SG11201506924YA - Tricyclic heterocycles as bet protein inhibitors - Google Patents

Tricyclic heterocycles as bet protein inhibitors

Info

Publication number
SG11201506924YA
SG11201506924YA SG11201506924YA SG11201506924YA SG11201506924YA SG 11201506924Y A SG11201506924Y A SG 11201506924YA SG 11201506924Y A SG11201506924Y A SG 11201506924YA SG 11201506924Y A SG11201506924Y A SG 11201506924YA SG 11201506924Y A SG11201506924Y A SG 11201506924YA
Authority
SG
Singapore
Prior art keywords
protein inhibitors
bet protein
tricyclic heterocycles
tricyclic
heterocycles
Prior art date
Application number
SG11201506924YA
Inventor
Andrew P Combs
Richard B Sparks
Thomas P Maduskuie Jr
James D Rodgers
Original Assignee
Incyte Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to US201361794812P priority Critical
Application filed by Incyte Corp filed Critical Incyte Corp
Priority to PCT/US2014/027872 priority patent/WO2014143768A1/en
Publication of SG11201506924YA publication Critical patent/SG11201506924YA/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06Peri-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/06Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D498/00Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16Peri-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
SG11201506924YA 2013-03-15 2014-03-14 Tricyclic heterocycles as bet protein inhibitors SG11201506924YA (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
US201361794812P true 2013-03-15 2013-03-15
PCT/US2014/027872 WO2014143768A1 (en) 2013-03-15 2014-03-14 Tricyclic heterocycles as bet protein inhibitors

Publications (1)

Publication Number Publication Date
SG11201506924YA true SG11201506924YA (en) 2015-09-29

Family

ID=50639971

Family Applications (2)

Application Number Title Priority Date Filing Date
SG11201506924YA SG11201506924YA (en) 2013-03-15 2014-03-14 Tricyclic heterocycles as bet protein inhibitors
SG10201707487VA SG10201707487VA (en) 2013-03-15 2014-03-14 Tricyclic heterocycles as bet protein inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG10201707487VA SG10201707487VA (en) 2013-03-15 2014-03-14 Tricyclic heterocycles as bet protein inhibitors

Country Status (20)

Country Link
US (3) US9227985B2 (en)
EP (1) EP2970282B1 (en)
JP (3) JP6243003B2 (en)
KR (1) KR20150136497A (en)
CN (2) CN105164131B (en)
AR (1) AR095326A1 (en)
AU (1) AU2014228175B2 (en)
BR (1) BR112015022942A2 (en)
CA (1) CA2903881A1 (en)
CL (1) CL2015002734A1 (en)
CR (1) CR20150513A (en)
EA (1) EA201591785A1 (en)
HK (1) HK1218650A1 (en)
IL (2) IL241158A (en)
MX (1) MX366703B (en)
PE (1) PE19902015A1 (en)
PH (1) PH12015502157A1 (en)
SG (2) SG11201506924YA (en)
TW (2) TW201930303A (en)
WO (1) WO2014143768A1 (en)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
JP6437452B2 (en) 2013-01-14 2018-12-12 インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
BR112015016793A2 (en) 2013-01-15 2017-07-11 Incyte Corp thiazolecarboxamides and pyridinecarboxamide compounds useful as pim kinase inhibitors
BR112015022942A2 (en) 2013-03-15 2017-07-18 Incyte Corp tricyclic heterocycles as inhibitors of bet protein
CN105473581B (en) 2013-06-21 2019-04-23 齐尼思表观遗传学有限公司 The dicyclic compound newly replaced as bromine structural domain inhibitor
AU2014284616B2 (en) 2013-06-21 2019-02-28 Zenith Epigenetics Ltd. Novel bicyclic bromodomain inhibitors
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
EA201690087A1 (en) 2013-07-31 2016-08-31 Зенит Эпидженетикс Корп. New quinazolinons as bromomodenial inhibitors
EP3036238A1 (en) 2013-08-23 2016-06-29 Incyte Corporation Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
CR20160542A (en) 2014-04-23 2017-04-25 Incyte Corp 1H-pyrrolo [2,3-c] pyridin-7 (6H) -ones YPIRAZOLO [3,4-c] PlRIDIN-7 (6H) -ones PROTEINS AS INHIBITORS BET
US9822124B2 (en) 2014-07-14 2017-11-21 Incyte Corporation Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors
US9580418B2 (en) 2014-07-14 2017-02-28 Incyte Corporation Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
WO2016087942A1 (en) 2014-12-01 2016-06-09 Zenith Epigenetics Corp. Substituted pyridines as bromodomain inhibitors
EP3230277B1 (en) 2014-12-11 2019-09-18 Zenith Epigenetics Ltd. Substituted heterocycles as bromodomain inhibitors
US10231953B2 (en) 2014-12-17 2019-03-19 Zenith Epigenetics Ltd. Inhibitors of bromodomains
CN105985282A (en) * 2015-01-28 2016-10-05 中国科学院广州生物医药与健康研究院 2-oxo-1,2-dihydrobenzo[cd]indole compound and application thereof
GB201504694D0 (en) 2015-03-19 2015-05-06 Glaxosmithkline Ip Dev Ltd Covalent conjugates
US9540347B2 (en) 2015-05-29 2017-01-10 Incyte Corporation Pyridineamine compounds useful as Pim kinase inhibitors
JP2018526393A (en) 2015-09-08 2018-09-13 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Tricyclic PI3K inhibitor compounds and methods of use
TW201722927A (en) 2015-09-09 2017-07-01 英塞特公司 Salts of a PIM kinase inhibitor
WO2017059251A1 (en) 2015-10-02 2017-04-06 Incyte Corporation Heterocyclic compounds useful as pim kinase inhibitors
TW201722966A (en) 2015-10-29 2017-07-01 英塞特公司 Amorphous solid form of a BET protein inhibitor
EP3412669A4 (en) * 2016-02-05 2019-09-04 Chia Tai Tianqing Pharmaceutical Group Co Ltd Tricyclic compound for bromodomain-containing protein inhibitor and preparation, pharmaceutical composition, and application thereof
TW201800410A (en) 2016-06-20 2018-01-01 英塞特公司 Crystalline solid forms of a BET inhibitor

Family Cites Families (135)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0314566A (en) * 1989-06-09 1991-01-23 Sankyo Co Ltd Benzimidazole derivative
US5244912A (en) * 1991-03-28 1993-09-14 Eli Lilly And Company 6-heterocyclic-4-amino-1,3,4,5-tetrahydrobenz(cd)indoles and pharmaceutical use thereof
FR2710915B1 (en) 1993-10-04 1995-11-24 Synthelabo piperidine derivatives, their preparation and their use in therapy.
FR2731708B1 (en) * 1995-03-13 1997-04-30 Synthelabo Piperidine derivatives, method of preparing them and their application in therapeutic
FR2747678B1 (en) 1996-04-22 1998-05-22 Synthelabo Compounds derived from imidazobenzoxazine, their preparation processes and their therapeutic uses
AU2001253114B2 (en) 2000-04-21 2005-08-25 Pharmacia & Upjohn Company Llc Compounds for treating fibromyalgia and chronic fatigue syndrome
SI1294358T1 (en) 2000-06-28 2004-12-31 Smithkline Beecham Plc Wet milling process
KR20030020450A (en) * 2000-08-08 2003-03-08 사노피-신델라보 Benzimidazole derivatives, preparation and therapeutic use thereof
US6919334B2 (en) 2002-09-12 2005-07-19 Wyeth Antidepressant azaheterocyclymethyl derivatives of 4,5-dihydroimidazo[1,4,5-de][1,4]benzoxazine
NZ539952A (en) 2002-11-22 2008-05-30 Japan Tobacco Inc Fused bicyclic nitrogen-containing heterocyclic compounds for treating diabetes, obesity and syndrome X
EP1462103A1 (en) 2003-03-25 2004-09-29 Faust Pharmaceuticals NO donors, combination products and uses as modulators of neurotransmitter release
JPWO2005080334A1 (en) * 2004-02-23 2007-08-02 大日本住友製薬株式会社 New heterocyclic compounds
DE102005011058A1 (en) * 2005-03-10 2006-09-14 Merck Patent Gmbh Substituted tetrahydro-pyrrolo-quinoline derivatives
KR20080035576A (en) 2005-08-05 2008-04-23 아스트라제네카 아베 Tricyclic benzimidazoles and their use as metabotropic glutamate receptor modulators
US8975259B2 (en) 2007-04-27 2015-03-10 University Of Rochester Compositions and methods for inhibiting G protein signaling
US7928111B2 (en) 2007-06-08 2011-04-19 Senomyx, Inc. Compounds including substituted thienopyrimidinone derivatives as ligands for modulating chemosensory receptors
US8633186B2 (en) 2007-06-08 2014-01-21 Senomyx Inc. Modulation of chemosensory receptors and ligands associated therewith
US9603848B2 (en) 2007-06-08 2017-03-28 Senomyx, Inc. Modulation of chemosensory receptors and ligands associated therewith
WO2009020559A2 (en) 2007-08-03 2009-02-12 The J. David Gladstone Institutes Agents that inhibit p-tefb interactions and methods of use thereof
JP5478262B2 (en) 2007-12-28 2014-04-23 田辺三菱製薬株式会社 Anticancer drug
DE102008052618A1 (en) 2008-10-21 2010-04-22 Henkel Ag & Co. Kgaa Tricyclic aldehydes and C, H-acidic compounds
WO2010111626A2 (en) 2009-03-27 2010-09-30 Takeda Pharmaceutical Company Limited Poly (adp-ribose) polymerase (parp) inhibitors
TW201103941A (en) * 2009-06-10 2011-02-01 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as TRPM8 channel modulators
TW201105681A (en) * 2009-06-10 2011-02-16 Janssen Pharmaceutica Nv Benzimidazole derivatives useful as TRPM8 channel modulators
GB0919432D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Use
WO2011054851A1 (en) 2009-11-05 2011-05-12 Glaxosmithkline Llc Novel process
GB0919426D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
EA023441B1 (en) 2009-11-05 2016-06-30 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Benzodiazepine inhibitor bromodomain
GB0919434D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
HUE026421T2 (en) 2009-11-05 2016-05-30 Glaxosmithkline Llc Benzodiazepine bromodomain inhibitor
GB0919431D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
CA2812043A1 (en) 2010-04-23 2011-10-27 Kineta, Inc. Pyrimidinedione anti-viral compounds
EP2569429A4 (en) 2010-05-14 2013-09-25 Dana Farber Cancer Inst Inc Compositions and methods for modulating metabolism
EP2571875A4 (en) 2010-05-14 2013-10-30 Dana Farber Cancer Inst Inc Male contraceptive compositions and methods of use
BR112012029005A2 (en) 2010-05-14 2016-07-26 Dana Farber Cancer Inst Inc compositions and methods of treating cancer, inflammatory disease and other disorders
CA2799403A1 (en) 2010-05-14 2011-11-17 Dana-Farber Cancer Institute, Inc. Compositions and methods for treating leukemia
JP5844358B2 (en) 2010-06-22 2016-01-13 グラクソスミスクライン エルエルシー Bromodomain inhibitors containing benzotriazolodiazepine compounds
US9249161B2 (en) 2010-12-02 2016-02-02 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
AR084070A1 (en) 2010-12-02 2013-04-17 Constellation Pharmaceuticals Inc The bromodomain inhibitors and uses thereof
RU2013138835A (en) 2011-02-09 2015-03-20 Ф. Хоффманн-Ля Рош Аг Heterocyclic compounds as pi3 kinase inhibitors
EP2677865A4 (en) 2011-02-23 2015-04-22 Icahn School Med Mount Sinai Inhibitors of bromodomains as modulators of gene expression
GB201106799D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106743D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
GB201106750D0 (en) 2011-04-21 2011-06-01 Glaxosmithkline Llc Novel compounds
US9422292B2 (en) 2011-05-04 2016-08-23 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
GB201107325D0 (en) 2011-05-04 2011-06-15 Glaxosmithkline Llc Novel compounds
EP2721031B1 (en) 2011-06-17 2016-01-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
EP2723338A2 (en) 2011-06-24 2014-04-30 The Trustees of Stevens Institute of Technology Selective inhibitors of histone deacetylase isoform 6 and methods thereof
JP2013010719A (en) 2011-06-30 2013-01-17 Dainippon Sumitomo Pharma Co Ltd Benzimidazolone and oxindole derivative, and pharmaceutical application of them
EP2736528A4 (en) 2011-07-29 2015-03-18 Philadelphia Children Hospital Compositions and methods for the treatment of hiv
GB201114103D0 (en) 2011-08-17 2011-09-28 Glaxosmithkline Llc Novel compounds
WO2013027168A1 (en) 2011-08-22 2013-02-28 Pfizer Inc. Novel heterocyclic compounds as bromodomain inhibitors
WO2013033269A1 (en) 2011-08-29 2013-03-07 Coferon, Inc. Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same
WO2013033270A2 (en) 2011-08-29 2013-03-07 Coferon, Inc. Bromodomain ligands capable of dimerizing in an aqueous solution, and methods of using same
AU2012303954B2 (en) * 2011-08-31 2017-06-22 Otsuka Pharmaceutical Co., Ltd. Quinolone compound
DE102011082013A1 (en) 2011-09-01 2013-03-07 Bayer Pharma AG 6H-thieno [3,2-f] [1,2,4] triazolo [4,3-a] [1,4] diazepines
EP2757887B1 (en) 2011-09-22 2017-04-26 VIIV Healthcare UK Limited Pyrrolopyridinone compounds and methods for treating hiv
WO2013044511A1 (en) 2011-09-30 2013-04-04 沈阳蓝桑医药生物技术研发有限公司 Pharmaceutical composition containing riligustilide and use thereof
JP5992049B2 (en) 2011-11-01 2016-09-14 レスバーロジックス コーポレイション Oral immediate release formulations for substituted quinazolinones
WO2013097052A1 (en) 2011-12-30 2013-07-04 Abbott Laboratories Bromodomain inhibitors
EP2830629A4 (en) 2012-03-28 2016-01-20 Icahn School Of Medicine Mount Sinai Compositions and methods for reactivating latent immunodeficiency virus
US20130281397A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
US20130281396A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
US20130281399A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
US20130281398A1 (en) 2012-04-19 2013-10-24 Rvx Therapeutics Inc. Treatment of diseases by epigenetic regulation
EP2838881B1 (en) 2012-04-20 2018-08-08 AbbVie Inc. Isoindolone derivatives
TWI602820B (en) 2012-06-06 2017-10-21 星宿藥物公司 Bromodomain inhibitors and uses thereof
US9624244B2 (en) 2012-06-06 2017-04-18 Constellation Pharmaceuticals, Inc. Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof
SG11201408324QA (en) 2012-06-12 2015-01-29 Abbvie Inc Pyridinone and pyridazinone derivatives
WO2014001356A1 (en) 2012-06-25 2014-01-03 Oncoethix Sa Method of treating lymphoma using thienotriazolodiazepine compounds
US9610332B2 (en) 2012-07-18 2017-04-04 Massachusetts Institute Of Technology Compositions and methods for modulating BRD4 bioactivity
JP2015524847A (en) 2012-08-16 2015-08-27 グラクソスミスクライン・リミテッド・ライアビリティ・カンパニーGlaxoSmithKline LLC Benzodiazepines for treating small cell lung cancer
ES2628005T3 (en) 2012-08-16 2017-08-01 Bayer Pharma AG 2,3-Benzodiazepines
CN104781259B (en) 2012-09-28 2018-06-01 拜耳制药股份公司 Inhibit the 5- aryl triazoles and azepine * of BET albumen
CN104968334B (en) 2012-09-28 2018-09-14 翁科埃斯克斯有限公司 Include the pharmaceutical preparation of thieno triazol diazepine compound
US9422290B2 (en) 2012-11-13 2016-08-23 Boehringer Ingelheim International Gmbh Triazolopyridazine
WO2014078257A1 (en) 2012-11-14 2014-05-22 Glaxosmithkline Llc Thieno[3,2-c]pyridin-4(5h)-ones as bet inhibitors
US9765039B2 (en) 2012-11-21 2017-09-19 Zenith Epigenetics Ltd. Biaryl derivatives as bromodomain inhibitors
US9073878B2 (en) 2012-11-21 2015-07-07 Zenith Epigenetics Corp. Cyclic amines as bromodomain inhibitors
CA2895404A1 (en) 2012-12-20 2014-06-26 Bayer Pharma Aktiengesellschaft Bet-protein-inhibiting dihydropyridopyrazinones
WO2014095775A1 (en) 2012-12-20 2014-06-26 Bayer Pharma Aktiengesellschaft Bet-protein-inhibiting dihydroquinoxalinones
US9271978B2 (en) 2012-12-21 2016-03-01 Zenith Epigenetics Corp. Heterocyclic compounds as bromodomain inhibitors
WO2014128655A1 (en) 2013-02-25 2014-08-28 Aurigene Discovery Technologies Limited Substituted imidazo[4,5-c]quinoline derivatives as bromodomain inhibitors
JP6404838B2 (en) 2013-02-27 2018-10-17 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
US9492460B2 (en) 2013-02-27 2016-11-15 Bristol-Myers Squibb Company Carbazole compounds useful as bromodomain inhibitors
WO2014164596A1 (en) 2013-03-11 2014-10-09 The Regents Of The University Of Michigan Bet bromodomain inhibitors and therapeutic methods using the same
EP2970285B1 (en) 2013-03-11 2019-04-17 AbbVie Inc. Fused tetracyclic bromodomain inhibitors
EP2970262A1 (en) 2013-03-11 2016-01-20 AbbVie Inc. Bromodomain inhibitors
CN105164130A (en) 2013-03-12 2015-12-16 艾伯维公司 Dihydro-pyrrolopyridinone bromodomain inhibitors
RU2015143192A (en) 2013-03-12 2017-04-17 Эббви Инк. Tetracyclic bromodomain inhibitors
WO2014165127A1 (en) 2013-03-12 2014-10-09 Abbvie Inc. Pyrrole amide inhibitors
EP3511323A1 (en) 2013-03-14 2019-07-17 GlaxoSmithKline Intellectual Property (No.2) Limited 2,3-disubstituted 1-acyl-4-amino-1,2,3,4-tetrahydroquinoline derivatives and their use as bromodomain inhibitors
WO2014140077A1 (en) 2013-03-14 2014-09-18 Glaxosmithkline Intellectual Property (No.2) Limited Furopyridines as bromodomain inhibitors
US9695179B2 (en) 2013-03-14 2017-07-04 Convergene Llc Methods and compositions for inhibition of bromodomain-containing proteins
US9714946B2 (en) 2013-03-14 2017-07-25 Dana-Farber Cancer Institute, Inc. Bromodomain binding reagents and uses thereof
KR20150128839A (en) 2013-03-15 2015-11-18 플렉시콘, 인코퍼레이티드 Heterocyclic compounds and uses thereof
AU2014236606A1 (en) 2013-03-15 2015-09-24 Epigenetix, Inc. Oxazolo(5,4-c)quinolin-2-one compounds as bromodomain inhibitors
BR112015022942A2 (en) 2013-03-15 2017-07-18 Incyte Corp tricyclic heterocycles as inhibitors of bet protein
EP2978757B1 (en) 2013-03-27 2017-02-08 Boehringer Ingelheim International GmbH Indolinone analogues as brd4 inhibitors
WO2014154762A1 (en) 2013-03-27 2014-10-02 Boehringer Ingelheim International Gmbh Dihydroquinazolinone analogues as brd4 inhibitors
TWI530499B (en) 2013-03-28 2016-04-21 Gilead Sciences Inc As Bromodomain (Bromodomain) benz imidazolone derivatives of inhibitors
EP2996689A1 (en) 2013-04-17 2016-03-23 Albert-Ludwigs-Universität Freiburg Compounds for use as bromodomain inhibitors
MX366623B (en) 2013-04-26 2019-07-16 Beigene Ltd Substituted5-(3,5-dimethylisoxazol-4-yl)indoline-2-ones.
TWI527811B (en) 2013-05-09 2016-04-01 Gilead Sciences Inc Benzimidazole derivatives as inhibitors of the bromodomain
CN105209467B (en) 2013-05-27 2018-06-08 诺华股份有限公司 Imidazo pyrrolidinone derivatives and its purposes in disease is treated
US8975417B2 (en) 2013-05-27 2015-03-10 Novartis Ag Pyrazolopyrrolidine derivatives and their use in the treatment of disease
AU2014272700B2 (en) 2013-05-28 2016-12-01 Novartis Ag Pyrazolo-pyrrolidin-4-one derivatives and their use in the treatment of disease
JP2016520118A (en) 2013-05-28 2016-07-11 ノバルティス アーゲー Pyrazolo-pyrrolidin-4-one derivatives as BET inhibitors and their use in the treatment of diseases
EP3010909A1 (en) 2013-06-17 2016-04-27 Bayer Pharma Aktiengesellschaft Substituted phenyl-2,3-benzodiazepines
AU2014284616B2 (en) 2013-06-21 2019-02-28 Zenith Epigenetics Ltd. Novel bicyclic bromodomain inhibitors
CN105473581B (en) 2013-06-21 2019-04-23 齐尼思表观遗传学有限公司 The dicyclic compound newly replaced as bromine structural domain inhibitor
AR096758A1 (en) 2013-06-28 2016-02-03 Abbvie Inc crystalline inhibitors bromodominios
CN105518007A (en) 2013-06-28 2016-04-20 艾伯维公司 Bromodomain inhibitors
EP3019502B1 (en) 2013-07-08 2017-05-17 Incyte Holdings Corporation Tricyclic heterocycles as bet protein inhibitors
US9975896B2 (en) 2013-07-25 2018-05-22 Dana-Farber Cancer Institute, Inc. Inhibitors of transcription factors and uses thereof
KR101672096B1 (en) 2013-09-30 2016-11-02 주식회사 엘지화학 Heterocyclic compound and organic light emitting device comprising the same
US9315501B2 (en) 2013-11-26 2016-04-19 Incyte Corporation Bicyclic heterocycles as BET protein inhibitors
WO2015081246A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015081203A1 (en) 2013-11-26 2015-06-04 Incyte Corporation Bicyclic heterocycles as bet protein inhibitors
WO2015095492A1 (en) 2013-12-19 2015-06-25 Incyte Corporation Tricyclic heterocycles as bet protein inhibitors
US9822107B2 (en) 2013-12-20 2017-11-21 Merck Sharp & Dohme Corp. Thiazole-substituted aminoheteroaryls as spleen tyrosine kinase inhibitors
CR20160542A (en) 2014-04-23 2017-04-25 Incyte Corp 1H-pyrrolo [2,3-c] pyridin-7 (6H) -ones YPIRAZOLO [3,4-c] PlRIDIN-7 (6H) -ones PROTEINS AS INHIBITORS BET
MX2016014299A (en) 2014-05-02 2017-01-27 Oncoethix Gmbh Method of treating resistant non-hodgkin lymphoma, medulloblastoma, and/or alk+non-small cell lung cancer using thienotriazolodiazepine compounds.
EP3137085A4 (en) 2014-05-02 2017-12-27 Oncoethix GmbH Method of treating acute myeloid leukemia and/or acute lymphoblastic leukemia using thienotriazolodiazepine compounds
WO2015169953A1 (en) 2014-05-08 2015-11-12 Oncoethix Gmbh Method of treating glioma using thienotriazolodiazepine compounds
EP3139959A1 (en) 2014-05-08 2017-03-15 Oncoethix GmbH Method of treating triple-negative breast cancer using thienotriazolodiazepine compounds
EP3148543A4 (en) 2014-05-30 2018-01-24 Icahn School of Medicine at Mount Sinai Small molecule transcription modulators of bromodomains
US9527864B2 (en) 2014-09-15 2016-12-27 Incyte Corporation Tricyclic heterocycles as BET protein inhibitors
JP2017533248A (en) 2014-11-10 2017-11-09 ジェネンテック, インコーポレイテッド Substituted pyrrolopyridines as inhibitors of bromodomains
CA2987384A1 (en) 2015-05-29 2016-12-08 Shionogi & Co., Ltd. Nitrogen-containing tricyclic derivative having hiv replication inhibitory activity
TW201722966A (en) 2015-10-29 2017-07-01 英塞特公司 Amorphous solid form of a BET protein inhibitor
US20170127985A1 (en) 2015-11-11 2017-05-11 Medtronic Minimed, Inc. Sensor set
WO2017127930A1 (en) 2016-01-28 2017-08-03 Neomed Institute Substituted [1,2,4]triazolo[4,3-a]pyridines, their preparation and their use as pharmaceuticals
EP3412669A4 (en) 2016-02-05 2019-09-04 Chia Tai Tianqing Pharmaceutical Group Co Ltd Tricyclic compound for bromodomain-containing protein inhibitor and preparation, pharmaceutical composition, and application thereof

Also Published As

Publication number Publication date
TWI667238B (en) 2019-08-01
BR112015022942A2 (en) 2017-07-18
MX2015013149A (en) 2016-01-08
PE19902015A1 (en) 2016-01-13
US9227985B2 (en) 2016-01-05
JP6243003B2 (en) 2017-12-06
IL241158D0 (en) 2015-11-30
AR095326A1 (en) 2015-10-07
IL267609D0 (en) 2019-08-29
MX366703B (en) 2019-07-22
CR20150513A (en) 2016-01-04
EA201591785A1 (en) 2015-12-30
EP2970282B1 (en) 2019-08-21
CN105164131B (en) 2018-12-28
US20140275030A1 (en) 2014-09-18
WO2014143768A1 (en) 2014-09-18
CA2903881A1 (en) 2014-09-18
PH12015502157A1 (en) 2016-01-25
CN105164131A (en) 2015-12-16
US9938294B2 (en) 2018-04-10
CN109593096A (en) 2019-04-09
TW201930303A (en) 2019-08-01
EP2970282A1 (en) 2016-01-20
SG10201707487VA (en) 2017-10-30
IL241158A (en) 2019-07-31
KR20150136497A (en) 2015-12-07
JP6529546B2 (en) 2019-06-12
TW201512198A (en) 2015-04-01
AU2014228175B2 (en) 2018-05-31
JP2019142973A (en) 2019-08-29
JP2016513716A (en) 2016-05-16
US20170210754A1 (en) 2017-07-27
US20180346481A1 (en) 2018-12-06
HK1218650A1 (en) 2017-03-03
JP2018008958A (en) 2018-01-18
AU2014228175A1 (en) 2015-10-08
US9624241B2 (en) 2017-04-18
CL2015002734A1 (en) 2016-03-28
US20160046650A1 (en) 2016-02-18

Similar Documents

Publication Publication Date Title
GB201311001D0 (en) Lucabella
EP3010503A4 (en) Novel bicyclic bromodomain inhibitors
HK1222646A1 (en) Benzimidazole derivatives as bromodomain inhibitors
EP2943204A4 (en) Beta-lactamase inhibitors
EP2970340A4 (en) Beta-lactamase inhibitors
RU2015137103A (en) Furopyridines as Bromodomain Inhibitors
RU2015143192A (en) Tetracyclic bromodomain inhibitors
EP3027604A4 (en) Novel quinazolinones as bromodomain inhibitors
IL243371D0 (en) Bromodomain inhibitors
IL241158D0 (en) Tricyclic heterocycles as bet protein inhibitors
HK1218909A1 (en) Dihydro pyrrolopyridinone bromodomain inhibitors
AU354793S (en) Lighting
SG11201510692TA (en) Crystalline bromodomain inhibitors
HK1222846A1 (en) Substituted benzylpyrazoles
HK1223617A1 (en) Tricyclic heterocycles as bet protein inhibitors bet
HK1221462A1 (en) Bicyclic heterocycles as fgfr inhibitors fgfr
IL256946A (en) Bromodomain inhibitors
PL2953956T3 (en) Heteropolyoxometalates
HK1221717A1 (en) Substituted benzylpyrazoles
AU350759S (en) Lighting
HK1221218A1 (en) Heterocyclic derivates
HK1211578A1 (en) Amidoimidazopyridazines as mknk-1 kinase inhibitors mknk-1
IL239827D0 (en) Methoblic triphosphatase inhibitors
AP201508713A0 (en) Tetrahydropyrrolothiazine compounds
HU4525U (en) Lamp