CA2443410A1 - Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof - Google Patents

Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof Download PDF

Info

Publication number
CA2443410A1
CA2443410A1 CA002443410A CA2443410A CA2443410A1 CA 2443410 A1 CA2443410 A1 CA 2443410A1 CA 002443410 A CA002443410 A CA 002443410A CA 2443410 A CA2443410 A CA 2443410A CA 2443410 A1 CA2443410 A1 CA 2443410A1
Authority
CA
Canada
Prior art keywords
alpha
oxooxazolidin
acetamide
hexan
azabicyclo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002443410A
Other languages
English (en)
French (fr)
Inventor
Yasumichi Fukuda
Milton L. Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Merck and Co Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2443410A1 publication Critical patent/CA2443410A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002443410A 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof Abandoned CA2443410A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US28395601P 2001-04-17 2001-04-17
US60/283,956 2001-04-17
US36392802P 2002-03-14 2002-03-14
US60/363,928 2002-03-14
PCT/US2002/011921 WO2003027083A1 (en) 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof

Publications (1)

Publication Number Publication Date
CA2443410A1 true CA2443410A1 (en) 2003-04-03

Family

ID=30117959

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002443410A Abandoned CA2443410A1 (en) 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof

Country Status (9)

Country Link
US (2) US6897230B2 (enExample)
EP (1) EP1385834B1 (enExample)
JP (1) JP2005503435A (enExample)
AT (1) ATE304536T1 (enExample)
AU (1) AU2002360238B2 (enExample)
CA (1) CA2443410A1 (enExample)
DE (1) DE60206154T2 (enExample)
ES (1) ES2248633T3 (enExample)
WO (1) WO2003027083A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005503435A (ja) * 2001-04-17 2005-02-03 メルク アンド カンパニー インコーポレーテッド ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体
DE60227794D1 (de) * 2001-04-26 2008-09-04 Eisai R&D Man Co Ltd Stickstoffhaltige verbindung mit kondensiertem ring und pyrazolylgruppe als substituent und medizinische zusammensetzung davon
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
AU2003223034A1 (en) * 2003-05-06 2004-11-26 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
CA2529292A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
CN1816545A (zh) * 2003-07-02 2006-08-09 默克制药公司 环丙基取代的噁唑烷酮抗生素及其衍生物
MXPA06000228A (es) * 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
US7687627B2 (en) 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
DK1680124T3 (en) * 2003-10-14 2017-08-21 Pfizer Prod Inc Bicyclic [3.1.0] derivatives as glycine transporter inhibitors
WO2007004032A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidiones containing cyclobutane as antibacterial agents
WO2008126795A1 (ja) * 2007-04-06 2008-10-23 Nippon Soda Co., Ltd. 有害生物防除剤組成物及び有害生物防除方法
JP5696142B2 (ja) 2009-06-26 2015-04-08 パナセア バイオテック リミテッド 新規アザビシクロヘキサン類
US9133116B2 (en) 2010-09-28 2015-09-15 Panacea Biotec Ltd. Bicyclic compounds
JP6162704B2 (ja) * 2011-10-11 2017-07-12 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ オキサゾリジノン誘導体のシラアナログ及びその合成
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
WO2018170664A1 (en) * 2017-03-20 2018-09-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
CN118164975B (zh) * 2024-05-14 2024-08-09 中国医学科学院医药生物技术研究所 一种季铵盐类噁唑烷酮衍生物及其可药用盐、制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053593A (en) * 1975-11-26 1977-10-11 Lew Frumoff Medical product combining antimicrobial, antiporasitic and vitamin complex
CA2119556C (en) * 1991-11-01 2004-07-06 Michael Robert Barbachyn Substituted aryl- and heteroaryl-phenyloxazolidinones
HUT74099A (en) * 1992-12-08 1996-11-28 Upjohn Co Tropone-substituted phenyloxazolidinone antibacterial agents and pharmaceutical compositions containing the same
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
MXPA02012045A (es) * 2000-06-05 2003-10-15 Dong A Pharm Co Ltd Nuevos derivados de oxazolidinona y proceso para su preparacion.
WO2002006278A1 (en) 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
JP2005503435A (ja) * 2001-04-17 2005-02-03 メルク アンド カンパニー インコーポレーテッド ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体
WO2003048136A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
MXPA06000228A (es) * 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
CA2529294A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
CA2529292A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof

Also Published As

Publication number Publication date
WO2003027083A1 (en) 2003-04-03
ES2248633T3 (es) 2006-03-16
US20030125367A1 (en) 2003-07-03
DE60206154D1 (de) 2005-10-20
ATE304536T1 (de) 2005-09-15
AU2002360238B2 (en) 2007-11-15
JP2005503435A (ja) 2005-02-03
US20050203144A1 (en) 2005-09-15
US6897230B2 (en) 2005-05-24
EP1385834A1 (en) 2004-02-04
EP1385834B1 (en) 2005-09-14
DE60206154T2 (de) 2006-06-29

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued