JP2009515872A5 - - Google Patents
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- Publication number
- JP2009515872A5 JP2009515872A5 JP2008539670A JP2008539670A JP2009515872A5 JP 2009515872 A5 JP2009515872 A5 JP 2009515872A5 JP 2008539670 A JP2008539670 A JP 2008539670A JP 2008539670 A JP2008539670 A JP 2008539670A JP 2009515872 A5 JP2009515872 A5 JP 2009515872A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- substituted
- lower alkoxy
- phenyl
- halogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 44
- 125000003545 alkoxy group Chemical group 0.000 claims 41
- 125000000217 alkyl group Chemical group 0.000 claims 13
- 125000003302 alkenyloxy group Chemical group 0.000 claims 12
- 150000003839 salts Chemical class 0.000 claims 10
- -1 piperazine diyl group Chemical group 0.000 claims 9
- 125000001424 substituent group Chemical group 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 7
- 125000005843 halogen group Chemical group 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 6
- 125000005036 alkoxyphenyl group Chemical group 0.000 claims 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 4
- 125000004076 pyridyl group Chemical group 0.000 claims 4
- 125000006383 alkylpyridyl group Chemical group 0.000 claims 3
- 125000005133 alkynyloxy group Chemical group 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- XJAPYEXYOMJEEL-UHFFFAOYSA-N C(=CCC)OC=1C=C(C=CC1OC(F)F)C=1OC=C(N1)CNC(C1=C(C=CC=C1)OCC)=O Chemical compound C(=CCC)OC=1C=C(C=CC1OC(F)F)C=1OC=C(N1)CNC(C1=C(C=CC=C1)OCC)=O XJAPYEXYOMJEEL-UHFFFAOYSA-N 0.000 claims 1
- 125000002252 acyl group Chemical group 0.000 claims 1
- 125000004450 alkenylene group Chemical group 0.000 claims 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000004414 alkyl thio group Chemical group 0.000 claims 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
- OHLYRXMTWPVGTB-UHFFFAOYSA-N n-[[2-[3-(cyclobutylmethoxy)-4-(difluoromethoxy)phenyl]-1,3-oxazol-4-yl]methyl]-3-methylpyridine-2-carboxamide Chemical compound CC1=CC=CN=C1C(=O)NCC1=COC(C=2C=C(OCC3CCC3)C(OC(F)F)=CC=2)=N1 OHLYRXMTWPVGTB-UHFFFAOYSA-N 0.000 claims 1
- CDFUGRNOTYDMPB-UHFFFAOYSA-N n-[[2-[3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide Chemical compound CCOC1=CC=CC=C1C(=O)NCC1=COC(C=2C=C(OCC3CC3)C(OC(F)F)=CC=2)=N1 CDFUGRNOTYDMPB-UHFFFAOYSA-N 0.000 claims 1
- IRACUEGUHBIDAI-UHFFFAOYSA-N n-[[2-[4-(difluoromethoxy)-3-(2-methylpropoxy)phenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide Chemical compound CCOC1=CC=CC=C1C(=O)NCC1=COC(C=2C=C(OCC(C)C)C(OC(F)F)=CC=2)=N1 IRACUEGUHBIDAI-UHFFFAOYSA-N 0.000 claims 1
- CZMBOKSRQLKALJ-UHFFFAOYSA-N n-[[2-[4-(difluoromethoxy)-3-(2-methylpropoxy)phenyl]-1,3-oxazol-4-yl]methyl]-3-methylpyridine-2-carboxamide Chemical compound C1=C(OC(F)F)C(OCC(C)C)=CC(C=2OC=C(CNC(=O)C=3C(=CC=CN=3)C)N=2)=C1 CZMBOKSRQLKALJ-UHFFFAOYSA-N 0.000 claims 1
- LJMSMNPASMREJG-UHFFFAOYSA-N n-[[2-[4-(difluoromethoxy)-3-ethoxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide Chemical compound C1=C(OC(F)F)C(OCC)=CC(C=2OC=C(CNC(=O)C=3C(=CC=CC=3)OCC)N=2)=C1 LJMSMNPASMREJG-UHFFFAOYSA-N 0.000 claims 1
- QPZHOQATADRGBT-UHFFFAOYSA-N n-[[2-[4-(difluoromethoxy)-3-prop-2-enoxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide Chemical compound CCOC1=CC=CC=C1C(=O)NCC1=COC(C=2C=C(OCC=C)C(OC(F)F)=CC=2)=N1 QPZHOQATADRGBT-UHFFFAOYSA-N 0.000 claims 1
- VFBILHPIHUPBPZ-UHFFFAOYSA-N n-[[2-[4-(difluoromethoxy)-3-propan-2-yloxyphenyl]-1,3-oxazol-4-yl]methyl]-2-ethoxybenzamide Chemical compound CCOC1=CC=CC=C1C(=O)NCC1=COC(C=2C=C(OC(C)C)C(OC(F)F)=CC=2)=N1 VFBILHPIHUPBPZ-UHFFFAOYSA-N 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 125000000466 oxiranyl group Chemical group 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008539670A JP5305914B2 (ja) | 2005-11-15 | 2006-11-14 | オキサゾール化合物及び医薬組成物 |
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2005330590 | 2005-11-15 | ||
| JP2005330590 | 2005-11-15 | ||
| PCT/JP2006/323066 WO2007058338A2 (en) | 2005-11-15 | 2006-11-14 | Oxazole compound and pharmaceutical composition |
| JP2008539670A JP5305914B2 (ja) | 2005-11-15 | 2006-11-14 | オキサゾール化合物及び医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009515872A JP2009515872A (ja) | 2009-04-16 |
| JP2009515872A5 true JP2009515872A5 (enExample) | 2012-02-23 |
| JP5305914B2 JP5305914B2 (ja) | 2013-10-02 |
Family
ID=37879936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008539670A Active JP5305914B2 (ja) | 2005-11-15 | 2006-11-14 | オキサゾール化合物及び医薬組成物 |
Country Status (22)
| Country | Link |
|---|---|
| US (9) | USRE46792E1 (enExample) |
| EP (1) | EP1954684B1 (enExample) |
| JP (1) | JP5305914B2 (enExample) |
| KR (1) | KR101439557B1 (enExample) |
| CN (1) | CN101309912B (enExample) |
| AR (3) | AR057891A1 (enExample) |
| AU (1) | AU2006316079B2 (enExample) |
| BR (1) | BRPI0618589B8 (enExample) |
| CA (1) | CA2627541C (enExample) |
| CY (1) | CY1115302T1 (enExample) |
| DK (1) | DK1954684T3 (enExample) |
| ES (1) | ES2483992T3 (enExample) |
| IL (1) | IL191008A (enExample) |
| MY (1) | MY153720A (enExample) |
| NO (1) | NO341440B1 (enExample) |
| PL (1) | PL1954684T3 (enExample) |
| PT (1) | PT1954684E (enExample) |
| RU (1) | RU2418793C2 (enExample) |
| SI (1) | SI1954684T1 (enExample) |
| TW (1) | TWI330639B (enExample) |
| WO (1) | WO2007058338A2 (enExample) |
| ZA (1) | ZA200803758B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4986927B2 (ja) * | 2007-05-14 | 2012-07-25 | 大塚製薬株式会社 | 医薬 |
| US8822513B2 (en) | 2010-03-01 | 2014-09-02 | Gtx, Inc. | Compounds for treatment of cancer |
| DK2303021T3 (en) | 2008-06-16 | 2019-04-08 | Univ Tennessee Res Found | RELATIONSHIPS FOR TREATING CANCER |
| US9029408B2 (en) | 2008-06-16 | 2015-05-12 | Gtx, Inc. | Compounds for treatment of cancer |
| US9447049B2 (en) | 2010-03-01 | 2016-09-20 | University Of Tennessee Research Foundation | Compounds for treatment of cancer |
| GB2465890A (en) * | 2008-12-05 | 2010-06-09 | Scynexis Inc | 2-Arylazole derivatives as antiprotozoal agents |
| KR101939704B1 (ko) | 2010-03-01 | 2019-01-17 | 지티엑스, 인코포레이티드 | 암 치료용 화합물 |
| US8513230B2 (en) | 2010-03-05 | 2013-08-20 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| NZ601967A (en) * | 2010-03-12 | 2015-03-27 | Omeros Corp | Pde10 inhibitors and related compositions and methods |
| CN103402359B (zh) | 2011-01-17 | 2016-08-24 | 卡尔约药物治疗公司 | 含烯烃核运输调节剂及其用途 |
| EP2736883B1 (en) | 2011-07-29 | 2019-09-04 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| EP2736887B1 (en) | 2011-07-29 | 2017-10-18 | Karyopharm Therapeutics, Inc. | Hydrazide containing nuclear transport modulators and uses thereof |
| US8809372B2 (en) | 2011-09-30 | 2014-08-19 | Asana Biosciences, Llc | Pyridine derivatives |
| US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
| CA2855021A1 (en) | 2011-11-09 | 2013-05-23 | Mylan Laboratories Ltd | Process for the preparation of roflumilast |
| IN2014DN09434A (enExample) | 2012-05-09 | 2015-07-17 | Karyopharm Therapeutics Inc | |
| CN109912526A (zh) * | 2012-08-30 | 2019-06-21 | 大塚制药株式会社 | 制造噁唑化合物的方法 |
| WO2014144772A1 (en) | 2013-03-15 | 2014-09-18 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| CN110386919B (zh) | 2013-06-21 | 2023-07-14 | 卡尔约药物治疗公司 | 核转运调节剂及其用途 |
| CN105085429B (zh) * | 2014-04-25 | 2019-12-10 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物上的应用 |
| NZ716462A (en) | 2014-04-28 | 2017-11-24 | Omeros Corp | Optically active pde10 inhibitor |
| NZ716494A (en) | 2014-04-28 | 2017-07-28 | Omeros Corp | Processes and intermediates for the preparation of a pde10 inhibitor |
| CN111484483B (zh) | 2014-08-15 | 2023-05-26 | 卡尔约药物治疗公司 | 赛灵克斯的多晶型物 |
| TWI689497B (zh) * | 2014-09-04 | 2020-04-01 | 南北兄弟藥業投資有限公司 | 芳雜環類衍生物及其在藥物中的應用 |
| CN107530313A (zh) | 2015-04-24 | 2018-01-02 | 奥默罗斯公司 | Pde10抑制剂以及相关组合物和方法 |
| CN106188027B (zh) * | 2015-09-02 | 2020-10-20 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物中的应用 |
| WO2017079678A1 (en) | 2015-11-04 | 2017-05-11 | Omeros Corporation | Solid state forms of a pde10 inhibitor |
| TWI726027B (zh) * | 2015-12-28 | 2021-05-01 | 日商大塚製藥股份有限公司 | 軟膏 |
| CN106279138B (zh) * | 2015-12-29 | 2019-03-01 | 广东东阳光药业有限公司 | 芳杂环类衍生物及其在药物中的应用 |
| US10526295B2 (en) | 2015-12-31 | 2020-01-07 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| EP4400167A3 (en) | 2018-04-04 | 2024-09-25 | Otsuka Pharmaceutical Co., Ltd. | Oxazole compound crystal |
| TW202227424A (zh) * | 2020-11-27 | 2022-07-16 | 大陸商瑞石生物醫藥有限公司 | 芳基或雜芳基取代５員芳雜環化合物及其用途 |
| CN112425610A (zh) * | 2021-01-22 | 2021-03-02 | 深圳市洛奇机电科技有限公司 | 一种防治君子兰叶斑病的农药悬浮剂的制备系统及其应用 |
| CN118843463A (zh) | 2022-03-25 | 2024-10-25 | 大塚制药株式会社 | 创伤治疗用组合物 |
| CN115785014B (zh) * | 2022-12-27 | 2025-01-24 | 瑞石生物医药有限公司 | 四唑衍生物及其用途 |
| GB202306663D0 (en) | 2023-05-05 | 2023-06-21 | Union Therapeutics As | Combination therapy |
| WO2025249530A1 (en) | 2024-05-29 | 2025-12-04 | Otsuka Pharmaceutical Co., Ltd. | Difamilast-containing composition |
| CN119798183B (zh) * | 2024-12-19 | 2026-03-24 | 上海药坦药物研究开发有限公司 | 一种噁唑类化合物的制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4735961A (en) * | 1984-05-07 | 1988-04-05 | Merck & Co., Inc. | Oxazoles and thiazoles containing an aminohydroxypropoxyphenyl moiety |
| MX15171A (es) * | 1988-03-08 | 1993-05-01 | Pfizer | Derivados de tiazolidinodiona hipoglicemicos |
| US5814651A (en) | 1992-12-02 | 1998-09-29 | Pfizer Inc. | Catechol diethers as selective PDEIV inhibitors |
| US20020169173A1 (en) | 1993-11-08 | 2002-11-14 | Smithkline Beecham Corporation | Oxazoles for treating cytokine mediated diseases |
| CA2193725A1 (en) * | 1994-06-24 | 1996-01-04 | David Cavalla | Aryl derivative compounds and uses to inhibit phosphodiesterase iv acti vity |
| AUPO156596A0 (en) | 1996-08-09 | 1996-09-05 | University Of Sydney, The | Synthetic polynucleotides |
| DE19632549A1 (de) | 1996-08-13 | 1998-02-19 | Merck Patent Gmbh | Arylalkanoylpyridazine |
| AU4015497A (en) | 1996-08-26 | 1998-03-19 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Thiazole derivatives useful as selective inhibitors of pde-iv |
| ATE240728T1 (de) | 1996-10-07 | 2003-06-15 | Lilly Co Eli | Neue verbindungen nutlich als neuroschützende mittel |
| US6020339A (en) | 1997-10-03 | 2000-02-01 | Merck & Co., Inc. | Aryl furan derivatives as PDE IV inhibitors |
| JP4518587B2 (ja) * | 1998-03-09 | 2010-08-04 | 興和創薬株式会社 | ２−フェニルモルホリン誘導体 |
| AR036237A1 (es) * | 2001-07-27 | 2004-08-25 | Bayer Corp | Derivados del acido indan acetico, intermediarios, y metodo para su preparacion, composicion farmaceutica y el uso de dichos derivados para la manufactura de un medicamento |
| CA2463469A1 (en) | 2001-10-16 | 2003-04-24 | Memory Pharmaceuticals Corporation | 4-(4-alkoxy-3-hydroxyphenyl)-2-pyrrolidone derivatives as pde-4 inhibitors for the treatment of neurological syndromes |
| DE60324898D1 (de) | 2002-02-25 | 2009-01-08 | Lilly Co Eli | Modulatoren von peroxisome proliferator-aktivierten rezeptoren |
| JP2004203871A (ja) * | 2002-12-13 | 2004-07-22 | Yamanouchi Pharmaceut Co Ltd | 医薬組成物 |
| TW200505913A (en) | 2003-03-28 | 2005-02-16 | Hoffmann La Roche | Novel oxazole derivatives, their manufacture and use as pharmaceutical agents |
| BRPI0511250A (pt) | 2004-05-17 | 2007-11-27 | Otsuka Pharma Co Ltd | composto de tiazol e uso deste |
| WO2006019833A1 (en) | 2004-07-26 | 2006-02-23 | Eli Lilly And Company | Oxazole derivatives as histamine h3 receptor agents, preparation and therapeutic uses |
| DE102004051277A1 (de) | 2004-10-21 | 2006-04-27 | Merck Patent Gmbh | Heterocyclische Carbonylverbindungen |
| US7790720B2 (en) * | 2005-03-31 | 2010-09-07 | Ucb Pharma, S.A. | Compounds comprising an oxazole or thiazole moiety, processes for making them, and their uses |
-
2006
- 2006-11-14 AU AU2006316079A patent/AU2006316079B2/en active Active
- 2006-11-14 RU RU2008123839/04A patent/RU2418793C2/ru active
- 2006-11-14 CA CA2627541A patent/CA2627541C/en active Active
- 2006-11-14 JP JP2008539670A patent/JP5305914B2/ja active Active
- 2006-11-14 US US15/623,249 patent/USRE46792E1/en active Active
- 2006-11-14 PT PT68234673T patent/PT1954684E/pt unknown
- 2006-11-14 DK DK06823467.3T patent/DK1954684T3/da active
- 2006-11-14 BR BRPI0618589A patent/BRPI0618589B8/pt active IP Right Grant
- 2006-11-14 TW TW095142068A patent/TWI330639B/zh active
- 2006-11-14 PL PL06823467T patent/PL1954684T3/pl unknown
- 2006-11-14 US US12/090,951 patent/US8637559B2/en not_active Ceased
- 2006-11-14 MY MYPI20081379A patent/MY153720A/en unknown
- 2006-11-14 ZA ZA200803758A patent/ZA200803758B/xx unknown
- 2006-11-14 ES ES06823467.3T patent/ES2483992T3/es active Active
- 2006-11-14 KR KR1020087014483A patent/KR101439557B1/ko active Active
- 2006-11-14 AR ARP060104973A patent/AR057891A1/es active IP Right Grant
- 2006-11-14 SI SI200631792T patent/SI1954684T1/sl unknown
- 2006-11-14 WO PCT/JP2006/323066 patent/WO2007058338A2/en not_active Ceased
- 2006-11-14 CN CN200680042484XA patent/CN101309912B/zh active Active
- 2006-11-14 EP EP06823467.3A patent/EP1954684B1/en active Active
-
2008
- 2008-04-23 NO NO20081930A patent/NO341440B1/no unknown
- 2008-04-27 IL IL191008A patent/IL191008A/en active IP Right Grant
-
2013
- 2013-12-12 US US14/104,871 patent/US20140100226A1/en not_active Abandoned
-
2014
- 2014-07-01 CY CY20141100485T patent/CY1115302T1/el unknown
-
2017
- 2017-04-11 US US15/485,203 patent/US20170216260A1/en not_active Abandoned
- 2017-07-10 AR ARP170101905A patent/AR109007A2/es unknown
- 2017-07-10 AR ARP170101904A patent/AR109006A2/es unknown
-
2018
- 2018-11-01 US US16/178,517 patent/US20190070151A1/en not_active Abandoned
-
2019
- 2019-11-12 US US16/681,360 patent/US20200078340A1/en not_active Abandoned
-
2022
- 2022-02-24 US US17/679,659 patent/US20220265613A1/en not_active Abandoned
-
2024
- 2024-01-05 US US18/405,633 patent/US20240148699A1/en not_active Abandoned
-
2025
- 2025-12-17 US US19/422,682 patent/US20260108497A1/en active Pending
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