EP0855024A4 - Histone deacetylase as target for antiprotozoal agents - Google Patents

Histone deacetylase as target for antiprotozoal agents

Info

Publication number
EP0855024A4
EP0855024A4 EP96930894A EP96930894A EP0855024A4 EP 0855024 A4 EP0855024 A4 EP 0855024A4 EP 96930894 A EP96930894 A EP 96930894A EP 96930894 A EP96930894 A EP 96930894A EP 0855024 A4 EP0855024 A4 EP 0855024A4
Authority
EP
European Patent Office
Prior art keywords
target
histone deacetylase
antiprotozoal agents
antiprotozoal
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96930894A
Other languages
German (de)
French (fr)
Other versions
EP0855024A1 (en
Inventor
Paula M Dulski
Anne M Gurnett
Robert W Myers
Sandra J Rattray
Dennis M Schmatz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602974.9A external-priority patent/GB9602974D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0855024A1 publication Critical patent/EP0855024A1/en
Publication of EP0855024A4 publication Critical patent/EP0855024A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
EP96930894A 1995-09-20 1996-09-16 Histone deacetylase as target for antiprotozoal agents Withdrawn EP0855024A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US406595P 1995-09-20 1995-09-20
US4065P 1995-09-20
GBGB9602974.9A GB9602974D0 (en) 1996-02-13 1996-02-13 Histone deacetylase as target for antiprotozal agents
GB9602974 1996-02-13
PCT/US1996/014826 WO1997011366A1 (en) 1995-09-20 1996-09-16 Histone deacetylase as target for antiprotozoal agents

Publications (2)

Publication Number Publication Date
EP0855024A1 EP0855024A1 (en) 1998-07-29
EP0855024A4 true EP0855024A4 (en) 2001-08-22

Family

ID=26308692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96930894A Withdrawn EP0855024A4 (en) 1995-09-20 1996-09-16 Histone deacetylase as target for antiprotozoal agents

Country Status (5)

Country Link
EP (1) EP0855024A4 (en)
JP (1) JPH11514857A (en)
AU (1) AU712801B2 (en)
CA (1) CA2231251A1 (en)
WO (1) WO1997011366A1 (en)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
EP1010705A4 (en) * 1997-09-02 2004-09-15 Sumitomo Pharma Novel cyclic tetrapeptide derivatives and medicinal use thereof
CZ20011342A3 (en) 1998-10-13 2001-09-12 Fujisawa Pharmaceutical Co., Ltd. Cyclic tetrapeptides
CA2386299A1 (en) * 1999-10-08 2001-04-19 Merck & Co., Inc. Antiprotozoal histone acetyl transferase inhibitors
PT1233958E (en) 1999-11-23 2011-09-20 Methylgene Inc Inhibitors of histone deacetylase
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
EP1170008A1 (en) * 2000-07-07 2002-01-09 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Valproic acid and derivatives thereof as histone deacetylase inhibitors
WO2002055017A2 (en) 2000-11-21 2002-07-18 Wake Forest University Method of treating autoimmune diseases
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
US20040087657A1 (en) 2001-10-16 2004-05-06 Richon Victoria M. Treatment of neurodegenerative diseases and cancer of the brain using histone deacetylase inhibitors
AU2003211362A1 (en) * 2002-02-21 2003-09-09 Osaka Industrial Promotion Organization N-hydroxycarboxamide derivative
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
KR100868813B1 (en) 2002-03-04 2008-11-14 슬로안-케테링인스티튜트퍼캔서리서치 Methods of inducing terminal differentiation
EP1663194B1 (en) 2003-08-26 2010-03-31 Merck HDAC Research, LLC Use of SAHA for treating mesothelioma
EP1667680A4 (en) 2003-08-29 2008-10-08 Aton Pharma Inc Combination methods of treating cancer
US7935724B2 (en) 2003-10-09 2011-05-03 Merck Hdac Research, Llc Thiophene and benzothiophene hydroxamic acid derivatives
AU2005230682B2 (en) 2004-04-05 2010-10-21 Merck Hdac Research, Llc Histone deacetylase inhibitor prodrugs
CA2937005A1 (en) 2005-03-22 2006-09-28 President And Fellows Of Harvard College Treatment of protein degradation disorders
KR20080032188A (en) 2005-07-14 2008-04-14 다케다 샌디에고, 인코포레이티드 Histone deacetylase inhibitors
ES2481413T3 (en) 2006-02-14 2014-07-30 The President And Fellows Of Harvard College Histone Deacetylase Inhibitors
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
WO2008013589A2 (en) 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Treatment of ras-expressing tumors
WO2007130429A2 (en) 2006-05-03 2007-11-15 The President And Fellows Of Harvard College Histone deacetylase and tubulin deacetylase inhibitors
MX2009003405A (en) 2006-09-28 2009-04-09 Merck & Co Inc Pharmaceutical compositions of hdac inhibitors and chelatable metal compounds, and metal-hdac inhibitor chelate complexes.
JP2008307007A (en) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag Human pluripotent stem cell induced from human tissue-originated undifferentiated stem cell after birth
RU2515611C2 (en) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Deacetylase inhibitors and their application
CA2763299C (en) 2009-06-26 2015-11-24 Asan Laboratories Co., Ltd. Method for treating or ameliorating mucocutaneous or ocular toxicities
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
WO2011139688A2 (en) 2010-04-28 2011-11-10 The J. David Gladstone Institutes Methods for generating cardiomyocytes
WO2012007725A2 (en) 2010-07-16 2012-01-19 Plasticell Ltd Method of reprogramming a cell
WO2013151186A1 (en) 2012-04-06 2013-10-10 国立大学法人京都大学 Method for inducing erythropoietin-producing cell
US11026381B2 (en) 2015-07-28 2021-06-08 Vilmorin & Cie Method for producing haploid, dihaploid and doubled haploid plants by isolated microspore culture
WO2017156147A1 (en) * 2016-03-08 2017-09-14 The Board Of Regents For Oklahoma State University Office Of Intellectual Property Management Technology Development Center Immune boosting dietary compounds for disease control and prevention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218478A (en) * 1979-01-05 1980-08-19 Ruiko Oiwa Trichostatin as an antiprotozoal agent
US5356927A (en) * 1992-12-02 1994-10-18 Thomas Jefferson University Methods of treating plasmodium and babesia parasitic infections

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9711366A1 *

Also Published As

Publication number Publication date
AU712801B2 (en) 1999-11-18
CA2231251A1 (en) 1997-03-27
EP0855024A1 (en) 1998-07-29
JPH11514857A (en) 1999-12-21
WO1997011366A1 (en) 1997-03-27
AU6979096A (en) 1997-04-09

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Legal Events

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