JP2020504184A5 - - Google Patents
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- Publication number
- JP2020504184A5 JP2020504184A5 JP2019557668A JP2019557668A JP2020504184A5 JP 2020504184 A5 JP2020504184 A5 JP 2020504184A5 JP 2019557668 A JP2019557668 A JP 2019557668A JP 2019557668 A JP2019557668 A JP 2019557668A JP 2020504184 A5 JP2020504184 A5 JP 2020504184A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- pharmaceutically acceptable
- isomer
- acceptable salt
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 22
- 150000003839 salts Chemical class 0.000 claims 22
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940127557 pharmaceutical product Drugs 0.000 claims 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
- 241000700584 Simplexvirus Species 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 claims 1
- 125000006705 (C5-C7) cycloalkyl group Chemical group 0.000 claims 1
- 241000253387 Rhodobiaceae Species 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000003551 oxepanyl group Chemical group 0.000 claims 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 1
- 125000005936 piperidyl group Chemical group 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 125000001412 tetrahydropyranyl group Chemical group 0.000 claims 1
- 125000000335 thiazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710014893 | 2017-01-09 | ||
| CN201710014893.9 | 2017-01-09 | ||
| PCT/CN2018/071964 WO2018127207A1 (zh) | 2017-01-09 | 2018-01-09 | 噻唑衍生物及其应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020504184A JP2020504184A (ja) | 2020-02-06 |
| JP2020504184A5 true JP2020504184A5 (enExample) | 2021-02-04 |
| JP7150343B2 JP7150343B2 (ja) | 2022-10-11 |
Family
ID=62789152
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019557668A Active JP7150343B2 (ja) | 2017-01-09 | 2018-01-09 | チアゾール誘導体およびその使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US10647710B2 (enExample) |
| EP (1) | EP3566749A4 (enExample) |
| JP (1) | JP7150343B2 (enExample) |
| CN (1) | CN110225781B (enExample) |
| WO (1) | WO2018127207A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3692039T3 (pl) | 2017-10-05 | 2023-04-17 | Innovative Molecules Gmbh | Enancjomery podstawionych tiazoli jako związki przeciwwirusowe |
| EP3819297B1 (en) * | 2018-07-06 | 2024-04-03 | Phaeno Therapeutics Co., Ltd. | Crystal forms of thiazole compound and application thereof |
| TW202038947A (zh) | 2018-11-28 | 2020-11-01 | 德商創新分子有限責任公司 | 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑 |
| JP2025517423A (ja) | 2022-05-20 | 2025-06-05 | ギリアード サイエンシーズ， インコーポレイテッド | 抗ウイルスインドリニル化合物及びその使用 |
| WO2025082442A1 (zh) * | 2023-10-17 | 2025-04-24 | 辉诺生物医药科技（杭州）有限公司 | (r)-5-卤素-2,3-二氢-1h-茚-2-羧酸的合成方法 |
| WO2026015762A1 (en) | 2024-07-12 | 2026-01-15 | Gilead Sciences, Inc. | (r)-5-fluoro-2-methyl-1-((r)-5-(pyridin-2-yl)-2,3-dihydro-1 h-indene-2-carbonyl)indoline-6-sulfonamide for treatment of viral infections unresponsive to treatment with a first antiviral therapy |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DOP2000000109A (es) * | 1999-12-23 | 2002-08-30 | Gerald Kleymann | Derivados de tiazolilamida |
| ES2338539T3 (es) * | 2001-11-01 | 2010-05-10 | Icagen, Inc. | Pirazolamidas para uso en el tratamiento del dolor. |
| DE10210319A1 (de) * | 2002-03-08 | 2003-09-18 | Bayer Ag | Thiazolylcarbonyl-Derivate |
| DE10226048A1 (de) * | 2002-06-12 | 2003-12-24 | Bayer Ag | Thiazolylsulfonamide |
| BRPI0607927A2 (pt) | 2005-02-11 | 2009-10-20 | Hoffmann La Roche | derivados de pirazol-pirimidina |
| DE102005014248A1 (de) * | 2005-03-30 | 2006-10-05 | Aicuris Gmbh & Co. Kg | Pharmazeutische Zubereitung von N-[5-(Aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)phenyl]acetamid |
| ES2843277T3 (es) | 2014-06-26 | 2021-07-16 | Heidelberg Immunotherapeutics Gmbh | Aplicación tópica para un anticuerpo anti-VHS |
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2018
- 2018-01-09 WO PCT/CN2018/071964 patent/WO2018127207A1/zh not_active Ceased
- 2018-01-09 EP EP18735824.7A patent/EP3566749A4/en active Pending
- 2018-01-09 CN CN201880005802.8A patent/CN110225781B/zh active Active
- 2018-01-09 JP JP2019557668A patent/JP7150343B2/ja active Active
- 2018-01-09 US US16/476,797 patent/US10647710B2/en active Active