JP2004521124A5 - - Google Patents

Download PDF

Info

Publication number
JP2004521124A5
JP2004521124A5 JP2002563891A JP2002563891A JP2004521124A5 JP 2004521124 A5 JP2004521124 A5 JP 2004521124A5 JP 2002563891 A JP2002563891 A JP 2002563891A JP 2002563891 A JP2002563891 A JP 2002563891A JP 2004521124 A5 JP2004521124 A5 JP 2004521124A5
Authority
JP
Japan
Prior art keywords
alkyl
group
substituted
ring
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2002563891A
Other languages
English (en)
Japanese (ja)
Other versions
JP2004521124A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2002/004680 external-priority patent/WO2002064094A2/en
Publication of JP2004521124A publication Critical patent/JP2004521124A/ja
Publication of JP2004521124A5 publication Critical patent/JP2004521124A5/ja
Pending legal-status Critical Current

Links

JP2002563891A 2001-02-09 2002-02-05 糖尿病および脂質障害用の２−アリールオキシ−２−アリールアルカン酸類 Pending JP2004521124A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26780901P 2001-02-09 2001-02-09
PCT/US2002/004680 WO2002064094A2 (en) 2001-02-09 2002-02-05 2-aryloxy-2-arylalkanoic acids for diabetes and lipid disorders

Publications (2)

Publication Number Publication Date
JP2004521124A JP2004521124A (ja) 2004-07-15
JP2004521124A5 true JP2004521124A5 (enExample) 2009-01-15

Family

ID=23020208

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2002563891A Pending JP2004521124A (ja) 2001-02-09 2002-02-05 糖尿病および脂質障害用の２−アリールオキシ−２−アリールアルカン酸類

Country Status (6)

Country Link
US (2) US7091230B2 (enExample)
EP (1) EP1366012A4 (enExample)
JP (1) JP2004521124A (enExample)
AU (1) AU2002251978B2 (enExample)
CA (1) CA2437118A1 (enExample)
WO (1) WO2002064094A2 (enExample)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7041691B1 (en) 1999-06-30 2006-05-09 Amgen Inc. Compounds for the modulation of PPARγ activity
US20030171399A1 (en) 2000-06-28 2003-09-11 Tularik Inc. Quinolinyl and benzothiazolyl modulators
AR030379A1 (es) * 2000-08-22 2003-08-20 Novartis Ag Combinaciones
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
CN1582168A (zh) * 2001-01-26 2005-02-16 先灵公司 用于治疗血管性疾病的固醇吸收抑制剂与心血管药剂的组合
ES2296894T3 (es) * 2001-01-26 2008-05-01 Schering Corporation Combinaciones de ezetimiba con aspirina para tratar estados vasculares.
AU2002247019C1 (en) 2001-01-26 2017-05-11 Organon Llc Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
AR034204A1 (es) * 2001-01-26 2004-02-04 Schering Corp Composiciones y combinaciones de acido nicotinico y derivados del mismo con inhibidor(es) de la absorcion de los esteroles, y el uso de los mismos para preparar medicamentos para el tratamiento para indicaciones vasculares
ATE369851T1 (de) * 2001-01-26 2007-09-15 Schering Corp Kombinationen von gallensäuresequestriermitteln und hemmern der sterolabsorption zur behandlung von kardiovaskulären indikationen
RU2756946C2 (ru) 2001-01-26 2021-10-07 Мерк Шарп И Доум Корп. Применение замещенных азетидинонов для лечения ситостеролемии
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
DE60216300T2 (de) 2001-09-21 2007-06-28 Schering Corp. Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
AU2003225027A1 (en) * 2002-04-16 2003-11-03 Merck And Co., Inc. Combination therapy using a ppar alpha/gamma agonist
CN101675927A (zh) * 2002-06-07 2010-03-24 科蒂科股份有限公司 治疗分子及方法-1
FR2845601B1 (fr) * 2002-10-11 2005-07-08 Servier Lab Nouvelle association entre un compose heterocyclique et un agent antioxydant et les compositions pharmaceutiques qui les contiennent
FR2845602B1 (fr) * 2002-10-11 2005-07-08 Servier Lab Association entre un ligand des recepteurs actives par les proliferateurs de peroxisomes et un agent antioxydant et les compositions pharmaceutiques qui les contiennent
CA2504878A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorption inhibitors for the treatment of demyelination
DE60322944D1 (de) * 2002-12-10 2008-09-25 Novartis Ag Kombinationen von einem dpp-iv inhibitor und einem ppar- alpha agonist
BRPI0406761A (pt) 2003-01-14 2005-12-20 Arena Pharm Inc Derivados de arila e heteroarila 1,2,3-trissubstituìdos como moduladores do metabolismo e a profilaxia e tratamento de distúrbios relacionados a estes tais como diabetes e hiper-glicemia
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
MXPA05009502A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
MXPA05009501A (es) 2003-03-07 2005-10-18 Schering Corp Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia.
EA200501607A1 (ru) * 2003-04-14 2006-06-30 ДЗЕ ИНСТИТЬЮТС ФОР ФАРМАСЬЮТИКАЛ ДИСКАВЕРИ, ЭлЭлСи Замещённые фенилалкановые кислоты
KR20060006953A (ko) 2003-04-30 2006-01-20 디 인스티튜트스 포 파마슈티컬 디스커버리, 엘엘씨 치환된 카르복실산
WO2004106542A1 (ja) * 2003-05-29 2004-12-09 Sankyo Company, Limited インスリン抵抗性改善剤及びそのスクリーニング方法
AR045697A1 (es) 2003-07-14 2005-11-09 Arena Pharm Inc Aril y heteroaril derivados fusionados como moduladores del metabolismo y la prevencion y tratamiento de trastornos relacionados con el mismo
US7223761B2 (en) 2003-10-03 2007-05-29 Amgen Inc. Salts and polymorphs of a potent antidiabetic compound
KR20060058632A (ko) * 2004-11-25 2006-05-30 주식회사 엘지생명과학 ＰＰＡＲ ｇａｍｍａ와 ＰＰＡＲ ａｌｐｈａ의 활성을항진시키는 신규 화합물, 그것의 제조방법, 및 그것을함유한 약제 조성물
KR100706600B1 (ko) * 2004-11-25 2007-04-12 주식회사 엘지생명과학 ＰＰＡＲ ｇａｍｍａ와 ＰＰＡＲ ａｌｐｈａ의 활성을항진시키는 신규 화합물, 그것의 제조방법, 및 그것을함유한 약제 조성물
BRPI0609352A2 (pt) * 2005-03-04 2011-10-18 Merck & Co Inc composto ou um sal farmaceuticamente aceitável do mesmo, composição farmacêutica, uso de um composto ou um sal farmaceuticamente aceitável do mesmo, e, métodos para tratar uma ou mais doenças, distúrbios ou condições, e para tratar diabetes melito não dependentes da insulina (tipo 2) em um paciente
US8288438B2 (en) * 2005-03-21 2012-10-16 Metabolex, Inc. Methods for avoiding edema in the treatment or prevention of PPARγ-responsive diseases, including cancer
US20070161006A1 (en) * 2006-01-10 2007-07-12 Vita Genomics, Inc. Single nucleotide polymorphisms in protein-tyrosine phosphatase receptor-type delta for the diagnosis of susceptibility to infection and asthma
KR20090066289A (ko) 2006-09-08 2009-06-23 로드아일랜드하스피틀 알코올 유발성 뇌 질환의 치료, 예방 및 역행
WO2008137105A1 (en) 2007-05-07 2008-11-13 Merck & Co., Inc. Method of treatment using fused aromatic compounds having anti-diabetic activity
US8383833B2 (en) * 2008-06-03 2013-02-26 Kaneka Corporation Method for producing optically active amino acid derivative
JP5374085B2 (ja) * 2008-07-22 2013-12-25 株式会社 資生堂 ４−アルキルレゾルシノールおよび４−アルケニルレゾルシノールの製造方法
CN101811968B (zh) * 2010-02-09 2014-07-30 深圳市有为化学技术有限公司 多官能团化苯甲酰甲酸羟基酮酯类化合物及含有该类化合物的光引发剂
SG188548A1 (en) 2010-09-22 2013-04-30 Arena Pharm Inc Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2013071077A1 (en) 2011-11-09 2013-05-16 Cornell University The use of pan-ppar agonists for prevention and treatment of huntington's disease and tauopathies
US9834520B2 (en) 2013-03-14 2017-12-05 Takeda Pharmaceutical Company Limited Heterocyclic compound
AU2016205361C1 (en) 2015-01-06 2021-04-08 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the S1P1 receptor
CA3002551A1 (en) 2015-06-22 2016-12-29 Arena Pharmaceuticals, Inc. Crystalline l-arginine salt of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclo-penta[b]indol-3-yl)acetic acid(com pound 1)for use in s1p1 receptor-associated disorders
CA3053418A1 (en) 2017-02-16 2018-08-23 Arena Pharmaceuticals, Inc. Compounds and methods for treatment of primary biliary cholangitis
CA3102136A1 (en) 2018-06-06 2019-12-12 Arena Pharmaceuticals, Inc. Methods of treating conditions related to the s1p1 receptor

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3378582A (en) 1964-03-20 1968-04-16 Merck & Co Inc (alpha-phenoxy)-and (alpha-phenylthio)-omegaphenyl-alkanoic acids
US3517050A (en) 1966-10-03 1970-06-23 Merck & Co Inc Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid
US3787423A (en) 1972-03-08 1974-01-22 Merck & Co Inc Beta-picolyloxy ester of(3-trifluoromethylphenoxy)(4-chlorophenyl)acetic acid and derivatives
US3816446A (en) 1972-04-11 1974-06-11 Merck & Co Inc (alpha-(3-trifluoromethylphenoxy)-4-chlorobenzyl)heterocycles
US3953465A (en) 1972-04-11 1976-04-27 Merck & Co., Inc. 2-[α-(3-Trifluoromethylphenoxyl)-4-chlorobenzyl]oxazole and methods for preparing the same
ZA765075B (en) 1975-09-25 1977-08-31 American Cyanamid Co Hypolipemic compounds and method of treatment
US4168385A (en) 1975-09-25 1979-09-18 American Cyanamid Company Hypolipemic phenylacetic acid derivatives
US4125732A (en) 1977-05-06 1978-11-14 American Cyanamid Company 2-Aryloxy-2-(phenoxyalkoxy)phenyl acetic acid and esters
US4820715A (en) 1984-06-28 1989-04-11 Bristol-Myers Company Anti-emetic quinuclidinyl benzamides
US4748272A (en) 1986-08-01 1988-05-31 Rorer Pharmaceutical Corp. Phenoxyphenylacetates for use as potential modulators of arichidonic acid pathways
US4920132A (en) 1987-11-03 1990-04-24 Rorer Pharmaceutical Corp. Quinoline derivatives and use thereof as antagonists of leukotriene D4
US5177095A (en) 1990-02-13 1993-01-05 Merck & Co., Inc. Triazole angiotensin II antagonists incorporating a substituted benzyl element
US5449682A (en) 1990-02-13 1995-09-12 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted benzyl element
US5183810A (en) 1990-02-13 1993-02-02 Merck & Co., Inc. Imidazole angiotensin II antagonists incorporating a substituted benzyl element
US5264439A (en) 1990-02-13 1993-11-23 Merck & Co., Inc. Quinazolinone, triazolinone and pyrimidinone angiotensin II antagonists incorporating a substituted benzyl element
US5240938A (en) 1991-02-13 1993-08-31 Merck & Co., Inc. Angiotensin II antagonists incorporating a substituted pyridoimidazolyl ring
DE4123341A1 (de) 1991-07-15 1993-01-21 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5420133A (en) 1993-03-19 1995-05-30 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
ATE189217T1 (de) 1993-03-19 2000-02-15 Merck & Co Inc Phenoxyphenylessigsäurederivate
US5334598A (en) 1993-03-19 1994-08-02 Merck & Co., Inc. Six-membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives
US5565485A (en) 1993-03-19 1996-10-15 Merck & Co., Inc. Biphenyl compounds useful or endothelin antagonists
US5374638A (en) 1993-03-19 1994-12-20 Merck & Co., Inc. Six membered ring fused imidazoles substituted with phenoxyphenylacetic acid derivatives used to treat asthma
US5401745A (en) 1993-03-19 1995-03-28 Merck & Co., Inc. Quinazolinones substituted with phenoxyphenylacetic acid derivatives
US5767310A (en) 1993-03-19 1998-06-16 Merck & Co., Inc. Phenoxyphenylacetic acid derivatives
US5391566A (en) * 1993-07-20 1995-02-21 Merck & Co., Inc. Benzimidazolinones substituted with phenoxyphenylacetic acid derivatives
US5559135A (en) 1994-09-14 1996-09-24 Merck & Co., Inc. Endothelin antagonists bearing pyridyl amides
US5538991A (en) 1994-09-14 1996-07-23 Merck & Co., Inc. Endothelin antagonists bearing 5-membered heterocyclic amides
AU3642795A (en) 1994-09-27 1996-04-19 Merck & Co., Inc. Endothelin receptor antagonists for the treatment of emesis
US5596124A (en) 1994-12-09 1997-01-21 American Cyanamid Company Method for safening herbicides in cereal crops using 5-aryloxy-1,2-(disubstituted)benzene compounds
DE19530032A1 (de) 1995-08-16 1997-02-20 Merck Patent Gmbh Endothelin-Rezeptor-Antagonisten
US5688974A (en) 1995-12-12 1997-11-18 Merck & Co., Inc. Process for the preparation of an endothelin antagonist
CA2238976A1 (en) 1995-12-12 1997-06-19 Merck & Co., Inc. Process for the preparation of an endothelin antagonist
US5708186A (en) 1995-12-12 1998-01-13 Merck & Co Inc Stereoselective process
JP2000501737A (ja) 1995-12-12 2000-02-15 メルク エンド カンパニー インコーポレーテッド 立体選択的方法
WO1997028115A1 (en) * 1996-02-02 1997-08-07 Merck & Co., Inc. Antidiabetic agents
EP0882029B1 (en) * 1996-02-02 2003-04-02 Merck & Co., Inc. Heterocyclic derivatives as antidiabetic and antiobesity agents
DE19614204A1 (de) 1996-04-10 1997-10-16 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung
AU7550398A (en) 1997-06-05 1998-12-21 Takeda Chemical Industries Ltd. Heterocyclic compounds, their production and use
CA2331120A1 (en) 1998-05-12 1999-11-18 Iwan Gunawan Phenyl oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
US6110963A (en) 1998-05-12 2000-08-29 American Home Products Corporation Aryl-oxo-acetic acids useful in the treatment of insulin resistance and hyperglycemia
CA2330623A1 (en) 1998-05-12 1999-11-18 Zenan Li 11-aryl-benzo[b]naphtho[2,3-d]furans and 11-aryl-benzo[b]naphtho[2,3-d]thiophenes useful in the treatment of insulin resistance and hyperglycemia
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US6624194B1 (en) 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
CA2400021A1 (en) * 2000-02-18 2001-08-23 Merck & Co., Inc. Aryloxyacetic acids for diabetes and lipid disorders

Similar Documents

Publication Publication Date Title
JP2004521124A5 (enExample)
JP2006522035A5 (enExample)
JP2009515872A5 (enExample)
WO2008108386A1 (ja) 医薬組成物
JP2005522480A5 (enExample)
JP2008500997A5 (enExample)
JP2011137006A5 (enExample)
RU95118736A (ru) Промежуточное соединение для получения гетероциклических соединений, обладающих антидиабетической активностью
JP2010535722A5 (enExample)
JP2004083852A5 (enExample)
JP2006526608A5 (enExample)
JP2013542213A5 (enExample)
JP2002543183A5 (enExample)
JP2007519721A5 (enExample)
JP2006509842A5 (enExample)
ATE271045T1 (de) Sauerstoffhaltige heterocyclische verbindungen
ATE526018T1 (de) Verbindungen zur behandlung von stoffwechselstörungen
JP2005536519A5 (enExample)
JP2010535706A5 (enExample)
JP2005517643A5 (enExample)
SI9210092B (en) N-phenylcarbamate compound, procedure for its preparation and biocidal composition for pest control
JP2005503435A5 (enExample)
JP2008512408A5 (enExample)
JP2005529164A5 (enExample)
JP2005526773A5 (enExample)