバード カレッジ | 二官能性ヒストンデアセチラーゼインヒビター |
| CN101484156B (zh) | 2006-05-03 | 2015-11-25 | 哈佛大学校长及研究员协会 | 组蛋白脱乙酰基酶和微管蛋白脱乙酰基酶抑制剂 |
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-
2007
- 2007-02-14 EP EP07757000.0A patent/EP2010168B1/en active Active
- 2007-02-14 ES ES07757000.0T patent/ES2481413T3/es active Active
- 2007-02-14 AU AU2007214458A patent/AU2007214458C1/en active Active
- 2007-02-14 US US12/279,398 patent/US8383855B2/en active Active
- 2007-02-14 WO PCT/US2007/062152 patent/WO2007095584A2/en not_active Ceased
- 2007-02-14 DK DK07757000.0T patent/DK2010168T3/da active
- 2007-02-14 MX MX2008010462A patent/MX2008010462A/es active IP Right Grant
- 2007-02-14 JP JP2008555472A patent/JP5409015B2/ja active Active
- 2007-02-14 CA CA2642288A patent/CA2642288C/en active Active
- 2007-02-14 CN CNA2007800087840A patent/CN101528679A/zh active Pending
- 2007-02-14 BR BRPI0707826-9A patent/BRPI0707826B1/pt active IP Right Grant
- 2007-02-14 PL PL07757000T patent/PL2010168T3/pl unknown
- 2007-02-14 CN CN201310483521.2A patent/CN103739515B/zh active Active
-
2008
- 2008-08-14 IL IL193458A patent/IL193458A/en active IP Right Grant
-
2013
- 2013-01-21 JP JP2013008195A patent/JP2013100327A/ja active Pending
- 2013-07-17 US US13/944,320 patent/US20140213620A1/en not_active Abandoned
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2014
- 2014-03-06 US US14/198,764 patent/US9199923B2/en active Active
-
2015
- 2015-09-23 US US14/862,679 patent/US9724321B2/en active Active
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2017
- 2017-06-29 US US15/637,078 patent/US10172821B2/en active Active
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