JP2020504122A5 - - Google Patents
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- Publication number
- JP2020504122A5 JP2020504122A5 JP2019535810A JP2019535810A JP2020504122A5 JP 2020504122 A5 JP2020504122 A5 JP 2020504122A5 JP 2019535810 A JP2019535810 A JP 2019535810A JP 2019535810 A JP2019535810 A JP 2019535810A JP 2020504122 A5 JP2020504122 A5 JP 2020504122A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- optionally substituted
- aryl
- heteroaryl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 Cc(cc1)ccc1N/C1=C\C*/C(/CC(CCCC2)CCN2c2cc(OC)ccc2)=N/C(/N)=N1 Chemical compound Cc(cc1)ccc1N/C1=C\C*/C(/CC(CCCC2)CCN2c2cc(OC)ccc2)=N/C(/N)=N1 0.000 description 5
- AQJLZOXYUHCQCV-UHFFFAOYSA-N CC(CCCc1ccc(C)cc1)CCc1nc(N)nc(Nc2ccccc2C)n1 Chemical compound CC(CCCc1ccc(C)cc1)CCc1nc(N)nc(Nc2ccccc2C)n1 AQJLZOXYUHCQCV-UHFFFAOYSA-N 0.000 description 2
- JUCGCZDYNSFCKZ-UHFFFAOYSA-N Cc(cc1)ccc1Nc1nc(CC2CCOCCCC2)nc(N)n1 Chemical compound Cc(cc1)ccc1Nc1nc(CC2CCOCCCC2)nc(N)n1 JUCGCZDYNSFCKZ-UHFFFAOYSA-N 0.000 description 1
- QYJQPVDGBPGYEX-UHFFFAOYSA-N Cc(cc1)ccc1Nc1nc(CN(CC2)c3c2cccc3)nc(N)n1 Chemical compound Cc(cc1)ccc1Nc1nc(CN(CC2)c3c2cccc3)nc(N)n1 QYJQPVDGBPGYEX-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382672.0 | 2016-12-29 | ||
| EP16382672 | 2016-12-29 | ||
| PCT/IB2017/058477 WO2018122775A1 (en) | 2016-12-29 | 2017-12-28 | Heteroaryl compounds and their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504122A JP2020504122A (ja) | 2020-02-06 |
| JP2020504122A5 true JP2020504122A5 (enExample) | 2021-02-12 |
| JP7171057B2 JP7171057B2 (ja) | 2022-11-15 |
Family
ID=57708486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019535810A Active JP7171057B2 (ja) | 2016-12-29 | 2017-12-28 | ヘテロアリール化合物およびその使用 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US11174242B2 (enExample) |
| EP (1) | EP3562811B1 (enExample) |
| JP (1) | JP7171057B2 (enExample) |
| CN (1) | CN110325516A (enExample) |
| AU (1) | AU2017388466B2 (enExample) |
| BR (1) | BR112019013571A2 (enExample) |
| CA (1) | CA3048357A1 (enExample) |
| IL (1) | IL267626B2 (enExample) |
| WO (1) | WO2018122775A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11174242B2 (en) | 2016-12-29 | 2021-11-16 | Minoryx Therapeutics S.L. | Heteroaryl compounds and their use |
| WO2020104578A2 (en) * | 2018-11-21 | 2020-05-28 | University Of Copenhagen | Modulators of free fatty acid receptor 1 and their use for treatment of diseases |
| EP4065563A1 (en) * | 2019-11-25 | 2022-10-05 | Gain Therapeutics SA | Heteroaryl compounds and therapeutic uses thereof in conditions associated with the alteration of the activity of beta-glucocerebrosidase |
| EP4117628A4 (en) * | 2020-03-10 | 2024-04-10 | University of Cincinnati | Materials and methods for the treatment of gaucher disease |
| CN117659017A (zh) * | 2022-08-25 | 2024-03-08 | 北京华益健康药物研究中心 | Trpml1/2调节剂化合物、药物组合物及其制备方法和应用 |
| WO2024206067A2 (en) * | 2023-03-24 | 2024-10-03 | Purdue Research Foundation | Symmetric aminoindole-linked triazine for a dual effect on alpha-synuclein and tau isoform 2n4r fibrillization |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA006301B1 (ru) * | 1999-01-22 | 2005-10-27 | Элан Фармасьютикалз, Инк. | Ацильные производные, используемые для лечения опосредованных vla-4 расстройств |
| CA2430951A1 (en) | 2000-12-07 | 2002-06-13 | Cv Therapeutics, Inc. | Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis |
| EP2140862A3 (en) * | 2001-01-31 | 2010-02-17 | H.Lundbeck A/S | Use of GAL 3 receptor antagonists for the treatment of depression and /or anxiety and compounds useful in such methods |
| US20030078271A1 (en) | 2001-01-31 | 2003-04-24 | Blackburn Thomas P. | Use of GAL3 receptor antagonists for the treatment of depression and/or anxiety and compounds useful in such methods |
| JP4469179B2 (ja) | 2002-01-23 | 2010-05-26 | バイエル ファーマセチカル コーポレーション | Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体 |
| ES2273047T3 (es) * | 2002-10-28 | 2007-05-01 | Bayer Healthcare Ag | Fenilaminopirimidinas sustituidas con heteroariloxi como inhibidores de rho-cinasa. |
| CN1199946C (zh) | 2002-10-29 | 2005-05-04 | 无锡杰西医药科技有限公司 | 一种特异性吲哚类化合物及制备方法与其在治疗和预防癌症等疾病中的应用 |
| JP2008535866A (ja) * | 2005-04-08 | 2008-09-04 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | ピリミジン誘導体 |
| US20090306038A1 (en) | 2005-09-13 | 2009-12-10 | Carceller Gonzalez Elena | 2-Aminopyrimidine derivatives as modulators of the histamine H4 receptor activity |
| JP5337405B2 (ja) | 2007-09-17 | 2013-11-06 | ザ・ホスピタル・フォー・シック・チルドレン | ゴーシェ病の治療方法 |
| US8138356B2 (en) | 2007-10-16 | 2012-03-20 | Angiogeney, Inc. | Chemical inhibitors of inhibitors of differentiation |
| AU2008345225A1 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| US20130023498A1 (en) * | 2008-02-20 | 2013-01-24 | The Wistar Institute and North Carolina State University | MicroRNA Modulators and Method for Identifying and Using the Same |
| EP2313411A1 (en) | 2008-06-10 | 2011-04-27 | Plexxikon, Inc. | 5h-pyrr0l0 [2,3-b]pyrazine derivatives for kinase modulation, and indications therefor |
| CN102647905B (zh) | 2009-10-19 | 2015-09-09 | 阿米库斯治疗学公司 | 用于预防和/或治疗溶酶体贮积失调的新颖组合物 |
| WO2012035055A1 (en) * | 2010-09-17 | 2012-03-22 | Glaxo Group Limited | Novel compounds |
| LT3673906T (lt) | 2011-03-18 | 2025-08-11 | Genzyme Corporation | Gliukozilceramido sintazės inhibitoriai |
| US9845327B2 (en) | 2011-06-22 | 2017-12-19 | The General Hospital Corporation | Treatment of proteinopathies |
| US8961959B2 (en) | 2011-10-17 | 2015-02-24 | The Regents Of The University Of Michigan | Glucosylceramide synthase inhibitors and therapeutic methods using the same |
| ES2924829T3 (es) | 2012-03-27 | 2022-10-11 | Amicus Therapeutics Inc | Compuestos novedosos para prevenir y/o tratar tesaurismosis lisosómicas y/o trastornos degenerativos del sistema nervioso central |
| US9687490B2 (en) * | 2012-10-24 | 2017-06-27 | Glucox Biotech Ab | Triazine derivatives for the treatment of conditions associated with nicotinamide adenine dinucleotide phosphate oxidase |
| EP3027590A1 (en) | 2013-07-31 | 2016-06-08 | Minoryx Therapeutics S.L. | Di(hetero)arylamides and sulfonamides, methods for their preparation and therapeutic uses thereof |
| US10738026B2 (en) * | 2014-02-12 | 2020-08-11 | Purdue Pharma L.P. | Isoquinoline derivatives and use thereof |
| DK3215511T3 (da) | 2014-11-06 | 2024-05-13 | Bial R&D Invest S A | Substituerede pyrazolo(1,5-a)pyrimidiner og deres anvendelse i behandlingen af medicinske lidelser |
| WO2016120808A1 (en) | 2015-01-28 | 2016-08-04 | Minoryx Therapeutics S.L. | Heteroarylaminoisoquinolines, methods for their preparation and therapeutic uses thereof |
| JP2018505226A (ja) | 2015-02-16 | 2018-02-22 | グルコックス・バイオテック・アーベー | Ｎ２−（３，４−ジメチルフェニル）−６−（（４−（ｐ−トリル）ピペラジン−１−イル）メチル）−１，３，５−トリアジン−２，４−ジアミン |
| MA42189A (fr) * | 2015-04-15 | 2018-04-18 | Biomarin Pharm Inc | Mã‰thodes de traitement des troubles du stockage lysosomal |
| US10308656B2 (en) | 2015-08-18 | 2019-06-04 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Small molecule inhibitors of Ku70/80 and uses thereof |
| CN105412114A (zh) * | 2015-12-11 | 2016-03-23 | 卢璐娇 | 6-{[4-(2-氟苯基)1-哌嗪基]甲基}-n-(萘基)-1,3,5-三嗪-2,4-二胺在制备血管生成抑制剂中的应用 |
| US11174242B2 (en) | 2016-12-29 | 2021-11-16 | Minoryx Therapeutics S.L. | Heteroaryl compounds and their use |
-
2017
- 2017-12-28 US US16/474,461 patent/US11174242B2/en active Active
- 2017-12-28 EP EP17829719.8A patent/EP3562811B1/en active Active
- 2017-12-28 JP JP2019535810A patent/JP7171057B2/ja active Active
- 2017-12-28 CA CA3048357A patent/CA3048357A1/en active Pending
- 2017-12-28 AU AU2017388466A patent/AU2017388466B2/en not_active Ceased
- 2017-12-28 CN CN201780086577.0A patent/CN110325516A/zh active Pending
- 2017-12-28 WO PCT/IB2017/058477 patent/WO2018122775A1/en not_active Ceased
- 2017-12-28 BR BR112019013571-5A patent/BR112019013571A2/pt active Search and Examination
-
2019
- 2019-06-25 IL IL267626A patent/IL267626B2/en unknown
-
2021
- 2021-10-06 US US17/495,542 patent/US11739072B2/en active Active
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