PE20050206A1 - Composicion farmaceutica que contiene un inhibidor de histona deacetilasa - Google Patents

Composicion farmaceutica que contiene un inhibidor de histona deacetilasa

Info

Publication number
PE20050206A1
PE20050206A1 PE2004000533A PE2004000533A PE20050206A1 PE 20050206 A1 PE20050206 A1 PE 20050206A1 PE 2004000533 A PE2004000533 A PE 2004000533A PE 2004000533 A PE2004000533 A PE 2004000533A PE 20050206 A1 PE20050206 A1 PE 20050206A1
Authority
PE
Peru
Prior art keywords
pharmaceutical composition
amino
inhibitor
composition containing
deacetilase
Prior art date
Application number
PE2004000533A
Other languages
English (en)
Inventor
Osamu Nakanishi
Tatsuo Sugawara
Hideyuki Migita
Yasuhiro Matsuba
Original Assignee
Schering Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag filed Critical Schering Ag
Publication of PE20050206A1 publication Critical patent/PE20050206A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Abstract

REFERIDA A UNA COMPOSICION FARMACEUTICA CUYOS INGREDIENTES ACTIVOS SON: (A) UNO DE LOS DERIVADOS DE HISTONA DEACETILASA TAL COMO LA N-(2-AMINOFENIL)-4-[N-(PIRIDIN-3-ILMETOXICARBONIL)AMINO METIL] BENZAMIDA, O UNA SAL DE LA MISMA DE FORMULA I; (B) UNA SUSTANCIA ANTICANCER COMO CISPLATINO, ETOPOSIDO, PACLITAXEL Y CARBOPLATINO, ENTRE OTRAS. A ES FENILO, HETEROCICLICO OPCIONALMENTE SUSTITUIDOS; X ES UN ENLACE, -(CH2)e-, -(CH3)g-O-(CH2)e-, ENTRE OTROS; e ES 1-4; g ES 0-4; Q ES -CONH-, -COONH-, -COSNH-, ENTRE OTROS; n ES 0-4; R1 Y R2 SON CADA UNO H, HALOGENO, AMINO, ENTRE OTROS; R3 ES HIDROXILO, AMINO. DICHA COMPOSICION TIENE UN EFECTO SINERGICO EN TRATAMIENTOS DE CANCER PULMONAR, OVARICO, PANCREATICO, DE COLON, ENTRE OTROS
PE2004000533A 2003-05-26 2004-05-25 Composicion farmaceutica que contiene un inhibidor de histona deacetilasa PE20050206A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2003148073 2003-05-26

Publications (1)

Publication Number Publication Date
PE20050206A1 true PE20050206A1 (es) 2005-03-26

Family

ID=33475383

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2004000533A PE20050206A1 (es) 2003-05-26 2004-05-25 Composicion farmaceutica que contiene un inhibidor de histona deacetilasa

Country Status (27)

Country Link
US (1) US20070098816A1 (es)
EP (1) EP1626719A1 (es)
JP (1) JP2006526031A (es)
KR (1) KR100938712B1 (es)
CN (2) CN1794991A (es)
AR (1) AR045318A1 (es)
AU (1) AU2004241873C1 (es)
BR (1) BRPI0410959A (es)
CA (4) CA2634765A1 (es)
CL (1) CL2004001278A1 (es)
CO (1) CO5660262A2 (es)
CR (1) CR8163A (es)
CU (1) CU23490B7 (es)
EC (1) ECSP056253A (es)
IL (1) IL171941A0 (es)
ME (1) MEP32308A (es)
MX (1) MXPA05012345A (es)
NO (1) NO20055417L (es)
NZ (1) NZ543591A (es)
PE (1) PE20050206A1 (es)
RS (1) RS20050884A (es)
RU (1) RU2322971C2 (es)
TW (1) TW200505424A (es)
UA (1) UA81499C2 (es)
UY (1) UY28330A1 (es)
WO (1) WO2004103369A1 (es)
ZA (1) ZA200509515B (es)

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WO2009067453A1 (en) * 2007-11-19 2009-05-28 Syndax Pharmaceuticals, Inc. Combinations of hdac inhibitors and proteasome inhibitors
US8293513B2 (en) * 2007-12-14 2012-10-23 Georgetown University Histone deacetylase inhibitors
CA2731730C (en) 2008-07-23 2017-06-13 President And Fellows Of Harvard College Deacetylase inhibitors and uses thereof
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US20130045240A1 (en) * 2009-08-25 2013-02-21 Abraxis Bioscience, Llc Combination therapy with nanoparticle compositions of taxane and hedgehog inhibitors
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SG2014014419A (en) 2011-09-13 2014-07-30 Pharmacyclics Inc Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
IN2014KN00929A (es) 2011-09-30 2015-08-21 Vertex Pharma
CN108685922A (zh) 2011-09-30 2018-10-23 沃泰克斯药物股份有限公司 用atr抑制剂治疗胰腺癌和非小细胞肺癌
WO2013085902A1 (en) * 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
PL2833973T3 (pl) 2012-04-05 2018-02-28 Vertex Pharmaceuticals Incorporated Związki użyteczne jako inhibitory kinazy ATR i ich terapie skojarzone
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
JP6320506B2 (ja) 2013-03-12 2018-05-09 セルジーン クオンティセル リサーチ，インク． ヒストンデメチラーゼ阻害剤
US9963452B2 (en) * 2013-03-14 2018-05-08 Augusta Pharmaceuticals Inc. Methods, compounds, and compositions for inhibition of ROS
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JP2003137866A (ja) * 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体

Also Published As

Publication number Publication date
AR045318A1 (es) 2005-10-26
NZ543591A (en) 2009-09-25
EP1626719A1 (en) 2006-02-22
CA2527191A1 (en) 2004-12-02
AU2004241873C1 (en) 2009-01-22
UY28330A1 (es) 2004-12-31
KR20060009371A (ko) 2006-01-31
AU2004241873A1 (en) 2004-12-02
KR100938712B1 (ko) 2010-01-25
MXPA05012345A (es) 2006-02-08
IL171941A0 (en) 2006-04-10
CO5660262A2 (es) 2006-07-31
CN1794991A (zh) 2006-06-28
NO20055417L (no) 2005-12-19
CA2634709A1 (en) 2004-12-02
CL2004001278A1 (es) 2005-05-06
ECSP056253A (es) 2006-10-25
CA2634765A1 (en) 2004-12-02
RU2005140570A (ru) 2006-06-10
MEP32308A (en) 2010-10-10
CU23490B7 (es) 2010-02-23
JP2006526031A (ja) 2006-11-16
AU2004241873B2 (en) 2008-05-08
NO20055417D0 (no) 2005-11-16
RS20050884A (en) 2008-04-04
TW200505424A (en) 2005-02-16
CA2634766A1 (en) 2004-12-02
UA81499C2 (en) 2008-01-10
BRPI0410959A (pt) 2006-07-04
AU2004241873B8 (en) 2008-05-29
CR8163A (es) 2006-07-14
RU2322971C2 (ru) 2008-04-27
ZA200509515B (en) 2006-07-26
WO2004103369A1 (en) 2004-12-02
CN101322707A (zh) 2008-12-17
US20070098816A1 (en) 2007-05-03

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Legal Events

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FG Grant, registration
FD Application declared void or lapsed