JP2017507122A5 - - Google Patents

Download PDF

Info

Publication number
JP2017507122A5
JP2017507122A5 JP2016549224A JP2016549224A JP2017507122A5 JP 2017507122 A5 JP2017507122 A5 JP 2017507122A5 JP 2016549224 A JP2016549224 A JP 2016549224A JP 2016549224 A JP2016549224 A JP 2016549224A JP 2017507122 A5 JP2017507122 A5 JP 2017507122A5
Authority
JP
Japan
Prior art keywords
alkyl
aryl
och
heteroaryl
membered
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2016549224A
Other languages
English (en)
Japanese (ja)
Other versions
JP2017507122A (ja
JP6517827B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2015/013754 external-priority patent/WO2015116923A1/en
Publication of JP2017507122A publication Critical patent/JP2017507122A/ja
Publication of JP2017507122A5 publication Critical patent/JP2017507122A5/ja
Application granted granted Critical
Publication of JP6517827B2 publication Critical patent/JP6517827B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2016549224A 2014-01-31 2015-01-30 イソインドリン組成物および神経変性疾患の治療方法 Active JP6517827B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461934528P 2014-01-31 2014-01-31
US61/934,528 2014-01-31
PCT/US2015/013754 WO2015116923A1 (en) 2014-01-31 2015-01-30 Isoindoline compositions and methods for treating neurodegenerative disease

Publications (3)

Publication Number Publication Date
JP2017507122A JP2017507122A (ja) 2017-03-16
JP2017507122A5 true JP2017507122A5 (enExample) 2018-03-08
JP6517827B2 JP6517827B2 (ja) 2019-05-22

Family

ID=53757753

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016549224A Active JP6517827B2 (ja) 2014-01-31 2015-01-30 イソインドリン組成物および神経変性疾患の治療方法

Country Status (15)

Country Link
US (5) US9796672B2 (enExample)
EP (3) EP3498692B1 (enExample)
JP (1) JP6517827B2 (enExample)
KR (1) KR102331422B1 (enExample)
CN (1) CN106163516B (enExample)
AU (1) AU2015210852B2 (enExample)
BR (1) BR112016017808B1 (enExample)
CA (1) CA2938212C (enExample)
DK (2) DK3099296T3 (enExample)
ES (2) ES2721001T3 (enExample)
IL (1) IL247003B (enExample)
MX (1) MX368755B (enExample)
NZ (1) NZ722599A (enExample)
RU (1) RU2692258C2 (enExample)
WO (1) WO2015116923A1 (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA037918B1 (ru) 2011-12-21 2021-06-07 Новира Терапьютикс, Инк. Противовирусные агенты против гепатита в
HK1208465A1 (en) 2012-08-28 2016-03-04 Janssen Sciences Ireland Uc Sulfamoyl-arylamides and the use thereof as medicaments for the treatment of hepatitis b
DK2961732T3 (en) 2013-02-28 2017-07-10 Janssen Sciences Ireland Uc SULFAMOYLARYLAMIDS AND USE THEREOF AS MEDICINES TO TREAT HEPATITIS B
WO2014161888A1 (en) 2013-04-03 2014-10-09 Janssen R&D Ireland N-phenyl-carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
JO3603B1 (ar) 2013-05-17 2020-07-05 Janssen Sciences Ireland Uc مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
ES2774749T3 (es) 2013-07-25 2020-07-22 Janssen Sciences Ireland Unlimited Co Derivados de pirrolamida sustituidos con glioxamida y su uso como medicamentos para el tratamiento de la hepatitis B
KR102290189B1 (ko) 2013-10-23 2021-08-17 얀센 사이언시즈 아일랜드 언리미티드 컴퍼니 카르복스아미드 유도체 및 b형 간염 치료용 의약으로서의 이의 용도
US9169212B2 (en) 2014-01-16 2015-10-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
US10392349B2 (en) 2014-01-16 2019-08-27 Novira Therapeutics, Inc. Azepane derivatives and methods of treating hepatitis B infections
DK3099296T3 (en) * 2014-01-31 2019-04-15 Cognition Therapeutics Inc ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
KR20160128305A (ko) 2014-02-05 2016-11-07 노비라 테라퓨틱스, 인코포레이티드 Hbv 감염의 치료를 위한 병용 요법
DK3102572T3 (en) 2014-02-06 2019-02-04 Janssen Sciences Ireland Uc SULFAMOYLPYRROLAMIDE DERIVATIVES AND THEIR USE AS MEDICINES TO TREAT HEPATITIS B
WO2016149581A1 (en) 2015-03-19 2016-09-22 Novira Therapeutics, Inc. Azocane and azonane derivatives and methods of treating hepatitis b infections
US10875876B2 (en) 2015-07-02 2020-12-29 Janssen Sciences Ireland Uc Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
HK1259410A1 (zh) 2015-09-29 2019-11-29 诺维拉治疗公司 乙型肝炎抗病毒剂的晶体形式
US11046670B2 (en) 2015-10-19 2021-06-29 Board Of Regents, The University Of Texas System Piperazinyl norbenzomorphan compounds and methods for using the same
EP3442524A2 (en) 2016-04-15 2019-02-20 Novira Therapeutics Inc. Combinations and methods comprising a capsid assembly inhibitor
EP3448520A4 (en) * 2016-04-29 2020-07-29 Board Of Regents, The University Of Texas System SIGMA RECEIVER BINDERS
CN107162944B (zh) * 2017-04-27 2019-02-26 湖南化工研究院有限公司 2,3-二甲基苯甲硫醚的制备方法
IL270251B2 (en) * 2017-05-15 2025-01-01 Cognition Therapeutics Inc 1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them
EP3704092A4 (en) * 2017-11-01 2021-08-25 Cognition Therapeutics, Inc. ISOINDOLINE COMPOSITIONS AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASE
EA202092171A1 (ru) 2018-03-14 2020-12-01 Янссен Сайенсиз Айрлэнд Анлимитед Компани Схема дозирования модулятора сборки капсида
JP6567153B1 (ja) * 2018-09-28 2019-08-28 学校法人東北工業大学 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム
CA3116348A1 (en) * 2018-10-31 2020-05-07 Polycore Therapeutics Llc Method for synthesizing d3 dopamine receptor agonists
MA55020A (fr) 2019-02-22 2021-12-29 Janssen Sciences Ireland Unlimited Co Dérivés d'amide utiles dans le traitement d'une infection par le virus de l'hépatite b ou de maladies induites par le virus de l'hépatite b
CN109734638A (zh) * 2019-03-08 2019-05-10 新昌县大船畈生物科技有限公司 一种食用香精香料的制备方法
CN109734639B (zh) * 2019-03-08 2020-10-09 漯河市卫龙生物技术有限公司 一种食用香精香料的制备方法
BR112021021454A2 (pt) 2019-05-06 2021-12-21 Janssen Sciences Ireland Unlimited Co Derivados de amida úteis no tratamento da infecção por hbv ou doenças induzidas por hbv
US12352719B2 (en) 2019-09-20 2025-07-08 KYCERA AVX Components Corporation Somatic cell-based electrical biosensor
CN112694427B (zh) * 2019-10-23 2022-11-18 江西天宇化工有限公司 一种制备2,3-二甲基苯甲硫醚的方法
EP4103604A4 (en) * 2020-02-13 2024-03-27 Cognition Therapeutics, Inc. Method of decreasing amyloid beta monomer levels in patients with cognitive decline
JP2023526515A (ja) 2020-05-20 2023-06-21 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ リソソーム蓄積症をヒスタチンペプチドで処置するための方法
EP4259129A4 (en) * 2020-12-11 2024-11-27 Cognition Therapeutics, Inc. COMPOSITIONS FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION (AMD)
IL306063A (en) * 2021-03-19 2023-11-01 Cognition Therapeutics Inc Preparations and methods for the treatment of neurological diseases
US20250177351A1 (en) * 2022-07-18 2025-06-05 Cognition Therapeutics, Inc. Isoindoline compositions and methods for treating neurodegenerative disease
WO2024130030A1 (en) * 2022-12-14 2024-06-20 Fred Hutchinson Cancer Center Method for treating neurological diseases through glial pruning regulation
WO2024196799A2 (en) * 2023-03-17 2024-09-26 Cognition Therapeutics, Inc. Isoindoline compositions and methods for treating neurodegenerative disease
CN117945980A (zh) 2024-01-24 2024-04-30 上海健康医学院 一种异吲哚硫亚胺类化合物及其制备和作为sigma-2受体抑制剂的应用

Family Cites Families (97)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA732136B (en) 1972-04-12 1974-03-27 Lilly Co Eli Dopamine derivatives
DE2753278A1 (de) 1977-11-30 1979-05-31 Basf Ag Aralkylpiperidinone
US4321386A (en) 1981-01-28 1982-03-23 Mead Johnson & Company Quaternary piperidinium halides
DE3222152A1 (de) 1982-06-12 1983-12-15 Bayer Ag, 5090 Leverkusen Substituierte maleinsaeureimide, verfahren zu ihrer herstellung und ihre verwendung als schaedlingsbekaempfungsmittel
EP0117647B1 (en) 1983-01-31 1988-08-17 Eli Lilly And Company Improvements in or relating to phenethanolamines
JPS62283922A (ja) 1986-05-30 1987-12-09 Tsumura Juntendo Inc 血小板凝集抑制剤
US4697024A (en) 1986-11-24 1987-09-29 Merrell Dow Pharmaceuticals Inc. Medroxalol intermediates
US4958029A (en) * 1987-01-13 1990-09-18 Banyu Pharmaceutical Co., Ltd. Process for the production of isoindoline derivatives, novel intermediates and process for their production
JPH01180822A (ja) 1988-01-12 1989-07-18 Dainippon Pharmaceut Co Ltd 抗遅延型アレルギー剤
JPH01305085A (ja) 1988-05-31 1989-12-08 Yamanouchi Pharmaceut Co Ltd ピリジルチアゾリジンカルボン酸アミド誘導体
JPH02215789A (ja) 1989-02-15 1990-08-28 Yamanouchi Pharmaceut Co Ltd チアゾロ[3,4―a]ピラジン誘導体
CA2071897A1 (en) 1989-12-28 1991-06-29 Richard A. Glennon Sigma receptor ligands and the use thereof
DE4000610A1 (de) 1990-01-11 1991-07-18 Knoll Ag Verfahren zur herstellung von optisch aktiven 3-amino-1-arylbutanen und 3-benzylamino-1-arylbutanen
JP2818958B2 (ja) 1990-02-23 1998-10-30 塩野義製薬株式会社 4―(4―アルコキシフェニル)―2―ブチルアミン誘導体およびその製造法
JPH045266A (ja) 1990-04-24 1992-01-09 Toyo Pharma- Kk ドパミン誘導体の製造方法
DE4142366A1 (de) 1991-07-15 1993-06-24 Thomae Gmbh Dr K Phenylalkylderivate, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US6011068A (en) 1991-08-23 2000-01-04 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
DK0724561T3 (da) 1991-08-23 2004-06-28 Nps Pharma Inc Calciumreceptoraktive arylalkylaminer
US6610493B1 (en) 1993-06-17 2003-08-26 Brigham And Women's Hospital Screening compounds for the ability to alter the production of amyloid-β peptide
CA2115900A1 (en) 1993-02-22 1994-08-23 Gerald W. Becker Pharmaceutical screens and antibodies
JPH06321781A (ja) 1993-05-13 1994-11-22 Yamanouchi Pharmaceut Co Ltd 血小板活性化因子拮抗剤
CN1147459C (zh) 1994-10-21 2004-04-28 Nps药物有限公司 钙受体活性化合物
JPH0915744A (ja) 1995-06-29 1997-01-17 Fuji Photo Film Co Ltd 磁気ヘッドの検査方法及びフィルムキャリア
JP3522930B2 (ja) 1995-12-06 2004-04-26 花王株式会社 抗菌剤及びこれを含有する口腔用組成物
EP0881220A4 (en) 1996-02-15 1999-04-21 Mitsubishi Chem Corp DIARYLSULTAME DERIVATIVES
KR19990087814A (ko) 1996-04-24 1999-12-27 다케다 야쿠힌 고교 가부시키가이샤 과지방혈증 방지제로서의 융합 이미다조피리딘유도체
US6218506B1 (en) 1997-02-05 2001-04-17 Northwestern University Amyloid β protein (globular assembly and uses thereof)
US6518315B1 (en) 1997-10-21 2003-02-11 The University Of Sydney Medicinal uses of phenylaikanols and derivatives
CO4980891A1 (es) 1997-11-14 2000-11-27 Sanofi Sa Asociacion de principios activos para el tratamiento de la demencia senil de tipo azheimer
CO5011072A1 (es) 1997-12-05 2001-02-28 Lilly Co Eli Etanolaminas pirazinil substituidas como agfonistas de los receptores
IL138686A0 (en) 1999-10-01 2001-10-31 Pfizer Prod Inc α- SULFONYLAMINO HYDROXAMIC ACID INHIBITORS OF MATRIX METALLOPROTEINASES FOR THE TREATMENT OF PERIPHERAL OR CENTRAL NERVOUS SYSTEM DISORDERS
WO2001030335A2 (en) 1999-10-22 2001-05-03 The Board Of Trustees Of The University Of Illinois Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease
DE10027151A1 (de) 2000-05-31 2001-12-06 Bayer Ag Herbizide Mittel auf Basis von substituierten Carbonsäureamiden
DE60105023T2 (de) 2000-06-28 2005-08-18 Smithkline Beecham P.L.C., Brentford Nassvermahlungsverfahren
EP1481061B1 (en) 2001-03-05 2011-06-15 Yissum Research Development Company Of The Hebrew University Of Jerusalem Denaturant stable and/or protease resistant, chaperone-like oligomeric proteins, polynucleotides encoding same and their uses
JP4312402B2 (ja) 2001-07-31 2009-08-12 有限会社大長企画 抗うつ剤、抗更年期障害剤、抗老人性痴呆症剤、抗アルツハイマー剤
WO2003016274A2 (en) 2001-08-21 2003-02-27 Sepracor, Inc. 2-substituted piperidines that are ligands for monoamine receptors and transporters
US6991814B2 (en) 2001-12-13 2006-01-31 Council Of Scientific And Industrial Research Herbal medicaments for the treatment of neurocerebrovascular disorders
EP1453528B1 (en) 2001-12-14 2009-07-22 Council of Scientific and Industrial Research Compositions containing curcuma extracts for the treatment of neurocerebrovascular disorders
JP2004002517A (ja) 2002-05-31 2004-01-08 Dae Sil Kim 生姜成分を含む石鹸の組成物及びその製造方法
DE10303974A1 (de) 2003-01-31 2004-08-05 Abbott Gmbh & Co. Kg Amyloid-β(1-42)-Oligomere, Verfahren zu deren Herstellung und deren Verwendung
DE10320560A1 (de) 2003-05-07 2004-01-29 Brosig, Stefan, Dr. Mittel zur Bekämpfung der Alzheimer Erkrankung und/oder der Parkinson Krankheit
US7829562B2 (en) 2003-06-12 2010-11-09 M's Science Corporation Sigma ligands for neuronal regeneration and functional recovery
WO2004110387A2 (en) 2003-06-12 2004-12-23 Agy Therapeutics, Inc. Sigma ligands for neuronal regeneration and functional recovery
HRP20060326A2 (hr) 2004-03-12 2007-02-28 Egis Gy�gyszergy�r Nyrt. Kombinirani farmaceutski kompozit za inhibiciju pada kognitivnih funkcija
WO2005115366A1 (ja) 2004-05-31 2005-12-08 Kaneka Corporation ウコン精油成分を含有する生活習慣病予防・改善剤
AU2005253776B8 (en) 2004-06-21 2012-02-02 King's College London Screening methods using c-Abl, Fyn and Syk in combination with tau protein
TW200613272A (en) 2004-08-13 2006-05-01 Astrazeneca Ab Isoindolone compounds and their use as metabotropic glutamate receptor potentiators
JP2008512417A (ja) 2004-09-10 2008-04-24 ユセベ ファルマ ソシエテ アノニム シグマ受容体リガンド
WO2006047254A1 (en) 2004-10-22 2006-05-04 Regents Of The University Of Minnesota Assemblies of oligomeric amyloid beta protein and uses thereof
WO2006066118A2 (en) 2004-12-15 2006-06-22 Neuralab Limited Contextual fear test for predicting efficacy of alzheimer immunotherapeutic treatment
ATE458754T1 (de) 2005-03-05 2010-03-15 Abbott Gmbh & Co Kg Screening-verfahren, verfahren zur aufreinigung nichtdiffundierbarer a-beta-oligomere, selektive antikörper gegen diese nichtdiffundierbaren a- beta-oligomere und verfahren zur herstellung dieser antikörper
WO2006138349A1 (en) 2005-06-15 2006-12-28 Kim Darrick S H L Synergistic pharmaceutical compositions useful in prevention and treatment of beta-amyloid protein-induced disease including sage and rosemary derived compounds
TW200726774A (en) 2005-06-30 2007-07-16 Merck & Co Inc Composition and method for producing stable amyloid beta oligomers
US20070021413A1 (en) 2005-07-20 2007-01-25 Peter Herold Diamino alcohols as therapeutic compounds
ITRM20060007A1 (it) 2006-01-05 2007-07-06 Univ Bari Recettore sigma-2 metodo di screening di ligandi specifici e uso degli stessi in metodi diagnostici o terapeutici
US20070218491A1 (en) 2006-02-08 2007-09-20 Oligomerix, Inc. Oligomerization of amyloid proteins
MX2008011754A (es) 2006-03-17 2008-09-30 Herbalscience Singapore Pte Ltd Extractos y metodos que comprenden especies de curcuma.
WO2007112288A2 (en) 2006-03-23 2007-10-04 Mount Sinai School Of Medicine Cardiovascular composition and use the same for the treatment of alzheimers disease
WO2007126473A2 (en) 2006-04-10 2007-11-08 Oligomerix, Inc. Oligomerization of amyloid proteins
US8357781B2 (en) 2006-06-01 2013-01-22 Janssen Alzheimer Immunotherapy Neuroactive fragments of APP
US7561775B2 (en) 2006-08-22 2009-07-14 Senko Advanced Components, Inc. Fiber optic protective shutter
CA2662723A1 (en) 2006-09-08 2008-03-13 Vib Vzw Means and methods for the production of amyloid oligomers
WO2008042755A2 (en) 2006-09-29 2008-04-10 Cognition Therapeutics, Inc. Inhibitors of cognitive decline
US20080131233A1 (en) 2006-10-17 2008-06-05 Yao Chun I Plate-shaped fastener device
US20100028333A1 (en) 2006-12-15 2010-02-04 Getty Krista L Receptor for amyloid beta and uses thereof
US20080171757A1 (en) 2007-01-11 2008-07-17 Government Of The Us, As Represented By The Secretary, Department Of Health And Human Serivces Methods to identify inhibitors of cell sickling
US9217036B2 (en) 2007-04-26 2015-12-22 Yale University Prion protein as a receptor for amyloid-β oligomers
CN101808647A (zh) 2007-05-15 2010-08-18 海利空医疗公司 通过抑制Gpr12治疗认知障碍的方法
CN101121670A (zh) 2007-09-11 2008-02-13 上海紫源制药有限公司 一种3,4-二甲氧基-N-[3-(4-甲氧基苯基)-1-甲基-正丙基]-β-苯乙胺盐酸盐的制备方法
WO2009048631A1 (en) 2007-10-11 2009-04-16 University Of Tennessee Research Foundation PREPARATION OF PURIFIED COVALENTYLY CROSS-LINKED A β OLIGOMERS AND USES THEREOF
US8304547B2 (en) 2007-10-24 2012-11-06 Astellas Pharma Inc. Azolecarboxamide compound or salt thereof
WO2009059214A1 (en) 2007-11-02 2009-05-07 The Regents Of The University Of California Abeta-binding small molecules
WO2009067493A2 (en) 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
CN102203124A (zh) 2008-07-25 2011-09-28 雅培制药有限公司 淀粉状蛋白β肽类似物,其寡聚物,用于制备的方法以及包括所述类似物或寡聚物的组合物,及其用途
WO2010062260A1 (en) 2008-11-29 2010-06-03 The Thailand Research Fund Virus and target cell interaction inhibition
WO2010088450A2 (en) 2009-01-30 2010-08-05 Celladon Corporation Methods for treating diseases associated with the modulation of serca
DK2408905T3 (en) 2009-03-16 2017-08-28 Pangu Biopharma Ltd Compositions and Methods comprising Histidyl-tRNA Synthetase Splicing Variants with Non-Canonical Biological Activities
US7972164B2 (en) 2009-03-24 2011-07-05 Tyco Electronics Corporation Connector assembly with a latch
CN105968022A (zh) * 2009-04-09 2016-09-28 考格尼申治疗股份有限公司 认知衰退的抑制剂
US9493834B2 (en) 2009-07-29 2016-11-15 Pharnext Method for detecting a panel of biomarkers
BR112012002246A2 (pt) * 2009-07-31 2019-09-24 Cognition Therapeutics Inc composto, composto ou sal farmaceutico aceitavel deste, composição farmaceutica, metodo para inibir, tratar e/ou reduzir o declinio cognitivol e/ou doença de akzhmer em um paciente
US20150160228A1 (en) 2010-02-05 2015-06-11 Susan Catalano Compositions and method for determining the efficacy of amyloidosis treatments
US20130071330A1 (en) 2010-02-26 2013-03-21 Susan Catalano Methods of identifying agents effective to treat cognitive decline and diseases associated therewith
WO2012027548A1 (en) 2010-08-25 2012-03-01 The Feinstein Institute For Medical Research Compounds and methods for prevention and treatment of alzheimer's and other diseases
SG192596A1 (en) 2011-02-02 2013-09-30 Cognition Therapeutics Inc Isolated compounds from turmeric oil and methods of use
US20170049723A1 (en) 2011-02-02 2017-02-23 Cognition Therapeutics, Inc. Isolated compounds from turmeric oil and methods of use
AU2012298617B2 (en) 2011-08-25 2016-07-14 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
CA2846604A1 (en) 2011-08-25 2013-02-28 Cognition Therapeutics, Inc. Compositions and methods for treating neurodegenerative disease
AT511906B1 (de) 2011-08-30 2016-05-15 Blum Gmbh Julius Schublade
WO2015020523A1 (en) 2013-08-07 2015-02-12 Stichting Vu-Vumc Biomarkers for early diagnosis of alzheimer's disease
DK3099296T3 (en) * 2014-01-31 2019-04-15 Cognition Therapeutics Inc ISO-INDOLINE DERIVATIVES, COMPOSITIONS AND METHODS FOR TREATING NEURODEGENERATIVE DISEASE
IL270251B2 (en) 2017-05-15 2025-01-01 Cognition Therapeutics Inc 1-Phenyl-1,1-dimethyl-2-(piperidinyl/pyrrolidinyl/piperazinyl)ethane derivatives and pharmaceutical preparations containing them
EP3704092A4 (en) * 2017-11-01 2021-08-25 Cognition Therapeutics, Inc. ISOINDOLINE COMPOSITIONS AND METHODS OF TREATMENT OF NEURODEGENERATIVE DISEASE
CN110283082A (zh) 2019-07-15 2019-09-27 泰州职业技术学院 一种3-苯基丙胺的制备方法
EP4103604A4 (en) * 2020-02-13 2024-03-27 Cognition Therapeutics, Inc. Method of decreasing amyloid beta monomer levels in patients with cognitive decline
EP4259129A4 (en) 2020-12-11 2024-11-27 Cognition Therapeutics, Inc. COMPOSITIONS FOR THE TREATMENT OF DRY AGE-RELATED MACULAR DEGENERATION (AMD)

Similar Documents

Publication Publication Date Title
JP2017507122A5 (enExample)
RU2016134677A (ru) Композиции изоиндолина и способы лечения нейродегенеративного заболевания
US12171744B2 (en) Pharmaceutical combinations for the treatment of cancer
JP7073270B2 (ja) 前立腺がんの内部放射線療法のための前立腺特異的膜抗原を標的とした高親和性薬剤
JP2017504635A5 (enExample)
JP2016515561A5 (enExample)
JP2016053042A5 (enExample)
RU2017145026A (ru) Соединение, ингибирующее brk
JP2017528498A5 (enExample)
JP2013529196A5 (enExample)
JP2014511892A5 (enExample)
RU2016134751A (ru) Соединения
JP2015520143A5 (enExample)
JP2015520769A5 (enExample)
JP2009536620A5 (enExample)
RU2018122864A (ru) Ингибиторы протеинкиназ, их способ получения и медицинское применение
JP2014521653A5 (enExample)
US10232058B2 (en) Prostate-specific membrane antigen-targeted photosensitizers for photodynamic therapy
AR040673A1 (es) Inhibidores micobacterianos, composicion farmaceutica y proceso de preparacion del compuesto
JP2013510120A5 (enExample)
JP2016508135A5 (enExample)
JP2014510149A5 (enExample)
RU2010123796A (ru) Способ лечения артрита
JP2005506982A5 (enExample)
KR20180114057A (ko) 피리미딘 7-원 고리 화합물, 이의 제조 방법, 이의 약제학적 조성물, 및 이의 용도