JP2017507122A5 - - Google Patents
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- JP2017507122A5 JP2017507122A5 JP2016549224A JP2016549224A JP2017507122A5 JP 2017507122 A5 JP2017507122 A5 JP 2017507122A5 JP 2016549224 A JP2016549224 A JP 2016549224A JP 2016549224 A JP2016549224 A JP 2016549224A JP 2017507122 A5 JP2017507122 A5 JP 2017507122A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aryl
- och
- heteroaryl
- membered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- WZFJLBOJKYGFEF-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(Cl)c1Cl)N(C1)Cc2c1ccc(N1CCNCC1)c2 Chemical compound CC(C)(CCc(cc1)cc(Cl)c1Cl)N(C1)Cc2c1ccc(N1CCNCC1)c2 WZFJLBOJKYGFEF-UHFFFAOYSA-N 0.000 description 1
- PTUWOVNKEBSQFQ-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(Cl)c1Cl)N(C1)Cc2c1cccc2N1CCNCC1 Chemical compound CC(C)(CCc(cc1)cc(Cl)c1Cl)N(C1)Cc2c1cccc2N1CCNCC1 PTUWOVNKEBSQFQ-UHFFFAOYSA-N 0.000 description 1
- AHZUPQMCJMEEEG-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(Cl)c1O)N(C1)Cc2c1cccc2F Chemical compound CC(C)(CCc(cc1)cc(Cl)c1O)N(C1)Cc2c1cccc2F AHZUPQMCJMEEEG-UHFFFAOYSA-N 0.000 description 1
- PIZPESOCQKGFKQ-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(Cl)c1OC)N(C1)Cc2c1cccc2C(N1CCNCC1)=O Chemical compound CC(C)(CCc(cc1)cc(Cl)c1OC)N(C1)Cc2c1cccc2C(N1CCNCC1)=O PIZPESOCQKGFKQ-UHFFFAOYSA-N 0.000 description 1
- JCAGXBJIOMJUGF-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(OC)c1Cl)N(C1)Cc2c1cccc2F Chemical compound CC(C)(CCc(cc1)cc(OC)c1Cl)N(C1)Cc2c1cccc2F JCAGXBJIOMJUGF-UHFFFAOYSA-N 0.000 description 1
- XZCZFWPQKLICKI-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(OC)c1O)N(C1)Cc2c1ccc(N1CCNCC1)c2 Chemical compound CC(C)(CCc(cc1)cc(OC)c1O)N(C1)Cc2c1ccc(N1CCNCC1)c2 XZCZFWPQKLICKI-UHFFFAOYSA-N 0.000 description 1
- CNLFWHNQKVQNGY-UHFFFAOYSA-N CC(C)(CCc(cc1)cc(OC)c1O)N(C1)Cc2c1cccc2N1CCNCC1 Chemical compound CC(C)(CCc(cc1)cc(OC)c1O)N(C1)Cc2c1cccc2N1CCNCC1 CNLFWHNQKVQNGY-UHFFFAOYSA-N 0.000 description 1
- NKBOGJLFBUBVAW-UHFFFAOYSA-N CC(C)(CCc(cc1)cc2c1[nH]nc2)N(C1)Cc2c1cccc2C(N1CCNCC1)=O Chemical compound CC(C)(CCc(cc1)cc2c1[nH]nc2)N(C1)Cc2c1cccc2C(N1CCNCC1)=O NKBOGJLFBUBVAW-UHFFFAOYSA-N 0.000 description 1
- 0 CC(C)(CCc1cc(*)c(C)cc1)N1Cc2c(*)c(*)c(*)c(*)c2C1 Chemical compound CC(C)(CCc1cc(*)c(C)cc1)N1Cc2c(*)c(*)c(*)c(*)c2C1 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461934528P | 2014-01-31 | 2014-01-31 | |
| US61/934,528 | 2014-01-31 | ||
| PCT/US2015/013754 WO2015116923A1 (en) | 2014-01-31 | 2015-01-30 | Isoindoline compositions and methods for treating neurodegenerative disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017507122A JP2017507122A (ja) | 2017-03-16 |
| JP2017507122A5 true JP2017507122A5 (enExample) | 2018-03-08 |
| JP6517827B2 JP6517827B2 (ja) | 2019-05-22 |
Family
ID=53757753
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016549224A Active JP6517827B2 (ja) | 2014-01-31 | 2015-01-30 | イソインドリン組成物および神経変性疾患の治療方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9796672B2 (enExample) |
| EP (3) | EP3498692B1 (enExample) |
| JP (1) | JP6517827B2 (enExample) |
| KR (1) | KR102331422B1 (enExample) |
| CN (1) | CN106163516B (enExample) |
| AU (1) | AU2015210852B2 (enExample) |
| BR (1) | BR112016017808B1 (enExample) |
| CA (1) | CA2938212C (enExample) |
| DK (2) | DK3498692T3 (enExample) |
| ES (2) | ES2721001T3 (enExample) |
| IL (1) | IL247003B (enExample) |
| MX (1) | MX368755B (enExample) |
| NZ (1) | NZ722599A (enExample) |
| RU (1) | RU2692258C2 (enExample) |
| WO (1) | WO2015116923A1 (enExample) |
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| EP2794565B1 (en) | 2011-12-21 | 2017-07-26 | Novira Therapeutics Inc. | Hepatitis b antiviral agents |
| CA2881057C (en) | 2012-08-28 | 2020-10-27 | Janssen Sciences Ireland Uc | Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b |
| JP6466348B2 (ja) | 2013-02-28 | 2019-02-06 | ヤンセン・サイエンシズ・アイルランド・アンリミテッド・カンパニー | スルファモイル−アリールアミドおよびｂ型肝炎を処置するための医薬品としてのその使用 |
| HUE033542T2 (en) | 2013-04-03 | 2017-12-28 | Janssen Sciences Ireland Uc | Their use as medicaments for the treatment of N-phenylcarboxamide derivatives and hepatitis B |
| TW202126620A (zh) | 2013-05-17 | 2021-07-16 | 愛爾蘭商健生科學愛爾蘭無限公司 | 胺磺醯基吡咯醯胺衍生物及其作為用於治療ｂ型肝炎藥物的用途 |
| WO2015011281A1 (en) | 2013-07-25 | 2015-01-29 | Janssen R&D Ireland | Glyoxamide substituted pyrrolamide derivatives and the use thereof as medicaments for the treatment of hepatitis b |
| MX368158B (es) | 2013-10-23 | 2019-09-20 | Janssen Sciences Ireland Uc | Derivados de carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b. |
| US9169212B2 (en) | 2014-01-16 | 2015-10-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| US10392349B2 (en) | 2014-01-16 | 2019-08-27 | Novira Therapeutics, Inc. | Azepane derivatives and methods of treating hepatitis B infections |
| WO2015116923A1 (en) * | 2014-01-31 | 2015-08-06 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| JP6553059B2 (ja) | 2014-02-05 | 2019-07-31 | ノヴィラ・セラピューティクス・インコーポレイテッド | Ｈｂｖ感染の治療のための併用療法 |
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| EP3271019A1 (en) | 2015-03-19 | 2018-01-24 | Novira Therapeutics Inc. | Azocane and azonane derivatives and methods of treating hepatitis b infections |
| US10875876B2 (en) | 2015-07-02 | 2020-12-29 | Janssen Sciences Ireland Uc | Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B |
| AR106192A1 (es) | 2015-09-29 | 2017-12-20 | Novira Therapeutics Inc | Formas cristalinas de un agente antiviral contra la hepatitis b |
| US11046670B2 (en) | 2015-10-19 | 2021-06-29 | Board Of Regents, The University Of Texas System | Piperazinyl norbenzomorphan compounds and methods for using the same |
| WO2017181141A2 (en) | 2016-04-15 | 2017-10-19 | Novira Therapeutics, Inc. | Combinations and methods comprising a capsid assembly inhibitor |
| AU2017257153A1 (en) | 2016-04-29 | 2018-11-22 | Board Of Regents, The University Of Texas System | Sigma receptor binders |
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| ES3063712T3 (en) * | 2017-05-15 | 2026-04-20 | Cognition Therapeutics Inc | Compositions for treating neurodegenerative diseases |
| US20200338045A1 (en) * | 2017-11-01 | 2020-10-29 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
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| AU2020223865A1 (en) | 2019-02-22 | 2021-07-15 | Janssen Sciences Ireland Unlimited Company | Amide derivatives useful in the treatment of HBV infection or HBV-induced diseases |
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| CN109734639B (zh) * | 2019-03-08 | 2020-10-09 | 漯河市卫龙生物技术有限公司 | 一种食用香精香料的制备方法 |
| BR112021021454A2 (pt) | 2019-05-06 | 2021-12-21 | Janssen Sciences Ireland Unlimited Co | Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv |
| US12352719B2 (en) | 2019-09-20 | 2025-07-08 | KYCERA AVX Components Corporation | Somatic cell-based electrical biosensor |
| CN112694427B (zh) * | 2019-10-23 | 2022-11-18 | 江西天宇化工有限公司 | 一种制备2,3-二甲基苯甲硫醚的方法 |
| KR20220142477A (ko) * | 2020-02-13 | 2022-10-21 | 카그니션 테라퓨틱스, 인코퍼레이티드 | 인지 저하 환자에서 아밀로이드 베타 단량체 수준을 감소시키는 방법 |
| IL298323B2 (en) | 2020-05-20 | 2023-10-01 | Univ Illinois | A method for treating lysosomal storage disease using histatin peptides |
| CN116867488A (zh) * | 2020-12-11 | 2023-10-10 | 考格尼申治疗股份有限公司 | 用于治疗干性老年性黄斑变性（amd）的组合物 |
| CA3212092A1 (en) * | 2021-03-19 | 2022-09-22 | Cognition Therapeutics, Inc. | Compositions and methods for treating neurologic diseases |
| WO2024020059A1 (en) * | 2022-07-18 | 2024-01-25 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| US20260216139A1 (en) * | 2022-12-14 | 2026-07-30 | Fred Hutchinson Cancer Center | Method for treating neurological diseases through glial pruning regulation |
| WO2024196799A2 (en) * | 2023-03-17 | 2024-09-26 | Cognition Therapeutics, Inc. | Isoindoline compositions and methods for treating neurodegenerative disease |
| CN117945980A (zh) * | 2024-01-24 | 2024-04-30 | 上海健康医学院 | 一种异吲哚硫亚胺类化合物及其制备和作为sigma-2受体抑制剂的应用 |
| WO2026064542A1 (en) | 2024-09-18 | 2026-03-26 | Cognition Therapeutics, Inc. | 2-(tert-butoxy)-4-(3-methyl-3-(5-(methylsulfonyl)isoindolin-2-yl)butyl)phenol fumarate salts in solid forms |
| WO2026064543A1 (en) | 2024-09-18 | 2026-03-26 | Cognition Therapeutics, Inc. | Process for preparing 2-(tert-butoxy)-4-(3-methyl-3-(5-methylsulfonyl)isoindolin-2-yl)butyl)phenol |
| WO2026119142A1 (zh) * | 2024-12-03 | 2026-06-11 | 浙江径科医药有限公司 | 一种氘代异吲哚啉化合物及其应用 |
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