|
US9266891B2
(en)
|
2012-11-16 |
2016-02-23 |
Boehringer Ingelheim International Gmbh |
Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
|
|
US9271978B2
(en)
|
2012-12-21 |
2016-03-01 |
Zenith Epigenetics Corp. |
Heterocyclic compounds as bromodomain inhibitors
|
|
SG11201510409QA
(en)
|
2013-06-21 |
2016-01-28 |
Zenith Epigenetics Corp |
Novel bicyclic bromodomain inhibitors
|
|
CA2915622C
(en)
|
2013-06-21 |
2020-08-18 |
Zenith Epigenetics Corp. |
Novel substituted bicyclic compounds as bromodomain inhibitors
|
|
GB201311891D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compound
|
|
GB201311888D0
(en)
|
2013-07-03 |
2013-08-14 |
Glaxosmithkline Ip Dev Ltd |
Novel compounds
|
|
US9855271B2
(en)
|
2013-07-31 |
2018-01-02 |
Zenith Epigenetics Ltd. |
Quinazolinones as bromodomain inhibitors
|
|
HRP20221389T1
(hr)
|
2013-10-18 |
2023-01-06 |
Celgene Quanticel Research, Inc. |
Inhibitori bromodomena
|
|
AU2013406206B2
(en)
*
|
2013-11-26 |
2017-07-20 |
Gilead Sciences, Inc. |
Quinoline derivatives as bromodomain inhibitors
|
|
GB201321737D0
(en)
*
|
2013-12-09 |
2014-01-22 |
Ucb Pharma Sa |
Therapeutic Agents
|
|
JP6469692B2
(ja)
*
|
2013-12-09 |
2019-02-13 |
ユーシービー バイオファルマ エスピーアールエル |
Tnf活性のモジュレーターとしてのイミダゾピリジン誘導体
|
|
US20180228907A1
(en)
|
2014-04-14 |
2018-08-16 |
Arvinas, Inc. |
Cereblon ligands and bifunctional compounds comprising the same
|
|
EP3227281A4
(en)
|
2014-12-01 |
2018-05-30 |
Zenith Epigenetics Ltd. |
Substituted pyridinones as bromodomain inhibitors
|
|
US10179125B2
(en)
|
2014-12-01 |
2019-01-15 |
Zenith Epigenetics Ltd. |
Substituted pyridines as bromodomain inhibitors
|
|
HK1245248B
(en)
|
2014-12-11 |
2020-05-15 |
恒翼生物医药(上海)股份有限公司 |
Substituted heterocycles as bromodomain inhibitors
|
|
HK1245247A1
(zh)
|
2014-12-17 |
2018-08-24 |
恒翼生物医药科技(上海)有限公司 |
溴结构域的抑制剂
|
|
GB201503720D0
(en)
*
|
2015-03-05 |
2015-04-22 |
Glaxosmithkline Ip No 2 Ltd |
Chemical compound
|
|
KR102616762B1
(ko)
|
2015-03-18 |
2023-12-20 |
아비나스 오퍼레이션스, 인코포레이티드 |
타겟화된 단백질들의 향상된 분해를 위한 화합물들 및 방법들
|
|
GB201504694D0
(en)
|
2015-03-19 |
2015-05-06 |
Glaxosmithkline Ip Dev Ltd |
Covalent conjugates
|
|
GB201504689D0
(en)
*
|
2015-03-19 |
2015-05-06 |
Glaxosmithkline Ip Dev Ltd |
Chemical compounds
|
|
GB201506660D0
(en)
*
|
2015-04-20 |
2015-06-03 |
Cellcentric Ltd |
Pharmaceutical compounds
|
|
WO2017024319A1
(en)
|
2015-08-06 |
2017-02-09 |
Dana-Farber Cancer Institute, Inc. |
Tunable endogenous protein degradation
|
|
US10836742B2
(en)
|
2015-08-11 |
2020-11-17 |
Neomed Institute |
N-substituted bicyclic lactams, their preparation and their use as pharmaceuticals
|
|
CA2994472A1
(en)
|
2015-08-11 |
2017-02-16 |
Neomed Institute |
Aryl-substituted dihydroquinolinones, their preparation and their use as pharmaceuticals
|
|
ES2904258T3
(es)
*
|
2015-08-12 |
2022-04-04 |
Neomed Inst |
Bencimidazoles sustituidos, su preparación y su uso como productos farmacéuticos
|
|
EP3337476A4
(en)
|
2015-08-19 |
2019-09-04 |
Arvinas, Inc. |
Compounds and methods for the targeted degradation of bromodomain-containing proteins
|
|
WO2017066876A1
(en)
|
2015-10-21 |
2017-04-27 |
Neomed Institute |
Substituted imidazopyridines, their preparation and their use as pharmaceuticals
|
|
CN108602821B
(zh)
*
|
2015-12-14 |
2021-06-29 |
恒元生物医药科技(苏州)有限公司 |
1h-咪唑并[4,5-b]吡啶基bet溴结构域抑制剂
|
|
US10519151B2
(en)
|
2016-01-28 |
2019-12-31 |
Neomed Institute |
Substituted [1,2,4]triazolo[4,3-A]pyridines, their preparation and their use as pharmaceuticals
|
|
EP3436006B1
(en)
|
2016-03-30 |
2025-07-30 |
Wisconsin Alumni Research Foundation |
Methods and compositions for modulating frataxin expression
|
|
WO2017197051A1
(en)
|
2016-05-10 |
2017-11-16 |
C4 Therapeutics, Inc. |
Amine-linked c3-glutarimide degronimers for target protein degradation
|
|
CN109641874A
(zh)
|
2016-05-10 |
2019-04-16 |
C4医药公司 |
用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
|
|
EP3454856B1
(en)
|
2016-05-10 |
2024-09-11 |
C4 Therapeutics, Inc. |
Heterocyclic degronimers for target protein degradation
|
|
ES2990061T3
(es)
|
2016-05-10 |
2024-11-28 |
C4 Therapeutics Inc |
Degronímeros espirocíclicos para la degradación de proteínas diana
|
|
GB201614940D0
(en)
*
|
2016-09-02 |
2016-10-19 |
Glaxosmithkline Intellectual Property (No 2) Ltd |
Chemical compounds
|
|
GB201614939D0
(en)
*
|
2016-09-02 |
2016-10-19 |
Glaxosmithkline Ip Dev Ltd |
Crystalline hydrate
|
|
US11459308B2
(en)
|
2016-12-05 |
2022-10-04 |
Microbiotix, Inc. |
Broad spectrum inhibitors of filoviruses
|
|
BR112019015484A2
(pt)
|
2017-01-31 |
2020-04-28 |
Arvinas Operations Inc |
ligantes de cereblon e compostos bifuncionais compreendendo os mesmos
|
|
WO2018148440A1
(en)
|
2017-02-08 |
2018-08-16 |
Dana-Farber Cancer Institute, Inc. |
Regulating chimeric antigen receptors
|
|
WO2018183679A1
(en)
|
2017-03-29 |
2018-10-04 |
Wisconsin Alumni Research Foundation |
Methods and compositions for modulating gene expression
|
|
EP3641762A4
(en)
|
2017-06-20 |
2021-03-10 |
C4 Therapeutics, Inc. |
N / O-LINKED DEGRONES AND DEGRONIMERS FOR PROTEIN DEGRADATION
|
|
CN109111437B
(zh)
*
|
2017-06-22 |
2022-03-04 |
中国科学院广州生物医药与健康研究院 |
一种苯并[d]异恶唑类化合物及其制备方法和应用
|
|
CN109280046B
(zh)
*
|
2017-07-21 |
2021-02-02 |
浙江海正药业股份有限公司 |
苯并咪唑类衍生物及其制备方法及其在医药上的用途
|
|
KR102651947B1
(ko)
*
|
2017-08-04 |
2024-03-26 |
브리스톨-마이어스 스큅 컴퍼니 |
Tlr7/8/9의 억제제로서 유용한 치환된 인돌 화합물
|
|
US20210038602A1
(en)
*
|
2018-01-25 |
2021-02-11 |
Boehringer Ingelheim International Gmbh |
Combination treatment of acute myeloid leukemia
|
|
JP2021512153A
(ja)
|
2018-01-26 |
2021-05-13 |
イエール ユニバーシティ |
タンパク質分解のイミド系モジュレーターおよび使用方法
|
|
US10442799B1
(en)
|
2018-04-07 |
2019-10-15 |
Fuqiang Ruan |
Heterocyclic compounds and uses thereof
|
|
MX2020010571A
(es)
|
2018-04-13 |
2021-01-08 |
Arvinas Operations Inc |
Ligandos de cereblon y compuestos bifuncionales que los comprenden.
|
|
EP3897631A4
(en)
|
2018-12-20 |
2022-11-23 |
C4 Therapeutics, Inc. |
TARGETED PROTEIN BREAKDOWN
|
|
JP2022053557A
(ja)
*
|
2019-02-08 |
2022-04-06 |
マルホ株式会社 |
ピリドン誘導体
|
|
WO2020219168A1
(en)
*
|
2019-04-24 |
2020-10-29 |
Convergene, Llc |
Small molecule bromodomain inhibitors and uses thereof
|
|
JP7642552B2
(ja)
|
2019-09-30 |
2025-03-10 |
協和キリン株式会社 |
Bet分解剤
|
|
WO2021127443A1
(en)
|
2019-12-19 |
2021-06-24 |
Arvinas Operations, Inc. |
Compounds and methods for the targeted degradation of androgen receptor
|
|
WO2021175432A1
(en)
|
2020-03-04 |
2021-09-10 |
Boehringer Ingelheim International Gmbh |
Method for administration of an anti cancer agent
|
|
WO2024050016A1
(en)
|
2022-08-31 |
2024-03-07 |
Oerth Bio Llc |
Compositions and methods for targeted inhibition and degradation of proteins in an insect cell
|
|
WO2025049555A1
(en)
|
2023-08-31 |
2025-03-06 |
Oerth Bio Llc |
Compositions and methods for targeted inhibition and degradation of proteins in an insect cell
|