JP2007504171A5 - - Google Patents
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- Publication number
- JP2007504171A5 JP2007504171A5 JP2006524953A JP2006524953A JP2007504171A5 JP 2007504171 A5 JP2007504171 A5 JP 2007504171A5 JP 2006524953 A JP2006524953 A JP 2006524953A JP 2006524953 A JP2006524953 A JP 2006524953A JP 2007504171 A5 JP2007504171 A5 JP 2007504171A5
- Authority
- JP
- Japan
- Prior art keywords
- lower alkyl
- substituted
- aryl
- heteroaryl
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 65
- 125000001072 heteroaryl group Chemical group 0.000 claims 39
- 150000001875 compounds Chemical class 0.000 claims 36
- 229910052801 chlorine Inorganic materials 0.000 claims 25
- 125000003118 aryl group Chemical group 0.000 claims 24
- 229910052794 bromium Inorganic materials 0.000 claims 23
- 229910052740 iodine Inorganic materials 0.000 claims 22
- 239000003937 drug carrier Substances 0.000 claims 21
- 239000000825 pharmaceutical preparation Substances 0.000 claims 21
- 125000003107 substituted aryl group Chemical group 0.000 claims 21
- 229910052731 fluorine Inorganic materials 0.000 claims 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 14
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims 14
- 229910052757 nitrogen Inorganic materials 0.000 claims 14
- 150000003839 salts Chemical class 0.000 claims 14
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 13
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims 12
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 9
- 125000000896 monocarboxylic acid group Chemical group 0.000 claims 9
- -1 R 9 ′ Chemical compound 0.000 claims 8
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 229920001817 Agar Polymers 0.000 claims 7
- 241000416162 Astragalus gummifer Species 0.000 claims 7
- 108010010803 Gelatin Proteins 0.000 claims 7
- GXCLVBGFBYZDAG-UHFFFAOYSA-N N-[2-(1H-indol-3-yl)ethyl]-N-methylprop-2-en-1-amine Chemical compound CN(CCC1=CNC2=C1C=CC=C2)CC=C GXCLVBGFBYZDAG-UHFFFAOYSA-N 0.000 claims 7
- 229920002732 Polyanhydride Polymers 0.000 claims 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 7
- 229920002472 Starch Polymers 0.000 claims 7
- 229920001615 Tragacanth Polymers 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 7
- 239000000654 additive Substances 0.000 claims 7
- 239000008272 agar Substances 0.000 claims 7
- 239000000783 alginic acid Substances 0.000 claims 7
- 235000010443 alginic acid Nutrition 0.000 claims 7
- 229920000615 alginic acid Polymers 0.000 claims 7
- 229960001126 alginic acid Drugs 0.000 claims 7
- 150000004781 alginic acids Chemical class 0.000 claims 7
- 125000003342 alkenyl group Chemical group 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 7
- 150000001412 amines Chemical class 0.000 claims 7
- 125000003710 aryl alkyl group Chemical group 0.000 claims 7
- 239000000872 buffer Substances 0.000 claims 7
- 239000008366 buffered solution Substances 0.000 claims 7
- 239000001913 cellulose Substances 0.000 claims 7
- 229920002678 cellulose Polymers 0.000 claims 7
- 125000000753 cycloalkyl group Chemical group 0.000 claims 7
- 239000003085 diluting agent Substances 0.000 claims 7
- 150000002148 esters Chemical class 0.000 claims 7
- 235000019441 ethanol Nutrition 0.000 claims 7
- 239000008273 gelatin Substances 0.000 claims 7
- 229920000159 gelatin Polymers 0.000 claims 7
- 235000019322 gelatine Nutrition 0.000 claims 7
- 235000011852 gelatine desserts Nutrition 0.000 claims 7
- 239000003921 oil Substances 0.000 claims 7
- 229920000515 polycarbonate Polymers 0.000 claims 7
- 239000004417 polycarbonate Substances 0.000 claims 7
- 229920000728 polyester Polymers 0.000 claims 7
- 229920005862 polyol Polymers 0.000 claims 7
- 150000003077 polyols Chemical class 0.000 claims 7
- 239000012439 solid excipient Substances 0.000 claims 7
- 239000000243 solution Substances 0.000 claims 7
- 239000002904 solvent Substances 0.000 claims 7
- 239000008107 starch Substances 0.000 claims 7
- 235000019698 starch Nutrition 0.000 claims 7
- 239000000126 substance Substances 0.000 claims 7
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 7
- 239000000454 talc Substances 0.000 claims 7
- 229910052623 talc Inorganic materials 0.000 claims 7
- 239000000196 tragacanth Substances 0.000 claims 7
- 235000010487 tragacanth Nutrition 0.000 claims 7
- 229940116362 tragacanth Drugs 0.000 claims 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 7
- 230000000996 additive effect Effects 0.000 claims 6
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 2
- 150000002367 halogens Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 150000002334 glycols Chemical class 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
- 0 *C(*)(C(C(*)(CC(N1*)=O)*C1=*)I)C1=C*c2c(*)c(*)c(*)c(*)c12 Chemical compound *C(*)(C(C(*)(CC(N1*)=O)*C1=*)I)C1=C*c2c(*)c(*)c(*)c(*)c12 0.000 description 1
- IJQYCPHUXHHUBJ-CYBMUJFWSA-N C[n]1c(c(Cl)ccc2)c2c(C[C@H](C(N2C)=O)NC2=C)c1 Chemical compound C[n]1c(c(Cl)ccc2)c2c(C[C@H](C(N2C)=O)NC2=C)c1 IJQYCPHUXHHUBJ-CYBMUJFWSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US49888203P | 2003-08-29 | 2003-08-29 | |
| PCT/US2004/028270 WO2005077344A2 (en) | 2003-08-29 | 2004-08-30 | Hydantoin derivatives as inhibitors of cellular necrosis |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116383A Division JP5401502B2 (ja) | 2003-08-29 | 2011-05-24 | 細胞壊死インヒビター |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2007504171A JP2007504171A (ja) | 2007-03-01 |
| JP2007504171A5 true JP2007504171A5 (enExample) | 2007-10-11 |
Family
ID=34860156
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006524953A Pending JP2007504171A (ja) | 2003-08-29 | 2004-08-30 | 細胞壊死インヒビター |
| JP2011116383A Expired - Lifetime JP5401502B2 (ja) | 2003-08-29 | 2011-05-24 | 細胞壊死インヒビター |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011116383A Expired - Lifetime JP5401502B2 (ja) | 2003-08-29 | 2011-05-24 | 細胞壊死インヒビター |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7491743B2 (enExample) |
| EP (3) | EP1663184A2 (enExample) |
| JP (2) | JP2007504171A (enExample) |
| AU (1) | AU2004315596B2 (enExample) |
| CA (1) | CA2536622C (enExample) |
| DK (1) | DK2384753T3 (enExample) |
| ES (1) | ES2567135T3 (enExample) |
| HU (1) | HUE027546T2 (enExample) |
| PL (1) | PL2384753T3 (enExample) |
| SI (1) | SI2384753T1 (enExample) |
| WO (1) | WO2005077344A2 (enExample) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004093871A1 (en) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Novel methods for the treatment of cancer |
| DK2384753T3 (en) * | 2003-08-29 | 2016-04-11 | Brigham & Womens Hospital | Hydantoin derivatives as inhibitors of cell necrosis |
| JP2007521835A (ja) * | 2004-02-10 | 2007-08-09 | トラスティーズ・オブ・ダートマウス・カレッジ | ニコチンアミドリボシドキナーゼ組成物およびそれらの使用方法 |
| US7920101B2 (en) * | 2004-10-08 | 2011-04-05 | Sharp Laboratories Of America, Inc. | Methods and systems for imaging device display standardization |
| US20070021421A1 (en) * | 2005-07-25 | 2007-01-25 | Hampton Thomas G | Measurement of gait dynamics and use of beta-blockers to detect, prognose, prevent and treat amyotrophic lateral sclerosis |
| US8324262B2 (en) * | 2005-12-20 | 2012-12-04 | The Brigham And Women's Hospital, Inc. | Tricyclic necrostatin compounds |
| EP2003119A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Acetamide als Modulatoren des EP2-Rezeptors |
| EP3034494A1 (en) | 2007-08-15 | 2016-06-22 | President and Fellows of Harvard College | Heterocyclic inhibitors of necroptosis |
| US8304421B2 (en) * | 2008-09-30 | 2012-11-06 | Vanderbilt University | Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents |
| WO2010075290A1 (en) * | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
| WO2010075561A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
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| US20140024598A1 (en) | 2010-11-01 | 2014-01-23 | Demetrios Vavvas | Methods and compositions for preserving retinal ganglion cells |
| US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
| CA2888805C (en) | 2011-10-21 | 2020-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for promoting axon regeneration and nerve function |
| JP2016514693A (ja) | 2013-03-15 | 2016-05-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハイブリッド型ネクロトーシス阻害剤 |
| WO2014152182A1 (en) * | 2013-03-15 | 2014-09-25 | President And Fellows Of Harvard College | Deuterated heterocyclic inhibitors of necroptosis |
| CN105394045B (zh) * | 2014-09-04 | 2020-02-14 | 中国科学院上海巴斯德研究所 | 一种肠道病毒的小分子化合物抑制剂及其应用 |
| TW201632516A (zh) | 2014-12-11 | 2016-09-16 | 哈佛大學校長及研究員協會 | 細胞壞死抑制劑與相關方法 |
| CA2972366C (en) | 2014-12-24 | 2020-04-21 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
| AU2015371824B2 (en) | 2014-12-24 | 2019-09-19 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
| ES2885474T3 (es) | 2015-10-13 | 2021-12-13 | Inst Nat Sante Rech Med | Derivados de sibirilina para la utilización en la prevención y/o tratamiento de trastornos asociados a la necroptosis celular |
| US10457678B2 (en) | 2015-10-13 | 2019-10-29 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Substituted pyrrolo[2,3-b]pyridines as inhibitors of cellular necroptosis |
| SG11201806302RA (en) | 2016-02-05 | 2018-08-30 | Denali Therapeutics Inc | Inhibitors of receptor-interacting protein kinase 1 |
| WO2018073321A1 (en) | 2016-10-18 | 2018-04-26 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Natural product derivatives for inhibiting cellular necroptosis, ferroptosis and oxytosis |
| LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
| WO2018154520A1 (en) | 2017-02-27 | 2018-08-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
| WO2020018888A1 (en) | 2018-07-20 | 2020-01-23 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
| WO2020103859A1 (en) | 2018-11-20 | 2020-05-28 | Sironax Ltd | RIP1 Inhibitors |
| US10744153B1 (en) * | 2019-07-01 | 2020-08-18 | Cloudbreak Therapeutics Llc | Compositions and methods for treating meibomian gland dysfunction |
| US20230129364A1 (en) * | 2019-12-26 | 2023-04-27 | Yonsei University, University - Industry Foundation (UIF) | Pyrrolidine derivative, and pharmaceutical composition for preventing or treating beta-amyloid or tau protein-associated diseases containing same |
| EP3875086A1 (en) * | 2020-03-04 | 2021-09-08 | Technische Universität Dresden | Dual-inhibitors of cellular necroptosis and ferroptosis for use in the treatment of organ transplant patients |
| KR20220161394A (ko) * | 2020-03-31 | 2022-12-06 | 마틴 오글트리 | Covid-19의 치료를 위한 방법 및 트롬복산 a2 수용체 길항제의 약학 조성물 |
| CA3183676A1 (en) | 2020-05-20 | 2021-11-25 | Sironax Ltd. | Piperazine cyclic ureas |
| US11654036B2 (en) | 2020-05-26 | 2023-05-23 | Elixir Medical Corporation | Anticoagulant compounds and methods and devices for their use |
| CN112263576A (zh) * | 2020-09-30 | 2021-01-26 | 浙江大学 | 化合物zju-37在制备肝脏疾病预防和/或治疗药物中的应用 |
| IL314082A (en) | 2022-01-12 | 2024-09-01 | Denali Therapeutics Inc | Crystal forms of (S)-5-benzyl-N-(5-methyl-4-oxo-2,3,4,5-tetrahydropyrido[3,2-b][1,4]oxazapin-3-yl)- H4- 1,2,4-triazole-3-carboxamide |
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2004
- 2004-08-30 DK DK10011481.8T patent/DK2384753T3/en active
- 2004-08-30 EP EP04821344A patent/EP1663184A2/en not_active Withdrawn
- 2004-08-30 US US10/930,690 patent/US7491743B2/en not_active Expired - Lifetime
- 2004-08-30 ES ES10011481.8T patent/ES2567135T3/es not_active Expired - Lifetime
- 2004-08-30 AU AU2004315596A patent/AU2004315596B2/en not_active Ceased
- 2004-08-30 JP JP2006524953A patent/JP2007504171A/ja active Pending
- 2004-08-30 WO PCT/US2004/028270 patent/WO2005077344A2/en not_active Ceased
- 2004-08-30 PL PL10011481.8T patent/PL2384753T3/pl unknown
- 2004-08-30 EP EP16000020.4A patent/EP3081214A3/en not_active Withdrawn
- 2004-08-30 SI SI200432313A patent/SI2384753T1/sl unknown
- 2004-08-30 EP EP10011481.8A patent/EP2384753B1/en not_active Expired - Lifetime
- 2004-08-30 CA CA2536622A patent/CA2536622C/en not_active Expired - Fee Related
- 2004-08-30 HU HUE10011481A patent/HUE027546T2/en unknown
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2008
- 2008-03-18 US US12/077,320 patent/US8143300B2/en active Active
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2011
- 2011-05-24 JP JP2011116383A patent/JP5401502B2/ja not_active Expired - Lifetime
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2012
- 2012-02-21 US US13/401,561 patent/US8741942B2/en not_active Expired - Lifetime