|
ZA732136B
(en)
|
1972-04-12 |
1974-03-27 |
Lilly Co Eli |
Dopamine derivatives
|
|
DE2753278A1
(de)
|
1977-11-30 |
1979-05-31 |
Basf Ag |
Aralkylpiperidinone
|
|
US4321386A
(en)
|
1981-01-28 |
1982-03-23 |
Mead Johnson & Company |
Quaternary piperidinium halides
|
|
DE3222152A1
(de)
|
1982-06-12 |
1983-12-15 |
Bayer Ag, 5090 Leverkusen |
Substituierte maleinsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
|
|
EP0117647B1
(en)
|
1983-01-31 |
1988-08-17 |
Eli Lilly And Company |
Improvements in or relating to phenethanolamines
|
|
JPS62283922A
(ja)
|
1986-05-30 |
1987-12-09 |
Tsumura Juntendo Inc |
血小板凝集抑制剤
|
|
US4697024A
(en)
|
1986-11-24 |
1987-09-29 |
Merrell Dow Pharmaceuticals Inc. |
Medroxalol intermediates
|
|
US4958029A
(en)
*
|
1987-01-13 |
1990-09-18 |
Banyu Pharmaceutical Co., Ltd. |
Process for the production of isoindoline derivatives, novel intermediates and process for their production
|
|
JPH01180822A
(ja)
|
1988-01-12 |
1989-07-18 |
Dainippon Pharmaceut Co Ltd |
抗遅延型アレルギー剤
|
|
JPH01305085A
(ja)
|
1988-05-31 |
1989-12-08 |
Yamanouchi Pharmaceut Co Ltd |
ピリジルチアゾリジンカルボン酸アミド誘導体
|
|
JPH02215789A
(ja)
|
1989-02-15 |
1990-08-28 |
Yamanouchi Pharmaceut Co Ltd |
チアゾロ[3,4―a]ピラジン誘導体
|
|
CA2071897A1
(en)
|
1989-12-28 |
1991-06-29 |
Richard A. Glennon |
Sigma receptor ligands and the use thereof
|
|
DE4000610A1
(de)
|
1990-01-11 |
1991-07-18 |
Knoll Ag |
Verfahren zur herstellung von optisch aktiven 3-amino-1-arylbutanen und 3-benzylamino-1-arylbutanen
|
|
JP2818958B2
(ja)
|
1990-02-23 |
1998-10-30 |
塩野義製薬株式会社 |
4―(4―アルコキシフェニル)―2―ブチルアミン誘導体およびその製造法
|
|
JPH045266A
(ja)
|
1990-04-24 |
1992-01-09 |
Toyo Pharma- Kk |
ドパミン誘導体の製造方法
|
|
DE4142366A1
(de)
|
1991-07-15 |
1993-06-24 |
Thomae Gmbh Dr K |
Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
|
|
US6011068A
(en)
|
1991-08-23 |
2000-01-04 |
Nps Pharmaceuticals, Inc. |
Calcium receptor-active molecules
|
|
DK0724561T3
(da)
|
1991-08-23 |
2004-06-28 |
Nps Pharma Inc |
Calciumreceptoraktive arylalkylaminer
|
|
US6610493B1
(en)
|
1993-06-17 |
2003-08-26 |
Brigham And Women's Hospital |
Screening compounds for the ability to alter the production of amyloid-β peptide
|
|
CA2115900A1
(en)
|
1993-02-22 |
1994-08-23 |
Gerald W. Becker |
Pharmaceutical screens and antibodies
|
|
JPH06321781A
(ja)
|
1993-05-13 |
1994-11-22 |
Yamanouchi Pharmaceut Co Ltd |
血小板活性化因子拮抗剤
|
|
CN1147459C
(zh)
|
1994-10-21 |
2004-04-28 |
Nps药物有限公司 |
钙受体活性化合物
|
|
JPH0915744A
(ja)
|
1995-06-29 |
1997-01-17 |
Fuji Photo Film Co Ltd |
磁気ヘッドの検査方法及びフィルムキャリア
|
|
JP3522930B2
(ja)
|
1995-12-06 |
2004-04-26 |
花王株式会社 |
抗菌剤及びこれを含有する口腔用組成物
|
|
EP0881220A4
(en)
|
1996-02-15 |
1999-04-21 |
Mitsubishi Chem Corp |
DIARYLSULTAME DERIVATIVES
|
|
KR19990087814A
(ko)
|
1996-04-24 |
1999-12-27 |
다케다 야쿠힌 고교 가부시키가이샤 |
과지방혈증 방지제로서의 융합 이미다조피리딘유도체
|
|
US6218506B1
(en)
|
1997-02-05 |
2001-04-17 |
Northwestern University |
Amyloid β protein (globular assembly and uses thereof)
|
|
US6518315B1
(en)
|
1997-10-21 |
2003-02-11 |
The University Of Sydney |
Medicinal uses of phenylaikanols and derivatives
|
|
CO4980891A1
(es)
|
1997-11-14 |
2000-11-27 |
Sanofi Sa |
Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
|
|
CO5011072A1
(es)
|
1997-12-05 |
2001-02-28 |
Lilly Co Eli |
Etanolaminas pirazinil substituidas como agfonistas de los receptores
|
|
IL138686A0
(en)
|
1999-10-01 |
2001-10-31 |
Pfizer Prod Inc |
α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS
|
|
WO2001030335A2
(en)
|
1999-10-22 |
2001-05-03 |
The Board Of Trustees Of The University Of Illinois |
Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease
|
|
DE10027151A1
(de)
|
2000-05-31 |
2001-12-06 |
Bayer Ag |
Herbizide Mittel auf Basis von substituierten Carbonsäureamiden
|
|
DE60105023T2
(de)
|
2000-06-28 |
2005-08-18 |
Smithkline Beecham P.L.C., Brentford |
Nassvermahlungsverfahren
|
|
EP1481061B1
(en)
|
2001-03-05 |
2011-06-15 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses
|
|
JP4312402B2
(ja)
|
2001-07-31 |
2009-08-12 |
有限会社大長企画 |
抗うつ剤、抗更年期障害剤、抗老人性痴呆症剤、抗アルツハイマー剤
|
|
WO2003016274A2
(en)
|
2001-08-21 |
2003-02-27 |
Sepracor, Inc. |
2-substituted piperidines that are ligands for monoamine receptors and transporters
|
|
US6991814B2
(en)
|
2001-12-13 |
2006-01-31 |
Council Of Scientific And Industrial Research |
Herbal medicaments for the treatment of neurocerebrovascular disorders
|
|
EP1453528B1
(en)
|
2001-12-14 |
2009-07-22 |
Council of Scientific and Industrial Research |
Compositions containing curcuma extracts for the treatment of neurocerebrovascular disorders
|
|
JP2004002517A
(ja)
|
2002-05-31 |
2004-01-08 |
Dae Sil Kim |
生姜成分を含む石鹸の組成物及びその製造方法
|
|
DE10303974A1
(de)
|
2003-01-31 |
2004-08-05 |
Abbott Gmbh & Co. Kg |
Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
|
|
DE10320560A1
(de)
|
2003-05-07 |
2004-01-29 |
Brosig, Stefan, Dr. |
Mittel zur Bekämpfung der Alzheimer Erkrankung und/oder der Parkinson Krankheit
|
|
US7829562B2
(en)
|
2003-06-12 |
2010-11-09 |
M's Science Corporation |
Sigma ligands for neuronal regeneration and functional recovery
|
|
WO2004110387A2
(en)
|
2003-06-12 |
2004-12-23 |
Agy Therapeutics, Inc. |
Sigma ligands for neuronal regeneration and functional recovery
|
|
HRP20060326A2
(hr)
|
2004-03-12 |
2007-02-28 |
Egis Gy�gyszergy�r Nyrt. |
Kombinirani farmaceutski kompozit za inhibiciju pada kognitivnih funkcija
|
|
WO2005115366A1
(ja)
|
2004-05-31 |
2005-12-08 |
Kaneka Corporation |
ウコン精油成分を含有する生活習慣病予防・改善剤
|
|
AU2005253776B8
(en)
|
2004-06-21 |
2012-02-02 |
King's College London |
Screening methods using c-Abl, Fyn and Syk in combination with tau protein
|
|
TW200613272A
(en)
|
2004-08-13 |
2006-05-01 |
Astrazeneca Ab |
Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
|
|
JP2008512417A
(ja)
|
2004-09-10 |
2008-04-24 |
ユセベ ファルマ ソシエテ アノニム |
シグマ受容体リガンド
|
|
WO2006047254A1
(en)
|
2004-10-22 |
2006-05-04 |
Regents Of The University Of Minnesota |
Assemblies of oligomeric amyloid beta protein and uses thereof
|
|
WO2006066118A2
(en)
|
2004-12-15 |
2006-06-22 |
Neuralab Limited |
Contextual fear test for predicting efficacy of alzheimer immunotherapeutic treatment
|
|
ATE458754T1
(de)
|
2005-03-05 |
2010-03-15 |
Abbott Gmbh & Co Kg |
Screening-verfahren, verfahren zur aufreinigung nichtdiffundierbarer a-beta-oligomere, selektive antikörper gegen diese nichtdiffundierbaren a- beta-oligomere und verfahren zur herstellung dieser antikörper
|
|
WO2006138349A1
(en)
|
2005-06-15 |
2006-12-28 |
Kim Darrick S H L |
Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease including sage and rosemary derived compounds
|
|
TW200726774A
(en)
|
2005-06-30 |
2007-07-16 |
Merck & Co Inc |
Composition and method for producing stable amyloid beta oligomers
|
|
US20070021413A1
(en)
|
2005-07-20 |
2007-01-25 |
Peter Herold |
Diamino alcohols as therapeutic compounds
|
|
ITRM20060007A1
(it)
|
2006-01-05 |
2007-07-06 |
Univ Bari |
Recettore sigma-2 metodo di screening di ligandi specifici e uso degli stessi in metodi diagnostici o terapeutici
|
|
US20070218491A1
(en)
|
2006-02-08 |
2007-09-20 |
Oligomerix, Inc. |
Oligomerization of amyloid proteins
|
|
MX2008011754A
(es)
|
2006-03-17 |
2008-09-30 |
Herbalscience Singapore Pte Ltd |
Extractos y metodos que comprenden especies de curcuma.
|
|
WO2007112288A2
(en)
|
2006-03-23 |
2007-10-04 |
Mount Sinai School Of Medicine |
Cardiovascular composition and use the same for the treatment of alzheimers disease
|
|
WO2007126473A2
(en)
|
2006-04-10 |
2007-11-08 |
Oligomerix, Inc. |
Oligomerization of amyloid proteins
|
|
US8357781B2
(en)
|
2006-06-01 |
2013-01-22 |
Janssen Alzheimer Immunotherapy |
Neuroactive fragments of APP
|
|
US7561775B2
(en)
|
2006-08-22 |
2009-07-14 |
Senko Advanced Components, Inc. |
Fiber optic protective shutter
|
|
CA2662723A1
(en)
|
2006-09-08 |
2008-03-13 |
Vib Vzw |
Means and methods for the production of amyloid oligomers
|
|
WO2008042755A2
(en)
|
2006-09-29 |
2008-04-10 |
Cognition Therapeutics, Inc. |
Inhibitors of cognitive decline
|
|
US20080131233A1
(en)
|
2006-10-17 |
2008-06-05 |
Yao Chun I |
Plate-shaped fastener device
|
|
US20100028333A1
(en)
|
2006-12-15 |
2010-02-04 |
Getty Krista L |
Receptor for amyloid beta and uses thereof
|
|
US20080171757A1
(en)
|
2007-01-11 |
2008-07-17 |
Government Of The Us, As Represented By The Secretary, Department Of Health And Human Serivces |
Methods to identify inhibitors of cell sickling
|
|
US9217036B2
(en)
|
2007-04-26 |
2015-12-22 |
Yale University |
Prion protein as a receptor for amyloid-β oligomers
|
|
CN101808647A
(zh)
|
2007-05-15 |
2010-08-18 |
海利空医疗公司 |
通过抑制Gpr12治疗认知障碍的方法
|
|
CN101121670A
(zh)
|
2007-09-11 |
2008-02-13 |
上海紫源制药有限公司 |
一种3,4-二甲氧基-N-[3-(4-甲氧基苯基)-1-甲基-正丙基]-β-苯乙胺盐酸盐的制备方法
|
|
WO2009048631A1
(en)
|
2007-10-11 |
2009-04-16 |
University Of Tennessee Research Foundation |
PREPARATION OF PURIFIED COVALENTYLY CROSS-LINKED A β OLIGOMERS AND USES THEREOF
|
|
US8304547B2
(en)
|
2007-10-24 |
2012-11-06 |
Astellas Pharma Inc. |
Azolecarboxamide compound or salt thereof
|
|
WO2009059214A1
(en)
|
2007-11-02 |
2009-05-07 |
The Regents Of The University Of California |
Abeta-binding small molecules
|
|
WO2009067493A2
(en)
|
2007-11-19 |
2009-05-28 |
Envivo Pharmaceuticals, Inc. |
1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
|
|
CN102203124A
(zh)
|
2008-07-25 |
2011-09-28 |
雅培制药有限公司 |
淀粉状蛋白β肽类似物,其寡聚物,用于制备的方法以及包括所述类似物或寡聚物的组合物,及其用途
|
|
WO2010062260A1
(en)
|
2008-11-29 |
2010-06-03 |
The Thailand Research Fund |
Virus and target cell interaction inhibition
|
|
WO2010088450A2
(en)
|
2009-01-30 |
2010-08-05 |
Celladon Corporation |
Methods for treating diseases associated with the modulation of serca
|
|
DK2408905T3
(en)
|
2009-03-16 |
2017-08-28 |
Pangu Biopharma Ltd |
Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities
|
|
US7972164B2
(en)
|
2009-03-24 |
2011-07-05 |
Tyco Electronics Corporation |
Connector assembly with a latch
|
|
CN105968022A
(zh)
*
|
2009-04-09 |
2016-09-28 |
考格尼申治疗股份有限公司 |
认知衰退的抑制剂
|
|
US9493834B2
(en)
|
2009-07-29 |
2016-11-15 |
Pharnext |
Method for detecting a panel of biomarkers
|
|
BR112012002246A2
(pt)
*
|
2009-07-31 |
2019-09-24 |
Cognition Therapeutics Inc |
composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente
|
|
US20150160228A1
(en)
|
2010-02-05 |
2015-06-11 |
Susan Catalano |
Compositions and method for determining the efficacy of amyloidosis treatments
|
|
US20130071330A1
(en)
|
2010-02-26 |
2013-03-21 |
Susan Catalano |
Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
|
|
WO2012027548A1
(en)
|
2010-08-25 |
2012-03-01 |
The Feinstein Institute For Medical Research |
Compounds and methods for prevention and treatment of alzheimer's and other diseases
|
|
SG192596A1
(en)
|
2011-02-02 |
2013-09-30 |
Cognition Therapeutics Inc |
Isolated compounds from turmeric oil and methods of use
|
|
US20170049723A1
(en)
|
2011-02-02 |
2017-02-23 |
Cognition Therapeutics, Inc. |
Isolated compounds from turmeric oil and methods of use
|
|
AU2012298617B2
(en)
|
2011-08-25 |
2016-07-14 |
Cognition Therapeutics, Inc. |
Compositions and methods for treating neurodegenerative disease
|
|
CA2846604A1
(en)
|
2011-08-25 |
2013-02-28 |
Cognition Therapeutics, Inc. |
Compositions and methods for treating neurodegenerative disease
|
|
AT511906B1
(de)
|
2011-08-30 |
2016-05-15 |
Blum Gmbh Julius |
Schublade
|
|
WO2015020523A1
(en)
|
2013-08-07 |
2015-02-12 |
Stichting Vu-Vumc |
Biomarkers for early diagnosis of alzheimer's disease
|
|
DK3099296T3
(en)
*
|
2014-01-31 |
2019-04-15 |
Cognition Therapeutics Inc |
ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
|
|
IL270251B2
(en)
|
2017-05-15 |
2025-01-01 |
Cognition Therapeutics Inc |
1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them
|
|
EP3704092A4
(en)
*
|
2017-11-01 |
2021-08-25 |
Cognition Therapeutics, Inc. |
ISOINDOLINE COMPOSITIONS AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASE
|
|
CN110283082A
(zh)
|
2019-07-15 |
2019-09-27 |
泰州职业技术学院 |
一种3-苯基丙胺的制备方法
|
|
EP4103604A4
(en)
*
|
2020-02-13 |
2024-03-27 |
Cognition Therapeutics, Inc. |
Method of decreasing amyloid beta monomer levels in patients with cognitive decline
|
|
EP4259129A4
(en)
|
2020-12-11 |
2024-11-27 |
Cognition Therapeutics, Inc. |
COMPOSITIONS FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION (AMD)
|