JP2005513026A5 - - Google Patents

Download PDF

Info

Publication number
JP2005513026A5
JP2005513026A5 JP2003545635A JP2003545635A JP2005513026A5 JP 2005513026 A5 JP2005513026 A5 JP 2005513026A5 JP 2003545635 A JP2003545635 A JP 2003545635A JP 2003545635 A JP2003545635 A JP 2003545635A JP 2005513026 A5 JP2005513026 A5 JP 2005513026A5
Authority
JP
Japan
Prior art keywords
substituted
compound
compound according
alkyl
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003545635A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005513026A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/036583 external-priority patent/WO2003043998A1/en
Publication of JP2005513026A publication Critical patent/JP2005513026A/ja
Publication of JP2005513026A5 publication Critical patent/JP2005513026A5/ja
Pending legal-status Critical Current

Links

JP2003545635A 2001-11-15 2002-11-15 高コレステロール血症、異脂肪血症および他の代謝障害;癌、および他の疾患を治療するn−置換複素環 Pending JP2005513026A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33479401P 2001-11-15 2001-11-15
US36273202P 2002-03-08 2002-03-08
US36270202P 2002-03-08 2002-03-08
PCT/US2002/036583 WO2003043998A1 (en) 2001-11-15 2002-11-15 N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases

Publications (2)

Publication Number Publication Date
JP2005513026A JP2005513026A (ja) 2005-05-12
JP2005513026A5 true JP2005513026A5 (enExample) 2006-01-12

Family

ID=27407005

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003545635A Pending JP2005513026A (ja) 2001-11-15 2002-11-15 高コレステロール血症、異脂肪血症および他の代謝障害;癌、および他の疾患を治療するn−置換複素環

Country Status (5)

Country Link
US (2) US7071218B2 (enExample)
EP (1) EP1456187A4 (enExample)
JP (1) JP2005513026A (enExample)
AU (1) AU2002352706A1 (enExample)
WO (1) WO2003043998A1 (enExample)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60022207T2 (de) 1999-08-31 2006-06-22 Incyte San Diego Incorporated, San Diego Benzyliden-thiazolidindione und analoga und ihre verwendung zur behandlung von diabetes
BR0207846A (pt) * 2001-03-07 2005-09-13 Incyte San Diego Inc Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
WO2002072543A2 (en) * 2001-03-08 2002-09-19 Maxia Pharmaceuticals, Inc. Rxr activating molecules
EP1421061A4 (en) * 2001-08-17 2004-12-22 Incyte San Diego Inc OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA
US7102000B2 (en) * 2002-03-08 2006-09-05 Incyte San Diego Inc. Heterocyclic amide derivatives for the treatment of diabetes and other diseases
US7196108B2 (en) * 2002-03-08 2007-03-27 Incyte San Diego Inc. Bicyclic heterocycles for the treatment of diabetes and other diseases
WO2004043955A1 (en) * 2002-11-13 2004-05-27 Rigel Pharmaceuticals, Inc. Rhodanine derivatives and pharmaceutical compositions containing them
US7521465B2 (en) * 2003-01-17 2009-04-21 Bexel Pharmaceuticals, Inc. Diphenyl ether derivatives
US20050038098A1 (en) * 2003-04-18 2005-02-17 Catherine Tachdjian Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases
US20060014231A1 (en) * 2004-06-24 2006-01-19 Luc Van Rompaey Methods and compositions to promote bone homeostasis
US7122700B2 (en) 2004-07-30 2006-10-17 Xerox Corporation Arylamine processes
WO2006041921A2 (en) * 2004-10-05 2006-04-20 Auspex Pharmaceuticals, Inc. Preparation and uses of rhodanine derivatives
JP4780372B2 (ja) * 2005-03-02 2011-09-28 独立行政法人産業技術総合研究所 キノキサリンジオン誘導体及びその製造方法並びにその用途
JP2009512637A (ja) * 2005-09-30 2009-03-26 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 異常脂血症、高コレステロール血症及び糖尿病の処置のためのrxrアゴニストとしてのジヒドロ−[1h]−キノリン−2−オン誘導体
ES2320955B1 (es) 2007-03-02 2010-03-16 Laboratorios Almirall S.A. Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida.
ES2329639B1 (es) 2007-04-26 2010-09-23 Laboratorios Almirall S.A. Nuevos derivados de 4,8-difenilpoliazanaftaleno.
EP2178371B1 (en) * 2007-07-13 2014-01-01 Board of Regents, The University of Texas System Heterocyclic modulators of cannabinoid receptors
US20110263664A1 (en) * 2007-11-15 2011-10-27 Musc Foundation For Research Development Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer
EP2108641A1 (en) 2008-04-11 2009-10-14 Laboratorios Almirall, S.A. New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors
WO2009131957A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising oxadiazole derivatives
WO2009131951A2 (en) 2008-04-21 2009-10-29 Institute For Oneworld Health Compounds, compositions and methods comprising isoxazole derivatives
EP2113503A1 (en) 2008-04-28 2009-11-04 Laboratorios Almirall, S.A. New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors
WO2009143041A1 (en) 2008-05-20 2009-11-26 Merck & Co., Inc. Efficient production of heterologous proteins using mannosyl transferase inhibitors
US9447049B2 (en) 2010-03-01 2016-09-20 University Of Tennessee Research Foundation Compounds for treatment of cancer
US9029408B2 (en) 2008-06-16 2015-05-12 Gtx, Inc. Compounds for treatment of cancer
US8822513B2 (en) 2010-03-01 2014-09-02 Gtx, Inc. Compounds for treatment of cancer
LT2303021T (lt) 2008-06-16 2019-06-25 University Of Tennessee Research Foundation Junginiai, skirti vėžio gydymui
US9334242B2 (en) 2008-06-16 2016-05-10 Gtx, Inc. Compounds for treatment of cancer
HUP0800768A2 (en) 2008-12-18 2012-08-28 Bioblocks Magyarorszag Gyogyszerkemiai Es Fejlesztoe Kft 1,3-heterocycles condensed with monoterpene skeleton, their use and pharmaceutical compositions comprising such compounds
US8343976B2 (en) 2009-04-20 2013-01-01 Institute For Oneworld Health Compounds, compositions and methods comprising pyrazole derivatives
US8575177B2 (en) * 2009-12-04 2013-11-05 Senhwa Biosciences, Inc. Pyrazolopyrimidines and related heterocycles as CK2 inhibitors
US8877795B2 (en) 2010-05-07 2014-11-04 The Board Of Trustees Of The Leland Stanford Junior University Identification of stabilizers of multimeric proteins
US8530687B2 (en) 2010-09-07 2013-09-10 University Of Florida Research Foundation, Inc. Catalysts, methods of making catalysts, and methods of use
WO2012153775A1 (ja) 2011-05-10 2012-11-15 国立大学法人神戸大学 Ras機能阻害作用を有するチオキソチアゾリジン誘導体
RU2015123315A (ru) 2012-11-25 2017-01-10 Зе Реджентс Оф Зе Юниверсити Оф Калифорния Пептиды, стимулирующие подкожный адипогенез
CN109568312A (zh) 2013-03-05 2019-04-05 田纳西大学研究基金会 用于治疗癌症的化合物
JP2016535997A (ja) * 2013-08-14 2016-11-24 ノース カロライナ セントラル ユニヴァーシティ Amp活性化プロテインキナーゼ(ampk)を調節する小分子を同定するハイスループットアッセイ
CN104447252A (zh) * 2013-09-18 2015-03-25 浙江天新药业有限公司 一种6-甲氧基-2-萘甲醛的制备方法
US10669296B2 (en) 2014-01-10 2020-06-02 Rgenix, Inc. LXR agonists and uses thereof
US10844102B2 (en) 2014-05-28 2020-11-24 The Regents Of The University Of California Peptides, compositions, and methods for stimulating subcutaneous adipogenesis
US20170114019A1 (en) 2014-06-04 2017-04-27 Haro Pharmaceutical Inc. 18-20 member bi-polycyclic compounds
JP6543342B2 (ja) 2014-08-14 2019-07-10 アルハマドシャー,マモウン,エム. 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション
CN109069461A (zh) 2016-01-11 2018-12-21 洛克菲勒大学 与髓源性抑制细胞相关的病症的治疗方法
IL298196A (en) 2017-02-17 2023-01-01 Eidos Therapeutics Inc Processes for preparing ag-10, its intermediates, and salts thereof
EP3713575A4 (en) 2017-11-21 2021-08-25 Rgenix, Inc. POLYMORPHS AND THEIR USES
KR20200135996A (ko) 2018-03-23 2020-12-04 에이도스 테라퓨틱스, 인코포레이티드 Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법
MA53238A (fr) 2018-08-17 2022-04-13 Eidos Therapeutics Inc Formules d'ag10
HUE067466T2 (hu) 2019-12-13 2024-10-28 Inspirna Inc Fémsók és alkalmazásuk
WO2022072783A1 (en) 2020-10-02 2022-04-07 Incyte Corporation Bicyclic dione compounds as inhibitors of kras

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4051842A (en) * 1975-09-15 1977-10-04 International Medical Corporation Electrode and interfacing pad for electrical physiological systems
DE2626348C3 (de) * 1976-06-11 1980-01-31 Siemens Ag, 1000 Berlin Und 8000 Muenchen Implantierbare Dosiereinrichtung
JPS5538359A (en) 1978-09-12 1980-03-17 Hamari Yakuhin Kogyo Kk Preparation of 2-(3-benzoylphenyl)-propionic acid
US4383529A (en) * 1980-11-03 1983-05-17 Wescor, Inc. Iontophoretic electrode device, method and gel insert
IL72684A (en) * 1984-08-14 1989-02-28 Israel State Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs
US4931279A (en) * 1985-08-16 1990-06-05 Bausch & Lomb Incorporated Sustained release formulation containing an ion-exchange resin
US4713244A (en) 1985-08-16 1987-12-15 Bausch & Lomb Incorporated Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent
US4668506A (en) 1985-08-16 1987-05-26 Bausch & Lomb Incorporated Sustained-release formulation containing and amino acid polymer
CA1325222C (en) 1985-08-23 1993-12-14 Lederle (Japan), Ltd. Process for producing 4-biphenylylacetic acid
US4713224A (en) * 1986-03-31 1987-12-15 The Boc Group, Inc. One-step process for purifying an inert gas
DE3874257T2 (de) * 1987-03-11 1993-02-11 Kanegafuchi Chemical Ind Hydroxystyren-derivate.
US5223522A (en) * 1988-03-08 1993-06-29 Pfizer Inc. Thiazolidinedione hypoglycemic agents
US5330998A (en) * 1988-03-08 1994-07-19 Pfizer Inc. Thiazolidinedione derivatives as hypoglycemic agents
IE62214B1 (en) 1988-05-25 1995-01-11 Warner Lambert Co Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents
CA2111445C (en) * 1991-07-22 1997-02-18 George J. Quallich Process for the preparation of intermediates in the synthesis of chiral thiazolidine-2,4-dione derivatives
DK0637297T3 (da) 1992-04-22 2000-09-18 Ligand Pharm Inc Forbindelser, der har selektivitet til retinoid-X-receptorer
US5780676A (en) * 1992-04-22 1998-07-14 Ligand Pharmaceuticals Incorporated Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors
ZA936492B (en) * 1992-09-10 1995-03-02 Lilly Co Eli Compounds useful as hypoglycemic agents and for treating Alzheimer's disease.
AU700706B2 (en) 1992-11-25 1999-01-14 Ligand Pharmaceuticals, Inc. RXR homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression
HUT74611A (en) * 1994-02-17 1997-01-28 American Home Prod Biphenyl derivatives with phosphodiesterase inhibitor activity and pharmaceutical compns. contg. them
US5691376A (en) * 1994-02-17 1997-11-25 American Home Products Corporation Substituted biphenyl derivatives
JPH09136877A (ja) 1995-06-16 1997-05-27 Takeda Chem Ind Ltd 複素環化合物、その製造法及び用途
EP0850067A4 (en) 1995-07-17 1999-12-15 Cird Galderma METHODS OF TREATING CANCER USING 6- 3- 1-ADAMANTYL] -4-HYDROXYPHENYL]
WO1997027191A1 (en) 1996-06-19 1997-07-31 Dr. Reddy's Research Foundation Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation
WO1998001132A1 (en) * 1996-07-08 1998-01-15 Centre International De Recherches Dermatologiques Galderma Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents
WO1999009965A2 (en) 1997-08-21 1999-03-04 Takeda Chemical Industries, Ltd. Anti-inflammatory agent
CA2309331A1 (en) 1997-11-12 1999-05-20 Institute Of Medicinal Molecular Design, Inc. Agent acting on retinoid receptor
US6262044B1 (en) * 1998-03-12 2001-07-17 Novo Nordisk A/S Modulators of protein tyrosine phosphatases (PTPASES)
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
ID27787A (id) * 1998-08-21 2001-04-26 Viro Pharma Inc Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan
WO2000018748A1 (en) 1998-09-30 2000-04-06 Roche Diagnostics Gmbh Rhodanine derivatives for the treatment and prevention of metabolic bone disorders
AU3111700A (en) 1998-12-04 2000-06-19 Structural Bioinformatics Inc. Methods and compositions for treating inflammatory diseases utilizing inhibitorsof tumor necrosis factor activity
AU3958200A (en) 1999-04-20 2000-11-02 Novo Nordisk A/S New compounds, their preparation and use
US6462032B1 (en) 1999-05-04 2002-10-08 Wyeth Cyclic regimens utilizing indoline derivatives
DE60022207T2 (de) 1999-08-31 2006-06-22 Incyte San Diego Incorporated, San Diego Benzyliden-thiazolidindione und analoga und ihre verwendung zur behandlung von diabetes
US6380229B1 (en) 1999-11-12 2002-04-30 Fujimoto Co., Ltd. 2-(N-cyanoimino)thiazolidin-4-one derivatives
FR2812876B1 (fr) 2000-08-08 2002-09-27 Galderma Res & Dev Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques
BR0207846A (pt) * 2001-03-07 2005-09-13 Incyte San Diego Inc Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas
WO2002072543A2 (en) 2001-03-08 2002-09-19 Maxia Pharmaceuticals, Inc. Rxr activating molecules
DE60204674T2 (de) 2001-03-14 2006-05-18 Eli Lilly And Co., Indianapolis Retinoid x rezeptormodulatoren
WO2002072099A1 (en) 2001-03-14 2002-09-19 Mitsubishi Pharma Corporation Therapeutic and/or preventive agent for diabetic ischemic heart disease
ATE442148T1 (de) * 2001-04-04 2009-09-15 Ortho Mcneil Janssen Pharm Kombinationstherapie durch glukoseresorptionshemmer und retinoid x rezeptorenmodulatoren
US6908939B2 (en) * 2001-12-21 2005-06-21 Galderma Research & Development S.N.C. Biaromatic ligand activators of PPARγ receptors
WO2004024061A2 (en) * 2002-04-30 2004-03-25 Merck & Co., Inc. Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers

Similar Documents

Publication Publication Date Title
JP2005513026A5 (enExample)
RU2563639C2 (ru) Замещенные соединения амида
US10442782B2 (en) Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
RU2419624C2 (ru) Сульфонамидные производные как активаторы гликокиназы, применимые для лечения диабета типа 2
CN102137592B (zh) 用于治疗癌症的化合物
JP5517935B2 (ja) 細胞壊死阻害剤としてのインドール及びインダゾール化合物
EP2383263B1 (en) Novel thiazolidinedione derivative and use thereof
JP5597542B2 (ja) Scd阻害薬としてのトリアゾール誘導体
WO2018213150A1 (en) Usp30 inhibitors
TW200410671A (en) Medicines for inhibiting the activation of AP-1
CN1378541A (zh) c-JUN N-末端激酶(JNK)和其它蛋白激酶的抑制剂
WO2001074771A1 (en) Pyrrole-2,5-dione derivatives for the treatment of diabetes
KR20080040046A (ko) 티아졸 유도체
JP2008513515A5 (enExample)
CN115697974A (zh) 基于咪唑3-氧化物衍生物的acss2抑制剂和其使用方法
US20240287098A1 (en) Compositions and methods for treating cancer
WO2015125842A1 (ja) トリアジン化合物及びその医薬用途
WO2008016175A1 (en) Activator for peroxisome proliferator activated receptor
WO2010137350A1 (ja) 神経栄養因子の活性が関与する疾患の治療または予防剤
CN112189012A (zh) 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物
JP2023123607A (ja) ベンゼン誘導体
RU2612533C2 (ru) Производные фенилгуанидина
CN110709393A (zh) Ldha活性抑制剂
KR20120047960A (ko) 글루코키나아제(gk) 활성화제로서 치환된 벤즈아미드 유도체
RU2435763C2 (ru) Ингибиторы тирозинфосфатазы белка человека и способы применения