JP2016515560A5 - - Google Patents

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Publication number
JP2016515560A5
JP2016515560A5 JP2016504660A JP2016504660A JP2016515560A5 JP 2016515560 A5 JP2016515560 A5 JP 2016515560A5 JP 2016504660 A JP2016504660 A JP 2016504660A JP 2016504660 A JP2016504660 A JP 2016504660A JP 2016515560 A5 JP2016515560 A5 JP 2016515560A5
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JP
Japan
Prior art keywords
alkyl
compound according
compound
optionally substituted
pyridyl
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JP2016504660A
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English (en)
Japanese (ja)
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JP2016515560A (ja
JP6370368B2 (ja
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Priority claimed from PCT/EP2014/056079 external-priority patent/WO2014154760A1/en
Publication of JP2016515560A publication Critical patent/JP2016515560A/ja
Publication of JP2016515560A5 publication Critical patent/JP2016515560A5/ja
Application granted granted Critical
Publication of JP6370368B2 publication Critical patent/JP6370368B2/ja
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JP2016504660A 2013-03-27 2014-03-26 Brd4阻害剤としてのインドリノン類似体 Active JP6370368B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13161486.9 2013-03-27
EP13161486 2013-03-27
PCT/EP2014/056079 WO2014154760A1 (en) 2013-03-27 2014-03-26 Indolinone analogues as brd4 inhibitors

Publications (3)

Publication Number Publication Date
JP2016515560A JP2016515560A (ja) 2016-05-30
JP2016515560A5 true JP2016515560A5 (enExample) 2017-04-27
JP6370368B2 JP6370368B2 (ja) 2018-08-08

Family

ID=47997211

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2016504660A Active JP6370368B2 (ja) 2013-03-27 2014-03-26 Brd4阻害剤としてのインドリノン類似体

Country Status (4)

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US (1) US9102684B2 (enExample)
EP (1) EP2978757B1 (enExample)
JP (1) JP6370368B2 (enExample)
WO (1) WO2014154760A1 (enExample)

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US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
WO2014080291A2 (en) 2012-11-21 2014-05-30 Rvx Therapeutics Inc. Biaryl derivatives as bromodomain inhibitors
MX2015007921A (es) 2012-12-21 2016-03-03 Zenith Epigenetics Corp Compuestos heterociclicos novedosos como inhibidores de bromodominio.
MX366703B (es) 2013-03-15 2019-07-22 Incyte Holdings Corp Heterociclos tricíclicos como inhibidores de la proteína bet.
CA2901083A1 (en) * 2013-04-26 2014-10-30 Beigene, Ltd. Substituted 5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones
WO2015004534A2 (en) 2013-06-21 2015-01-15 Zenith Epigenetics Corp. Novel substituted bicyclic compounds as bromodomain inhibitors
CN105407888B (zh) 2013-06-21 2019-05-21 齐尼思表观遗传学有限公司 新双环溴结构域抑制剂
WO2015006193A1 (en) 2013-07-08 2015-01-15 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
JP6542212B2 (ja) 2013-07-31 2019-07-10 ゼニス・エピジェネティクス・リミテッドZenith Epigenetics Ltd. ブロモドメイン阻害剤としての新規キナゾリノン
WO2015081189A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9399640B2 (en) 2013-11-26 2016-07-26 Incyte Corporation Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors
US9309246B2 (en) 2013-12-19 2016-04-12 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
SI3674302T1 (sl) 2014-04-23 2023-07-31 Incyte Holdings Corporation 1h-pirolo(2,3-c)piridin-7(6h)-oni in pirazolo(3,4-c)piridin-7(6h)-oni kot zaviralci proteinov bet
US9902702B2 (en) * 2014-07-15 2018-02-27 Bristol-Myers Squibb Company Spirocycloheptanes as inhibitors of rock
ES2855225T3 (es) 2014-09-15 2021-09-23 Incyte Corp Heterociclos tricíclicos para su uso como inhibidores de proteínas BET
JP6788584B2 (ja) 2014-10-31 2020-11-25 マサチューセッツ インスティテュート オブ テクノロジー Crisprについての超並列コンビナトリアル遺伝学
CA2966303A1 (en) * 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridines as bromodomain inhibitors
CA2966298A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Ltd. Substituted pyridinones as bromodomain inhibitors
WO2016092375A1 (en) 2014-12-11 2016-06-16 Zenith Epigenetics Corp. Substituted heterocycles as bromodomain inhibitors
CN107406438B (zh) 2014-12-17 2021-05-14 恒翼生物医药科技(上海)有限公司 溴结构域的抑制剂
AU2016279965A1 (en) * 2015-06-16 2018-02-08 Orion Corporation Spiro[cyclobutane-1,3'-indolin]-2'-one derivatives as bromodomain inhibitors
WO2016203335A1 (en) 2015-06-18 2016-12-22 Pfizer Inc. Novel pyrido[2,3-b]pyrazinones as bet-family bromodomain inhibitors
US20170121347A1 (en) 2015-10-29 2017-05-04 Incyte Corporation Amorphous solid form of a bet protein inhibitor
CR20190027A (es) 2016-06-20 2019-05-16 Incyte Corp Formas sólidas cristalinas de un inhibidor de bet
WO2018109271A1 (en) * 2016-12-13 2018-06-21 Orion Corporation New bromodomain inhibitors
CN107739370B (zh) * 2017-10-26 2021-03-30 中国药科大学 吡咯酮类brd4蛋白抑制剂的制备方法以及用途
CN109928979B (zh) * 2017-12-15 2021-08-06 四川科伦博泰生物医药股份有限公司 吲哚酮类衍生物及其制备方法和用途
CN108383771A (zh) * 2018-01-08 2018-08-10 华东师范大学 手性3,3-二取代异吲哚啉-1-酮衍生物及其合成方法和应用
US11931343B2 (en) 2018-08-27 2024-03-19 Arcus Biosciences, Inc. CD73 inhibitors
US11396502B2 (en) 2018-11-13 2022-07-26 Incyte Corporation Substituted heterocyclic derivatives as PI3K inhibitors
US11161838B2 (en) 2018-11-13 2021-11-02 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
US11078204B2 (en) 2018-11-13 2021-08-03 Incyte Corporation Heterocyclic derivatives as PI3K inhibitors
SG11202110714VA (en) * 2019-04-09 2021-10-28 Plexxikon Inc Condensed azines for ep300 or cbp modulation and indications therefor
AU2020360170A1 (en) 2019-09-30 2022-05-19 Kyowa Kirin Co., Ltd. Bet degrader
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
EP3912625A1 (en) 2020-05-20 2021-11-24 Kaerus Bioscience Limited Novel maxi-k potassium channel openers for the treatment of fragile x associated disorders
US11833155B2 (en) 2020-06-03 2023-12-05 Incyte Corporation Combination therapy for treatment of myeloproliferative neoplasms
JP2025529185A (ja) * 2022-08-30 2025-09-04 パンネックス セラピューティクス インコーポレイテッド パネキシン-1調節剤及びパネキシン-1が関与する疾患の治療方法
WO2025233532A1 (en) 2024-05-10 2025-11-13 Les Laboratoires Servier Maxi-k potassium channel openers and therapeutic applications thereof

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GB0919423D0 (en) * 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds

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