JP2012503653A5 - - Google Patents
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- Publication number
- JP2012503653A5 JP2012503653A5 JP2011529012A JP2011529012A JP2012503653A5 JP 2012503653 A5 JP2012503653 A5 JP 2012503653A5 JP 2011529012 A JP2011529012 A JP 2011529012A JP 2011529012 A JP2011529012 A JP 2011529012A JP 2012503653 A5 JP2012503653 A5 JP 2012503653A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- substituted
- ribosyl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 20
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- -1 deoxyribose sugars Chemical class 0.000 claims 5
- 125000004404 heteroalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 239000001257 hydrogen Substances 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000004172 4-methoxyphenyl group Chemical group [H]C1=C([H])C(OC([H])([H])[H])=C([H])C([H])=C1* 0.000 claims 3
- 125000002015 acyclic group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 1
- PYMYPHUHKUWMLA-LMVFSUKVSA-N Ribose Natural products OC[C@@H](O)[C@@H](O)[C@@H](O)C=O PYMYPHUHKUWMLA-LMVFSUKVSA-N 0.000 claims 1
- 125000002877 alkyl aryl group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- HMFHBZSHGGEWLO-UHFFFAOYSA-N alpha-D-Furanose-Ribose Natural products OCC1OC(O)C(O)C1O HMFHBZSHGGEWLO-UHFFFAOYSA-N 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 230000005907 cancer growth Effects 0.000 claims 1
- 125000006165 cyclic alkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000001301 oxygen Substances 0.000 claims 1
- 125000000548 ribosyl group Chemical class C1([C@H](O)[C@H](O)[C@H](O1)CO)* 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 235000000346 sugar Nutrition 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9932408P | 2008-09-23 | 2008-09-23 | |
| US61/099,324 | 2008-09-23 | ||
| PCT/US2009/005273 WO2010039187A2 (en) | 2008-09-23 | 2009-09-23 | Fused diimidazodiazepine compounds and methods of use and manufacture thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012503653A JP2012503653A (ja) | 2012-02-09 |
| JP2012503653A5 true JP2012503653A5 (enExample) | 2015-04-30 |
| JP5802872B2 JP5802872B2 (ja) | 2015-11-04 |
Family
ID=42074054
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529012A Active JP5802872B2 (ja) | 2008-09-23 | 2009-09-23 | 縮合ジイミダゾジアゼピン化合物並びにその使用及び製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8518901B2 (enExample) |
| EP (1) | EP2350086B1 (enExample) |
| JP (1) | JP5802872B2 (enExample) |
| AU (1) | AU2009300357B2 (enExample) |
| CA (1) | CA2738650C (enExample) |
| WO (1) | WO2010039187A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9322831B2 (en) | 2008-09-23 | 2016-04-26 | The Johns Hopkins University | DDX3 as a biomarker for cancer and methods related thereto |
| EP2683386B1 (en) * | 2011-03-09 | 2017-07-05 | The Johns Hopkins University | Compounds and methods of use in ablative radiotherapy |
| AU2013313974A1 (en) * | 2012-09-04 | 2015-03-12 | Niigata University | Cancer diagnostic and therapeutic method targeting molecules expressed in cancer stem cells |
| WO2015200779A2 (en) * | 2014-06-26 | 2015-12-30 | The Johns Hopkins University | Methods of prevention and treatment of viral disease by use of ddx3 inhibitors |
| KR20220062038A (ko) * | 2019-09-13 | 2022-05-13 | 오리제니스 게엠베하 | 예를 들어 자가면역 질환의 치료를 위한 lrrk2, nuak1 및/또는 tyk2 키나제 조정제로서의 1,4-디히드로벤조[d]피라졸로[3,4-f][1,3]디아제핀 유도체 및 관련 화합물 |
| CA3154131A1 (en) * | 2019-09-13 | 2021-03-18 | Origenis Gmbh | 1,4-dihydrobenzo[d]pyrazolo[3,4-f][1,3]diazepine derivatives and related compounds as lrrk2, nuak1 and/or tyk2 kinase modulators for the treatment of e.g. autoimmune disease |
| EP4395765A4 (en) | 2021-08-31 | 2025-07-02 | Natsar Pharmaceuticals Inc | INTRAVENOUS FORMULATIONS OF RK-33 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| TW201311B (enExample) | 1991-06-17 | 1993-03-01 | Hoffmann La Roche | |
| CA2631871A1 (en) * | 2005-12-16 | 2007-10-25 | Genentech, Inc. | Tetracyclic kinase inhibitors |
-
2009
- 2009-09-23 WO PCT/US2009/005273 patent/WO2010039187A2/en not_active Ceased
- 2009-09-23 EP EP09818080.5A patent/EP2350086B1/en active Active
- 2009-09-23 CA CA2738650A patent/CA2738650C/en active Active
- 2009-09-23 JP JP2011529012A patent/JP5802872B2/ja active Active
- 2009-09-23 AU AU2009300357A patent/AU2009300357B2/en active Active
- 2009-09-23 US US13/061,612 patent/US8518901B2/en active Active
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