CN110225781B - 噻唑衍生物及其应用 - Google Patents

噻唑衍生物及其应用 Download PDF

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Publication number
CN110225781B
CN110225781B CN201880005802.8A CN201880005802A CN110225781B CN 110225781 B CN110225781 B CN 110225781B CN 201880005802 A CN201880005802 A CN 201880005802A CN 110225781 B CN110225781 B CN 110225781B
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China
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compound
pharmaceutically acceptable
acceptable salt
stereoisomer
synthesis
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CN201880005802.8A
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English (en)
Chinese (zh)
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CN110225781A (zh
Inventor
贺海鹰
江志赶
石卫华
夏建华
黎健
陈曙辉
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Huinuo Biomedical Technology Hangzhou Co ltd
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Huinuo Biomedical Technology Hangzhou Co ltd
Medshine Discovery Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201880005802.8A 2017-01-09 2018-01-09 噻唑衍生物及其应用 Active CN110225781B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710014893 2017-01-09
CN2017100148939 2017-01-09
PCT/CN2018/071964 WO2018127207A1 (zh) 2017-01-09 2018-01-09 噻唑衍生物及其应用

Publications (2)

Publication Number Publication Date
CN110225781A CN110225781A (zh) 2019-09-10
CN110225781B true CN110225781B (zh) 2022-05-17

Family

ID=62789152

Family Applications (1)

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CN201880005802.8A Active CN110225781B (zh) 2017-01-09 2018-01-09 噻唑衍生物及其应用

Country Status (5)

Country Link
US (1) US10647710B2 (enExample)
EP (1) EP3566749A4 (enExample)
JP (1) JP7150343B2 (enExample)
CN (1) CN110225781B (enExample)
WO (1) WO2018127207A1 (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3692039T3 (pl) 2017-10-05 2023-04-17 Innovative Molecules Gmbh Enancjomery podstawionych tiazoli jako związki przeciwwirusowe
WO2020007355A1 (zh) * 2018-07-06 2020-01-09 南京明德新药研发有限公司 噻唑类化合物的晶型及其应用
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑
WO2023225162A1 (en) 2022-05-20 2023-11-23 Gilead Sciences, Inc. Antiviral indolinyl compounds and uses thereof
WO2025082442A1 (zh) * 2023-10-17 2025-04-24 辉诺生物医药科技（杭州）有限公司 (r)-5-卤素-2,3-二氢-1h-茚-2-羧酸的合成方法
WO2026015762A1 (en) 2024-07-12 2026-01-15 Gilead Sciences, Inc. (r)-5-fluoro-2-methyl-1-((r)-5-(pyridin-2-yl)-2,3-dihydro-1 h-indene-2-carbonyl)indoline-6-sulfonamide for treatment of viral infections unresponsive to treatment with a first antiviral therapy
WO2026035900A1 (en) 2024-08-07 2026-02-12 Assembly Biosciences, Inc. Tricyclic compounds for treatment of hsv
WO2026035899A1 (en) 2024-08-07 2026-02-12 Assembly Biosciences, Inc. Azetidine compounds for treatment of hsv

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434812A (zh) * 1999-12-23 2003-08-06 拜尔公司 噻唑基酰胺衍生物
DE10210319A1 (de) * 2002-03-08 2003-09-18 Bayer Ag Thiazolylcarbonyl-Derivate
DE10226048A1 (de) * 2002-06-12 2003-12-24 Bayer Ag Thiazolylsulfonamide
CN101115755A (zh) * 2005-02-11 2008-01-30 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的吡唑并-嘧啶衍生物
CN101151019A (zh) * 2005-03-30 2008-03-26 艾库里斯有限及两合公司 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺的药物制剂
WO2015197763A1 (en) * 2014-06-26 2015-12-30 Deutsches Krebsforschungszentrum Topical application for an anti-hsv antibody

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2002363250A1 (en) * 2001-11-01 2003-05-12 Icagen, Inc. Pyrazole-amides and-sulfonamides

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434812A (zh) * 1999-12-23 2003-08-06 拜尔公司 噻唑基酰胺衍生物
DE10210319A1 (de) * 2002-03-08 2003-09-18 Bayer Ag Thiazolylcarbonyl-Derivate
DE10226048A1 (de) * 2002-06-12 2003-12-24 Bayer Ag Thiazolylsulfonamide
CN101115755A (zh) * 2005-02-11 2008-01-30 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的吡唑并-嘧啶衍生物
CN101151019A (zh) * 2005-03-30 2008-03-26 艾库里斯有限及两合公司 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺的药物制剂
WO2015197763A1 (en) * 2014-06-26 2015-12-30 Deutsches Krebsforschungszentrum Topical application for an anti-hsv antibody

Also Published As

Publication number Publication date
CN110225781A (zh) 2019-09-10
US20190375744A1 (en) 2019-12-12
EP3566749A1 (en) 2019-11-13
US10647710B2 (en) 2020-05-12
JP2020504184A (ja) 2020-02-06
JP7150343B2 (ja) 2022-10-11
WO2018127207A1 (zh) 2018-07-12
EP3566749A4 (en) 2020-09-23

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Effective date of registration: 20211104

Address after: 310018 room 1-404, Heda Medicine Valley Center, No. 291, Fucheng Road, Xiasha street, Hangzhou Economic and Technological Development Zone, Hangzhou, Zhejiang Province

Applicant after: Huinuo biomedical technology (Hangzhou) Co.,Ltd.

Address before: Room 218, No. 9 Commercial Office Building, Gaoxin Road, Nanjing High-tech Development Zone, Jiangsu Province

Applicant before: Nanjing Mingde New Drug Development Co.,Ltd.

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