CN110225781A - 噻唑衍生物及其应用 - Google Patents

噻唑衍生物及其应用 Download PDF

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Publication number
CN110225781A
CN110225781A CN201880005802.8A CN201880005802A CN110225781A CN 110225781 A CN110225781 A CN 110225781A CN 201880005802 A CN201880005802 A CN 201880005802A CN 110225781 A CN110225781 A CN 110225781A
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China
Prior art keywords
compound
synthesis
400mhz
nmr
pharmaceutically acceptable
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CN201880005802.8A
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English (en)
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CN110225781B (zh
Inventor
贺海鹰
江志赶
石卫华
夏建华
黎健
陈曙辉
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Huinuo Biomedical Technology Hangzhou Co ltd
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Medshine Discovery Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

本发明公开了新的噻唑类化合物，尤其是式(I)所示化合物，其药物组合物及其在制备治疗与单纯疱疹病毒相关疾病的药物中的应用。

Description

PCT国内申请，说明书已公开。

Claims (23)

  1. PCT国内申请，权利要求书已公开。
CN201880005802.8A 2017-01-09 2018-01-09 噻唑衍生物及其应用 Active CN110225781B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710014893 2017-01-09
CN2017100148939 2017-01-09
PCT/CN2018/071964 WO2018127207A1 (zh) 2017-01-09 2018-01-09 噻唑衍生物及其应用

Publications (2)

Publication Number Publication Date
CN110225781A true CN110225781A (zh) 2019-09-10
CN110225781B CN110225781B (zh) 2022-05-17

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CN201880005802.8A Active CN110225781B (zh) 2017-01-09 2018-01-09 噻唑衍生物及其应用

Country Status (5)

Country Link
US (1) US10647710B2 (zh)
EP (1) EP3566749A4 (zh)
JP (1) JP7150343B2 (zh)
CN (1) CN110225781B (zh)
WO (1) WO2018127207A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3692039T1 (sl) 2017-10-05 2023-04-28 Innovative Molecules Gmbh Enantomeri substituiranih tiazolov kot protivirusne spojine
CN112384512B (zh) * 2018-07-06 2022-03-29 辉诺生物医药科技（杭州）有限公司 噻唑类化合物的晶型及其应用
TW202038947A (zh) 2018-11-28 2020-11-01 德商創新分子有限責任公司 在與溶瘤病毒之組合療法中治療癌症的解旋酶引子酶抑制劑

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434812A (zh) * 1999-12-23 2003-08-06 拜尔公司 噻唑基酰胺衍生物
DE10210319A1 (de) * 2002-03-08 2003-09-18 Bayer Ag Thiazolylcarbonyl-Derivate
DE10226048A1 (de) * 2002-06-12 2003-12-24 Bayer Ag Thiazolylsulfonamide
CN101115755A (zh) * 2005-02-11 2008-01-30 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的吡唑并-嘧啶衍生物
CN101151019A (zh) * 2005-03-30 2008-03-26 艾库里斯有限及两合公司 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺的药物制剂
WO2015197763A1 (en) * 2014-06-26 2015-12-30 Deutsches Krebsforschungszentrum Topical application for an anti-hsv antibody

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE455104T1 (de) * 2001-11-01 2010-01-15 Icagen Inc Pyrazolamide zur anwendung in der behandlung von schmerz

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1434812A (zh) * 1999-12-23 2003-08-06 拜尔公司 噻唑基酰胺衍生物
DE10210319A1 (de) * 2002-03-08 2003-09-18 Bayer Ag Thiazolylcarbonyl-Derivate
DE10226048A1 (de) * 2002-06-12 2003-12-24 Bayer Ag Thiazolylsulfonamide
CN101115755A (zh) * 2005-02-11 2008-01-30 弗·哈夫曼-拉罗切有限公司 作为mglur2拮抗剂的吡唑并-嘧啶衍生物
CN101151019A (zh) * 2005-03-30 2008-03-26 艾库里斯有限及两合公司 N-[5-(氨基磺酰基)-4-甲基-1,3-噻唑-2-基]-n-甲基-2-[4-(2-吡啶基)苯基]乙酰胺的药物制剂
WO2015197763A1 (en) * 2014-06-26 2015-12-30 Deutsches Krebsforschungszentrum Topical application for an anti-hsv antibody

Also Published As

Publication number Publication date
CN110225781B (zh) 2022-05-17
JP2020504184A (ja) 2020-02-06
WO2018127207A1 (zh) 2018-07-12
JP7150343B2 (ja) 2022-10-11
EP3566749A1 (en) 2019-11-13
US20190375744A1 (en) 2019-12-12
EP3566749A4 (en) 2020-09-23
US10647710B2 (en) 2020-05-12

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