JP2005503435A - ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 - Google Patents

ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 Download PDF

Info

Publication number
JP2005503435A
JP2005503435A JP2003530673A JP2003530673A JP2005503435A JP 2005503435 A JP2005503435 A JP 2005503435A JP 2003530673 A JP2003530673 A JP 2003530673A JP 2003530673 A JP2003530673 A JP 2003530673A JP 2005503435 A JP2005503435 A JP 2005503435A
Authority
JP
Japan
Prior art keywords
ylmethyl
acetamide
azabicyclo
hexane
oxooxazolidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2003530673A
Other languages
English (en)
Japanese (ja)
Other versions
JP2005503435A5 (enExample
Inventor
保路 福田
ミルトン エル． ハモンド，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyorin Pharmaceutical Co Ltd
Original Assignee
Kyorin Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyorin Pharmaceutical Co Ltd filed Critical Kyorin Pharmaceutical Co Ltd
Publication of JP2005503435A publication Critical patent/JP2005503435A/ja
Publication of JP2005503435A5 publication Critical patent/JP2005503435A5/ja
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2003530673A 2001-04-17 2002-04-17 ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体 Pending JP2005503435A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28395601P 2001-04-17 2001-04-17
US36392802P 2002-03-14 2002-03-14
PCT/US2002/011921 WO2003027083A1 (en) 2001-04-17 2002-04-17 Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof

Publications (2)

Publication Number Publication Date
JP2005503435A true JP2005503435A (ja) 2005-02-03
JP2005503435A5 JP2005503435A5 (enExample) 2006-01-12

Family

ID=30117959

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2003530673A Pending JP2005503435A (ja) 2001-04-17 2002-04-17 ビシクロ［３．１．０］ヘキサン含有オキサゾリジノン抗生物質及びその誘導体

Country Status (9)

Country Link
US (2) US6897230B2 (enExample)
EP (1) EP1385834B1 (enExample)
JP (1) JP2005503435A (enExample)
AT (1) ATE304536T1 (enExample)
AU (1) AU2002360238B2 (enExample)
CA (1) CA2443410A1 (enExample)
DE (1) DE60206154T2 (enExample)
ES (1) ES2248633T3 (enExample)
WO (1) WO2003027083A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521281A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体
WO2008126795A1 (ja) * 2007-04-06 2008-10-23 Nippon Soda Co., Ltd. 有害生物防除剤組成物及び有害生物防除方法
JP2014530232A (ja) * 2011-10-11 2014-11-17 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ オキサゾリジノン誘導体のシラアナログ及びその合成

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
EP2048142A3 (en) * 2001-04-26 2009-04-22 Eisai R&D Management Co., Ltd. Nitrogen-containing condensed cyclic compound having a pyrazolyl group as a substituent group and pharmaceutical composition thereof
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
AU2003215861A1 (en) * 2003-04-07 2004-11-01 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
AU2003223034A1 (en) * 2003-05-06 2004-11-26 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
UA88448C2 (ru) * 2003-07-02 2009-10-26 Мерк Энд Ко., Инк. Оксазолидиноновые антибиотики с замещенной циклопропильной группой и их производные
CA2529292A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
US20070293493A1 (en) * 2003-07-02 2007-12-20 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
US7687627B2 (en) 2003-09-08 2010-03-30 Wockhardt Limited Substituted piperidino phenyloxazolidinones having antimicrobial activity with improved in vivo efficacy
EA009903B1 (ru) * 2003-10-14 2008-04-28 Пфайзер Продактс Инк. Бициклические [3.1.0] производные в качестве ингибиторов переносчиков глицина
WO2007004032A1 (en) * 2005-07-06 2007-01-11 Pharmacia & Upjohn Company Llc Oxazolidiones containing cyclobutane as antibacterial agents
RU2012102094A (ru) 2009-06-26 2013-08-10 Панацеа Биотек Лтд. Новые азабициклогексаны
BR112013007566A2 (pt) 2010-09-28 2016-08-02 Panacea Biotec Ltd novos compostos bicíclicos
CN107400126A (zh) * 2016-05-19 2017-11-28 陕西合成药业股份有限公司 新型噁唑烷酮类化合物及其制备方法和在医学上的应用
WO2018170664A1 (en) * 2017-03-20 2018-09-27 Merck Sharp & Dohme Corp. Oxazolidinone compounds and methods of use thereof as antibacterial agents
CN118164975B (zh) * 2024-05-14 2024-08-09 中国医学科学院医药生物技术研究所 一种季铵盐类噁唑烷酮衍生物及其可药用盐、制备方法和应用

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4053593A (en) * 1975-11-26 1977-10-11 Lew Frumoff Medical product combining antimicrobial, antiporasitic and vitamin complex
EP0610265B1 (en) * 1991-11-01 1996-12-27 PHARMACIA & UPJOHN COMPANY Substituted aryl- and heteroarylphenyloxazolidinones useful as antibacterial agents
DE69316240T2 (de) * 1992-12-08 1998-05-20 Upjohn Co Durch eine tropon gruppe substituierte phenyloxazolidinone-derivate als antibakterielles mittel
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
MY116093A (en) * 1996-02-26 2003-11-28 Upjohn Co Azolyl piperazinyl phenyl oxazolidinone antimicrobials
US6608081B2 (en) * 1999-08-12 2003-08-19 Ortho-Mcneil Pharmaceutical, Inc. Bicyclic heterocyclic substituted phenyl oxazolidinone antibacterials, and related compositions and methods
NZ522990A (en) * 2000-06-05 2003-08-29 Dong A Pharm Novel oxazolidinone derivatives and a process for the preparation thereof
WO2002006278A1 (en) 2000-07-17 2002-01-24 Ranbaxy Laboratories Limited Oxazolidinone derivatives as antimicrobials
ES2248633T3 (es) * 2001-04-17 2006-03-16 MERCK & CO., INC. Antibioticos oxazolidinona que contienen biciclo (3,1,o)hexano y derivados de los mismos.
WO2003048136A1 (en) * 2001-11-29 2003-06-12 Merck & Co., Inc. Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
AU2004256085B2 (en) * 2003-07-02 2007-12-06 Kyorin, Pharmaceutical Co., Ltd. Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
US20070293493A1 (en) * 2003-07-02 2007-12-20 Milton Hammond Oxazolidinone antibiotics and derivatives thereof
MXPA06000228A (es) * 2003-07-02 2006-06-27 Merck & Co Inc Antibioticos de oxazolidinona sustituidos con un grupo ciclopropilo y derivados de los mismos.
CA2529292A1 (en) * 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007521281A (ja) * 2003-07-02 2007-08-02 メルク アンド カンパニー インコーポレーテッド シクロプロピル基置換されたオキサゾリジノン抗生物質およびこれらの誘導体
WO2008126795A1 (ja) * 2007-04-06 2008-10-23 Nippon Soda Co., Ltd. 有害生物防除剤組成物及び有害生物防除方法
JP2014530232A (ja) * 2011-10-11 2014-11-17 カウンシル オブ サイエンティフィク アンド インダストリアル リサーチ オキサゾリジノン誘導体のシラアナログ及びその合成

Also Published As

Publication number Publication date
AU2002360238B2 (en) 2007-11-15
US20030125367A1 (en) 2003-07-03
EP1385834A1 (en) 2004-02-04
ES2248633T3 (es) 2006-03-16
US6897230B2 (en) 2005-05-24
EP1385834B1 (en) 2005-09-14
CA2443410A1 (en) 2003-04-03
ATE304536T1 (de) 2005-09-15
US20050203144A1 (en) 2005-09-15
DE60206154T2 (de) 2006-06-29
DE60206154D1 (de) 2005-10-20
WO2003027083A1 (en) 2003-04-03

Similar Documents

Publication Publication Date Title
EP1385834B1 (en) Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
US7582659B2 (en) Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereof
AU2002360238A1 (en) Bicyclo[3,1,0]hexane containing oxazolidinone antibiotic and derivatives thereof
AU2004256085B2 (en) Cyclopropyl Group Substituted Oxazolydinone Antibiotics and Derivatives Thereof
AU767380B2 (en) Bicyclic oxazolidinones as antibacterial agent
US6686363B2 (en) Cyclopropyl containing oxazolidinone antibiotics and derivatives thereof
JP2005511688A6 (ja) シクロプロピル含有オキサゾリジノン抗生物質及びその誘導体
JP2006522791A (ja) 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体
US20060247286A1 (en) Oxazolidinone antibiotics and derivatives thereof
US20070293493A1 (en) Oxazolidinone antibiotics and derivatives thereof
AU2002362028B2 (en) Cyclopropyl hexane containing oxazolidinone antibiotics and derivatives thereof

Legal Events

Date Code Title Description
A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20050401

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20081118

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20090414