DE10107683A1 - 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie - Google Patents

2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Info

Publication number
DE10107683A1
DE10107683A1 DE10107683A DE10107683A DE10107683A1 DE 10107683 A1 DE10107683 A1 DE 10107683A1 DE 10107683 A DE10107683 A DE 10107683A DE 10107683 A DE10107683 A DE 10107683A DE 10107683 A1 DE10107683 A1 DE 10107683A1
Authority
DE
Germany
Prior art keywords
alkyl
pyridyl
substituted
fluorophenyl
imidazole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE10107683A
Other languages
German (de)
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merckle GmbH
Original Assignee
Merckle GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merckle GmbH filed Critical Merckle GmbH
Priority to DE10107683A priority Critical patent/DE10107683A1/de
Priority to AT02716791T priority patent/ATE282605T1/de
Priority to RU2003128068/04A priority patent/RU2284326C2/ru
Priority to IL15705002A priority patent/IL157050A0/xx
Priority to CZ20032224A priority patent/CZ20032224A3/cs
Priority to DE50201565T priority patent/DE50201565D1/de
Priority to DK02716791T priority patent/DK1362045T3/da
Priority to AU2002247726A priority patent/AU2002247726C1/en
Priority to PCT/EP2002/001746 priority patent/WO2002066458A2/de
Priority to ES02716791T priority patent/ES2233808T3/es
Priority to PT02716791T priority patent/PT1362045E/pt
Priority to MXPA03007380A priority patent/MXPA03007380A/es
Priority to KR1020037010839A priority patent/KR100642231B1/ko
Priority to BR0207254-8A priority patent/BR0207254A/pt
Priority to HU0303155A priority patent/HUP0303155A3/hu
Priority to EP02716791A priority patent/EP1362045B1/de
Priority to PL02367397A priority patent/PL367397A1/xx
Priority to HK03109068.5A priority patent/HK1056725B/xx
Priority to CA002453078A priority patent/CA2453078A1/en
Priority to US10/467,064 priority patent/US7253191B2/en
Priority to JP2002565973A priority patent/JP2004521913A/ja
Priority to CNB028051548A priority patent/CN1291984C/zh
Priority to SK1024-2003A priority patent/SK10242003A3/sk
Publication of DE10107683A1 publication Critical patent/DE10107683A1/de
Priority to IS6914A priority patent/IS6914A/is
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Communicable Diseases (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Transplantation (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Obesity (AREA)
DE10107683A 2001-02-19 2001-02-19 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie Withdrawn DE10107683A1 (de)

Priority Applications (24)

Application Number Priority Date Filing Date Title
DE10107683A DE10107683A1 (de) 2001-02-19 2001-02-19 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
MXPA03007380A MXPA03007380A (es) 2001-02-19 2002-02-19 Derivados de imidazol 2-tio sustituidos y el uso de los mismos en la industria farmaceutica.
BR0207254-8A BR0207254A (pt) 2001-02-19 2002-02-19 Composto, composição farmacêutica, uso de pelo menos um composto, e, método para tratar distúrbios associados com um sistema imune perturbado
IL15705002A IL157050A0 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
CZ20032224A CZ20032224A3 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
DE50201565T DE50201565D1 (de) 2001-02-19 2002-02-19 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie
DK02716791T DK1362045T3 (da) 2001-02-19 2002-02-19 2-Thio-substituerede imidazolderivater og deres anvendelse inden for farmacien
AU2002247726A AU2002247726C1 (en) 2001-02-19 2002-02-19 2-Thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
PCT/EP2002/001746 WO2002066458A2 (de) 2001-02-19 2002-02-19 2-thio-substituierte imidazolderivate und ihre verwendung in der pharmazie
ES02716791T ES2233808T3 (es) 2001-02-19 2002-02-19 Derivados 2-tioimidazol sustituidos y su uso en la industria farmaceutica.
PT02716791T PT1362045E (pt) 2001-02-19 2002-02-19 Derivados de imidazole 2-tio substituidos e seu uso na industria farmaceutica
AT02716791T ATE282605T1 (de) 2001-02-19 2002-02-19 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie
KR1020037010839A KR100642231B1 (ko) 2001-02-19 2002-02-19 2-티오-치환 이미다졸 유도체류 및 제약에서의 그 용도
EP02716791A EP1362045B1 (de) 2001-02-19 2002-02-19 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie
SK1024-2003A SK10242003A3 (sk) 2001-02-19 2002-02-19 2-Tiosubstituované imidazolové deriváty a ich použitie vo farmácii
HU0303155A HUP0303155A3 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives, the use thereof and pharmaceutical compositions containing them
PL02367397A PL367397A1 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
HK03109068.5A HK1056725B (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
CA002453078A CA2453078A1 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and their use in pharmacy
US10/467,064 US7253191B2 (en) 2001-02-19 2002-02-19 2-thio-substituted imidazole derivatives and the use thereof in the pharmaceutical industry
JP2002565973A JP2004521913A (ja) 2001-02-19 2002-02-19 ２−チオ置換イミダゾール誘導体及び医薬におけるそれらの使用
CNB028051548A CN1291984C (zh) 2001-02-19 2002-02-19 2－硫－取代咪唑衍生物及其药学用途
RU2003128068/04A RU2284326C2 (ru) 2001-02-19 2002-02-19 2-тиозамещенные производные имидазола, их применение и фармацевтическое средство на их основе
IS6914A IS6914A (is) 2001-02-19 2003-08-15 2-þíó-útskiptar imídasólafleiður og notkun þeirraí lyfjaiðnaðinum

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10107683A DE10107683A1 (de) 2001-02-19 2001-02-19 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Publications (1)

Publication Number Publication Date
DE10107683A1 true DE10107683A1 (de) 2002-08-29

Family

ID=7674545

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10107683A Withdrawn DE10107683A1 (de) 2001-02-19 2001-02-19 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE50201565T Expired - Lifetime DE50201565D1 (de) 2001-02-19 2002-02-19 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50201565T Expired - Lifetime DE50201565D1 (de) 2001-02-19 2002-02-19 2-thio-subsituierte imidazolderivative und ihre verwendung in der pharmazie

Country Status (22)

Country Link
US (1) US7253191B2 (enExample)
EP (1) EP1362045B1 (enExample)
JP (1) JP2004521913A (enExample)
KR (1) KR100642231B1 (enExample)
CN (1) CN1291984C (enExample)
AT (1) ATE282605T1 (enExample)
AU (1) AU2002247726C1 (enExample)
BR (1) BR0207254A (enExample)
CA (1) CA2453078A1 (enExample)
CZ (1) CZ20032224A3 (enExample)
DE (2) DE10107683A1 (enExample)
DK (1) DK1362045T3 (enExample)
ES (1) ES2233808T3 (enExample)
HU (1) HUP0303155A3 (enExample)
IL (1) IL157050A0 (enExample)
IS (1) IS6914A (enExample)
MX (1) MXPA03007380A (enExample)
PL (1) PL367397A1 (enExample)
PT (1) PT1362045E (enExample)
RU (1) RU2284326C2 (enExample)
SK (1) SK10242003A3 (enExample)
WO (1) WO2002066458A2 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097633A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh 2-thio-substituierte imidazolderivate und ihre verwendung in der pharmazie
DE10256881A1 (de) * 2002-12-05 2004-06-24 Beiersdorf Ag Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
DE102013102069A1 (de) 2013-03-01 2014-09-04 Fsp Fluid Systems Partners Holding Ag Proportional-Wegeventil sowie hydraulische Schaltung und hydropneumatisches Federungssystem mit einem derartigen Ventil

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
DE10238045A1 (de) * 2002-08-20 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie
KR20070020070A (ko) 2004-05-26 2007-02-16 얀센 파마슈티카 엔.브이. Ｃｃｒ２ 수용체 길항제로서의 머캅토이미다졸류
CA2565280A1 (en) 2004-05-26 2005-12-15 Janssen Pharmaceutica N.V. Mercaptoimidazoles as ccr2 receptor antagonists
CN101001844A (zh) * 2004-08-11 2007-07-18 詹森药业有限公司 作为ccr2受体拮抗剂的巯基咪唑
EP1853581B1 (en) * 2005-02-28 2010-06-02 Merckle Gmbh 2-sulfinyl- and 2-sulfonyl-substituted imidazole derivatives and their use as cytokine inhibitors
EP1894925A1 (en) * 2006-08-24 2008-03-05 Merckle Gmbh Imidazole compounds having an antiinflammatory effect
WO2008085008A1 (en) * 2007-01-11 2008-07-17 Mogam Biotechnology Research Institute T-cell inhibiting compounds and their use for the treatment of t-cell-mediated diseases
US8143294B2 (en) * 2007-12-31 2012-03-27 Michael Burnet 2-sulfanyl-substituted imidazole derivatives and their use as cytokine inhibitors
CN102249992A (zh) * 2011-07-05 2011-11-23 广东工业大学 一种制备2-氨基异烟酸的方法
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US11739078B2 (en) * 2019-02-22 2023-08-29 Insilico Medicine Ip Limited Methods of inhibiting kinases

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1509975A (fr) * 1965-10-21 1968-01-19 Geigy Ag J R Dérivés de l'imidazole et leur préparation
US4190666A (en) 1975-08-11 1980-02-26 E. I. Du Pont De Nemours And Company Anti-inflammatory 4,5-diarly-2-(substituted-thio)imidazoles and their corresponding sulfoxides and sulfones
DK16778A (da) 1977-02-09 1978-08-10 Du Pont Imidazolderivater deres anvendelser og fremstilling
DE2963572D1 (en) * 1978-04-11 1982-10-21 Ciba Geigy Ag Mercapto-imidazole derivatives, their preparation, mercapto-imidazole derivatives for the treatment of inflammatory diseases and their pharmaceutical compositions
DE2823197A1 (de) 1978-05-24 1979-11-29 Schering Ag Neue imidazolderivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3025484A1 (de) 1980-07-03 1982-02-04 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3141063A1 (de) 1981-10-13 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue imidazol-derivate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische praeparate
DE3504678A1 (de) 1985-02-12 1986-08-14 A. Nattermann & Cie GmbH, 5000 Köln Neue imidazolyl-oxyalkansaeuren und -thioalkansaeuren, ihre derivate und verfahren zu ihrer herstellung
US4686231A (en) 1985-12-12 1987-08-11 Smithkline Beckman Corporation Inhibition of 5-lipoxygenase products
JPS6440467A (en) 1987-08-04 1989-02-10 Hisamitsu Pharmaceutical Co Novel substituted diphenylimidazole derivative
FR2626691B1 (fr) 1988-02-02 1990-05-25 France Etat Multiplieur numerique generalise et filtre numerique mettant en oeuvre ce multiplieur
CA2073443A1 (en) 1990-01-12 1991-07-13 Andrew William Bridge 2-substituted 4,5-diphenyl-imidazoles
IL104369A0 (en) 1992-01-13 1993-05-13 Smithkline Beecham Corp Novel compounds and compositions
US5364875A (en) 1992-05-11 1994-11-15 The Du Pont Merck Pharmaceutical Company Imidazoles linked to bicyclic heterocyclic groups for the treatment of atherosclerosis
US5474995A (en) 1993-06-24 1995-12-12 Merck Frosst Canada, Inc. Phenyl heterocycles as cox-2 inhibitors
WO1995003297A1 (en) 1993-07-21 1995-02-02 Smithkline Beecham Corporation Imidazoles for treating cytokine mediated disease
US5620999A (en) 1994-07-28 1997-04-15 Weier; Richard M. Benzenesulfonamide subtituted imidazolyl compounds for the treatment of inflammation
AU8757098A (en) 1997-06-30 1999-02-10 Ortho-Mcneil Pharmaceutical, Inc. 2-substituted imidazoles useful in the treatment of inflammatory diseases
DE19842833B4 (de) 1998-09-18 2005-04-14 Merckle Gmbh 2-Arylalkylthio-imidazole, 2-Arylalkenylthio-imidazole und 2-Arylalkinylthio-imidazole als Entzündungs-Hemmstoffe und Hemmstoffe der Cytokin-Freisetzung
DE10107683A1 (de) 2001-02-19 2002-08-29 Merckle Gmbh Chem Pharm Fabrik 2-Thio-substituierte Imidazolderivate und ihre Verwendung in der Pharmazie

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003097633A1 (de) * 2002-05-17 2003-11-27 Merckle Gmbh 2-thio-substituierte imidazolderivate und ihre verwendung in der pharmazie
US7442713B2 (en) 2002-05-17 2008-10-28 Merckle Gmbh 2-thio-substituted imidazole derivatives and their use in pharmaceutics
DE10256881A1 (de) * 2002-12-05 2004-06-24 Beiersdorf Ag Neue topische Verwendung von Bis-Arylimidazo[1,2-a]thiolanderivaten
DE102013102069A1 (de) 2013-03-01 2014-09-04 Fsp Fluid Systems Partners Holding Ag Proportional-Wegeventil sowie hydraulische Schaltung und hydropneumatisches Federungssystem mit einem derartigen Ventil

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CA2453078A1 (en) 2002-08-29
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RU2003128068A (ru) 2005-01-27
EP1362045B1 (de) 2004-11-17
WO2002066458A2 (de) 2002-08-29
JP2004521913A (ja) 2004-07-22
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CZ20032224A3 (en) 2004-06-16
AU2002247726B2 (en) 2006-01-19
RU2284326C2 (ru) 2006-09-27
BR0207254A (pt) 2004-02-10
HK1056725A1 (en) 2004-02-27
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US7253191B2 (en) 2007-08-07
PL367397A1 (en) 2005-02-21
EP1362045A2 (de) 2003-11-19
AU2002247726C1 (en) 2006-08-17
PT1362045E (pt) 2005-04-29
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