RS20050884A - Pharmaceutical composition containing histone deacetylase inhibitor - Google Patents

Pharmaceutical composition containing histone deacetylase inhibitor

Info

Publication number
RS20050884A
RS20050884A YUP-2005/0884A YUP20050884A RS20050884A RS 20050884 A RS20050884 A RS 20050884A YU P20050884 A YUP20050884 A YU P20050884A RS 20050884 A RS20050884 A RS 20050884A
Authority
RS
Serbia
Prior art keywords
pharmaceutical composition
composition containing
histone deacetylase
deacetylase inhibitor
containing histone
Prior art date
Application number
YUP-2005/0884A
Other languages
English (en)
Inventor
Osamu Nakanishi
Taisuo Sugawara
Hideyuki Migita
Yasuhiro Matsuba
Original Assignee
Schering Aktiengesellschaft,
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Aktiengesellschaft, filed Critical Schering Aktiengesellschaft,
Priority to MEP-323/08A priority Critical patent/MEP32308A/xx
Publication of RS20050884A publication Critical patent/RS20050884A/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Opisan je lek protiv raka koji obezbeđuje sinergističko dejstvo derivata benzamida, kao što N-(2-aminofenil)-4-[N-(piridin-3-ilmetoksikarbonil)aminoetil]benzamid (MS-275), koji je inhibitor histonske deacetilaze, prilikom kombinovane upotrebe sa još jednom aktivnom antikancerskom supstancom.
YUP-2005/0884A 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor RS20050884A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MEP-323/08A MEP32308A (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2003148073 2003-05-26
PCT/JP2004/007562 WO2004103369A1 (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Publications (1)

Publication Number Publication Date
RS20050884A true RS20050884A (en) 2008-04-04

Family

ID=33475383

Family Applications (1)

Application Number Title Priority Date Filing Date
YUP-2005/0884A RS20050884A (en) 2003-05-26 2004-05-26 Pharmaceutical composition containing histone deacetylase inhibitor

Country Status (27)

Country Link
US (1) US20070098816A1 (sr)
EP (1) EP1626719A1 (sr)
JP (1) JP2006526031A (sr)
KR (1) KR100938712B1 (sr)
CN (2) CN101322707A (sr)
AR (1) AR045318A1 (sr)
AU (1) AU2004241873C1 (sr)
BR (1) BRPI0410959A (sr)
CA (4) CA2634709A1 (sr)
CL (1) CL2004001278A1 (sr)
CO (1) CO5660262A2 (sr)
CR (1) CR8163A (sr)
CU (1) CU23490B7 (sr)
EC (1) ECSP056253A (sr)
IL (1) IL171941A0 (sr)
ME (1) MEP32308A (sr)
MX (1) MXPA05012345A (sr)
NO (1) NO20055417L (sr)
NZ (1) NZ543591A (sr)
PE (1) PE20050206A1 (sr)
RS (1) RS20050884A (sr)
RU (1) RU2322971C2 (sr)
TW (1) TW200505424A (sr)
UA (1) UA81499C2 (sr)
UY (1) UY28330A1 (sr)
WO (1) WO2004103369A1 (sr)
ZA (1) ZA200509515B (sr)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6777217B1 (en) 1996-03-26 2004-08-17 President And Fellows Of Harvard College Histone deacetylases, and uses related thereto
US20030129724A1 (en) 2000-03-03 2003-07-10 Grozinger Christina M. Class II human histone deacetylases, and uses related thereto
US7244853B2 (en) 2001-05-09 2007-07-17 President And Fellows Of Harvard College Dioxanes and uses thereof
ES2425083T3 (es) 2003-09-25 2013-10-11 Astellas Pharma Inc. Agente antitumoral que comprende FK228 como inhibidor de histona desacetilasa y doxorrubicina como inhibidor de topoisomerasa II
US7446126B2 (en) * 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
EP1712552A1 (en) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
MX2007011148A (es) * 2005-03-11 2008-02-22 Univ Colorado Inhibidores de histona desacetilasa que sensibilizan celulas cancerosas respecto a los inhibidores de factor de crecimiento.
CN101495116A (zh) 2005-03-22 2009-07-29 哈佛大学校长及研究员协会 蛋白降解病症的治疗
CN101263121A (zh) 2005-07-14 2008-09-10 塔克达圣地亚哥公司 组蛋白脱乙酰基酶抑制剂
JP5409015B2 (ja) * 2006-02-14 2014-02-05 プレジデント アンド フェロウズ オブ ハーバード カレッジ ヒストンデアセチラーゼ阻害剤
WO2008091349A1 (en) 2006-02-14 2008-07-31 The President And Fellows Of Harvard College Bifunctional histone deacetylase inhibitors
AU2007248656B2 (en) 2006-05-03 2013-04-04 Dana-Farber Cancer Institute, Inc. Histone deacetylase and tubulin deacetylase inhibitors
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
DK2099442T3 (en) * 2006-12-26 2015-02-16 Pharmacyclics Inc Method of using histone deacetylase inhibitors and monitoring biomarkers in combination therapy
US20090131367A1 (en) * 2007-11-19 2009-05-21 The Regents Of The University Of Colorado Combinations of HDAC Inhibitors and Proteasome Inhibitors
WO2009079375A1 (en) * 2007-12-14 2009-06-25 Georgetown University Histone deacetylase inhibitors
RU2515611C2 (ru) 2008-07-23 2014-05-20 Президент Энд Феллоуз Оф Гарвард Колледж Ингибиторы деацетилазы и их применение
MY149058A (en) * 2008-08-29 2013-07-15 Bayer Ip Gmbh N-(2-aminophenyl)-4-[n-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (ms-275) polymorph b
GB2462893B (en) * 2008-08-29 2010-10-13 Bayer Schering Pharma Ag N-(2-aminophenyl)-4-[N-(pyridine-3-yl)-methoxycarbonyl-aminomethyl]-benzamide (MS-275) polymorph B
MX2011006503A (es) 2008-12-19 2011-09-06 Vertex Pharma Derivados de pirazina utiles como inhibidores de la cinasa de atr.
US20120034302A1 (en) * 2009-02-11 2012-02-09 Liangping Yu Particulate composition and the method of making the same
EP2424516A4 (en) * 2009-05-01 2014-04-02 Oncozyme Pharma Inc PENTAMIDINE COMBINATIONS FOR THE TREATMENT OF CANCER
EP2440519A1 (en) * 2009-06-08 2012-04-18 Gilead Sciences, Inc. Alkanoylamino benzamide aniline hdac inihibitor compounds
WO2011019393A2 (en) 2009-08-11 2011-02-17 President And Fellows Of Harvard College Class- and isoform-specific hdac inhibitors and uses thereof
RU2561055C2 (ru) * 2009-08-25 2015-08-20 АБРАКСИС БАЙОСАЙЕНС, ЭлЭлСи Комбинированная терапия композициями наночастиц таксана и ингибиторами хэджхог
SG185524A1 (en) 2010-05-12 2012-12-28 Vertex Pharma Compounds useful as inhibitors of atr kinase
US9492423B2 (en) 2011-09-13 2016-11-15 Pharmacyclics Llc Formulations of histone deacetylase inhibitor in combination with bendamustine and uses thereof
KR102056586B1 (ko) * 2011-09-30 2019-12-18 버텍스 파마슈티칼스 인코포레이티드 Ａｔｒ 억제제를 이용한 췌장암 및 비소세포 폐암의 치료
MX353461B (es) 2011-09-30 2018-01-15 Vertex Pharma PROCESOS PARA PREPARAR COMPUESTOS ÚTILES COMO INHIBIDORES DE CINASA ATAXIA TELANGIECTASIA MUTADA Y Rad3 RELACIONADOS (ATR).
WO2013085902A1 (en) * 2011-12-05 2013-06-13 The University Of Texas M.D. Combination therapy methods for treating an inflammatory breast cancer
CA2869309C (en) 2012-04-05 2021-02-09 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase and combination therapies thereof
US8999632B2 (en) 2012-10-04 2015-04-07 Vertex Pharmaceuticals Incorporated Method for measuring ATR inhibition mediated increases in DNA damage
EP2968282B1 (en) 2013-03-12 2018-05-09 Celgene Quanticel Research, Inc. Histone dementhylase inhibitors
US9963452B2 (en) * 2013-03-14 2018-05-08 Augusta Pharmaceuticals Inc. Methods, compounds, and compositions for inhibition of ROS
EA201592012A8 (ru) * 2014-02-21 2018-10-31 Общество С Ограниченной Ответственностью "Биолаб 612" Применение флагеллина для улучшенной химиотерапии
CN107001330A (zh) 2014-09-17 2017-08-01 赛尔基因昆蒂赛尔研究公司 组蛋白脱甲基酶抑制剂
RU2768621C1 (ru) 2015-09-30 2022-03-24 Вертекс Фармасьютикалз Инкорпорейтед Способ лечения рака с использованием комбинации повреждающих днк средств и ингибиторов atr
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11596612B1 (en) 2022-03-08 2023-03-07 PTC Innovations, LLC Topical anesthetics

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2697752B1 (fr) * 1992-11-10 1995-04-14 Rhone Poulenc Rorer Sa Compositions antitumorales contenant des dérivés du taxane.
US6174905B1 (en) * 1996-09-30 2001-01-16 Mitsui Chemicals, Inc. Cell differentiation inducer
JP3354090B2 (ja) * 1996-09-30 2002-12-09 シエーリング アクチエンゲゼルシャフト 分化誘導剤
US6794392B1 (en) * 1996-09-30 2004-09-21 Schering Aktiengesellschaft Cell differentiation inducer
US5753637A (en) * 1996-10-09 1998-05-19 Ideal Ideas, Inc. Method of treating acne conditions
ES2185378T3 (es) * 1998-09-25 2003-04-16 Warner Lambert Co Quimioterapia de cancer con acetildinalina en combinacion con gemcitabina, capecitabina o cisplatina.
AU4144400A (en) * 1999-04-27 2000-11-10 Mitsubishi Pharma Corporation Preventives/remedies for liver diseases
JP2003513912A (ja) * 1999-11-10 2003-04-15 ワーナー−ランバート・カンパニー 組合せ化学療法
US6905669B2 (en) * 2001-04-24 2005-06-14 Supergen, Inc. Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase
CZ20022216A3 (cs) * 2001-07-02 2003-05-14 Warner-Lambert Company Kombinační chemoterapie
JP2003137866A (ja) * 2001-11-01 2003-05-14 Sankyo Co Ltd フェニレンジアミン誘導体

Also Published As

Publication number Publication date
NZ543591A (en) 2009-09-25
CA2634709A1 (en) 2004-12-02
CA2634765A1 (en) 2004-12-02
BRPI0410959A (pt) 2006-07-04
AU2004241873A1 (en) 2004-12-02
NO20055417D0 (no) 2005-11-16
AU2004241873B8 (en) 2008-05-29
UA81499C2 (en) 2008-01-10
MEP32308A (en) 2010-10-10
MXPA05012345A (es) 2006-02-08
CU23490B7 (es) 2010-02-23
PE20050206A1 (es) 2005-03-26
AU2004241873C1 (en) 2009-01-22
CO5660262A2 (es) 2006-07-31
CA2634766A1 (en) 2004-12-02
CN101322707A (zh) 2008-12-17
CR8163A (es) 2006-07-14
KR20060009371A (ko) 2006-01-31
EP1626719A1 (en) 2006-02-22
RU2322971C2 (ru) 2008-04-27
TW200505424A (en) 2005-02-16
CN1794991A (zh) 2006-06-28
WO2004103369A1 (en) 2004-12-02
AU2004241873B2 (en) 2008-05-08
AR045318A1 (es) 2005-10-26
UY28330A1 (es) 2004-12-31
JP2006526031A (ja) 2006-11-16
CL2004001278A1 (es) 2005-05-06
CA2527191A1 (en) 2004-12-02
ECSP056253A (es) 2006-10-25
ZA200509515B (en) 2006-07-26
IL171941A0 (en) 2006-04-10
KR100938712B1 (ko) 2010-01-25
NO20055417L (no) 2005-12-19
US20070098816A1 (en) 2007-05-03
RU2005140570A (ru) 2006-06-10

Similar Documents

Publication Publication Date Title
UA81499C2 (en) Pharmaceutical composition containing histone deacetylase inhibitor
NO20055216L (no) Nye hydroksamater som terapeutiske midler
BR0308081A (pt) Inibidores de histona desacetilase
PL371100A1 (en) Sulfonylamino-derivatives as novel inhibitors of histone deacetylase
PL370982A1 (en) Carbonylamino-derivatives as novel inhibitors of histone deacetylase
MXPA06000013A (es) Agente terapeutico para sarcoma de tejido suave.
EA200801492A1 (ru) Фармацевтическое применение замещенных амидов
MY142177A (en) Benzamide derivatives useful as histone deacetylase inhibitors
MXPA04007775A (es) Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa.
NO20061253L (no) Acetylenderivater som inhibitorer av histon deacetylase
GB2427405A (en) Novel hydroxamates as therapeutic agents
WO2008101907A3 (en) N-adamantyl benzamides as inhibitors of 11-beta-hydroxysteroid dehydrogenase
AP1787A (en) Novel perindopril salt and pharmaceutical compositions containing same.
WO2006063294A3 (en) Novel inhibitors of histone deacetylase for the treatment of disease
TW200638927A (en) Bambuterol and integrin inhibitor combination
ZA200708749B (en) Hydroxamates as histone deacetylase inhibitors and pharmaceutical formulations containing them
PA8633001A1 (es) Composicion farmaceutica antimicobacterial
MXPA02010828A (es) Composicion farmaceutica en capsulas que comprende un antiinflamatorio no esteroideo y un analgesico opiaceo para el manejo del dolor.
ATE402703T1 (de) Tablette enthaltend efletirizin und pseudoephedrin
TH81162A (th) สารผสมทางเภสัชกรรมที่มีตัวยับยั้งฮิสโตนดีอะซีทิลเลส
TH81162B (th) สารผสมทางเภสัชกรรมที่มีตัวยับยั้งฮิสโตนดีอะซีทิลเลส
MY140524A (en) Piperazinyl-, piperidinyl- and morpholinyl-derivatives as novel inhibitors of histone deacetylase