SI2384753T1 - Hidantoinski derivati kot inhibitorji celične nekroze - Google Patents
Hidantoinski derivati kot inhibitorji celične nekrozeInfo
- Publication number
- SI2384753T1 SI2384753T1 SI200432313A SI200432313A SI2384753T1 SI 2384753 T1 SI2384753 T1 SI 2384753T1 SI 200432313 A SI200432313 A SI 200432313A SI 200432313 A SI200432313 A SI 200432313A SI 2384753 T1 SI2384753 T1 SI 2384753T1
- Authority
- SI
- Slovenia
- Prior art keywords
- inhibitors
- hydantoin derivatives
- cellular necrosis
- necrosis
- cellular
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49888203P | 2003-08-29 | 2003-08-29 | |
EP10011481.8A EP2384753B1 (en) | 2003-08-29 | 2004-08-30 | Hydantoin derivatives as inhibitors of cellular necrosis |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2384753T1 true SI2384753T1 (sl) | 2016-06-30 |
Family
ID=34860156
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200432313A SI2384753T1 (sl) | 2003-08-29 | 2004-08-30 | Hidantoinski derivati kot inhibitorji celične nekroze |
Country Status (11)
Country | Link |
---|---|
US (3) | US7491743B2 (sl) |
EP (3) | EP2384753B1 (sl) |
JP (2) | JP2007504171A (sl) |
AU (1) | AU2004315596B2 (sl) |
CA (1) | CA2536622C (sl) |
DK (1) | DK2384753T3 (sl) |
ES (1) | ES2567135T3 (sl) |
HU (1) | HUE027546T2 (sl) |
PL (1) | PL2384753T3 (sl) |
SI (1) | SI2384753T1 (sl) |
WO (1) | WO2005077344A2 (sl) |
Families Citing this family (36)
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WO2004094409A1 (en) * | 2003-03-27 | 2004-11-04 | Lankenau Institute For Medical Research | Novel ido inhibitors and methods of use |
EP2384753B1 (en) | 2003-08-29 | 2016-01-06 | The Brigham and Women's Hospital, Inc. | Hydantoin derivatives as inhibitors of cellular necrosis |
AU2005211773B2 (en) * | 2004-02-10 | 2009-06-25 | Trustees Of Dartmouth College | Nicotinamide riboside kinase compositions and methods for using the same |
US7920101B2 (en) * | 2004-10-08 | 2011-04-05 | Sharp Laboratories Of America, Inc. | Methods and systems for imaging device display standardization |
WO2007014219A2 (en) * | 2005-07-25 | 2007-02-01 | The Curavita Corporation | Measurement of gait dynamics and use of beta-blockers to detect, prognose, prevent and treat amyotrophic lateral sclerosis |
CN101674826A (zh) * | 2005-12-20 | 2010-03-17 | 哈佛大学校长及研究员协会 | 化合物、筛选和治疗方法 |
EP2003119A1 (de) * | 2007-06-13 | 2008-12-17 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Acetamide als Modulatoren des EP2-Rezeptors |
EP2192838A4 (en) | 2007-08-15 | 2011-07-27 | Harvard College | HETEROCYCLIC NEKROPTOSIS HEMMER |
US8304421B2 (en) * | 2008-09-30 | 2012-11-06 | Vanderbilt University | Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents |
WO2010075290A1 (en) * | 2008-12-22 | 2010-07-01 | President And Fellows Of Harvard College | Unsaturated heterocyclic inhibitors of necroptosis |
EP3000468A1 (en) | 2008-12-23 | 2016-03-30 | President and Fellows of Harvard College | Small molecule inhibitors of necroptosis |
AU2011242465B2 (en) * | 2010-04-23 | 2017-01-19 | Massachusetts Eye And Ear Infirmary | Methods and compositions for preserving photoreceptor and retinal pigment epithelial cells |
US20140024598A1 (en) | 2010-11-01 | 2014-01-23 | Demetrios Vavvas | Methods and compositions for preserving retinal ganglion cells |
US9643977B2 (en) | 2011-03-11 | 2017-05-09 | President And Fellows Of Harvard College | Necroptosis inhibitors and methods of use therefor |
CA2888805C (en) | 2011-10-21 | 2020-07-14 | Massachusetts Eye And Ear Infirmary | Methods and compositions for promoting axon regeneration and nerve function |
JP2016514693A (ja) * | 2013-03-15 | 2016-05-23 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ハイブリッド型ネクロトーシス阻害剤 |
WO2014152182A1 (en) * | 2013-03-15 | 2014-09-25 | President And Fellows Of Harvard College | Deuterated heterocyclic inhibitors of necroptosis |
CN105394045B (zh) * | 2014-09-04 | 2020-02-14 | 中国科学院上海巴斯德研究所 | 一种肠道病毒的小分子化合物抑制剂及其应用 |
CA2970525A1 (en) | 2014-12-11 | 2016-06-16 | President And Fellows Of Harvard College | Inhibitors of cellular necrosis and related methods |
CA2972294C (en) | 2014-12-24 | 2018-09-25 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
WO2016101885A1 (en) | 2014-12-24 | 2016-06-30 | National Institute Of Biological Sciences, Beijing | Necrosis inhibitors |
DK3362449T3 (da) | 2015-10-13 | 2021-07-19 | Inst Nat Sante Rech Med | Sibirilin-derivater til anvendelse til at forebygge og/eller behandle lidelser associeret med cellulær nekroptose |
DK3362450T3 (da) | 2015-10-13 | 2020-09-14 | Inst Nat Sante Rech Med | N1- og N7-substituerede sibirilin-derivater og anvendelse deraf som inhibitorer af cellulær nekroptose |
KR20180114910A (ko) | 2016-02-05 | 2018-10-19 | 데날리 테라퓨틱스 인크. | 수용체-상호작용 단백질 키나제 1의 억제제 |
US11224586B2 (en) | 2016-10-18 | 2022-01-18 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Natural product derivatives for inhibiting cellular necroptosis, ferroptosis and oxytosis |
LT3552017T (lt) | 2016-12-09 | 2022-05-10 | Denali Therapeutics Inc. | Junginiai, naudotini kaip ripk1 inhibitoriai |
WO2018154520A1 (en) | 2017-02-27 | 2018-08-30 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors |
US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
WO2020044206A1 (en) | 2018-08-29 | 2020-03-05 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides as kinase inhibitors for use in the treatment cancer |
WO2020103859A1 (en) | 2018-11-20 | 2020-05-28 | Sironax Ltd | RIP1 Inhibitors |
US10744153B1 (en) * | 2019-07-01 | 2020-08-18 | Cloudbreak Therapeutics Llc | Compositions and methods for treating meibomian gland dysfunction |
EP4083037A4 (en) * | 2019-12-26 | 2024-01-24 | Yonsei Univ Univ Industry Foundation Uif | PYRROLIDINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING DISEASES ASSOCIATED WITH BETA-AMYLOID OR TAU PROTEIN CONTAINING THE LATTER |
EP3875086A1 (en) * | 2020-03-04 | 2021-09-08 | Technische Universität Dresden | Dual-inhibitors of cellular necroptosis and ferroptosis for use in the treatment of organ transplant patients |
KR20220161394A (ko) * | 2020-03-31 | 2022-12-06 | 마틴 오글트리 | Covid-19의 치료를 위한 방법 및 트롬복산 a2 수용체 길항제의 약학 조성물 |
US11654036B2 (en) | 2020-05-26 | 2023-05-23 | Elixir Medical Corporation | Anticoagulant compounds and methods and devices for their use |
CN112263576A (zh) * | 2020-09-30 | 2021-01-26 | 浙江大学 | 化合物zju-37在制备肝脏疾病预防和/或治疗药物中的应用 |
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-
2004
- 2004-08-30 EP EP10011481.8A patent/EP2384753B1/en active Active
- 2004-08-30 WO PCT/US2004/028270 patent/WO2005077344A2/en active Application Filing
- 2004-08-30 US US10/930,690 patent/US7491743B2/en active Active
- 2004-08-30 PL PL10011481.8T patent/PL2384753T3/pl unknown
- 2004-08-30 EP EP04821344A patent/EP1663184A2/en not_active Withdrawn
- 2004-08-30 EP EP16000020.4A patent/EP3081214A3/en not_active Withdrawn
- 2004-08-30 DK DK10011481.8T patent/DK2384753T3/en active
- 2004-08-30 JP JP2006524953A patent/JP2007504171A/ja active Pending
- 2004-08-30 CA CA2536622A patent/CA2536622C/en not_active Expired - Fee Related
- 2004-08-30 SI SI200432313A patent/SI2384753T1/sl unknown
- 2004-08-30 ES ES10011481.8T patent/ES2567135T3/es active Active
- 2004-08-30 HU HUE10011481A patent/HUE027546T2/en unknown
- 2004-08-30 AU AU2004315596A patent/AU2004315596B2/en not_active Ceased
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2008
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Also Published As
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AU2004315596A1 (en) | 2005-08-25 |
EP1663184A2 (en) | 2006-06-07 |
CA2536622A1 (en) | 2005-08-25 |
DK2384753T3 (en) | 2016-04-11 |
PL2384753T3 (pl) | 2016-09-30 |
EP3081214A3 (en) | 2016-11-16 |
US7491743B2 (en) | 2009-02-17 |
JP5401502B2 (ja) | 2014-01-29 |
JP2007504171A (ja) | 2007-03-01 |
US8741942B2 (en) | 2014-06-03 |
EP2384753B1 (en) | 2016-01-06 |
CA2536622C (en) | 2014-02-11 |
WO2005077344A2 (en) | 2005-08-25 |
HUE027546T2 (en) | 2016-10-28 |
EP2384753A1 (en) | 2011-11-09 |
US20110144169A1 (en) | 2011-06-16 |
JP2011157404A (ja) | 2011-08-18 |
EP3081214A2 (en) | 2016-10-19 |
ES2567135T3 (es) | 2016-04-20 |
US20120149702A1 (en) | 2012-06-14 |
US8143300B2 (en) | 2012-03-27 |
WO2005077344A3 (en) | 2006-03-16 |
US20050119260A1 (en) | 2005-06-02 |
AU2004315596B2 (en) | 2011-11-24 |
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