JP2004514663A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004514663A5 JP2004514663A5 JP2002544387A JP2002544387A JP2004514663A5 JP 2004514663 A5 JP2004514663 A5 JP 2004514663A5 JP 2002544387 A JP2002544387 A JP 2002544387A JP 2002544387 A JP2002544387 A JP 2002544387A JP 2004514663 A5 JP2004514663 A5 JP 2004514663A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- formula
- alkyl
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 150000002431 hydrogen Chemical class 0.000 claims 6
- 239000002253 acid Substances 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 239000012458 free base Substances 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 230000004913 activation Effects 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 208000000094 Chronic Pain Diseases 0.000 claims 2
- 201000005569 Gout Diseases 0.000 claims 2
- 208000002193 Pain Diseases 0.000 claims 2
- 208000000491 Tendinopathy Diseases 0.000 claims 2
- 206010043255 Tendonitis Diseases 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000012907 medicinal substance Substances 0.000 claims 2
- 201000008482 osteoarthritis Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 201000004415 tendinitis Diseases 0.000 claims 2
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- GJFNRSDCSTVPCJ-UHFFFAOYSA-N 1,8-bis(dimethylamino)naphthalene Chemical compound C1=CC(N(C)C)=C2C(N(C)C)=CC=CC2=C1 GJFNRSDCSTVPCJ-UHFFFAOYSA-N 0.000 claims 1
- 125000001637 1-naphthyl group Chemical group [H]C1=C([H])C([H])=C2C(*)=C([H])C([H])=C([H])C2=C1[H] 0.000 claims 1
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 230000006806 disease prevention Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 1
- -1 methoxy-1-naphthyl Chemical group 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000008024 pharmaceutical diluent Substances 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0028702.9A GB0028702D0 (en) | 2000-11-24 | 2000-11-24 | Organic compounds |
| GB0028702.9 | 2000-11-24 | ||
| PCT/EP2001/013605 WO2002042248A2 (en) | 2000-11-24 | 2001-11-22 | Naphthalene derivatives |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007236718A Division JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004514663A JP2004514663A (ja) | 2004-05-20 |
| JP2004514663A5 true JP2004514663A5 (enExample) | 2005-04-07 |
| JP4836396B2 JP4836396B2 (ja) | 2011-12-14 |
Family
ID=9903825
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002544387A Expired - Fee Related JP4836396B2 (ja) | 2000-11-24 | 2001-11-22 | ナフタレン誘導体 |
| JP2007236718A Pending JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007236718A Pending JP2008050361A (ja) | 2000-11-24 | 2007-09-12 | ナフタレン誘導体 |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7045533B2 (enExample) |
| EP (2) | EP1339663B1 (enExample) |
| JP (2) | JP4836396B2 (enExample) |
| KR (1) | KR100810948B1 (enExample) |
| CN (1) | CN1224598C (enExample) |
| AR (1) | AR035505A1 (enExample) |
| AT (1) | ATE540013T1 (enExample) |
| AU (1) | AU2002226350A1 (enExample) |
| BR (1) | BR0115605A (enExample) |
| CA (1) | CA2427844C (enExample) |
| CZ (1) | CZ20031424A3 (enExample) |
| EC (1) | ECSP034574A (enExample) |
| ES (1) | ES2378881T3 (enExample) |
| GB (1) | GB0028702D0 (enExample) |
| HU (1) | HUP0302125A3 (enExample) |
| IL (1) | IL155235A0 (enExample) |
| MX (1) | MXPA03004593A (enExample) |
| MY (1) | MY129613A (enExample) |
| NO (1) | NO330005B1 (enExample) |
| NZ (1) | NZ548553A (enExample) |
| PE (1) | PE20020532A1 (enExample) |
| PT (1) | PT1339663E (enExample) |
| RU (1) | RU2354646C2 (enExample) |
| SK (1) | SK6222003A3 (enExample) |
| TW (1) | TWI314140B (enExample) |
| WO (1) | WO2002042248A2 (enExample) |
| ZA (1) | ZA200302916B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0028702D0 (en) * | 2000-11-24 | 2001-01-10 | Novartis Ag | Organic compounds |
| US7067539B2 (en) * | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
| US7507767B2 (en) | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
| AU2003211442A1 (en) | 2002-02-19 | 2003-09-09 | Shionogi And Co., Ltd. | Antipruritics |
| EP1487436A4 (en) | 2002-03-08 | 2009-06-03 | Signal Pharm Inc | POLYTHERAPY FOR TREATING, PREVENTING OR MANAGING PROLIFERATIVE DISORDERS AND CANCERS |
| RU2304580C2 (ru) | 2002-07-29 | 2007-08-20 | Ф.Хоффманн-Ля Рош Аг | Новые бензодиоксолы |
| AU2003278929A1 (en) * | 2002-10-18 | 2004-05-13 | Amylin Pharmaceuticals, Inc. | Treatment of pancreatitis with amylin |
| WO2004052846A1 (en) * | 2002-12-06 | 2004-06-24 | Bayer Healthcare Ag | Tetrahydro-naphthalene derivatives |
| US7544716B2 (en) * | 2002-12-09 | 2009-06-09 | Xention Limited | Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists |
| TW200505902A (en) | 2003-03-20 | 2005-02-16 | Schering Corp | Cannabinoid receptor ligands |
| UA82872C2 (en) | 2003-03-28 | 2008-05-26 | Janssen Pharmaceutica Nv | Benzo [1,2,5] thiadiazole compounds |
| EP1670787B1 (en) | 2003-09-11 | 2012-05-30 | iTherX Pharma, Inc. | Cytokine inhibitors |
| SE0303490D0 (sv) * | 2003-12-19 | 2003-12-19 | Astrazeneca Ab | New use V |
| GB0504950D0 (en) * | 2005-03-10 | 2005-04-20 | Novartis Ag | Organic compositions |
| EA200801120A1 (ru) * | 2005-10-18 | 2008-08-29 | Сигма-Тау Индустрие Фармасьютике Риуните С.П.А. | Нафтильные производные в качестве ингибиторов агрегирования бета-амилоида |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| IE20070928A1 (en) * | 2007-12-21 | 2009-09-30 | Giuliani Int Ltd | Multi target ligands |
| MX2010009507A (es) * | 2008-02-28 | 2010-09-24 | Novartis Ag | Combinacion que comprende un compuesto que se enlaza con los receptores de cannabinoides, y un opioide. |
| CN103819419B (zh) * | 2008-09-04 | 2016-12-07 | 亚德生化公司 | 调节尿酸含量的化合物、组合物及其使用方法 |
| JP5164755B2 (ja) * | 2008-09-09 | 2013-03-21 | キヤノン株式会社 | ビス−アセチルアミノフェニル化合物の結晶の製造方法 |
| DK2346819T3 (da) * | 2008-11-17 | 2013-05-13 | Hoffmann La Roche | Naphthyleddikesyre |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| HRP20181656T1 (hr) | 2010-01-04 | 2018-12-14 | Nippon Soda Co., Ltd. | Heterociklički spoj koji sadrži dušik i poljoprivredni/hortikulturni germicid |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| EP2531510B1 (en) | 2010-02-01 | 2014-07-23 | Novartis AG | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| ES2527849T3 (es) | 2010-02-02 | 2015-01-30 | Novartis Ag | Derivados de ciclohexilamida como antagonistas del receptor de CRF |
| WO2012090177A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Cannabinoid receptor modulators |
| WO2012090179A2 (en) | 2010-12-30 | 2012-07-05 | Lupin Limited | Isoquinoline derivatives as cannabinoid receptor modulators |
| AR086411A1 (es) | 2011-05-20 | 2013-12-11 | Nippon Soda Co | Compuesto heterociclico conteniendo nitrogeno y fungicida para el uso en agricultura y jardineria |
| US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
| IN2014MN00226A (enExample) | 2011-07-05 | 2015-09-25 | Lupin Ltd | |
| CN104271579A (zh) | 2012-05-03 | 2015-01-07 | 诺华股份有限公司 | 作为生长素释放肽受体激动剂的2,7-二氮杂-螺[4,5]癸烷-7-基衍生物的l-苹果酸盐及其结晶 |
| GB2532990A (en) | 2014-12-05 | 2016-06-08 | Schlumberger Holdings | Corrosion inhibition |
| GB2543498A (en) * | 2015-10-19 | 2017-04-26 | Schlumberger Holdings | Corrosion inhibition |
| JP6941611B2 (ja) | 2015-12-17 | 2021-09-29 | バイオカイン セラピューティックス リミテッド | ケモカイン活性および／または癌細胞成長を阻害するための小分子 |
| WO2017103931A1 (en) | 2015-12-17 | 2017-06-22 | Biokine Therapeutics Ltd. | Small molecules against cancer |
| CN109316479B (zh) * | 2018-10-22 | 2023-09-05 | 河南省锐达医药科技有限公司 | 一种萘酚类化合物的制备及其在癌症治疗方面的应用 |
| RU2684117C1 (ru) * | 2018-10-29 | 2019-04-04 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Способ получения N-(нафталин-2-ил)бензамидина |
| RU2694263C1 (ru) * | 2019-02-14 | 2019-07-11 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Санкт-Петербургский государственный химико-фармацевтический университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО СПХФУ Минздрава России) | Анальгезирующее и противовоспалительное средство с противомикробной активностью |
| CN114096524B (zh) | 2019-05-15 | 2025-03-04 | 阿龙拜欧有限公司 | 用于治疗癌症、抑制趋化因子活性和/或诱导细胞死亡的小分子 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1874581A (en) * | 1930-01-15 | 1932-08-30 | Gen Aniline Works Inc | Aromatic monoaroyl diamines |
| FR1110460A (fr) * | 1954-09-03 | 1956-02-13 | Cfmc | Nouveaux colorants azoïques, complexes métallifères en dérivant et produits intermédiaires utilisables pour leur préparation |
| DE1016717B (de) | 1956-04-30 | 1957-10-03 | Kalle & Co Ag | Verfahren zur Herstellung aromatischer Amine mit sekundaerer Aminogruppe |
| CH505152A (de) * | 1968-11-21 | 1971-03-31 | Shell Int Research | Verfahren zur Herstellung von Phosphonsäureestern, Phosphinsäureestern bzw. Phosphinoxiden |
| US3932381A (en) * | 1973-02-12 | 1976-01-13 | Eastman Kodak Company | Magenta image-providing phenylazo-naphthyl dyes |
| US4067903A (en) * | 1975-10-04 | 1978-01-10 | Basf Aktiengesellschaft | Manufacture of arylamines |
| EP0264883A3 (en) * | 1986-10-21 | 1990-04-04 | Banyu Pharmaceutical Co., Ltd. | Substituted pyridine derivatives |
| US5013837A (en) * | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
| RU2051146C1 (ru) * | 1991-06-28 | 1995-12-27 | Институт молекулярной генетики РАН | 5-замещенные нафталин-1-сульфониламиды и способ их получения |
| CA2136220A1 (en) | 1992-05-21 | 1993-11-25 | Mark S. Cushman | Stilbene derivatives as anticancer agents |
| US5430062A (en) * | 1992-05-21 | 1995-07-04 | Research Corporation Technologies, Inc. | Stilbene derivatives as anticancer agents |
| US5773663A (en) * | 1996-05-01 | 1998-06-30 | American Cyanamid Company | Fungicidal methods, compounds and compositions containing benzophenones |
| CZ294096B6 (cs) | 1995-01-20 | 2004-10-13 | Americanácyanamidácompany | Benzofenonové sloučeninyŹ způsob jejich výrobyŹ fungicidní prostředky s jejich obsahem a způsob ochrany rostlin |
| US5679866A (en) * | 1995-01-20 | 1997-10-21 | American Cyanamid Company | Fungicidal methods, compounds and compositions containing benzophenones |
| US6090850A (en) * | 1996-02-05 | 2000-07-18 | Eli Lilly And Company | Naphthyl glyoxamides as SPLA2 inhibitors |
| US5929117A (en) * | 1996-08-12 | 1999-07-27 | Celgene Corporation | Immunotherapeutic agents |
| IT1298159B1 (it) * | 1997-01-28 | 1999-12-20 | Hoffmann La Roche | Derivati di un 5-aroilnaftalene |
| SI0966436T1 (en) | 1997-02-21 | 2003-04-30 | Bayer Aktiengesellschaft | Aryl sulfonamides and analogues thereof and their use in the treatment of neurodegenerative diseases |
| FR2760744B1 (fr) * | 1997-03-12 | 1999-04-23 | Rhodia Chimie Sa | Procede d'acylation d'un compose aromatique |
| US5945567A (en) * | 1997-08-20 | 1999-08-31 | American Cyanamid Company | Fungicidal 2-methoxybenzophenones |
| US5939429A (en) * | 1997-09-30 | 1999-08-17 | Virginia Commonwealth University | Cardiovascular uses of cannabinoid compounds |
| US6022884A (en) | 1997-11-07 | 2000-02-08 | Amgen Inc. | Substituted pyridine compounds and methods of use |
| GB0028702D0 (en) * | 2000-11-24 | 2001-01-10 | Novartis Ag | Organic compounds |
-
2000
- 2000-11-24 GB GBGB0028702.9A patent/GB0028702D0/en not_active Ceased
-
2001
- 2001-11-20 TW TW090128718A patent/TWI314140B/zh active
- 2001-11-21 MY MYPI20015337A patent/MY129613A/en unknown
- 2001-11-22 PT PT01995657T patent/PT1339663E/pt unknown
- 2001-11-22 PE PE2001001166A patent/PE20020532A1/es not_active Application Discontinuation
- 2001-11-22 SK SK622-2003A patent/SK6222003A3/sk not_active Application Discontinuation
- 2001-11-22 RU RU2003117459/04A patent/RU2354646C2/ru not_active IP Right Cessation
- 2001-11-22 AU AU2002226350A patent/AU2002226350A1/en not_active Abandoned
- 2001-11-22 ES ES01995657T patent/ES2378881T3/es not_active Expired - Lifetime
- 2001-11-22 HU HU0302125A patent/HUP0302125A3/hu unknown
- 2001-11-22 AT AT01995657T patent/ATE540013T1/de active
- 2001-11-22 EP EP01995657A patent/EP1339663B1/en not_active Expired - Lifetime
- 2001-11-22 KR KR1020037005038A patent/KR100810948B1/ko not_active Expired - Fee Related
- 2001-11-22 MX MXPA03004593A patent/MXPA03004593A/es active IP Right Grant
- 2001-11-22 BR BR0115605-5A patent/BR0115605A/pt active Search and Examination
- 2001-11-22 EP EP10175729.2A patent/EP2338886A3/en not_active Withdrawn
- 2001-11-22 US US10/432,120 patent/US7045533B2/en not_active Expired - Fee Related
- 2001-11-22 WO PCT/EP2001/013605 patent/WO2002042248A2/en not_active Ceased
- 2001-11-22 CN CNB018194389A patent/CN1224598C/zh not_active Expired - Fee Related
- 2001-11-22 JP JP2002544387A patent/JP4836396B2/ja not_active Expired - Fee Related
- 2001-11-22 AR ARP010105448A patent/AR035505A1/es not_active Application Discontinuation
- 2001-11-22 IL IL15523501A patent/IL155235A0/xx not_active IP Right Cessation
- 2001-11-22 CA CA2427844A patent/CA2427844C/en not_active Expired - Fee Related
- 2001-11-22 NZ NZ548553A patent/NZ548553A/en unknown
- 2001-11-22 CZ CZ20031424A patent/CZ20031424A3/cs unknown
-
2003
- 2003-04-11 ZA ZA200302916A patent/ZA200302916B/en unknown
- 2003-04-29 EC EC2003004574A patent/ECSP034574A/es unknown
- 2003-05-22 NO NO20032327A patent/NO330005B1/no not_active IP Right Cessation
-
2007
- 2007-09-12 JP JP2007236718A patent/JP2008050361A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2004514663A5 (enExample) | ||
| RU2003117459A (ru) | Нафталиновые производные | |
| CN101687792B (zh) | 具有快速皮肤和生物膜穿透速度的非甾体抗炎药的前药及其医药用途 | |
| DK2041068T3 (en) | POSITIVELY CHARGED, WATER SOLUBLE PRODRUGS OF IBUPROFEN WITH VERY FAST SKIN PENETRATION SPEED | |
| EP3388417A1 (en) | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate | |
| JP2007507494A5 (enExample) | ||
| JP2011051993A5 (enExample) | ||
| ES2437346T3 (es) | Procedimiento para la producción de derivado de diamina | |
| CA2440037A1 (en) | Benzimidazole derivatives for modulating the rage receptor | |
| JP2003509349A5 (enExample) | ||
| ES2694685T3 (es) | Profármacos solubles en agua cargados positivamente de ácidos n-arilantranílicos con muy rápida velocidad de penetración en la piel | |
| JP2002521329A5 (enExample) | ||
| RU2007101653A (ru) | Производные 1-азабицикло[3.3.1]нонанов | |
| JP2003519228A5 (enExample) | ||
| CN101500983A (zh) | 具有快速皮肤穿透速度的带正电荷的水溶性二氟尼柳及相关化合物的前药 | |
| RU99127433A (ru) | Эрголиновые производные и их применение в качестве антагонистов рецепторов соматостатина | |
| JP2005516898A5 (enExample) | ||
| RU2004133387A (ru) | Фармацевтический препарат с немедленным высвобождением | |
| JPWO2021093839A5 (enExample) | ||
| CN1181819C (zh) | 使用五氟苯磺酰胺的综合疗法 | |
| CA2589744A1 (en) | Pyrrolinidium derivatives as m3 muscarinic receptors | |
| RU2008138749A (ru) | Производные камптотецина и их применение | |
| KR920016418A (ko) | Nmda 길항제 | |
| JPH1036365A5 (enExample) | ||
| RU2005138143A (ru) | Митилиндолы и метилпирролопиридины в качестве l-1-адренергических агонистов |