JP2005503435A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2005503435A5 JP2005503435A5 JP2003530673A JP2003530673A JP2005503435A5 JP 2005503435 A5 JP2005503435 A5 JP 2005503435A5 JP 2003530673 A JP2003530673 A JP 2003530673A JP 2003530673 A JP2003530673 A JP 2003530673A JP 2005503435 A5 JP2005503435 A5 JP 2005503435A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- alkoxy
- halogen
- groups
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000217 alkyl group Chemical group 0.000 claims 31
- 125000003545 alkoxy group Chemical group 0.000 claims 24
- 229910052736 halogen Inorganic materials 0.000 claims 24
- 150000002367 halogens Chemical class 0.000 claims 24
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 13
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 13
- -1 amino, imino Chemical group 0.000 claims 12
- 239000001257 hydrogen Substances 0.000 claims 10
- 125000004442 acylamino group Chemical group 0.000 claims 9
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 7
- 125000002252 acyl group Chemical group 0.000 claims 6
- 125000004423 acyloxy group Chemical group 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229910052799 carbon Inorganic materials 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 125000004663 dialkyl amino group Chemical group 0.000 claims 5
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 5
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 4
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims 3
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000000033 alkoxyamino group Chemical group 0.000 claims 3
- 125000004429 atom Chemical group 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- 125000004647 alkyl sulfenyl group Chemical group 0.000 claims 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
- 125000001589 carboacyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- KZNICNPSHKQLFF-UHFFFAOYSA-N succinimide Chemical compound O=C1CCC(=O)N1 KZNICNPSHKQLFF-UHFFFAOYSA-N 0.000 claims 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 1
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 claims 1
- 125000004750 (C1-C6) alkylaminosulfonyl group Chemical group 0.000 claims 1
- 125000004916 (C1-C6) alkylcarbonyl group Chemical group 0.000 claims 1
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 claims 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 1
- 125000006569 (C5-C6) heterocyclic group Chemical group 0.000 claims 1
- 125000001960 7 membered carbocyclic group Chemical group 0.000 claims 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims 1
- 125000003342 alkenyl group Chemical group 0.000 claims 1
- 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 1
- 125000004644 alkyl sulfinyl group Chemical group 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims 1
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 1
- 125000006254 cycloalkyl carbonyl group Chemical group 0.000 claims 1
- 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 1
- 125000004472 dialkylaminosulfonyl group Chemical group 0.000 claims 1
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims 1
- 150000004677 hydrates Chemical class 0.000 claims 1
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 claims 1
- 125000002349 hydroxyamino group Chemical group [H]ON([H])[*] 0.000 claims 1
- 229910052757 nitrogen Inorganic materials 0.000 claims 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 claims 1
- XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical compound C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 229960002317 succinimide Drugs 0.000 claims 1
- 0 C*[C@@](/C=C1)*(*(*)(C2)CC3(*)C2(*)C3(C)*)=CC=CC=C1N(CC(C*)O1)C1=O Chemical compound C*[C@@](/C=C1)*(*(*)(C2)CC3(*)C2(*)C3(C)*)=CC=CC=C1N(CC(C*)O1)C1=O 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US28395601P | 2001-04-17 | 2001-04-17 | |
| US36392802P | 2002-03-14 | 2002-03-14 | |
| PCT/US2002/011921 WO2003027083A1 (en) | 2001-04-17 | 2002-04-17 | Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005503435A JP2005503435A (ja) | 2005-02-03 |
| JP2005503435A5 true JP2005503435A5 (enExample) | 2006-01-12 |
Family
ID=30117959
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003530673A Pending JP2005503435A (ja) | 2001-04-17 | 2002-04-17 | ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US6897230B2 (enExample) |
| EP (1) | EP1385834B1 (enExample) |
| JP (1) | JP2005503435A (enExample) |
| AT (1) | ATE304536T1 (enExample) |
| AU (1) | AU2002360238B2 (enExample) |
| CA (1) | CA2443410A1 (enExample) |
| DE (1) | DE60206154T2 (enExample) |
| ES (1) | ES2248633T3 (enExample) |
| WO (1) | WO2003027083A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005503435A (ja) * | 2001-04-17 | 2005-02-03 | メルク アンド カンパニー インコーポレーテッド | ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 |
| DE60227794D1 (de) * | 2001-04-26 | 2008-09-04 | Eisai R&D Man Co Ltd | Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon |
| US6875784B2 (en) | 2002-10-09 | 2005-04-05 | Pharmacia & Upjohn Company | Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives |
| AU2003215861A1 (en) * | 2003-04-07 | 2004-11-01 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| AU2003223034A1 (en) * | 2003-05-06 | 2004-11-26 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| CA2529292A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| AU2004256085B2 (en) * | 2003-07-02 | 2007-12-06 | Kyorin, Pharmaceutical Co., Ltd. | Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof |
| CA2529294A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| CN1816545A (zh) * | 2003-07-02 | 2006-08-09 | 默克制药公司 | 环丙基取代的噁唑烷酮抗生素及其衍生物 |
| MXPA06000228A (es) * | 2003-07-02 | 2006-06-27 | Merck & Co Inc | Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos. |
| US7687627B2 (en) | 2003-09-08 | 2010-03-30 | Wockhardt Limited | Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy |
| DK1680124T3 (en) * | 2003-10-14 | 2017-08-21 | Pfizer Prod Inc | Bicyclic [3.1.0] derivatives as glycine transporter inhibitors |
| WO2007004032A1 (en) * | 2005-07-06 | 2007-01-11 | Pharmacia & Upjohn Company Llc | Oxazolidiones containing cyclobutane as antibacterial agents |
| WO2008126795A1 (ja) * | 2007-04-06 | 2008-10-23 | Nippon Soda Co., Ltd. | 有害生物防除剤組成物及び有害生物防除方法 |
| JP5696142B2 (ja) | 2009-06-26 | 2015-04-08 | パナセア バイオテック リミテッド | 新規アザビシクロヘキサン類 |
| US9133116B2 (en) | 2010-09-28 | 2015-09-15 | Panacea Biotec Ltd. | Bicyclic compounds |
| JP6162704B2 (ja) * | 2011-10-11 | 2017-07-12 | カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ | オキサゾリジノン誘導体のシラアナログ及びその合成 |
| CN107400126A (zh) * | 2016-05-19 | 2017-11-28 | 陕西合成药业股份有限公司 | 新型噁唑烷酮类化合物及其制备方法和在医学上的应用 |
| WO2018170664A1 (en) * | 2017-03-20 | 2018-09-27 | Merck Sharp & Dohme Corp. | Oxazolidinone compounds and methods of use thereof as antibacterial agents |
| CN118164975B (zh) * | 2024-05-14 | 2024-08-09 | 中国医学科学院医药生物技术研究所 | 一种季铵盐类噁唑烷酮衍生物及其可药用盐、制备方法和应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4053593A (en) * | 1975-11-26 | 1977-10-11 | Lew Frumoff | Medical product combining antimicrobial, antiporasitic and vitamin complex |
| CA2119556C (en) * | 1991-11-01 | 2004-07-06 | Michael Robert Barbachyn | Substituted aryl- and heteroaryl-phenyloxazolidinones |
| HUT74099A (en) * | 1992-12-08 | 1996-11-28 | Upjohn Co | Tropone-substituted phenyloxazolidinone antibacterial agents and pharmaceutical compositions containing the same |
| DE4425612A1 (de) * | 1994-07-20 | 1996-04-04 | Bayer Ag | 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone |
| HRP960159A2 (en) * | 1995-04-21 | 1997-08-31 | Bayer Ag | Benzocyclopentane oxazolidinones containing heteroatoms |
| MY116093A (en) * | 1996-02-26 | 2003-11-28 | Upjohn Co | Azolyl piperazinyl phenyl oxazolidinone antimicrobials |
| US6608081B2 (en) * | 1999-08-12 | 2003-08-19 | Ortho-Mcneil Pharmaceutical, Inc. | Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods |
| MXPA02012045A (es) * | 2000-06-05 | 2003-10-15 | Dong A Pharm Co Ltd | Nuevos derivados de oxazolidinona y proceso para su preparacion. |
| WO2002006278A1 (en) | 2000-07-17 | 2002-01-24 | Ranbaxy Laboratories Limited | Oxazolidinone derivatives as antimicrobials |
| JP2005503435A (ja) * | 2001-04-17 | 2005-02-03 | メルク アンド カンパニー インコーポレーテッド | ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 |
| WO2003048136A1 (en) * | 2001-11-29 | 2003-06-12 | Merck & Co., Inc. | Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof |
| US7141588B2 (en) * | 2002-02-25 | 2006-11-28 | Pfizer, Inc. | N-aryl-2-oxazolidinone-5-carboxamides and their derivatives |
| TW200500360A (en) * | 2003-03-01 | 2005-01-01 | Astrazeneca Ab | Hydroxymethyl compounds |
| MXPA06000228A (es) * | 2003-07-02 | 2006-06-27 | Merck & Co Inc | Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos. |
| CA2529294A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
| AU2004256085B2 (en) * | 2003-07-02 | 2007-12-06 | Kyorin, Pharmaceutical Co., Ltd. | Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof |
| CA2529292A1 (en) * | 2003-07-02 | 2005-01-20 | Merck & Co., Inc. | Oxazolidinone antibiotics and derivatives thereof |
-
2002
- 2002-04-17 JP JP2003530673A patent/JP2005503435A/ja active Pending
- 2002-04-17 US US10/123,285 patent/US6897230B2/en not_active Expired - Fee Related
- 2002-04-17 CA CA002443410A patent/CA2443410A1/en not_active Abandoned
- 2002-04-17 AU AU2002360238A patent/AU2002360238B2/en not_active Ceased
- 2002-04-17 DE DE60206154T patent/DE60206154T2/de not_active Expired - Fee Related
- 2002-04-17 ES ES02795477T patent/ES2248633T3/es not_active Expired - Lifetime
- 2002-04-17 AT AT02795477T patent/ATE304536T1/de not_active IP Right Cessation
- 2002-04-17 WO PCT/US2002/011921 patent/WO2003027083A1/en not_active Ceased
- 2002-04-17 EP EP02795477A patent/EP1385834B1/en not_active Expired - Lifetime
-
2004
- 2004-05-12 US US10/843,643 patent/US20050203144A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2005503435A5 (enExample) | ||
| RU2481346C2 (ru) | Ингибиторы фосфатидилинозитол-3-киназы | |
| JP2002524570A5 (ja) | Ｍｄｍ２およびｐ５３間相互作用の阻害剤としてのピペラジン−４−フェニル誘導体 | |
| AR044990A1 (es) | Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos | |
| CA2457054A1 (en) | Activator of peroxisome proliferator-activated receptor .delta. | |
| JP2001526269A5 (enExample) | ||
| RU2006112593A (ru) | Производные 2, 4-ди(гетеро)ариламинопиримидина в качестве ингибиторов zap-70 и/или syk | |
| ATE354562T1 (de) | Cyclohexylsulfon-derivate als gamma-secretase- inhibitoren | |
| JP2006517220A5 (enExample) | ||
| JP2001526218A5 (enExample) | ||
| JP2013544276A5 (enExample) | ||
| CA2487542A1 (en) | Indole, azaindole and related heterocyclic 4-alkenyl piperidine amides | |
| JP2008510828A5 (enExample) | ||
| JP2006507326A5 (enExample) | ||
| JP2010510233A5 (enExample) | ||
| RU2004119963A (ru) | Ингибиторы вич интегразы | |
| RU2006120078A (ru) | Производные фосфиновой кислоты, ингибиторы бета-секретазы, предназначенные для лечения болезни альцгеймера | |
| JP2008534453A5 (enExample) | ||
| CA2539349A1 (en) | 7-amino alkylidenyl-heterocyclic quinolones and naphthyridones | |
| JP2005517643A5 (enExample) | ||
| JP2010536821A5 (enExample) | ||
| KR920006322A (ko) | 벤젠, 피리딘 및 피리미딘 유도체 | |
| JP2008514650A5 (enExample) | ||
| JP2005526773A5 (enExample) | ||
| RU2014126367A (ru) | Производные n-(4-хинолинметил)сульфонамидов и их применение в качестве антигельминтных средств |