JP2005513026A5 - - Google Patents
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- Publication number
- JP2005513026A5 JP2005513026A5 JP2003545635A JP2003545635A JP2005513026A5 JP 2005513026 A5 JP2005513026 A5 JP 2005513026A5 JP 2003545635 A JP2003545635 A JP 2003545635A JP 2003545635 A JP2003545635 A JP 2003545635A JP 2005513026 A5 JP2005513026 A5 JP 2005513026A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound
- compound according
- alkyl
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 C*C(C*)=C[C@@](C)C=CC(*)=N Chemical compound C*C(C*)=C[C@@](C)C=CC(*)=N 0.000 description 3
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33479401P | 2001-11-15 | 2001-11-15 | |
| US36273202P | 2002-03-08 | 2002-03-08 | |
| US36270202P | 2002-03-08 | 2002-03-08 | |
| PCT/US2002/036583 WO2003043998A1 (en) | 2001-11-15 | 2002-11-15 | N-substituted heterocycles for the treatment of hypercholesteremia, dyslipidemia and other metabolic disorders, cancer, and other diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005513026A JP2005513026A (ja) | 2005-05-12 |
| JP2005513026A5 true JP2005513026A5 (enExample) | 2006-01-12 |
Family
ID=27407005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003545635A Pending JP2005513026A (ja) | 2001-11-15 | 2002-11-15 | 高コレステロール血症、異脂肪血症および他の代謝障害;癌、および他の疾患を治療するn−置換複素環 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US7071218B2 (enExample) |
| EP (1) | EP1456187A4 (enExample) |
| JP (1) | JP2005513026A (enExample) |
| AU (1) | AU2002352706A1 (enExample) |
| WO (1) | WO2003043998A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60022207T2 (de) | 1999-08-31 | 2006-06-22 | Incyte San Diego Incorporated, San Diego | Benzyliden-thiazolidindione und analoga und ihre verwendung zur behandlung von diabetes |
| BR0207846A (pt) * | 2001-03-07 | 2005-09-13 | Incyte San Diego Inc | Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas |
| WO2002072543A2 (en) * | 2001-03-08 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Rxr activating molecules |
| EP1421061A4 (en) * | 2001-08-17 | 2004-12-22 | Incyte San Diego Inc | OXIME DERIVATIVES FOR THE TREATMENT OF DYSLIPIDEMIA AND HYPERCHOLESTEROLEMIA |
| US7102000B2 (en) * | 2002-03-08 | 2006-09-05 | Incyte San Diego Inc. | Heterocyclic amide derivatives for the treatment of diabetes and other diseases |
| US7196108B2 (en) * | 2002-03-08 | 2007-03-27 | Incyte San Diego Inc. | Bicyclic heterocycles for the treatment of diabetes and other diseases |
| WO2004043955A1 (en) * | 2002-11-13 | 2004-05-27 | Rigel Pharmaceuticals, Inc. | Rhodanine derivatives and pharmaceutical compositions containing them |
| US7521465B2 (en) * | 2003-01-17 | 2009-04-21 | Bexel Pharmaceuticals, Inc. | Diphenyl ether derivatives |
| US20050038098A1 (en) * | 2003-04-18 | 2005-02-17 | Catherine Tachdjian | Substituted dihydronaphthalene and isochroman compounds for the treatment of metabolic disorders, cancer and other diseases |
| US20060014231A1 (en) * | 2004-06-24 | 2006-01-19 | Luc Van Rompaey | Methods and compositions to promote bone homeostasis |
| US7122700B2 (en) | 2004-07-30 | 2006-10-17 | Xerox Corporation | Arylamine processes |
| WO2006041921A2 (en) * | 2004-10-05 | 2006-04-20 | Auspex Pharmaceuticals, Inc. | Preparation and uses of rhodanine derivatives |
| JP4780372B2 (ja) * | 2005-03-02 | 2011-09-28 | 独立行政法人産業技術総合研究所 | キノキサリンジオン誘導体及びその製造方法並びにその用途 |
| JP2009512637A (ja) * | 2005-09-30 | 2009-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | 異常脂血症、高コレステロール血症及び糖尿病の処置のためのrxrアゴニストとしてのジヒドロ−[1h]−キノリン−2−オン誘導体 |
| ES2320955B1 (es) | 2007-03-02 | 2010-03-16 | Laboratorios Almirall S.A. | Nuevos derivados de 3-((1,2,4)triazolo(4,3-a)piridin-7-il)benzamida. |
| ES2329639B1 (es) | 2007-04-26 | 2010-09-23 | Laboratorios Almirall S.A. | Nuevos derivados de 4,8-difenilpoliazanaftaleno. |
| EP2178371B1 (en) * | 2007-07-13 | 2014-01-01 | Board of Regents, The University of Texas System | Heterocyclic modulators of cannabinoid receptors |
| US20110263664A1 (en) * | 2007-11-15 | 2011-10-27 | Musc Foundation For Research Development | Inhibitors of PIM-1 Protein Kinases, Compositions and Methods for Treating Prostate Cancer |
| EP2108641A1 (en) | 2008-04-11 | 2009-10-14 | Laboratorios Almirall, S.A. | New substituted spiro[cycloalkyl-1,3'-indo]-2'(1'H)-one derivatives and their use as p38 mitogen-activated kinase inhibitors |
| WO2009131957A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising oxadiazole derivatives |
| WO2009131951A2 (en) | 2008-04-21 | 2009-10-29 | Institute For Oneworld Health | Compounds, compositions and methods comprising isoxazole derivatives |
| EP2113503A1 (en) | 2008-04-28 | 2009-11-04 | Laboratorios Almirall, S.A. | New substituted indolin-2-one derivatives and their use as p39 mitogen-activated kinase inhibitors |
| WO2009143041A1 (en) | 2008-05-20 | 2009-11-26 | Merck & Co., Inc. | Efficient production of heterologous proteins using mannosyl transferase inhibitors |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| LT2303021T (lt) | 2008-06-16 | 2019-06-25 | University Of Tennessee Research Foundation | Junginiai, skirti vėžio gydymui |
| US9334242B2 (en) | 2008-06-16 | 2016-05-10 | Gtx, Inc. | Compounds for treatment of cancer |
| HUP0800768A2 (en) | 2008-12-18 | 2012-08-28 | Bioblocks Magyarorszag Gyogyszerkemiai Es Fejlesztoe Kft | 1,3-heterocycles condensed with monoterpene skeleton, their use and pharmaceutical compositions comprising such compounds |
| US8343976B2 (en) | 2009-04-20 | 2013-01-01 | Institute For Oneworld Health | Compounds, compositions and methods comprising pyrazole derivatives |
| US8575177B2 (en) * | 2009-12-04 | 2013-11-05 | Senhwa Biosciences, Inc. | Pyrazolopyrimidines and related heterocycles as CK2 inhibitors |
| US8877795B2 (en) | 2010-05-07 | 2014-11-04 | The Board Of Trustees Of The Leland Stanford Junior University | Identification of stabilizers of multimeric proteins |
| US8530687B2 (en) | 2010-09-07 | 2013-09-10 | University Of Florida Research Foundation, Inc. | Catalysts, methods of making catalysts, and methods of use |
| WO2012153775A1 (ja) | 2011-05-10 | 2012-11-15 | 国立大学法人神戸大学 | Ras機能阻害作用を有するチオキソチアゾリジン誘導体 |
| RU2015123315A (ru) | 2012-11-25 | 2017-01-10 | Зе Реджентс Оф Зе Юниверсити Оф Калифорния | Пептиды, стимулирующие подкожный адипогенез |
| CN109568312A (zh) | 2013-03-05 | 2019-04-05 | 田纳西大学研究基金会 | 用于治疗癌症的化合物 |
| JP2016535997A (ja) * | 2013-08-14 | 2016-11-24 | ノース カロライナ セントラル ユニヴァーシティ | Amp活性化プロテインキナーゼ(ampk)を調節する小分子を同定するハイスループットアッセイ |
| CN104447252A (zh) * | 2013-09-18 | 2015-03-25 | 浙江天新药业有限公司 | 一种6-甲氧基-2-萘甲醛的制备方法 |
| US10669296B2 (en) | 2014-01-10 | 2020-06-02 | Rgenix, Inc. | LXR agonists and uses thereof |
| US10844102B2 (en) | 2014-05-28 | 2020-11-24 | The Regents Of The University Of California | Peptides, compositions, and methods for stimulating subcutaneous adipogenesis |
| US20170114019A1 (en) | 2014-06-04 | 2017-04-27 | Haro Pharmaceutical Inc. | 18-20 member bi-polycyclic compounds |
| JP6543342B2 (ja) | 2014-08-14 | 2019-07-10 | アルハマドシャー,マモウン,エム. | 血清半減期を延長するための、調節可能リンカーを介した薬学的活性剤とトランスサイレチンリガンドのコンジュゲーション |
| CN109069461A (zh) | 2016-01-11 | 2018-12-21 | 洛克菲勒大学 | 与髓源性抑制细胞相关的病症的治疗方法 |
| IL298196A (en) | 2017-02-17 | 2023-01-01 | Eidos Therapeutics Inc | Processes for preparing ag-10, its intermediates, and salts thereof |
| EP3713575A4 (en) | 2017-11-21 | 2021-08-25 | Rgenix, Inc. | POLYMORPHS AND THEIR USES |
| KR20200135996A (ko) | 2018-03-23 | 2020-12-04 | 에이도스 테라퓨틱스, 인코포레이티드 | Ag10을 사용하여 ttr 아밀로이드증을 치료하는 방법 |
| MA53238A (fr) | 2018-08-17 | 2022-04-13 | Eidos Therapeutics Inc | Formules d'ag10 |
| HUE067466T2 (hu) | 2019-12-13 | 2024-10-28 | Inspirna Inc | Fémsók és alkalmazásuk |
| WO2022072783A1 (en) | 2020-10-02 | 2022-04-07 | Incyte Corporation | Bicyclic dione compounds as inhibitors of kras |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4051842A (en) * | 1975-09-15 | 1977-10-04 | International Medical Corporation | Electrode and interfacing pad for electrical physiological systems |
| DE2626348C3 (de) * | 1976-06-11 | 1980-01-31 | Siemens Ag, 1000 Berlin Und 8000 Muenchen | Implantierbare Dosiereinrichtung |
| JPS5538359A (en) | 1978-09-12 | 1980-03-17 | Hamari Yakuhin Kogyo Kk | Preparation of 2-(3-benzoylphenyl)-propionic acid |
| US4383529A (en) * | 1980-11-03 | 1983-05-17 | Wescor, Inc. | Iontophoretic electrode device, method and gel insert |
| IL72684A (en) * | 1984-08-14 | 1989-02-28 | Israel State | Pharmaceutical compositions for controlled transdermal delivery of cholinergic or anticholinergic basic drugs |
| US4931279A (en) * | 1985-08-16 | 1990-06-05 | Bausch & Lomb Incorporated | Sustained release formulation containing an ion-exchange resin |
| US4713244A (en) | 1985-08-16 | 1987-12-15 | Bausch & Lomb Incorporated | Sustained-release formulation containing an amino acid polymer with a lower alkyl (C1 -C4) polar solvent |
| US4668506A (en) | 1985-08-16 | 1987-05-26 | Bausch & Lomb Incorporated | Sustained-release formulation containing and amino acid polymer |
| CA1325222C (en) | 1985-08-23 | 1993-12-14 | Lederle (Japan), Ltd. | Process for producing 4-biphenylylacetic acid |
| US4713224A (en) * | 1986-03-31 | 1987-12-15 | The Boc Group, Inc. | One-step process for purifying an inert gas |
| DE3874257T2 (de) * | 1987-03-11 | 1993-02-11 | Kanegafuchi Chemical Ind | Hydroxystyren-derivate. |
| US5223522A (en) * | 1988-03-08 | 1993-06-29 | Pfizer Inc. | Thiazolidinedione hypoglycemic agents |
| US5330998A (en) * | 1988-03-08 | 1994-07-19 | Pfizer Inc. | Thiazolidinedione derivatives as hypoglycemic agents |
| IE62214B1 (en) | 1988-05-25 | 1995-01-11 | Warner Lambert Co | Arylmethylenyl derivatives of thiazolidinones, imidazolidinones and oxazolidinones useful as antiallergy agents and antiinflammatory agents |
| CA2111445C (en) * | 1991-07-22 | 1997-02-18 | George J. Quallich | Process for the preparation of intermediates in the synthesis of chiral thiazolidine-2,4-dione derivatives |
| DK0637297T3 (da) | 1992-04-22 | 2000-09-18 | Ligand Pharm Inc | Forbindelser, der har selektivitet til retinoid-X-receptorer |
| US5780676A (en) * | 1992-04-22 | 1998-07-14 | Ligand Pharmaceuticals Incorporated | Compounds having selective activity for Retinoid X Receptors, and means for modulation of processes mediated by Retinoid X Receptors |
| ZA936492B (en) * | 1992-09-10 | 1995-03-02 | Lilly Co Eli | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease. |
| AU700706B2 (en) | 1992-11-25 | 1999-01-14 | Ligand Pharmaceuticals, Inc. | RXR homodimer formation and bridged bicyclic aromatic compounds and their use in modulating gene expression |
| HUT74611A (en) * | 1994-02-17 | 1997-01-28 | American Home Prod | Biphenyl derivatives with phosphodiesterase inhibitor activity and pharmaceutical compns. contg. them |
| US5691376A (en) * | 1994-02-17 | 1997-11-25 | American Home Products Corporation | Substituted biphenyl derivatives |
| JPH09136877A (ja) | 1995-06-16 | 1997-05-27 | Takeda Chem Ind Ltd | 複素環化合物、その製造法及び用途 |
| EP0850067A4 (en) | 1995-07-17 | 1999-12-15 | Cird Galderma | METHODS OF TREATING CANCER USING 6- 3- 1-ADAMANTYL] -4-HYDROXYPHENYL] |
| WO1997027191A1 (en) | 1996-06-19 | 1997-07-31 | Dr. Reddy's Research Foundation | Novel polymorphic forms of troglitazone having enhanced anti-diabetic activity and a process for their preparation |
| WO1998001132A1 (en) * | 1996-07-08 | 1998-01-15 | Centre International De Recherches Dermatologiques Galderma | Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents |
| WO1999009965A2 (en) | 1997-08-21 | 1999-03-04 | Takeda Chemical Industries, Ltd. | Anti-inflammatory agent |
| CA2309331A1 (en) | 1997-11-12 | 1999-05-20 | Institute Of Medicinal Molecular Design, Inc. | Agent acting on retinoid receptor |
| US6262044B1 (en) * | 1998-03-12 | 2001-07-17 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPASES) |
| US6331633B1 (en) | 1998-05-08 | 2001-12-18 | Calyx Therapeutics Inc. | Heterocyclic analogs of diphenylethylene compounds |
| ID27787A (id) * | 1998-08-21 | 2001-04-26 | Viro Pharma Inc | Senyawa, komposisi dan metode untuk pengobatan atau pencegahan infeksi yang disebabkan oleh virus dan penyakit-penyakit yang berkaitan |
| WO2000018748A1 (en) | 1998-09-30 | 2000-04-06 | Roche Diagnostics Gmbh | Rhodanine derivatives for the treatment and prevention of metabolic bone disorders |
| AU3111700A (en) | 1998-12-04 | 2000-06-19 | Structural Bioinformatics Inc. | Methods and compositions for treating inflammatory diseases utilizing inhibitorsof tumor necrosis factor activity |
| AU3958200A (en) | 1999-04-20 | 2000-11-02 | Novo Nordisk A/S | New compounds, their preparation and use |
| US6462032B1 (en) | 1999-05-04 | 2002-10-08 | Wyeth | Cyclic regimens utilizing indoline derivatives |
| DE60022207T2 (de) | 1999-08-31 | 2006-06-22 | Incyte San Diego Incorporated, San Diego | Benzyliden-thiazolidindione und analoga und ihre verwendung zur behandlung von diabetes |
| US6380229B1 (en) | 1999-11-12 | 2002-04-30 | Fujimoto Co., Ltd. | 2-(N-cyanoimino)thiazolidin-4-one derivatives |
| FR2812876B1 (fr) | 2000-08-08 | 2002-09-27 | Galderma Res & Dev | Nouveaux composes bi-aromatiques activateurs des recepteurs de type ppar-gamma et leur utilisation dans des compositions cosmetiques ou pharmaceutiques |
| BR0207846A (pt) * | 2001-03-07 | 2005-09-13 | Incyte San Diego Inc | Derivados heterocìclicos para o tratamento de câncer e outras doenças proliferativas |
| WO2002072543A2 (en) | 2001-03-08 | 2002-09-19 | Maxia Pharmaceuticals, Inc. | Rxr activating molecules |
| DE60204674T2 (de) | 2001-03-14 | 2006-05-18 | Eli Lilly And Co., Indianapolis | Retinoid x rezeptormodulatoren |
| WO2002072099A1 (en) | 2001-03-14 | 2002-09-19 | Mitsubishi Pharma Corporation | Therapeutic and/or preventive agent for diabetic ischemic heart disease |
| ATE442148T1 (de) * | 2001-04-04 | 2009-09-15 | Ortho Mcneil Janssen Pharm | Kombinationstherapie durch glukoseresorptionshemmer und retinoid x rezeptorenmodulatoren |
| US6908939B2 (en) * | 2001-12-21 | 2005-06-21 | Galderma Research & Development S.N.C. | Biaromatic ligand activators of PPARγ receptors |
| WO2004024061A2 (en) * | 2002-04-30 | 2004-03-25 | Merck & Co., Inc. | Aryl-link-aryl substituted thiazolidine-dione and oxazolidine-dione as sodium channel blockers |
-
2002
- 2002-11-15 EP EP02789654A patent/EP1456187A4/en not_active Withdrawn
- 2002-11-15 US US10/298,024 patent/US7071218B2/en not_active Expired - Fee Related
- 2002-11-15 AU AU2002352706A patent/AU2002352706A1/en not_active Abandoned
- 2002-11-15 JP JP2003545635A patent/JP2005513026A/ja active Pending
- 2002-11-15 WO PCT/US2002/036583 patent/WO2003043998A1/en not_active Ceased
-
2006
- 2006-03-20 US US11/385,204 patent/US20060160796A1/en not_active Abandoned
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