EP0855024A4 - Histone desacetylase comme cible pour des agents antiprotozoaires - Google Patents

Histone desacetylase comme cible pour des agents antiprotozoaires

Info

Publication number
EP0855024A4
EP0855024A4 EP96930894A EP96930894A EP0855024A4 EP 0855024 A4 EP0855024 A4 EP 0855024A4 EP 96930894 A EP96930894 A EP 96930894A EP 96930894 A EP96930894 A EP 96930894A EP 0855024 A4 EP0855024 A4 EP 0855024A4
Authority
EP
European Patent Office
Prior art keywords
target
histone deacetylase
antiprotozoal agents
antiprotozoal
agents
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96930894A
Other languages
German (de)
English (en)
Other versions
EP0855024A1 (fr
Inventor
Paula M Dulski
Anne M Gurnett
Robert W Myers
Sandra J Rattray
Dennis M Schmatz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9602974.9A external-priority patent/GB9602974D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0855024A1 publication Critical patent/EP0855024A1/fr
Publication of EP0855024A4 publication Critical patent/EP0855024A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/18—Testing for antimicrobial activity of a material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/126—Tetrapeptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
EP96930894A 1995-09-20 1996-09-16 Histone desacetylase comme cible pour des agents antiprotozoaires Withdrawn EP0855024A4 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US406595P 1995-09-20 1995-09-20
US4065P 1995-09-20
GB9602974 1996-02-13
GBGB9602974.9A GB9602974D0 (en) 1996-02-13 1996-02-13 Histone deacetylase as target for antiprotozal agents
PCT/US1996/014826 WO1997011366A1 (fr) 1995-09-20 1996-09-16 Histone desacetylase comme cible pour des agents antiprotozoaires

Publications (2)

Publication Number Publication Date
EP0855024A1 EP0855024A1 (fr) 1998-07-29
EP0855024A4 true EP0855024A4 (fr) 2001-08-22

Family

ID=26308692

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96930894A Withdrawn EP0855024A4 (fr) 1995-09-20 1996-09-16 Histone desacetylase comme cible pour des agents antiprotozoaires

Country Status (5)

Country Link
EP (1) EP0855024A4 (fr)
JP (1) JPH11514857A (fr)
AU (1) AU712801B2 (fr)
CA (1) CA2231251A1 (fr)
WO (1) WO1997011366A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) * 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
AU732299B2 (en) * 1997-09-02 2001-04-12 Japan Energy Corporation Novel cyclic tetrapeptide derivatives and pharmaceutical use thereof
PL348648A1 (en) 1998-10-13 2002-06-03 Fujisawa Pharmaceutical Co Cyclic tetrapeptide compound and use thereof
EP1222308A4 (fr) * 1999-10-08 2005-02-16 Merck & Co Inc Inhibiteurs d'histone acetyle transferase antiprotozoaire
KR20100035666A (ko) 1999-11-23 2010-04-05 메틸진 인크. 히스톤 디아세틸라제의 억제제
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
EP1170008A1 (fr) * 2000-07-07 2002-01-09 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Acide valproique et ses dérivés en tant qu' inhibiteurs de la déacétylase de l' histone
WO2002055017A2 (fr) 2000-11-21 2002-07-18 Wake Forest University Methode de traitement de maladies auto-immunes
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
JP4638148B2 (ja) 2001-10-16 2011-02-23 スローン − ケタリング・インスティテュート・フォー・キャンサー・リサーチ 神経変性疾患および脳の癌の処置
JPWO2003070691A1 (ja) * 2002-02-21 2005-06-09 財団法人大阪産業振興機構 Ｎ−ヒドロキシカルボキサミド誘導体
US7456219B2 (en) 2002-03-04 2008-11-25 Merck Hdac Research, Llc Polymorphs of suberoylanilide hydroxamic acid
EP2266552A3 (fr) 2002-03-04 2011-03-02 Merck HDAC Research, LLC Procédés d'induction de différentiation de terminal
BRPI0413826A (pt) 2003-08-26 2006-10-24 Aton Pharma Inc processo de tratamento de cáncer com inibidores de hdac
EP2226072A1 (fr) 2003-08-29 2010-09-08 Aton Pharma, Inc. Combinaisons à base d'acide suberoylanilide hydroxamique et d'agents antimétabolites pour le traitement du cancer
JP2007508318A (ja) 2003-10-09 2007-04-05 エートン ファーマ インコーポレーティッド チオフェンおよびベンゾチオフェンヒドロキサム酸誘導体
CA2561617A1 (fr) 2004-04-05 2005-10-20 Aton Pharma, Inc. Promedicaments sous forme d'inhibiteurs d'histones desacetylases
EP3354265A1 (fr) 2005-03-22 2018-08-01 President and Fellows of Harvard College Traitement des troubles de la dégradation de protéines
ZA200800901B (en) 2005-07-14 2010-05-26 Takeda San Diego Inc Histone deacetylase inhibitors
MX2008010462A (es) 2006-02-14 2009-04-17 Harvard College Inhibidores de histona desacetilasa.
JP5441416B2 (ja) 2006-02-14 2014-03-12 プレジデント アンド フェロウズ オブ ハーバード カレッジ 二官能性ヒストンデアセチラーゼインヒビター
CA2650520A1 (fr) 2006-04-24 2008-01-31 Gloucester Pharmaceuticals Traitement de tumeurs exprimant ras
EP2019674B1 (fr) 2006-05-03 2016-11-23 The President and Fellows of Harvard College Inhibiteurs d'histone désacétylases et de tubuline désacétylases
MX2009003405A (es) 2006-09-28 2009-04-09 Merck & Co Inc Composiciones farmaceuticas de inhibidores de la histona desacetilasa y compuestos quelantes de metal, y complejos de quelato de metal-inhibidor de histona desacetilasa.
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
ES2621849T3 (es) 2009-06-26 2017-07-05 Sunny Pharmtech Inc. Método de tratamiento o mejora de toxicidades mucocutáneas u oculares.
WO2011019393A2 (fr) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Inhibiteurs de hdac classe- et isoforme-spécifiques et utilisations de ceux-ci
JP5988961B2 (ja) 2010-04-28 2016-09-07 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ 心筋細胞を発生させるための方法
WO2012007725A2 (fr) 2010-07-16 2012-01-19 Plasticell Ltd Procédé de reprogrammation d'une cellule
JP6112733B2 (ja) 2012-04-06 2017-04-12 国立大学法人京都大学 エリスロポエチン産生細胞の誘導方法
WO2017017108A1 (fr) 2015-07-28 2017-02-02 Vilmorin & Cie Procédé de production de plantes haploïdes, dihaploïdes et amphihaploïdes par la culture de microspores isolés
US20190054057A1 (en) * 2016-03-08 2019-02-21 The Board Of Regents For Oklahoma State University Office Of Intellectual Property Management Immune boosting dietary compounds for disease control and prevention

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4218478A (en) * 1979-01-05 1980-08-19 Ruiko Oiwa Trichostatin as an antiprotozoal agent
US5356927A (en) * 1992-12-02 1994-10-18 Thomas Jefferson University Methods of treating plasmodium and babesia parasitic infections

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
No further relevant documents disclosed *
See also references of WO9711366A1 *

Also Published As

Publication number Publication date
JPH11514857A (ja) 1999-12-21
AU712801B2 (en) 1999-11-18
EP0855024A1 (fr) 1998-07-29
CA2231251A1 (fr) 1997-03-27
WO1997011366A1 (fr) 1997-03-27
AU6979096A (en) 1997-04-09

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Legal Events

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