JP2004521913A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2004521913A5 JP2004521913A5 JP2002565973A JP2002565973A JP2004521913A5 JP 2004521913 A5 JP2004521913 A5 JP 2004521913A5 JP 2002565973 A JP2002565973 A JP 2002565973A JP 2002565973 A JP2002565973 A JP 2002565973A JP 2004521913 A5 JP2004521913 A5 JP 2004521913A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- group
- substituted
- phenyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 15
- 125000001424 substituent group Chemical group 0.000 claims 14
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 13
- 125000003118 aryl group Chemical group 0.000 claims 13
- 229910052736 halogen Inorganic materials 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 11
- 125000005842 heteroatom Chemical group 0.000 claims 11
- 229910052760 oxygen Inorganic materials 0.000 claims 11
- 125000006413 ring segment Chemical group 0.000 claims 11
- 229910052717 sulfur Inorganic materials 0.000 claims 11
- 229910052799 carbon Inorganic materials 0.000 claims 9
- 150000002367 halogens Chemical class 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- 125000004768 (C1-C4) alkylsulfinyl group Chemical group 0.000 claims 7
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 6
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims 6
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 6
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 5
- 125000003277 amino group Chemical group 0.000 claims 5
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 4
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- 229910052739 hydrogen Inorganic materials 0.000 claims 4
- -1 2,2,6,6-tetramethylpiperidinyl Chemical group 0.000 claims 3
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 230000003287 optical effect Effects 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
- 125000004939 6-pyridyl group Chemical group N1=CC=CC=C1* 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000004688 alkyl sulfonyl alkyl group Chemical group 0.000 claims 1
- 125000005001 aminoaryl group Chemical group 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- NBGMRMDAEWWFIR-UHFFFAOYSA-N imidazole-2-thione Chemical compound S=C1N=CC=N1 NBGMRMDAEWWFIR-UHFFFAOYSA-N 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000003107 substituted aryl group Chemical group 0.000 claims 1
- 0 CS(c(cc1)ccc1SC(*1)=NC(c(cc2)ccc2F)=C1C1=CC=CCC=C1)=* Chemical compound CS(c(cc1)ccc1SC(*1)=NC(c(cc2)ccc2F)=C1C1=CC=CCC=C1)=* 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10107683A DE10107683A1 (de) | 2001-02-19 | 2001-02-19 | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| PCT/EP2002/001746 WO2002066458A2 (de) | 2001-02-19 | 2002-02-19 | 2-thio-substituierte imidazolderivate und ihre verwendung in der pharmazie |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004521913A JP2004521913A (ja) | 2004-07-22 |
| JP2004521913A5 true JP2004521913A5 (enExample) | 2006-04-20 |
Family
ID=7674545
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002565973A Pending JP2004521913A (ja) | 2001-02-19 | 2002-02-19 | ２−チオ置換イミダゾール誘導体及び医薬におけるそれらの使用 |
Country Status (22)
| Country | Link |
|---|---|
| US (1) | US7253191B2 (enExample) |
| EP (1) | EP1362045B1 (enExample) |
| JP (1) | JP2004521913A (enExample) |
| KR (1) | KR100642231B1 (enExample) |
| CN (1) | CN1291984C (enExample) |
| AT (1) | ATE282605T1 (enExample) |
| AU (1) | AU2002247726C1 (enExample) |
| BR (1) | BR0207254A (enExample) |
| CA (1) | CA2453078A1 (enExample) |
| CZ (1) | CZ20032224A3 (enExample) |
| DE (2) | DE10107683A1 (enExample) |
| DK (1) | DK1362045T3 (enExample) |
| ES (1) | ES2233808T3 (enExample) |
| HU (1) | HUP0303155A3 (enExample) |
| IL (1) | IL157050A0 (enExample) |
| IS (1) | IS6914A (enExample) |
| MX (1) | MXPA03007380A (enExample) |
| PL (1) | PL367397A1 (enExample) |
| PT (1) | PT1362045E (enExample) |
| RU (1) | RU2284326C2 (enExample) |
| SK (1) | SK10242003A3 (enExample) |
| WO (1) | WO2002066458A2 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10107683A1 (de) | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10222103A1 (de) | 2002-05-17 | 2003-11-27 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10238045A1 (de) * | 2002-08-20 | 2004-03-04 | Merckle Gmbh Chem.-Pharm. Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
| DE10256881A1 (de) * | 2002-12-05 | 2004-06-24 | Beiersdorf Ag | Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten |
| ATE425161T1 (de) | 2004-05-26 | 2009-03-15 | Janssen Pharmaceutica Nv | Mercaptoimidazole als ccr2-rezeptorantagonisten |
| EP1756089B1 (en) * | 2004-05-26 | 2008-10-22 | Janssen Pharmaceutica N.V. | Mercaptoimidazoles as ccr2 receptor antagonists |
| JP2008509201A (ja) * | 2004-08-11 | 2008-03-27 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | Ｃｃｒ２受容体アンタゴニストとしてのメルカプトイミダゾール |
| RU2007135955A (ru) * | 2005-02-28 | 2009-04-10 | Меркле Гмбх (De) | 2-сульфинил-и 2-сульфонилзамещенные производные имидазола и их применение в качестве ингибиторов цитокина |
| EP1894925A1 (en) * | 2006-08-24 | 2008-03-05 | Merckle Gmbh | Imidazole compounds having an antiinflammatory effect |
| WO2008085008A1 (en) * | 2007-01-11 | 2008-07-17 | Mogam Biotechnology Research Institute | T-cell inhibiting compounds and their use for the treatment of t-cell-mediated diseases |
| US8143294B2 (en) | 2007-12-31 | 2012-03-27 | Michael Burnet | 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors |
| CN102249992A (zh) * | 2011-07-05 | 2011-11-23 | 广东工业大学 | 一种制备2-氨基异烟酸的方法 |
| DE102013102069A1 (de) | 2013-03-01 | 2014-09-04 | Fsp Fluid Systems Partners Holding Ag | Proportional-Wegeventil sowie hydraulische Schaltung und hydropneumatisches Federungssystem mit einem derartigen Ventil |
| US20190060286A1 (en) | 2016-02-29 | 2019-02-28 | University Of Florida Research Foundation, Incorpo | Chemotherapeutic Methods |
| US11795160B2 (en) | 2019-02-22 | 2023-10-24 | Insilico Medicine Ip Limited | Kinase inhibitors |
| AU2022225035A1 (en) | 2021-02-24 | 2023-08-31 | Insilico Medicine Ip Limited | Analogs for the treatment of disease |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1155580A (en) * | 1965-10-21 | 1969-06-18 | Geigy Ag J R | New Imidazole Derivatives their Production and Use |
| US4190666A (en) * | 1975-08-11 | 1980-02-26 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones |
| DK16778A (da) | 1977-02-09 | 1978-08-10 | Du Pont | Imidazolderivater deres anvendelser og fremstilling |
| DE2963572D1 (en) * | 1978-04-11 | 1982-10-21 | Ciba Geigy Ag | Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions |
| DE2823197A1 (de) | 1978-05-24 | 1979-11-29 | Schering Ag | Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3025484A1 (de) * | 1980-07-03 | 1982-02-04 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3141063A1 (de) * | 1981-10-13 | 1983-04-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate |
| DE3504678A1 (de) * | 1985-02-12 | 1986-08-14 | A. Nattermann & Cie GmbH, 5000 Köln | Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung |
| US4686231A (en) | 1985-12-12 | 1987-08-11 | Smithkline Beckman Corporation | Inhibition of 5-lipoxygenase products |
| JPS6440467A (en) | 1987-08-04 | 1989-02-10 | Hisamitsu Pharmaceutical Co | Novel substituted diphenylimidazole derivative |
| FR2626691B1 (fr) | 1988-02-02 | 1990-05-25 | France Etat | Multiplieur numerique generalise et filtre numerique mettant en oeuvre ce multiplieur |
| MX9203711A (es) | 1990-01-12 | 1992-07-01 | Rhone Poulenc Rorer Sa | Derivados de imidazol y composiciones farmaceuticas que los contienen. |
| IL104369A0 (en) | 1992-01-13 | 1993-05-13 | Smithkline Beecham Corp | Novel compounds and compositions |
| US5364875A (en) * | 1992-05-11 | 1994-11-15 | The Du Pont Merck Pharmaceutical Company | Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis |
| US5474995A (en) | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| AU7629594A (en) | 1993-07-21 | 1995-02-20 | Smithkline Beecham Corporation | Imidazoles for treating cytokine mediated disease |
| US5620999A (en) | 1994-07-28 | 1997-04-15 | Weier; Richard M. | Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation |
| AU8757098A (en) * | 1997-06-30 | 1999-02-10 | Ortho-Mcneil Pharmaceutical, Inc. | 2-substituted imidazoles useful in the treatment of inflammatory diseases |
| DE19842833B4 (de) | 1998-09-18 | 2005-04-14 | Merckle Gmbh | 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung |
| DE10107683A1 (de) | 2001-02-19 | 2002-08-29 | Merckle Gmbh Chem Pharm Fabrik | 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie |
-
2001
- 2001-02-19 DE DE10107683A patent/DE10107683A1/de not_active Withdrawn
-
2002
- 2002-02-19 EP EP02716791A patent/EP1362045B1/de not_active Expired - Lifetime
- 2002-02-19 DK DK02716791T patent/DK1362045T3/da active
- 2002-02-19 PL PL02367397A patent/PL367397A1/xx not_active Application Discontinuation
- 2002-02-19 IL IL15705002A patent/IL157050A0/xx unknown
- 2002-02-19 SK SK1024-2003A patent/SK10242003A3/sk not_active Application Discontinuation
- 2002-02-19 WO PCT/EP2002/001746 patent/WO2002066458A2/de not_active Ceased
- 2002-02-19 DE DE50201565T patent/DE50201565D1/de not_active Expired - Lifetime
- 2002-02-19 HU HU0303155A patent/HUP0303155A3/hu unknown
- 2002-02-19 US US10/467,064 patent/US7253191B2/en not_active Expired - Fee Related
- 2002-02-19 BR BR0207254-8A patent/BR0207254A/pt not_active IP Right Cessation
- 2002-02-19 CZ CZ20032224A patent/CZ20032224A3/cs unknown
- 2002-02-19 PT PT02716791T patent/PT1362045E/pt unknown
- 2002-02-19 CN CNB028051548A patent/CN1291984C/zh not_active Expired - Fee Related
- 2002-02-19 KR KR1020037010839A patent/KR100642231B1/ko not_active Expired - Fee Related
- 2002-02-19 MX MXPA03007380A patent/MXPA03007380A/es active IP Right Grant
- 2002-02-19 ES ES02716791T patent/ES2233808T3/es not_active Expired - Lifetime
- 2002-02-19 AT AT02716791T patent/ATE282605T1/de not_active IP Right Cessation
- 2002-02-19 CA CA002453078A patent/CA2453078A1/en not_active Abandoned
- 2002-02-19 JP JP2002565973A patent/JP2004521913A/ja active Pending
- 2002-02-19 RU RU2003128068/04A patent/RU2284326C2/ru not_active IP Right Cessation
- 2002-02-19 AU AU2002247726A patent/AU2002247726C1/en not_active Ceased
-
2003
- 2003-08-15 IS IS6914A patent/IS6914A/is unknown